20052020

Research output per year

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Personal profile

Biography

Dr Dominic De Nardo is a Group Leader in the Department of Anatomy and Developmental Biology at Monash University. He currently supervises 2 PhD students and several undergraduate students in his group with a focus on understanding the molecular mechanisms controlling innate immune responses. In addition to his group, Dr De Nardo also supervises the members of Professor Ben Kile’s lab at Monash University, following his recruitment as the Dean of Medicine at the University of Adelaide.

Dr De Nardo received his PhD in 2009 from the University of Melbourne, Australia, where he developed a keen interest in macrophages and the innate immune system while working on mechanisms of Toll-like receptor activation. He then accepted a postdoctoral position with Professor Eicke Latz at the Institute of Innate Immunity in Bonn, Germany. During his postdoc Dominic identified the molecular mechanism underlying the ability of HDL to reduce inflammation, co-authored several studies published in journals such as Nature Immunology and Immunity and secured funding to lead a junior group. In 2014 he was awarded the Seymour and Vivian Milstein Young Investigator Award for notable contributions to basic research by the International Cytokine and Interferon Society (ICIS). Dr De Nardo returned to Melbourne in late 2014 to continue his research at the Walter and Eliza Hall Institute of Medical Research, before moving in 2019 to work with Professor Kile at Monash University.

Research interests

Dr De Nardo's research focuses on understanding the molecular mechanisms controlling activation and regulation of innate immune receptors and signaling pathways, and their roles in inflammation during health and disease. He has extensive expertise in numerous innate immune pathways including, Toll-like receptors (TLRs), Inflammasomes and cytosolic nucleic acid sensing receptors (cGAS-STING).

Education/Academic qualification

Innate Immunity, PhD, University of Melbourne

Macrophage Biology, BSc (Hons), University of Melbourne

Genetics, Biochemistry and Molecular Biology, BSc, University of Melbourne

Research area keywords

  • Innate Immunity
  • Toll-like receptor
  • cGAS-STING
  • Inflammasomes
  • Macrophages
  • Signalling pathways

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Research Output

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Editorial: Immunomodulation of innate immune cells

Almeida, C. R., Bottazzi, B., De Nardo, D. & Lawlor, K. E., 11 Feb 2020, In : Frontiers in Immunology. 3 p., 101.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

Understanding early TLR signaling through the Myddosome

Balka, K. R. & De Nardo, D., 1 Feb 2019, In : Journal of leukocyte biology. 105, 2, p. 339-351 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

A mutation outside the dimerization domain causing atypical STING-associated vasculopathy with onset in infancy

Saldanha, R. G., Balka, K. R., Davidson, S., Wainstein, B. K., Wong, M., Macintosh, R., Loo, C. K. C., Weber, M. A., Kamath, V., CIRCA, AADRY, Moghaddas, F., De Nardo, D., Gray, P. E. & Masters, S. L., 6 Jul 2018, In : Frontiers in Immunology. 9, JUL, 8 p., 1535.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
10 Citations (Scopus)

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface

Moghaddas, F., Zeng, P., Zhang, Y., Schützle, H., Brenner, S., Hofmann, S. R., Berner, R., Zhao, Y., Lu, B., Chen, X., Zhang, L., Cheng, S., Winkler, S., Lehmberg, K., Canna, S. W., Czabotar, P. E., Wicks, I. P., De Nardo, D., Hedrich, C. M., Zeng, H. & 1 others, Masters, S. L., 1 Dec 2018, In : Journal of Allergy and Clinical Immunology. 142, 6, p. 1956-1967.e6 18 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
13 Citations (Scopus)