20092019
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Personal profile

Biography

Our lab uses cryogenic electron microscopy (cryo-EM) to elucidate the structure and dynamics of large macromolecules involved in processes of fundamental biological and medical importance. In addition, we develop new computational methods for solving the most challenging problems in cryo-EM image processing and integrative structural biology. Biological topics include cancer biology, transcription regulation and mRNA export. Cryo-EM images will be acquired at the newly established Clive and Vera Ramaciotti Centre for Structural Cryo-EM, housing the world-class FEI Titan KRIOS instrument.

Related Links:

  • http://simplecryoem.com

Keywords

  • electron microscopy
  • Transcription factors
  • transcription regulation
  • single-particle

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Projects 2016 2019

Research Output 2009 2019

AgarFix: Simple and accessible stabilization of challenging single-particle cryo-EM specimens through crosslinking in a matrix of agar

Adamus, K., Le, S. N., Elmlund, H., Boudes, M. & Elmlund, D., 16 Jul 2019, (Accepted/In press) In : Journal of Structural Biology. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The TAFs of TFIID bind and rearrange the topology of the TATA-less RPS5 promoter

Le, S. N., Brown, C. R., Harvey, S., Boeger, H., Elmlund, H. & Elmlund, D., 4 Jul 2019, In : International Journal of Molecular Sciences. 20, 13, 12 p., 3290.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE

Reboul, C. F., Kiesewetter, S., Eager, M., Belousoff, M., Cui, T., De Sterck, H., Elmlund, D. & Elmlund, H., Nov 2018, In : Journal of Structural Biology. 204, 2, p. 172-181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-particle cryo-EM—Improved ab initio 3D reconstruction with SIMPLE/PRIME

Reboul, C. F., Eager, M., Elmlund, D. & Elmlund, H., 1 Jan 2018, In : Protein Science. 27, 1, p. 51-61 11 p.

Research output: Contribution to journalArticleResearchpeer-review

High-resolution cryo-EM: the nuts and bolts

Elmlund, D., Le, S. N. & Elmlund, H., 1 Oct 2017, In : Current Opinion in Structural Biology. 46, 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review