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Personal profile


All my career, I've had a keen interest in cell differentiation & mature function and how errors in these processes lead to human disease. During my PhD, I investigatied myogenesis with Prof. Christina A. Mitchell. This work determined the molecular basis for an apoptosis driven muscle wasting later identified in Reducing Body Myopathy. I then moved into the field of epidermal research in the laboratory of Prof. Fiona M. Watt, investigating the mechanisms regulating proliferation and different modes of epidermal differentiation utilising mouse genetic models. These findings revealed a regulatory axis dysregulated in sebaceous carcinoma and in psoriasis-like differentiation of the interfollicular epidermis. I have since joined the laboratory of Prof Ian M. Smyth and in keeping with my research interest to better understand human disease using mouse models, currently work on the mechanisms underlying two epithelial disorders, Harlequin Ichthyosis and Polycystic Kidney Disease.

Research area keywords

  • Epidermis
  • Skin
  • Kidney Disease
  • Ichthyosis

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Research Output

ABCA12 regulates insulin secretion from β-cells

Ursino, G. M., Fu, Y., Cottle, D. L., Mukhamedova, N., Jones, L. K., Low, H., Tham, M. S., Gan, W. J., Mellett, N. A., Das, P. P., Weir, J. M., Ditiatkovski, M., Fynch, S., Thorn, P., Thomas, H. E., Meikle, P. J., Parkington, H. C., Smyth, I. M. & Sviridov, D., 4 Mar 2020, In : EMBO Reports. 21, 3, 19 p., e48692.

Research output: Contribution to journalArticleResearchpeer-review

AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease

Conduit, S. E., Davies, E. M., Ooms, L. M., Gurung, R., Mcgrath, M. J., Hakim, S., Cottle, D. L., Smyth, I. M., Dyson, J. M. & Mitchell, C. A., 1 Jan 2020, In : Human Molecular Genetics. 29, 1, p. 31-48 18 p.

Research output: Contribution to journalArticleResearchpeer-review

CBE1 Is a Manchette- and Mitochondria-Associated Protein With a Potential Role in Somatic Cell Proliferation

Pleuger, C., Lehti, M. S., Cooper, M., O'Connor, A. E., Merriner, D. J., Smyth, I. M., Cottle, D. L., Fietz, D., Bergmann, M. & O'Bryan, M. K., 1 Nov 2019, In : Endocrinology. 160, 11, p. 2573-2586 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell Death and Disease. 9, 11, 12 p., 1072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

BJD Research Letter: A profile of lipid dysregulation in Harlequin Ichthyosis

Ip, S. C. I., Cottle, D. L., Jones, L. K., Weir, J. M., Kelsell, D. P., O'Toole, E. A., Meikle, P. J. & Smyth, I. M., Nov 2017, In : British Journal of Dermatology. 177, 5, p. e217-e219 3 p.

Research output: Contribution to journalLetterResearchpeer-review

1 Citation (Scopus)

Press / Media


Denny Cottle


1 item of Media coverage

Press/Media: Research