Projects per year
Personal profile
Biography
Dr Denuja Karunakaran, Laboratory Head, Cardiometabolic Immunity.
Dr Karunakaran is a macrophage biologist with research interests in cardiometabolic diseases and therapeutics. She completed her PhD in platelet biology at Monash University, followed by the National Heart Foundation postdoctoral fellowship at the University of New South Wales (UNSW), an Endowed Cardiovascular Genetics Postdoctoral Fellowship at the Ottawa Heart Institute, Canada and an Institute for Molecular Bioscience (IMB) Fellowship at The University of Queensland. Her research has resulted in seminal discoveries published in Circulation, Circulation Research, Blood, ATVB, Science Advances and Nature Metabolism. She’s the recipient of numerous awards, including the 2020 Queensland Women in STEM Prize, 2019 American Society for Investigative Pathology Young Scientist Leadership Award and the AHA 2017 ATVB Early Career Investigator Award finalist. Funded by a 2022 NHMRC Ideas grant and Diabetes Australia, her research program currently focuses on inflammation, cell death (specifically necroptosis), the clearance of these dying cells (efferocytosis) and the relationship between the circadian clock and the above processes in the broader context of cardiometabolic diseases (including atherosclerosis, obesity and diabetes).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 3 Active
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Development of PET-CT imaging in mouse models to screen for new anti-inflammatory therapies
Bubb, K., Chen, B., Karunakaran, D. & Thomas, J.
Monash University – Internal Department Contribution
1/01/24 → 31/12/25
Project: Research
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Inflammatory Cell Death, Circadian Rhythm & Obesity: A Surprising Triad
Karunakaran, D., Smith, B., Mauvoisin, D. & Dadley-Moore, D.
1/08/22 → 31/12/25
Project: Research
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HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages
Gupta, K. D., Ramnath, D., von Pein, J. B., Curson, J. E. B., Wang, Y., Abrol, R., Kakkanat, A., Moradi, S. V., Gunther, K. S., Murthy, A. M. V., Stocks, C. J., Kapetanovic, R., Reid, R. C., Iyer, A., Ilka, Z. C., Nauseef, W. M., Plan, M., Luo, L., Stow, J. L., Schroder, K., & 6 others , 24 Jan 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 4, 12 p., e2212813120.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Wang, Y., Abrol, R., Mak, J. Y. W., Das Gupta, K., Ramnath, D., Karunakaran, D., Fairlie, D. P. & Sweet, M. J., Jun 2023, In: The FEBS Journal. 290, 11, p. 2805-2832 28 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access25 Citations (Scopus) -
Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies
Preston, S. P., Stutz, M. D., Allison, C. C., Nachbur, U., Gouil, Q., Tran, B. M., Duvivier, V., Arandjelovic, P., Cooney, J. P., Mackiewicz, L., Meng, Y., Schaefer, J., Bader, S. M., Peng, H., Valaydon, Z., Rajasekaran, P., Jennison, C., Lopaticki, S., Farrell, A., Ryan, M., & 13 others , Dec 2022, In: Gastroenterology. 163, 6, p. 1643-1657.e14 29 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access41 Citations (Scopus) -
The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms
Ramnath, D., Das Gupta, K., Wang, Y., Abrol, R., Curson, J. E. B., Lim, J., Reid, R. C., Mansell, A., Blumenthal, A., Karunakaran, D., Fairlie, D. P. & Sweet, M. J., Feb 2022, In: Journal of Leukocyte Biology. 111, 2, p. 327-336 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
14 Citations (Scopus) -
RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice
Karunakaran, D., Nguyen, M-A., Geoffrion, M., Vreeken, D., Lister, Z., Cheng, H. S., Otte, N., Essebier, P., Wyatt, H., Kandiah, J. W., Jung, R., Alenghat, F. J., Mompeon, A., Lee, R., Pan, C., Gordon, E., Rasheed, A., Lusis, A. J., Liu, P., Matic, L. P., & 7 others , 12 Jan 2021, In: Circulation. 143, 2, p. 163-177 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access124 Citations (Scopus)