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Personal profile

Biography

All my career, I've had a keen interest in cell differentiation & mature function and how errors in these processes lead to human disease. During my PhD, I investigatied myogenesis with Prof. Christina A. Mitchell. This work determined the molecular basis for an apoptosis driven muscle wasting later identified in Reducing Body Myopathy. I then moved into the field of epidermal research in the laboratory of Prof. Fiona M. Watt, investigating the mechanisms regulating proliferation and different modes of epidermal differentiation utilising mouse genetic models. These findings revealed a regulatory axis dysregulated in sebaceous carcinoma and in psoriasis-like differentiation of the interfollicular epidermis. I have since joined the laboratory of Prof Ian M. Smyth and in keeping with my research interest to better understand human disease using mouse models, currently work on the mechanisms underlying two epithelial disorders, Harlequin Ichthyosis and Polycystic Kidney Disease.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research area keywords

  • Epidermis
  • Skin
  • Kidney Disease
  • Ichthyosis

Network

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