20102019

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2019

Protease-associated import systems are widespread in Gram-negative bacteria

Grinter, R., Leung, B., Wijeyewickrema, L. C., Littler, D., Beckham, S., Pike, R. N., Walker, D., Greening, C. & Lithgow, T., 1 Oct 2019, In : PLoS Genetics. 15, 10, 24 p., e1008435.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)
2018

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Grinter, R., Hay, I. D., Song, J., Wang, J., Teng, D., Dhanesakaran, V., Wilksch, J. J., Davies, M. R., Littler, D., Beckham, S. A., Henderson, I. R., Strugnell, R. A., Dougan, G. & Lithgow, T., 2 Aug 2018, In : PLoS Biology. 16, 8, 21 p., e2006026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)
2017

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Littler, D. R., Ang, S. Y., Moriel, D. G., Kocan, M., Kleifeld, O., Johnson, M. D., Tran, M. T., Paton, A. W., Paton, J. C., Summers, R. J., Schembri, M. A., Rossjohn, J. & Beddoe, T., 8 Sep 2017, In : The Journal of Biological Chemistry. 292, 36, p. 15143-15158 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)
2016

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: Design, synthesis and biological evaluation

Buskes, M. J., Harvey, K. L., Richards, B. J., Kalhor, R., Christoff, R. M., Gardhi, C. K., Littler, D. R., Cope, E. D., Prinz, B., Weiss, G. E., O'Brien, N. J., Crabb, B. S., Deady, L. W., Gilson, P. R. & Abbott, B. M., 22 Apr 2016, In : Organic and Biomolecular Chemistry. 14, 20, p. 4617-4639 23 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12

Jaafar, N. R., Littler, D., Beddoe, T., Rossjohn, J., Illias, R. M., Mahadi, N. M., Mackeen, M. M., Murad, A. M. A. & Bakar, F. D. A., Nov 2016, In : Acta Crystallographica. Section F: Structural Biology Communications. F72, 11, p. 831-839 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit

Littler, D. R., Bullen, H. E., Harvey, K. L., Beddoe, T., Crabb, B. S., Rossjohn, J. & Gilson, P. R., 2 Dec 2016, In : The Journal of Biological Chemistry. 291, 49, p. 25375-25386 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2015

Cloning, expression, purification and crystallographic studies of galectin-11 from domestic sheep (Ovis aries)

Sakthivel, D., Littler, D., Shahine, A. E., Troy, S. T., Johnson, M. D., Rossjohn, J., Piedrafita, D. M. & Beddoe, T. C., 2015, In : Acta Crystallographica. Section F: Structural Biology Communications. 71, Pt 8, p. 993-997 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The structure of the cytomegalovirus-encoded m04 glycoprotein, a prototypical member of the m02 family of immunoevasins

Berry, R., Vivian, J. P., Deuss, F. A., Balaji, G. R., Saunders, P. M., Lin, J., Littler, D., Brooks, A. G. & Rossjohn, J., 2014, In : The Journal of Biological Chemistry. 289, 34, p. 23753 - 23763 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2013

A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

Nijenhuis, W., Von Castelmur, E., Littler, D., De Marco, V., Tromer, E., Vleugel, M., Van Osch, M. H. J., Snel, B., Perrakis, A. & Kops, G. J. P. L., 15 Apr 2013, In : Journal of Cell Biology. 201, 2, p. 217-231 15 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB5 toxin

Ng, N. M-Y., Littler, D., Le Nours, J., Paton, A. W., Paton, J. C., Rossjohn, J. & Beddoe, T. C., 2013, In : Acta Crystallographica. Section F: Structural Biology Communications. 69, 8, p. 912 - 915 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit

Ng, N. M-Y., Littler, D., Paton, A. W., Le Nours, J., Rossjohn, J., Paton, J. C. & Beddoe, T. C., 2013, In : Structure. 21, 11, p. 2003 - 2013 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2011

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases

Luna-Vargas, M. P. A., Christodoulou, E., Alfieri, A., van Dijk, W. J., Stadnik, M., Hibbert, R. G., Sahtoe, D. D., Clerici, M., De Marco, V., Littler, D., Celie, P. H. N., Sixma, T. K. & Perrakis, A., Aug 2011, In : Journal of Structural Biology. 175, 2, p. 113-119 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)