20092019
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Our lab uses cryogenic electron microscopy (cryo-EM) to elucidate the structure and dynamics of large macromolecules involved in processes of fundamental biological and medical importance. In addition, we develop new computational methods for solving the most challenging problems in cryo-EM image processing and integrative structural biology. Biological topics include cancer biology, transcription regulation and mRNA export. Cryo-EM images will be acquired at the newly established Clive and Vera Ramaciotti Centre for Structural Cryo-EM, housing the world-class FEI Titan KRIOS instrument.

Related Links:

  • http://simplecryoem.com

Keywords

  • electron microscopy
  • Transcription factors
  • transcription regulation
  • single-particle

Projects 2016 2019

Research Output 2009 2018

Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE

Reboul, C. F., Kiesewetter, S., Eager, M., Belousoff, M., Cui, T., De Sterck, H., Elmlund, D. & Elmlund, H., 1 Jan 2018, (Accepted/In press) In : Journal of Structural Biology. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-particle cryo-EM—Improved ab initio 3D reconstruction with SIMPLE/PRIME

Reboul, C. F., Eager, M., Elmlund, D. & Elmlund, H., 1 Jan 2018, In : Protein Science. 27, 1, p. 51-61 11 p.

Research output: Contribution to journalArticleResearchpeer-review

High-resolution cryo-EM: the nuts and bolts

Elmlund, D., Le, S. N. & Elmlund, H., 1 Oct 2017, In : Current Opinion in Structural Biology. 46, 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

A stochastic hill climbing approach for simultaneous 2D alignment and clustering of cryogenic electron microscopy images

Reboul, C. F., Bonnet, F., Elmlund, D. & Elmlund, H., 7 Jun 2016, In : Structure. 24, 6, p. 988-996 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cryogenic electron microscopy and single-particle analysis

Elmlund, D. A. & Elmlund, H. O., 2015, In : Annual Review of Biochemistry. 84, p. 499 - 517 19 p.

Research output: Contribution to journalArticleResearchpeer-review