Personal profile
Biography
Dr Diana Tan is a Research Fellow at the Monash Health Translational Precinct, working within the Cell-Based and Regenerative Therapies for Inflammatory Bowel Disease Group at the Centre for Inflammatory Diseases (CID), Monash University.
Diana holds a PhD in Immunology and a Bachelor of Science in Biotechnology. She completed her doctoral studies under the supervision of Professors Stephen Holdsworth and Richard Kitching, internationally recognised leaders in autoimmune kidney disease research.
After a career break to raise her young family, Diana returned to research as an early career investigator, bringing a renewed focus and passion to the study of immune regulation. Her expertise lies in regulatory T cells (Tregs) and their role in maintaining immune tolerance. Her early work using an experimental model of ANCA-associated vasculitis (AAV) has contributed to our understanding of Treg biology in autoimmune disease.
Diana's current research explores the intersection between gut inflammation, the microbiome, and immune regulation, with the goal of developing innovative, cell-based therapies for inflammatory bowel disease (IBD). She is particularly interested in translating preclinical discoveries into meaningful therapeutic strategies.
Education/Academic qualification
Medical Research, Doctor of Philosophy, T cell tolerance in the modulation of autoimmune anti-myeloperoxidase ANCA-associated glomerulonephritis, Monash University
Award Date: 6 Dec 2012
Bachelor of Science, Honours (H1), The Role of Subcellular Targeting of > Rhinovirus 3C Protease, Monash University
Award Date: 1 Dec 2005
Biotechnology, Bachelor of Science, Monash University
Award Date: 1 Dec 2004
Research area keywords
- Autoimmunity
- Kidney Disease
- Inflammation
- Tolerance
- ANCA Vasculitis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis
Nagai, K., Koo Yuk Cheong, D., Cao Le, A., Tan, D. S. Y., Ooi, J. D. & Gan, P.-Y., 2025, In: Frontiers in Immunology. 16, 8 p., 1589130.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Unravelling the Link between the Gut Microbiome and Autoimmune Kidney Diseases: A Potential New Therapeutic Approach
Tan, D. S. Y., Akelew, Y., Snelson, M., Nguyen, J. & O’Sullivan, K. M., May 2024, In: International Journal of Molecular Sciences. 25, 9, 27 p., 4817.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Myeloperoxidase peptide-based nasal tolerance in experimental ANCA-associated GN
Gan, P. Y., Tan, D. S. Y., Ooi, J., Alikhan, M., Kitching, A. R. & Holdsworth, S. R., 2016, In: Journal of the American Society of Nephrology. 27, 2, p. 385 - 391 7 p.Research output: Contribution to journal › Article › Research › peer-review
18 Link opens in a new tab Citations (Scopus) -
Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function
Odobasic, D., Kitching, A. R., Yang, Y. H., O'Sullivan, K., Muljadi, R. C. M., Edgtton, K. L., Tan, D. S. Y., Summers, S. A., Morand, E. F. & Holdsworth, S. R., 2013, In: Blood. 121, 20, p. 4195 - 4204 10 p.Research output: Contribution to journal › Article › Research › peer-review
140 Link opens in a new tab Citations (Scopus) -
Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN
Tan, D. S. Y., Gan, P. Y., O'Sullivan, K., Hammett, M. V., Summers, S. A., Ooi, J., Lundgren, B. A., Boyd, R. L., Scott, H. S., Kitching, A. R., Chidgey, A. P. & Holdsworth, S. R., 2013, In: Journal of the American Society of Nephrology. 24, 4, p. 573 - 585 13 p.Research output: Contribution to journal › Article › Research › peer-review
42 Link opens in a new tab Citations (Scopus)