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Research Output 2005 2019

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2019

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Jiang, M., Fan, J., Qu, X., Li, S., Nilsson, S. K., Sun, Y. B. Y., Chen, Y., Yu, D., Liu, D., Liu, B-C., Tang, M., Chen, W., Ren, Y., Nikolic-Paterson, D. J., Jiang, X., Li, J. & Yu, X., 9 Aug 2019, In : Frontiers in Pharmacology. 10, 17 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities

Wiede, F., Brodnicki, T. C., Goh, P. K., Leong, Y. A., Jones, G. W., Yu, D., Baxter, A. G., Jones, S. A., Kay, T. W. H. & Tiganis, T., 1 Jun 2019, In : Diabetes. 68, 6, p. 1251-1266 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
24 Citations (Scopus)

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

Wiede, F., Sacirbegovic, F., Leong, Y. A., Yu, D. & Tiganis, T., 1 Jan 2017, In : Journal of Autoimmunity. 76, p. 85-100 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
114 Citations (Scopus)

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

Leong, Y. A., Chen, Y., Ong, H. S., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B. J., Wei, Y., Hou, Z., Zotos, D., Fenix, K. A., Atnerkar, A., Preston, S., Chipman, J. G., Beilman, G. J., Allison, C. C., Sun, L., Wang, P., Xu, J. & 10 others, Toe, J. G., Lu, H. K., Tao, Y., Palendira, U., Dent, A. L., Landay, A. L., Pellegrini, M., Comerford, I., Lewin, S. R. & Yu, D., 3 Aug 2016, In : Nature Immunology. 17, 10, p. 1187-1196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

He, J., Zhang, X., Wei, Y., Sun, X., Chen, Y., Deng, J., Jin, Y., Gan, Y., Hu, X., Jia, R., Xu, C., Hou, Z., Leong, Y. A., Zhu, L., Feng, J., An, Y., Jia, Y., Li, C., Liu, X., Ye, H. & 12 others, Ren, L., Li, R., Yao, H., Li, Y., Chen, S., Zhang, X., Su, Y., Guo, J., Shen, N., Morand, E. F., Yu, D. & Li, Z., Sep 2016, In : Nature Medicine. 22, 9, p. 991-993 3 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Severe malaria infections impair germinal center responses by inhibiting T follicular helper cell differentiation

Ryg-Cornejo, V., Ioannidis, L. J., Ly, A., Chiu, C. Y., Tellier, J., Hill, D. L., Preston, S. P., Pellegrini, M., Yu, D., Nutt, S. L., Kallies, A. & Hansen, D. S., 5 Jan 2016, In : Cell Reports. 14, 1, p. 68-81 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice

Chevalier, N., Macia, L., Tan, J. K., Mason, L. J., Robert, R., Thorburn, A. N., Wong, C. H. Y., Tsai, L. M., Bourne, K., Brink, R., Yu, D. & Mackay, C. R., 4 Apr 2016, In : Arthritis and Rheumatology. 68, 4, p. 1026-1038 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
15 Citations (Scopus)

A pathogenetic role for IL-21 in primary Sjogren syndrome

Kwok, S-K., Lee, J., Yu, D., Kang, K. Y., Cho, M-L., Kim, H-R., Ju, J. H., Lee, S-H., Park, S-H. & Kim, H-Y., 2015, In : Nature Reviews Rheumatology. 11, 6, p. 368 - 374 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Control of lymphocyte homeostasis and effector function by the aryl hydrocarbon receptor

Wang, H. H., Wei, Y. & Yu, D., 2015, In : International Immunopharmacology. 28, 2, p. 818 - 824 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
44 Citations (Scopus)

Follicular helper T-cell memory: establishing new frontiers during antibody response

Tsai, L. M-C. & Yu, D., 2014, In : Immunology and Cell Biology. 92, 1, p. 57 - 63 7 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

Palmer, C. P-S., Ostrowski, M., Gouillou, M., Tsai, L. M-C., Yu, D., Zhou, J., Henstridge, D. C., Maisa, A., Hearps, A. C., Lewin, S. R., Landay, A. L., Jaworowski, A., McCune, J. M. & Crowe, S. M., 2014, In : AIDS. 28, 3, p. 297 - 309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion

Chevalier, N., Thorburn, A. N., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P. M. & Mackay, C. R., 2014, In : Journal of Immunology. 193, 10, p. 4845 - 4858 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
23 Citations (Scopus)

Characteristics of Sjogren's syndrome in rheumatoid arthritis

He, J., Ding, Y., Feng, M., Guo, J., Sun, X., Zhao, J., Yu, D. & Li, Z., 2013, In : Rheumatology. 52, 6, p. 1084 - 1089 6 p.

Research output: Contribution to journalArticleResearchpeer-review

283 Citations (Scopus)

Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure

He, J., Tsai, L. M., Leong, Y. A., Hu, X. J., Ma, C. S., Chevalier, N., Sun, X., Vandenberg, K., Rockman, S., Ding, Y., Zhu, L., Wei, W., Wang, C., Karnowski, A., Belz, G. T., Ghali, J. R., Cook, M. C., Riminton, S., Veillette, A., Schwartzberg, P. L. & 7 others, Mackay, F., Brink, R., Tangye, S. G., Vinuesa, C. G., Mackay, C. R., Li, Z. G. & Yu, D., 2013, In : Immunity. 39, p. 770 - 781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Efficient production of recombinant IL-21 proteins for pre-clinical studies by a two-step dilution refolding method

Chen, Z. C., Cui, Y., Leong, Y. A. & Yu, D., 2013, In : International Immunopharmacology. 16, 3, p. 376 - 381 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
144 Citations (Scopus)

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

Lee, S. K., Rigby, R. J., Zotos, D., Tsai, L. M., Kawamoto, S., Marshall, J. L., Ramiscal, R. R., Chan, T. D., Gatto, D., Brink, R., Yu, D., Fagarasan, S., Tarlinton, D. M., Cunningham, A. F. & Vinuesa, C. G., 2011, In : Journal of Experimental Medicine. 208, 7, p. 1377 - 1388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G. & Mackay, C. R., 2011, In : Journal of Immunology. 186, 10, p. 5556 - 5568 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
28 Citations (Scopus)

Evidence for microRNA-mediated regulation in rheumatic diseases

Luo, X., Tsai, L., Shen, N. & Yu, D., 2010, In : Annals of the Rheumatic Diseases. 69, Suppl 1, p. i30 - i36 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Heparanase in primary human osteoblasts

Smith, P. N., Freeman, C., Yu, D., Chen, M., Gatenby, P. A., Parish, C. R. & Li, R. W., 2010, In : Journal of Orthopaedic Research. 28, 10, p. 1315 - 1322 8 p.

Research output: Contribution to journalArticleResearchpeer-review

458 Citations (Scopus)

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Linterman, M. A., Beaton, L., Yu, D., Ramiscal, R. R., Srivastava, M., Hogan, J. J., Verma, N. K., Smyth, M. J., Rigby, R. J. & Vinuesa, C., 2010, In : Journal of Experimental Medicine. 207, 2, p. 353 - 363 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

MicroRNAs in common diseases and potential therapeutic applications

Tsai, L. & Yu, D., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, 1, p. 102 - 107 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

Yu, D. & Vinuesa, C., 2010, In : Cellular & Molecular Immunology. 7, p. 198 - 203 6 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)

The elusive identity of T follicular helper cells

Yu, D. & Vinuesa, C. G., 2010, In : Trends in Immunology. 31, 10, p. 377 - 383 7 p.

Research output: Contribution to journalArticleOther

56 Citations (Scopus)

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

Athanasopoulos, V., Barker, A., Yu, D., Tan, A. H-M., Srivastava, M., Contreras, N., Wang, J., Lam, K-P., Brown, S. HJ., Goodnow, C. C., Dixon, N. E., Leedman, P. J., Saint, R. & Vinuesa, C., 2010, In : FEBS Journal. 277, 9, p. 2109 - 2127 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
391 Citations (Scopus)

Follicular helper T cells are required for systemic autoimmunity

Linterman, M. A., Rigby, R. J., Wong, R. K., Yu, D., Brink, R., Cannons, J. L., Schwartzberg, P. L., Cook, M. C., Walters, G. D. & Vinuesa, C., 2009, In : Journal of Experimental Medicine. 206, 3, p. 561 - 576 16 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Logic and extent of miRNA-mediated control of autoimmune gene expression

Vinuesa, C., Rigby, R. & Yu, D., 2009, In : International Reviews of Immunology. 28, 3-4, p. 112 - 138 27 p.

Research output: Contribution to journalArticleResearchpeer-review

1352 Citations (Scopus)

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay-Fisson, F., Artis, D., Xavier, R. J., Teixeira, M. M. & Mackay, C. R., 2009, In : Nature. 461, 7268, p. 1282 - 1286 5 p.

Research output: Contribution to journalArticleResearchpeer-review

676 Citations (Scopus)

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

Yu, D., Rao, S., Tsai, L. M., Lee, S. K., He, Y., Sutcliffe, E. L., Srivastava, M., Linterman, M., Zheng, L., Simpson, N., Ellyard, J. I., Parish, I. A., Ma, C. S., Li, Q-J., Parish, C. R., Mackay, C. R. & Vinuesa, C. G., 2009, In : Immunity. 31, 3, p. 457 - 468 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
491 Citations (Scopus)

A fundamental role for interleukin-21 in the generation of T follicular helper cells

Vogelzang, A., McGuire, H. N., Yu, D., Sprent, J., Mackay, C. R. & King, C., 2008, In : Immunity. 29, 1, p. 127 - 137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Axon growth and guidance genes identify T-dependent germinal centre B cells

Yu, D., Cook, M. C., Shin, D-M., Silva, D. G., Marshall, J., Toellner, K-M., Havran, W. L., Caroni, P., Cooke, M. P., Morse III, H. C., MacLennan, I. CM., Goodnow, C. C. & Vinuesa, C., 2008, In : Immunology and Cell Biology. 86, 1, p. 3 - 14 12 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

Li, R. W., Freeman, C., Yu, D., Hindmarsh, E. J., Tymms, K. E. & Parish, C. R., 2008, In : Arthritis and Rheumatism. 58, 6, p. 1590 - 1600 11 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL

Wu, Z., Jia, X., de la Cruz, L., Su, X-C., Marzolf, B., Troisch, P., Zak, D., Hamilton, A., Whittle, B., Yu, D., Sheahan, D., Bertram, E., Aderem, A., Otting, G., Goodnow, C. C. & Hoyne, G. F., 2008, In : Immunity. 29, 6, p. 863 - 875 13 p.

Research output: Contribution to journalArticleResearchpeer-review

351 Citations (Scopus)

Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei, W., Ma, G-H., Hu, G., Yu, D., McLeish, T., Su, Z-G. & Shen, Z-Y., 2008, In : Journal of the American Chemical Society. 130, 47, p. 15808 - 15810 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
297 Citations (Scopus)

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Yu, D., Tan, A. H-M., Hu, X., Athanasopoulos, V., Simpson, N., Silva, D. G., Hutloff, A., Giles, K. M., Leedman, P. J., Lam, K. P., Goodnow, C. C. & Vinuesa, C. G., 2007, In : Nature. 450, 7167, p. 299 - 303 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
600 Citations (Scopus)

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Vinuesa, C., Cook, M. C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K. M., Yu, D., Domaschenz, H., Whittle, B., Lambe, T., Roberts, I. S., Copley, R. R., Bell, J. I., Cornall, R. J. & Goodnow, C. C., 2005, In : Nature. 435, 7041, p. 452 - 458 7 p.

Research output: Contribution to journalArticleResearchpeer-review