All my career, I've had a keen interest in cell differentiation & mature function and how errors in these processes lead to human disease. During my PhD, I investigatied myogenesis with Prof. Christina A. Mitchell. This work determined the molecular basis for an apoptosis driven muscle wasting later identified in Reducing Body Myopathy. I then moved into the field of epidermal research in the laboratory of Prof. Fiona M. Watt, investigating the mechanisms regulating proliferation and different modes of epidermal differentiation utilising mouse genetic models. These findings revealed a regulatory axis dysregulated in sebaceous carcinoma and in psoriasis-like differentiation of the interfollicular epidermis. I have since joined the laboratory of Prof Ian M. Smyth and in keeping with my research interest to better understand human disease using mouse models, currently work on the mechanisms underlying two epithelial disorders, Harlequin Ichthyosis and Polycystic Kidney Disease.