• Monash Biomedicine Discovery institute Department of Microbiology Office 152, 19 Innovation Walk, Monash University Victoria 3800 Australia Web monash.edu/discovery-institute

Accepting PhD Students

1992 …2021
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Research Output 1992 2019

2019

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke

Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In : Aging Cell. 18, 5, 13 p., e12980.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain

Wehrhahn, M. C., Keighley, C., Kurtovic, J., Knight, D. R., Hong, S., Hutton, M. L., Lyras, D., Wang, Q., Leong, R., Borody, T., Edye, M. & Riley, T. V., 1 Feb 2019, In : Anaerobe. 55, p. 117-123 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

Tague, A. J., Putsathit, P., Hutton, M. L., Hammer, K. A., Wales, S. M., Knight, D. R., Riley, T. V., Lyras, D., Keller, P. A. & Pyne, S. G., 15 May 2019, In : European Journal of Medicinal Chemistry. 170, p. 203-224 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., 12 Aug 2019, (Accepted/In press) In : Nature Microbiology. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Clostridial genetics: Genetic manipulation of the pathogenic Clostridia

Kuehne, S., Rood, J. I. & Lyras, D., Jun 2019, In : Microbiology spectrum. 7, 3, 16 p., GPP3-0040-2018.

Research output: Contribution to journalArticleResearchpeer-review

Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis

Huang, J., Kelly, C. P., Bakirtzi, K., Villafuerte Gálvez, J. A., Lyras, D., Mileto, S. J., Larcombe, S., Xu, H., Yang, X., Shields, K. S., Zhu, W., Zhang, Y., Goldsmith, J. D., Patel, I. J., Hansen, J., Huang, M., Ylä-Herttuala, S., Moss, A. C., Paredes-Sabja, D., Pothoulakis, C. & 3 others, Shah, Y. M., Wang, J. & Cheng, X., Feb 2019, In : Nature Microbiology. 4, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Enterotoxic clostridia: Clostridioides difficile infections

Mileto, S., Das, A. & Lyras, D., 24 May 2019, In : Microbiology spectrum. 7, 3, 26 p., GPP3-0015-2018.

Research output: Contribution to journalArticleOtherpeer-review

Hyperimmune bovine colostrum reduces gastrointestinal carriage of uropathogenic Escherichia coli

Larcombe, S., Hutton, M. L. & Lyras, D., 1 Feb 2019, In : Human Vaccines & Immunotherapeutics. 15, 2, p. 508-513 6 p.

Research output: Contribution to journalArticleResearchpeer-review

In silico identification of novel toxin homologs and associated mobile genetic elements in clostridium perfringens

Lacey, J. A., Johanesen, P. A., Lyras, D. & Moore, R. J., 29 Jan 2019, In : Pathogens. 8, 1, 14 p., 16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lectin activity of the TcdA and TcdB toxins of Clostridium difficile

Hartley-Tassell, L. E., Awad, M. M., Seib, K. L., Scarselli, M., Savino, S., Tiralongo, J., Lyras, D., Day, C. J. & Jennings, M. P., 1 Mar 2019, In : Infection and Immunity. 87, 3, 9 p., e00676-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Open Access
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pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens

Watts, T. D., Vidor, C. J., Awad, M. M., Lyras, D., Rood, J. I. & Adams, V., 1 Mar 2019, In : Plasmid. 102, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Status of vaccine research and development for Clostridium difficile

Riley, T. V., Lyras, D. & Douce, G. R., 19 Mar 2019, (Accepted/In press) In : Vaccine. 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Virulence Plasmids of the Pathogenic Clostridia

Revitt-Mills, S. A., Vidor, C. J., Watts, T. D., Lyras, D., Rood, J. I. & Adams, V., 17 May 2019, In : Microbiology spectrum. 7, 3, 28 p., GPP3-0034-2018.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Antibacterial activity of rhodomyrtone on Clostridium difficile vegetative cells and spores in vitro

Srisuwan, S., Mackin, K. E., Hocking, D. M., Lyras, D., Bennett-Wood, V. R., Voravuthikunchai, S. P. & Robins-Browne, R. M., 1 Nov 2018, In : International Journal of Antimicrobial Agents. 52, 5, p. 724-729 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens

Adams, V., Han, X., Lyras, D. & Rood, J. I., Sep 2018, In : Plasmid. 99, p. 32-39 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota

Lacey, J. A., Stanley, D., Keyburn, A. L., Ford, M., Chen, H., Johanesen, P., Lyras, D. & Moore, R. J., 1 Dec 2018, In : Veterinary Microbiology. 227, p. 119-126 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract

Rabi, R., Larcombe, S., Mathias, R., McGowan, S., Awad, M. & Lyras, D., 18 Apr 2018, In : PLoS Pathogens. 14, 4, 25 p., e1007004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Clostridium sordellii pathogenicity locus plasmid pCS1-1 encodes a novel clostridial conjugation locus

Vidor, C. J., Watts, T. D., Adams, V., Bulach, D., Couchman, E., Rood, J. I., Fairweather, N. F., Awad, M. & Lyras, D., 16 Jan 2018, In : mBio. 9, 1, 14 p., e01761-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Communication ambassadors—an Australian social media initiative to develop communication skills in early career scientists

Wang, J. T. H., Power, C. J., Kahler, C. M., Lyras, D., Young, P. R., Iredell, J. & Robins-Browne, R., Mar 2018, In : Journal of Microbiology and Biology Education. 19, 1, 4 p., 1428.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Diverse bacterial species contribute to antibiotic-associated diarrhoea and gastrointestinal damage

Larcombe, S., Hutton, M. L., Riley, T. V., Abud, H. E. & Lyras, D., Nov 2018, In : Journal of Infection. 77, 5, p. 417-426 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Expansion of the Clostridium perfringens toxin-based typing scheme

Rood, J. I., Adams, V., Lacey, J. A., Lyras, D., McClane, B. A., Melville, S. B., Moore, R. J., Popoff, M. R., Sarker, M. R., Songer, J. G., Uzal, F. A. & Van Immerseel, F., 1 Oct 2018, In : Anaerobe. 53, p. 5-10 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of large cryptic plasmids in Clostridioides (Clostridium) difficile

Amy, J., Bulach, D., Knight, D., Riley, T., Johanesen, P. & Lyras, D., 1 Mar 2018, In : Plasmid. 96-97, p. 25-38 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Intestinal colonization traits of pandemic multidrug-resistant Escherichia coli ST131

Sarkar, S., Hutton, M. L., Vagenas, D., Ruter, R., Schuller, S., Lyras, D., Schembri, M. A. & Totsika, M., 15 Sep 2018, In : Journal of Infectious Diseases. 218, 6, p. 979-990 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Whole genome analysis reveals the diversity and evolutionary relationships between necrotic enteritis-causing strains of Clostridium perfringens

Lacey, J. A., Allnutt, T. R., Vezina, B., Van, T. T. H., Stent, T., Han, X., Rood, J. I., Wade, B., Keyburn, A. L., Seemann, T., Chen, H., Haring, V., Johanesen, P. A., Lyras, D. & Moore, R. J., 22 May 2018, In : BMC Genomics. 19, 1, 22 p., 379.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

Hutton, M. L., Cunningham, B. A., Mackin, K. E., Lyon, S. A., James, M. L., Rood, J. I. & Lyras, D., 16 Jun 2017, In : Scientific Reports. 7, 1, 13 p., 3665.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Conjugation-mediated horizontal gene transfer of Clostridium perfringens plasmids in the chicken gastrointestinal tract results in the formation of new virulent strains

Lacey, J. A., Keyburn, A. L., Ford, M. E., Portela, R. W., Johanesen, P. A., Lyras, D. & Moore, R. J., 1 Dec 2017, In : Applied and Environmental Microbiology. 83, 24, 13 p., e01814-17.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp.

John-White, M., Dumsday, G. J., Johanesen, P., Lyras, D., Drinkwater, N. & McGowan, S., 1 Jul 2017, In : Acta Crystallographica. Section F: Structural Biology Communications. F73, 7, p. 386-392 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Options for improving effectiveness of rotavirus vaccines in developing countries

Tissera, M. S., Cowley, D., Bogdanovic-Sakran, N., Hutton, M. L., Lyras, D., Kirkwood, C. D. & Buttery, J. P., 3 Apr 2017, In : Human Vaccines & Immunotherapeutics. 13, 4, p. 921-927 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Structural characterization of Clostridium sordellii spores of diverse human, animal, and environmental origin and comparison to Clostridium difficile spores

Rabi, R., Turnbull, L., Whitchurch, C. B., Awad, M. & Lyras, D., 1 Sep 2017, In : mSphere. 2, 5, 12 p., e00343-17.

Research output: Contribution to journalArticleResearchpeer-review

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X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2

Unterweger, B., Drinkwater, N., Johanesen, P., Lyras, D., Dumsday, G. J. & McGowan, S., 1 May 2017, In : Proteins: Structure, Function, and Bioinformatics. 85, 5, p. 945-950 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

CdtR regulates TcdA and TcdB production in Clostridium difficile

Lyon, S. A., Hutton, M. L., Rood, J. I., Cheung, J. K. & Lyras, D., 14 Jul 2016, In : PLoS Pathogens. 12, 7, 19 p., e1005758.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Clostridium difficile infection

Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H. & Kuijper, E. J., 7 Apr 2016, In : Nature Reviews Disease Primers. 2, 20 p., 201620.

Research output: Contribution to journalReview ArticleOtherpeer-review

CYP101J2, CYP101J3, and CYP101J4, 1,8-cineolehydroxylating cytochrome P450 monooxygenases from Sphingobium yanoikuyae strain B2

Unterweger, B., Bulach, D. M., Scoble, J., Midgley, D. J., Greenfield, P., Lyras, D., Johanesen, P. & Dumsday, G. J., Nov 2016, In : Applied and Environmental Microbiology. 82, 22, p. 6507-6517 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Detection and characterisation of Clostridium difficile in Australian Thoroughbred foals

Bailey, K. E., Squires, E. L. (ed.), Symes, S. J., Mackin, K. E., Rousseau, J. D., Lyras, D., Weese, J. S., Axon, J. E., Russell, C. M., Hartley, C. A., Browning, G. F. & Gilkerson, J. R., 2016, p. 23 - 23. 1 p.

Research output: Contribution to conferenceAbstractOther

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

Masters, S. L., Lagou, V., Jeru, I., Baker, P. J., Van Eyck, L., Parry, D. A., Lawless, D., De Nardo, D., Garcia-Perez, J. E., Dagley, L. F., Holley, C. L., Dooley, J., Moghaddas, F., Pasciuto, E., Jeandel, P-Y., Sciot, R., Lyras, D., Webb, A. I., Nicholson, S. E., De Somer, L. & 12 others, van Nieuwenhove, E., Ruuth-Praz, J., Copin, B., Cochet, E., Medlej-Hashim, M., Megarbane, A., Schroder, K., Savic, S., Goris, A., Amselem, S., Wouters, C. & Liston, A., 30 Mar 2016, In : Science Translational Medicine. 8, 332, 10 p., 332ra45.

Research output: Contribution to journalArticleResearchpeer-review

Functional analysis of an feoB mutant in Clostridium perfringens strain 13

Awad, M. M., Cheung, J. K., Tan, J. E., McEwan, A. G., Lyras, D. & Rood, J. I., Oct 2016, In : Anaerobe. 41, p. 10-17 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Genomic diversity of necrotic enteritis-associated strains of Clostridium perfringens: A review

Lacey, J. A., Johanesen, P. A., Lyras, D. & Moore, R. J., 31 May 2016, In : Avian Pathology. 45, 3, p. 302-307 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea

Larcombe, S., Hutton, M. L. & Lyras, D., Jun 2016, In : Trends in Microbiology. 24, 6, p. 463-476 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Methods for determining transfer of mobile genetic elements in Clostridium difficile

Johanesen, P. & Lyras, D., 2016, Methods in Molecular Biology. Roberts, A. P. & Mullany, P. (eds.). 2nd ed. New York NY USA: Humana Press, Vol. 1476. p. 199-213 15 p. (Methods in Molecular Biology; vol. 1476).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

Cowardin, C. A., Buonomo, E. L., Saleh, M. M., Wilson, M. G., Burgess, S. L., Kuehne, S. A., Schwan, C., Eichhoff, A. M., Koch-Nolte, F., Lyras, D., Aktories, K., Minton, N. P. & Petri, W. A., 11 Jul 2016, In : Nature Microbiology. 1, 8, 10 p., 16108.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Sialidase NanS enhances non-TcsL mediated cytotoxicity of Clostridium sordellii

Awad, M. M., Singleton, J. & Lyras, D., 17 Jun 2016, In : Toxins. 8, 6, 15 p., 189.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., MacKin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J. & Wong, C. H. Y., 1 Nov 2016, In : Nature Medicine. 22, 11, p. 1277-1284 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta

Kim, M. L., Chae, J. J., Park, Y. H., De Nardo, D., Stirzaker, R. A., Ko, H-J., Tye, H., Cengia, L., Di Rago, L., Metcalf, D., Roberts, A. W., Kastner, D. L., Lew, A. M., Lyras, D., Kile, B. T., Croker, B. A. & Masters, S. L., 2015, In : Journal of Experimental Medicine. 212, 6, p. 927-938 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibiotic resistance, virulence factors and genetics of clostridium sordellii

Vidor, C., Awad, M. M. & Lyras, D., 2015, In : Research in Microbiology. 166, 4, p. 368 - 374 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria

Wales, S. M., Hammer, K. A., King, A. M., Tague, A. J., Lyras, D., Riley, T. V., Keller, P. A. & Pyne, S. J., 2015, In : Organic and Biomolecular Chemistry. 13, 20, p. 5743 - 5756 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Clostridium difficile drug pipeline: challenges in discovery and development of new agents

Jarrad, A. M., Karoli, T., Blaskovich, M. A. T., Lyras, D. & Cooper, M. A., 2015, In : Journal of Medicinal Chemistry. 58, 13, p. 5164 - 5185 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Clostridium difficile infection: Current and emerging therapeutics

Jarrad, A. M., Blaskovich, M. A. T., Lyras, D. & Cooper, M. A., Dec 2015, In : Current Treatment Options in Infectious Diseases. 7, 4, p. 317-334 18 p.

Research output: Contribution to journalReview ArticleOtherpeer-review