Denise O'Connor is Professor (Research) and Deputy Director of the Wiser Health Care Unit in the School of Public Health and Preventive Medicine, Monash University and NHMRC Investigator Leadership Fellow.

Denise is an implementation scientist and health services researcher and her research explores the causes of, and the design and evaluation of solutions to address, research translation problems. This includes reducing low-value care and improving uptake of effective and efficient models of healthcare service delivery. 

Denise is lead investigator of Wiser Healthcare (www.wiserhealthcare.org.au), a national research collaboration that works in partnership with health agencies and consumers to ensure better value healthcare for Australians, with a particular focus on reducing overdiagnosis, overtesting and overtreatment. She is also investigator of the Australia and New Zealand Musculoskeletal Clinical Trials Network (anzmusc.org), a collaboration of researchers, clinicians and consumers who aim to optimise musculoskeletal health by conducting high-quality, clinical and implementation trials.

She is Director of the Australasian Satellite of Cochrane Collaboration Effective Practice and Organisation of Care, which publishes reviews of interventions to improve health care delivery and systems, and Editor with Cochrane Musculoskeletal. 

To support her research, she has been awarded three NHMRC Fellowships (Early Career, Translating Research into Practice (TRIP) and Investigator Leadership) and grant funding from other organisations including the Australian Department of Health and Aged Care, the Victorian Department of Health, Cabrini Health and the HCF Research Foundation.