• Monash Biomedicine Discovery institute Department of Microbiology Office 152, 19 Innovation Walk, Monash University Victoria 3800 Australia Web monash.edu/discovery-institute

Accepting PhD Students

1992 …2021
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Research Output 1992 2019

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Article
2015

Plasmid partitioning systems of conjugative plasmids from Clostridium perfringens

Adams, V., Watts, T. D., Bulach, D. M., Lyras, D. & Rood, J. I., 2015, In : Plasmid. 80, p. 90-96 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics

Wales, S. M., Hammer, K. A., Somphol, K., Kemker, I., Schroder, D. C., Tague, A. J., Brkic, Z., King, A. M., Lyras, D., Riley, T. V., Bremner, J. B., Keller, P. A. & Pyne, S. G., 2015, In : Organic and Biomolecular Chemistry. 13, 44, p. 10813 - 10824 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The pore-forming alpha-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner

Chakravorty, A., Awad, M. M., Cheung, J. K. T., Hiscox, T. J., Lyras, D. & Rood, J. I., 2015, In : Toxins. 7, 2, p. 516 - 534 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Clostridium difficile virulence factors: insights into an anaerobic spore-forming pathogen

Awad, M. M., Johanesen, P. A., Carter, G. P., Rose, E. & Lyras, D., 2014, In : Gut Microbes. 5, 5, p. 579 - 593 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Emergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain

Lim, S. K., Stuart, R. L., Mackin, K. E., Carter, G. P., Kotsanas, D., Francis, M. J., Easton, M., Dimovski, K., Elliott, B., Riley, T. V., Hogg, G. G., Paul, E., Korman, T., Seemann, T., Stinear, T. P., Lyras, D. & Jenkin, G. A., 2014, In : Clinical Infectious Diseases. 58, 12, p. 1723 - 1730 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms

Carter, G. P., Larcombe, S., Li, L., Jayawardena, D., Awad, M. M., Songer, J. G. & Lyras, D., 2014, In : International Journal of Medical Microbiology. 304, 8, p. 1147 - 1159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Opioid analgesics stop the development of clostridial gas gangrene

Chakravorty, A., Awad, M. M., Hiscox, T. J., Cheung, K-L. J., Choo, J. M. F., Lyras, D. & Rood, J. I., 2014, In : Journal of Infectious Diseases. 210, 3, p. 483 - 492 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of toxin production in the pathogenic clostridia

Carter, G. P., Cheung, J. K-L., Larcombe, S. & Lyras, D., 2014, In : Molecular Microbiology. 91, 2, p. 221 - 231 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Small animal models for the study of Clostridium difficile disease pathogenesis

Hutton, M. L., Mackin, K. E., Chakravorty, A. & Lyras, D., 2014, In : FEMS Microbiology Letters. 352, 2, p. 140 - 149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments

Adams, V., Bantwal, R., Stevenson, L., Cheung, K-L. J., Awad, M. M., Nicholson, A. J., Carter, G. P., Mackin, K. E., Rood, J. I. & Lyras, D., 2014, In : Applied and Environmental Microbiology. 80, 12, p. 3597-3603 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Epsilon toxin is essential for the virulence of Clostridium perfringens type D infection in sheep, goats, and mice

Garcia, J. P., Adams, V. M., Beingesser, J., Hughes, M. L., Poon, R., Lyras, D., Hill, A., McClane, B. A., Rood, J. I. & Uzal, F. A., 2013, In : Infection and Immunity. 81, 7, p. 2405 - 2414 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia

Squire, M. M., Carter, G. P., Mackin, K. E., Chakravorty, A., Noren, T., Elliott, B., Lyras, D. & Riley, T. V., 2013, In : Emerging infectious diseases. 19, 5, p. 790 - 792 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile

Mackin, K., Carter, G. P., Howarth, P., Rood, J. I. & Lyras, D., 2013, In : PLoS ONE. 8, 11, 16 p., e79666.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2012

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

Porter, C. J., Bantwal, R., Bannam, T. L., Rosado, C. J., Pearce, M. C., Adams, V. M., Lyras, D., Whisstock, J. C. & Rood, J. I., 2012, In : Molecular Microbiology. 83, 2, p. 275 - 288 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The peptidoglycan hydrolase TcpG is required for efficient conjugative transfer of pCW3 in Clostridium perfringens

Bantwal, R., Bannam, T. L., Porter, C. J., Quinsey, N. S., Lyras, D., Adams, V. M. & Rood, J. I., 2012, In : Plasmid. 67, 2, p. 139 - 147 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of toxin A and toxin B in the virulence of clostridium difficile

Carter, G. P., Rood, J. I. & Lyras, D., 2012, In : Trends in Microbiology. 20, 1, p. 21 - 29 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Walk, S., Jain, R., Trivedi, I., Grossman, S., Newton, D., Thelen, T., Hao, Y., Songer, J. G., Carter, G., Lyras, D., Young, V. & Aronoff, D., 2011, In : Anaerobe. 17, 5, p. 252 - 256 5 p.

Research output: Contribution to journalArticleResearchpeer-review

TcsL Is an Essential Virulence Factor in Clostridium sordellii ATCC 9714

Carter, G. P., Awad, M. M., Hao, Y., Thelen, T., Bergin, I. L., Howarth, P. M., Seemann, T., Rood, J. I., Aronoff, D. M. & Lyras, D., 2011, In : Infection and Immunity. 79, 3, p. 1025 - 1032 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile

Carter, G. P., Douce, G. R., Govind, R., Howarth, P. M., Mackin, K. E., Spencer, J., Buckley, A. M., Antunes, A., Kotsanas, D., Jenkin, G. A., Dupuy, B., Rood, J. I. & Lyras, D., 2011, In : PLoS Pathogens. 7, 10 (Art. No: e1002317), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The cysteine protease alpha-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis

Chakravorty, A., Awad, M., Hiscox, T., Cheung, K-L., Carter, G., Choo, J., Lyras, D. & Rood, J., 2011, In : PLoS ONE. 6, 7, 7 p., e22762.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives

Carter, G. P., Rood, J. I. & Lyras, D., 2010, In : Gut Microbes. 1, 1, p. 58 - 64 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene

Kennedy, C. L., Lyras, D., Cheung, K-L. J., Hiscox, T. J., Emmins, J. J. & Rood, J. I., 2009, In : Microbes and Infection. 11, 3, p. 413 - 418 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis

Kennedy, C. L., Lyras, D., Cordner, L. M., Melton-Witt, J., Emmins, J. J., Tweten, R. K. & Rood, J. I., 2009, In : Infection and Immunity. 77, 3, p. 943 - 951 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum

Kennedy, C. L., Smith, D. J., Lyras, D., Chakravorty, A. & Rood, J. I., 2009, In : PLoS Pathogens. 5, 7 (e1000516), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence

Chiarezza, M., Lyras, D., Pidot, S. J., Flores-Diaz, M., Awad, M. M., Kennedy, C. L., Cordner, L. M., Das, T. P., Poon, R., Hughes, M. L., Emmins, J. J., Alape-Giron, A. & Rood, J. I., 2009, In : Infection and Immunity. 77, 10, p. 4421 - 4428 8 p.

Research output: Contribution to journalArticleResearchpeer-review

tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens

Lyras, D., Adams, V. M., Ballard, S. A., Teng, W. L., Howarth, P., Crellin, P., Bannam, T. L., Songer, J. G. & Rood, J. I., 2009, In : Journal of Bacteriology. 191, 20, p. 6345 - 6351 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Toxin B is essential for virulence of Clostridium difficile

Lyras, D., O'Connor, J. R., Howarth, P. M., Sambol, S. P., Carter, G. P., Phumoonna, T., Poon, R., Adams, V. M., Vedantam, G., Johnson, S., Gerding, D. & Rood, J. I., 2009, In : Nature. 458, 7242, p. 1176 - 1179 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens

Tennant, S. M., Hartland, E. L., Phumoonna, T., Lyras, D., Rood, J. I., Robins-Browne, R. M. & van Driel, I. R., 2008, In : Infection and Immunity. 76, p. 639 - 645 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular and cellular basis of microvascular perfusion deficits induced by clostridium perfringens and clostridium septicum

Hickey, M. J., Kwan, R., Awad, M. M., Kennedy, C. L., Young, L. F., Hall, P. H., Cordner, L. M., Lyras, D., Emmins, J. J. & Rood, J. I., 2008, In : PLoS Pathogens. 4, 4, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator

Carter, G. P., Lyras, D., Allen, D. L., Mackin, K., Howarth, P., O'Connor, J. R. & Rood, J. I., 2007, In : Journal of Bacteriology. 189, 10, p. 7290 - 7301 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Construction and analysis of chromosomal Clostridium difficile mutants

O'Connor, J. R., Lyras, D., Farrow, K. A., Adams, V. M., Powell, D. R., Hinds, J., Cheung, K-L. J. & Rood, J. I., 2006, In : Molecular Microbiology. 61, 5, p. 1335 - 1351 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens

Bannam, T. L., Teng, W. L., Bulach, D. M., Lyras, D. & Rood, J. I., 2006, In : Journal of Bacteriology. 188, 13, p. 4942 - 4951 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function

Adams, V. M., Lucet, I., Tynan, F. E., Chiarezza, M., Howarth, P., Kim, J., Rossjohn, J., Lyras, D. & Rood, J. I., 2006, In : Molecular Microbiology. 60, 3, p. 591 - 601 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Identification of the structural and functional domains of the large serine recombinase TnpX from Clostridium perfringens

Lucet, I. S., Tynan, F. E., Adams, V. M., Rossjohn, J., Lyras, D. & Rood, J. I., 2005, In : Journal of Biological Chemistry. 280, 4, p. 2503 - 2511 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The alpha-toxin of Clostridium septicum is essential for virulence

Kennedy, C. L., Krejany, E. O., Young, L. F., O'Connor, J. R., Awad, M. M., Boyd, R. L., Emmins, J. J., Lyras, D. & Rood, J. I., 2005, In : Molecular Microbiology. 57, 5, p. 1357 - 1366 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
2003

Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia

Shultz, T. R., Tapsall, J. W., White, P. A., Ryan, C. S., Lyras, D., Rood, J. I., Binotto, E. W. & Richardson, C. J. L., 2003, In : Journal of Antimicrobial Chemotherapy. 1, p. 856 - 859 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Environmental Response and Autoregulation of Clostridium difficile TXeR, a Sigma Factor for Toxin Gene Expression

Mani, N., Lyras, D., Barosso, L., Howarth, P., Wilkins, T., Sonenshein, A. L., Rood, J. I. & Dupuy, B., 2002, In : Journal of Bacteriology. 184, 21, p. 5971 - 5978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of Essential Residues in the Erm(B) rRNA Methyltransferase of Clostridium perfringens

Farrow, K. A., Lyras, D., Polekhina, G., Koutsis, K., Parker, M. W. & Rood, J. I., 2002, In : Antimicrobial Agents and Chemotherapy. 46, 5, p. 1253 - 1261 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The clostridial mobilisable transposons

Adams, V., Lyras, D., Farrow, K. A. & Rood, J. I., 2002, In : Cellular and Molecular Life Sciences. 59, 12, p. 2033 - 2043 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile

Farrow, K. A., Lyras, D. & Rood, J. I., 2001, In : Microbiology. 147, p. 2717 - 2728 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of pCW3-encoded tetracycline resistance in clostridium perfringens involves a host-encoded factor

Johanesen, P. A., Lyras, D. & Rood, J. I., 2001, In : Plasmid. 46, 3, p. 229 - 232 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcriptional analysis of the tet(P) operon from Clostridium perfringens

Johanesen, P. A., Lyras, D., Bannam, T. L. & Rood, J. I., 2001, In : Journal of Bacteriology. 183, 24, p. 7110 - 7119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: Excision and circularization is mediated by the large resolvase, TndX

Wang, H., Roberts, A. P., Lyras, D., Rood, J. I., Wilks, M. & Mullany, P., 1 Jul 2000, In : Journal of Bacteriology. 182, 13, p. 3775-3783 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: Excision and circulation is mediated by the large resolvase, TndX

Wang, H., Roberts, A. P., Lyras, D., Rood, J. I., Wilks, M. & Mullany, P., 2000, In : Journal of Bacteriology. p. 3775 - 3783 9 p.

Research output: Contribution to journalArticleResearchpeer-review