Denise Wootten

Research output

Research output per year 2006 2012 2013 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 100 Article
• 9 Review Article
• 3 Chapter (Book)
• 3 Comment / Debate
• 3 More
  • 1 Abstract
  • 1 Editorial
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

  Harikumar, K. G., Zhao, P., Cary, B. P., Xu, X., Desai, A. J., Dong, M., Mobbs, J. I., Toufaily, C., Furness, S. G. B., Christopoulos, A., Belousoff, M. J., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2024, In: PLoS Biology. 22, 7, 26 p., e3002673.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

• Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein

  Cao, J., Belousoff, M. J., Danev, R., Christopoulos, A., Wootten, D. & Sexton, P. M., 7 May 2024, In: Biochemistry. 63, 9, p. 1089-1096 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  1 Citation (Scopus)

• Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists

  Keov, P., Christopoulos, G., Hick, C. A., Glendorf, T., Ballarín-González, B., Wootten, D. & Sexton, P. M., May 2024, In: Molecular Pharmacology. 105, 5, p. 359-373 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide-1 Analogue

  Chandrashekar, C., Lin, F., Nishiuchi, Y., Mohammed, S. F., White, B. F., Arsenakis, Y., Yuliantie, E., Zhao, P., van Dun, S., Koijen, A., Kajihara, Y., Wootten, D., Dodd, G. T., van den Bos, L. J., Wade, J. D. & Hossain, M. A., 9 May 2024, In: Journal of Medicinal Chemistry. 67, 9, p. 7276-7282 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  1 Citation (Scopus)

• Impact of secretin receptor homo-dimerization on natural ligand binding

  Harikumar, K. G., Piper, S. J., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Dec 2024, In: Nature Communications. 15, 1, 12 p., 4390.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

• Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3

  Russell, I. C., Zhang, X., Bumbak, F., McNeill, S. M., Josephs, T. M., Leeming, M. G., Christopoulos, G., Venugopal, H., Flocco, M. M., Sexton, P. M., Wootten, D. & Belousoff, M. J., 5 Mar 2024, In: Biochemistry. 63, 5, p. 625-631 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)

• Structural insight into selectivity of amylin and calcitonin receptor agonists

  Cao, J., Belousoff, M. J., Gerrard, E., Danev, R., Fletcher, M. M., Dal Maso, E., Schreuder, H., Lorenz, K., Evers, A., Tiwari, G., Besenius, M., Li, Z., Johnson, R. M., Wootten, D. & Sexton, P. M., Feb 2024, In: Nature Chemical Biology. 20, 2, p. 162-169 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)

• The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation

  McNeill, S. M., Lu, J., Marion C. Carino, C., Inoue, A., Zhao, P., Sexton, P. M. & Wootten, D., Apr 2024, In: Biochemical Pharmacology. 222, 20 p., 116119.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  5 Citations (Scopus)
• 2023

  Glycosylation Improves the Proteolytic Stability of Exenatide

  Chandrashekar, C., Nishiuchi, Y., White, B. F., Arsenakis, Y., Lin, F., McNeill, S. M., Zhao, P., van Dun, S., Koijen, A., Kajihara, Y., Wootten, D., van den Bos, L. J., Wade, J. D. & Hossain, M. A., 21 Jun 2023, In: Bioconjugate Chemistry. 34, 6, p. 1014-1018 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)

• GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

  Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R. M., Ahlqvist, E., Thorleifsson, G., Gao, Η., Εvangelou, Ε., Benyamin, B., & 78 othersScott, R. A., Isaacs, A., Zhao, J. H., Willems, S. M., Johnson, T., Gieger, C., Grallert, H., Meisinger, C., Müller-Nurasyid, M., Strawbridge, R. J., Goel, A., Rybin, D., Albrecht, E., Jackson, A. U., Stringham, H. M., Corrêa, I. R., Farber-Eger, E., Steinthorsdottir, V., Uitterlinden, A. G., Munroe, P. B., Brown, M. J., Schmidberger, J., Holmen, O., Thorand, B., Hveem, K., Wilsgaard, T., Mohlke, K. L., Wang, Z., GWA-PA Consortium, Shmeliov, A., den Hoed, M., Loos, R. J. F., Kratzer, W., Haenle, M., Koenig, W., Boehm, B. O., Tan, T. M., Tomas, A., Salem, V., Barroso, I., Tuomilehto, J., Boehnke, M., Florez, J. C., Hamsten, A., Watkins, H., Njølstad, I., Wichmann, H. E., Caulfield, M. J., Khaw, K. T., van Duijn, C. M., Hofman, A., Wareham, N. J., Langenberg, C., Whitfield, J. B., Martin, N. G., Montgomery, G., Scapoli, C., Tzoulaki, I., Elliott, P., Thorsteinsdottir, U., Stefansson, K., Brittain, E. L., McCarthy, M. I., Froguel, P., Sexton, P. M., Wootten, D., Groop, L., Dupuis, J., Meigs, J. B., Deganutti, G., Demirkan, A., Pers, T. H., Reynolds, C. A., Aulchenko, Y. S., Kaakinen, M. A., Jones, B., Prokopenko, I. & Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), 7 Sept 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  22 Citations (Scopus)

• Molecular insights into peptide agonist engagement with the PTH receptor

  Cary, B. P., Gerrard, E. J., Belousoff, M. J., Fletcher, M. M., Jiang, Y., Russell, I. C., Piper, S. J., Wootten, D. & Sexton, P. M., 1 Jun 2023, In: Structure. 31, 6, p. 668-676.e5 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• New Insights into the Structure and Function of Class B1 GPCRs

  Cary, B. P., Zhang, X., Cao, J., Johnson, R. M., Piper, S. J., Gerrard, E. J., Wootten, D. & Sexton, P. M., 1 Jun 2023, In: Endocrine Reviews. 44, 3, p. 492-517 26 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access
  20 Citations (Scopus)

• Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

  Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Nawaratne, V., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y. L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P., Danev, R., & 4 othersValant, C., Miao, Y., Christopoulos, A. & Thal, D. M., 30 May 2023, In: eLife. 12, 52 p., e83477.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  14 Citations (Scopus)

• The next decade in structural biology

  Walsh, M. A., Nannenga, B. L., Gonen, T., Sexton, P. M., Wootten, D., Chiu, W., Sun, F., Carragher, B., Potter, C. S., Agard, D. & Burley, S. K., 2 Nov 2023, In: Structure. 31, 11, p. 1284-1288 5 p.

  Research output: Contribution to journal › Comment / Debate › Other › peer-review

• Xanomeline displays concomitant orthosteric and allosteric binding modes at the M₄ mAChR

  Burger, W. A. C., Pham, V., Vuckovic, Z., Powers, A. S., Mobbs, J. I., Laloudakis, Y., Glukhova, A., Wootten, D., Tobin, A. B., Sexton, P. M., Paul, S. M., Felder, C. C., Danev, R., Dror, R. O., Christopoulos, A., Valant, C. & Thal, D. M., Dec 2023, In: Nature Communications. 14, 1, 11 p., 5440.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  15 Citations (Scopus)
• 2022

  A structural basis for amylin receptor phenotype

  Cao, J., Belousoff, M. J., Liang, Y. L., Johnson, R. M., Josephs, T. M., Fletcher, M. M., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 25 Mar 2022, In: Science. 375, 6587, 14 p., eabm9609.

  Research output: Contribution to journal › Article › Research › peer-review
  36 Citations (Scopus)

• Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

  Deganutti, G., Liang, Y. L., Zhang, X., Khoshouei, M., Clydesdale, L., Belousoff, M. J., Venugopal, H., Truong, T. T., Glukhova, A., Keller, A. N., Gregory, K. J., Leach, K., Christopoulos, A., Danev, R., Reynolds, C. A., Zhao, P., Sexton, P. M. & Wootten, D., 2022, In: Nature Communications. 13, 18 p., 92.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  42 Citations (Scopus)

• Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35

  Qin, C. X., Norling, L. V., Vecchio, E. A., Brennan, E. P., May, L. T., Wootten, D., Godson, C., Perretti, M. & Ritchie, R. H., Oct 2022, In: British Journal of Pharmacology. 179, 19, p. 4617-4639 23 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access
  29 Citations (Scopus)

• Implications of ligand-receptor binding kinetics on GLP-1R signalling

  Zhao, P., Truong, T. T., Merlin, J., Sexton, P. M. & Wootten, D., May 2022, In: Biochemical Pharmacology. 199, 13 p., 114985.

  Research output: Contribution to journal › Article › Research › peer-review
  11 Citations (Scopus)

• Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM

  Piper, S. J., Johnson, R. M., Wootten, D. & Sexton, P. M., 18 Jul 2022, In: Chemical Reviews. 122, 17, p. 13989–14017 29 p.

  Research output: Contribution to journal › Article › Research › peer-review
  24 Citations (Scopus)

• Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

  Milburn, J. E., Harikumar, K. G., Piper, S. J., Raval, S., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., 1 Jun 2022, In: Molecular Pharmacology. 101, 6, p. 400-407 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

• Structural and functional diversity among agonist-bound states of the GLP-1 receptor

  Cary, B. P., Deganutti, G., Zhao, P., Truong, T. T., Piper, S. J., Liu, X., Belousoff, M. J., Danev, R., Sexton, P. M., Wootten, D. & Gellman, S. H., Mar 2022, In: Nature Chemical Biology. 18, 3, p. 256-263 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  29 Citations (Scopus)

• Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors

  Lu, J., Piper, S. J., Zhao, P., Miller, L. J., Wootten, D. & Sexton, P. M., 1 Aug 2022, In: International Journal of Molecular Sciences. 23, 15, 38 p., 8069.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access
  20 Citations (Scopus)

• Understanding VPAC receptor family peptide binding and selectivity

  Piper, S. J., Deganutti, G., Lu, J., Zhao, P., Liang, Y. L., Lu, Y., Fletcher, M. M., Hossain, M. A., Christopoulos, A., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., Dec 2022, In: Nature Communications. 13, 1, 20 p., 7013.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  5 Citations (Scopus)
• 2021

  AM833 is a novel agonist of calcitonin family G protein–coupled receptors: Pharmacological comparison with six selective and nonselective agonists

  Fletcher, M. M., Keov, P., Truong, T. T., Mennen, G., Hick, C. A., Zhao, P., Furness, S. G. B., Kruse, T., Clausen, T. R., Wootten, D. & Sexton, P. M., 1 Jun 2021, In: Journal of Pharmacology and Experimental Therapeutics. 377, 3, p. 417-440 24 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  34 Citations (Scopus)

• Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon

  Liu, M., Zhao, P., Uddin, M. H., Li, W., Lin, F., Chandrashekar, C., Nishiuchi, Y., Kajihara, Y., Forbes, B. E., Wootten, D., Wade, J. D. & Hossain, M. A., 8 Sept 2021, In: Bioconjugate Chemistry. 32, 10, p. 2148–2153 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)

• Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor

  Johnson, R. M., Zhang, X., Piper, S. J., Nettleton, T. J., Vandekolk, T. H., Langmead, C. J., Danev, R., Sexton, P. M. & Wootten, D., 12 Nov 2021, In: Biochemical and Biophysical Research Communications. 578, p. 84-90 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

  Harikumar, K. G., Coudrat, T., Desai, A. J., Dong, M., Dengler, D. G., Furness, S. G. B., Christopoulos, A., Wootten, D., Sergienko, E. A., Sexton, P. M. & Miller, L. J., 7 Dec 2021, In: Frontiers in Endocrinology. 12, 13 p., 789957.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  6 Citations (Scopus)

• Evolving cryo-EM structural approaches for GPCR drug discovery

  Zhang, X., Johnson, R. M., Drulyte, I., Yu, L., Kotecha, A., Danev, R., Wootten, D., Sexton, P. M. & Belousoff, M. J., 2 Sept 2021, In: Structure. 29, 9, p. 963-974.e6 18 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  44 Citations (Scopus)

• Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

  Deganutti, G., Atanasio, S., Rujan, R. M., Sexton, P. M., Wootten, D. & Reynolds, C. A., 26 Aug 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 720561.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  4 Citations (Scopus)

• Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

  Yuliantie, E., van der Velden, W. J. C., Labroska, V., Dai, A., Zhao, F., Darbalaei, S., Deganutti, G., Xu, T., Zhou, Q., Yang, D., Rosenkilde, M. M., Sexton, P. M., Wang, M. W. & Wootten, D., Oct 2021, In: Biochemical Pharmacology. 192, 16 p., 114715.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• Positive allosteric mechanisms of adenosine A₁ receptor-mediated analgesia

  Draper-Joyce, C. J., Bhola, R., Wang, J., Bhattarai, A., Nguyen, A. T. N., Cowie-Kent, I., O’Sullivan, K., Chia, L. Y., Venugopal, H., Valant, C., Thal, D. M., Wootten, D., Panel, N., Carlsson, J., Christie, M. J., White, P. J., Scammells, P., May, L. T., Sexton, P. M., Danev, R., & 4 othersMiao, Y., Glukhova, A., Imlach, W. L. & Christopoulos, A., 23 Sept 2021, In: Nature. 597, p. 571–576 25 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  96 Citations (Scopus)

• Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

  Miller, L. J., Harikumar, K. G., Wootten, D. & Sexton, P. M., 2 Jun 2021, In: Frontiers in Endocrinology. 12, 7 p., 684656.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access
  24 Citations (Scopus)

• Routine sub-2.5 Å cryo-EM structure determination of GPCRs

  Danev, R., Belousoff, M., Liang, Y. L., Zhang, X., Eisenstein, F., Wootten, D. & Sexton, P. M., Dec 2021, In: Nature Communications. 12, 1, 10 p., 4333.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  37 Citations (Scopus)

• Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes

  Zhang, X., Belousoff, M. J., Liang, Y. L., Danev, R., Sexton, P. M. & Wootten, D., 13 Jul 2021, In: Cell Reports. 36, 2, 15 p., 109374.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  35 Citations (Scopus)

• Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

  Josephs, T. M., Belousoff, M. J., Liang, Y. L., Piper, S. J., Cao, J., Garama, D. J., Leach, K., Gregory, K. J., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 9 Apr 2021, In: Science. 372, 6538, 11 p., eabf7258.

  Research output: Contribution to journal › Article › Research › peer-review
  58 Citations (Scopus)

• Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

  Mobbs, J. I., Belousoff, M. J., Harikumar, K. G., Piper, S. J., Xu, X., Furness, S. G. B., Venugopal, H., Christopoulos, A., Danev, R., Wootten, D., Thal, D. M., Miller, L. J. & Sexton, P. M., 4 Jun 2021, In: PLoS Biology. 19, 6, 28 p., e3001295.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  41 Citations (Scopus)
• 2020

  Activation of the GLP-1 receptor by a non-peptidic agonist

  Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In: Nature. 577, 7790, p. 432-436 5 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  130 Citations (Scopus)

• Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide

  Chang, R., Zhang, X., Qiao, A., Dai, A., Belousoff, M. J., Tan, Q., Shao, L., Zhong, L., Lin, G., Liang, Y. L., Ma, L., Han, S., Yang, D., Danev, R., Wang, M. W., Wootten, D., Wu, B. & Sexton, P. M., 10 Jul 2020, In: Journal of Biological Chemistry. 295, 28, p. 9313-9325 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  30 Citations (Scopus)

• Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

  Zhang, X., Belousoff, M. J., Zhao, P., Kooistra, A. J., Truong, T. T., Ang, S. Y., Underwood, C. R., Egebjerg, T., Šenel, P., Stewart, G. D., Liang, Y-L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S. G. B., Miller, L. J., Reedtz-Runge, S., Langmead, C. J., Gloriam, D. E., Danev, R., & 2 othersSexton, P. M. & Wootten, D., 5 Nov 2020, In: Molecular Cell. 80, 3, p. 485-500 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  122 Citations (Scopus)

• Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors

  Darbalaei, S., Yuliantie, E., Dai, A., Chang, R., Zhao, P., Yang, D., Wang, M. W., Sexton, P. M. & Wootten, D., Oct 2020, In: Biochemical Pharmacology. 180, 16 p., 114150.

  Research output: Contribution to journal › Article › Research › peer-review
  24 Citations (Scopus)

• Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

  Ma, S., Shen, Q., Zhao, L. H., Mao, C., Zhou, X. E., Shen, D. D., de Waal, P. W., Bi, P., Li, C., Jiang, Y., Wang, M. W., Sexton, P. M., Wootten, D., Melcher, K., Zhang, Y. & Xu, H. E., 6 Feb 2020, In: Molecular Cell. 77, 3, p. 669-680.e4 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  63 Citations (Scopus)

• Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors

  Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., Prodan, N., Sexton, P. M., Siow, A., Walker, C. S., Watkins, H. A., Williams, G. M., Wootten, D., Yang, S. H., Harris, P. W. R. & Hay, D. L., 10 Apr 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 246-262 17 p.

  Research output: Contribution to journal › Article › Research › peer-review
  29 Citations (Scopus)

• Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors

  Yuliantie, E., Darbalaei, S., Dai, A., Zhao, P., Yang, D., Sexton, P. M., Wang, M-W. & Wootten, D., Jul 2020, In: Biochemical Pharmacology. 177, 13 p., 114001.

  Research output: Contribution to journal › Article › Research › peer-review
  39 Citations (Scopus)

• Rational development of a high-affinity secretin receptor antagonist

  Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In: Biochemical Pharmacology. 177, 13 p., 113929.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• Structural basis for allosteric modulation of class b g protein-coupled receptors

  Wootten, D. & Miller, L. J., 6 Jan 2020, In: Annual Review of Pharmacology and Toxicology. 60, p. 89-107 19 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  28 Citations (Scopus)

• Structural basis of G_s and G_i recognition by the human glucagon receptor

  Qiao, A., Han, S., Li, X., Li, Z., Zhao, P., Dai, A., Chang, R., Tai, L., Tan, Q., Chu, X., Ma, L., Thorsen, T. S., Reedtz-Runge, S., Yang, D., Wang, M-W., Sexton, P. M., Wootten, D., Sun, F., Zhao, Q. & Wu, B., 20 Mar 2020, In: Science. 367, 6484, p. 1346-1352 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  116 Citations (Scopus)

• Structure and Dynamics of Adrenomedullin Receptors AM₁ and AM₂ Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

  Liang, Y. L., Belousoff, M. J., Fletcher, M. M., Zhang, X., Khoshouei, M., Deganutti, G., Koole, C., Furness, S. G. B., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Danev, R., Wootten, D. & Sexton, P. M., 10 Apr 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 263-284 22 p.

  Research output: Contribution to journal › Article › Research › peer-review
  62 Citations (Scopus)

• Structure and dynamics of the active Gs-coupled human secretin receptor

  Dong, M., Deganutti, G., Piper, S. J., Liang, Y. L., Khoshouei, M., Belousoff, M. J., Harikumar, K. G., Reynolds, C. A., Glukhova, A., Furness, S. G. B., Christopoulos, A., Danev, R., Wootten, D., Sexton, P. M. & Miller, L. J., 1 Dec 2020, In: Nature Communications. 11, 1, 17 p., 4137.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  37 Citations (Scopus)

• The metabolic effects of mirabegron are mediated primarily by β₃-adrenoceptors

  Dehvari, N., Sato, M., Bokhari, M. H., Kalinovich, A., Ham, S., Gao, J., Nguyen, H. T. M., Whiting, L., Mukaida, S., Merlin, J., Chia, L. Y., Wootten, D., Summers, R. J., Evans, B. A., Bengtsson, T. & Hutchinson, D. S., 1 Oct 2020, In: Pharmacology Research & Perspectives. 8, 5, 16 p., e00643.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  13 Citations (Scopus)