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Personal profile


Dr Dominic De Nardo received his PhD in 2009 from the University of Melbourne, Australia, where he developed a keen interest in macrophages and the innate immune system while working on mechanisms of Toll-like receptor activation. He then accepted a postdoctoral position with Professor Eicke Latz at the Institute of Innate Immunity in Bonn, Germany. During his postdoc Dominic identified the molecular mechanism underlying the ability of HDL to reduce inflammation, co-authored several studies published in journals such as Nature Immunology and Immunity and secured funding to lead a junior group. In 2014 he was awarded the Seymour and Vivian Milstein Young Investigator Award for notable contributions to basic research by the International Cytokine and Interferon Society (ICIS). Dominic returned to Melbourne in late 2014 to continue his research within the Inflammation Division at the Walter and Eliza Hall Institute of Medical Research. In 2019 he joined the lab of Professor Ben Kile within the Monash Biomedical Discovery Intsitute at Monash University.

Research interests

My research focuses on understanding the molecular mechanisms controlling activation and regulation of innate immune receptors and signaling pathways, and their roles in inflammation during health and disease. I have worked on numerous innate immune pathways including, Toll-like receptors, Inflammasomes and cytosolic nucleic acid sensing receptors.

Education/Academic qualification

Innate Immunity, PhD, University of Melbourne

Macrophage Biology, BSc (Hons), University of Melbourne

Genetics, Biochemistry and Molecular Biology, BSc, University of Melbourne

Research area keywords

  • Innate Immunity
  • Toll-like receptor
  • Inflammasomes
  • Macrophages
  • Signalling pathways

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Research Output 2005 2019

6 Citations (Scopus)

Understanding early TLR signaling through the Myddosome

Balka, K. R. & De Nardo, D., 1 Feb 2019, In : Journal of leukocyte biology. 105, 2, p. 339-351 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

A mutation outside the dimerization domain causing atypical STING-associated vasculopathy with onset in infancy

Saldanha, R. G., Balka, K. R., Davidson, S., Wainstein, B. K., Wong, M., Macintosh, R., Loo, C. K. C., Weber, M. A., Kamath, V., CIRCA, AADRY, Moghaddas, F., De Nardo, D., Gray, P. E. & Masters, S. L., 6 Jul 2018, In : Frontiers in Immunology. 9, JUL, 8 p., 1535.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
8 Citations (Scopus)

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

Moghaddas, F., Zeng, P., Zhang, Y., Schützle, H., Brenner, S., Hofmann, S. R., Berner, R., Zhao, Y., Lu, B., Chen, X., Zhang, L., Cheng, S., Winkler, S., Lehmberg, K., Canna, S. W., Czabotar, P. E., Wicks, I. P., De Nardo, D., Hedrich, C. M., Zeng, H. & 1 others, Masters, S. L., 1 Dec 2018, In : Journal of Allergy and Clinical Immunology. 142, 6, p. 1956-1967.e6 18 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
1 Citation (Scopus)

Emerging concepts in innate immunity

Pelka, K. & De Nardo, D., 1 Jan 2018, Innate Immune Activation. De Nardo, D. & De Nardo, C. M. (eds.). Humana Press, 18 p. (Methods in Molecular Biology; vol. 1714).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Generation of innate immune reporter cells using retroviral transduction

Gloria, Y. C., Latz, E. & De Nardo, D., 1 Jan 2018, Innate Immune Activation. Humana Press, p. 97-117 21 p. (Methods in Molecular Biology; vol. 1714).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review