20092020

Research output per year

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Personal profile

Biography

Our lab uses cryogenic electron microscopy (cryo-EM) to elucidate the structure and dynamics of large macromolecules involved in processes of fundamental biological and medical importance. In addition, we develop new computational methods for solving the most challenging problems in cryo-EM image processing and integrative structural biology. Biological topics include cancer biology, transcription regulation and mRNA export. Cryo-EM images will be acquired at the newly established Clive and Vera Ramaciotti Centre for Structural Cryo-EM, housing the world-class FEI Titan KRIOS instrument.

Related Links:

  • http://simplecryoem.com

Research area keywords

  • electron microscopy
  • Transcription factors
  • transcription regulation
  • single-particle

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Projects

Research Output

Point-group symmetry detection in three-dimensional charge density of biomolecules

Reboul, C. F., Kiesewetter, S., Elmlund, D. & Elmlund, H., 1 Apr 2020, In : Bioinformatics. 36, 7, p. 2237-2243 7 p.

Research output: Contribution to journalArticleResearchpeer-review

AgarFix: Simple and accessible stabilization of challenging single-particle cryo-EM specimens through crosslinking in a matrix of agar

Adamus, K., Le, S. N., Elmlund, H., Boudes, M. & Elmlund, D., 1 Sep 2019, In : Journal of Structural Biology. 207, 3, p. 327-331 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The TAFs of TFIID bind and rearrange the topology of the TATA-less RPS5 promoter

Le, S. N., Brown, C. R., Harvey, S., Boeger, H., Elmlund, H. & Elmlund, D., 4 Jul 2019, In : International Journal of Molecular Sciences. 20, 13, 12 p., 3290.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE

Reboul, C. F., Kiesewetter, S., Eager, M., Belousoff, M., Cui, T., De Sterck, H., Elmlund, D. & Elmlund, H., Nov 2018, In : Journal of Structural Biology. 204, 2, p. 172-181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Single-particle cryo-EM—Improved ab initio 3D reconstruction with SIMPLE/PRIME

Reboul, C. F., Eager, M., Elmlund, D. & Elmlund, H., 1 Jan 2018, In : Protein Science. 27, 1, p. 51-61 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)