• Monash Biomedicine Discovery institute Department of Microbiology Office 152, 19 Innovation Walk, Monash University Victoria 3800 Australia Web monash.edu/discovery-institute

Accepting PhD Students

1992 …2021
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Personal profile

Biography


A superbug of our own creation

The rapid evolution of bacteria and the excessive use of antibiotics have turned our hospitals from institutions of healing to incubators of new breeds of superbugs. The challenge for researchers such as Dr Dena Lyras is to uncover the secrets and weaknesses of bacteria that are changing before their eyes.




Dena has spent her research career developing world-leading knowledge of the bacterium Clostridium difficile, a gut bacterium that causes disease in the intestines. The bacterium usually attacks hospital patients that are being treated with antibiotics for other, unrelated, infections.

Over the past decade the bug has undergone a radical evolution that has allowed it to thrive in hospital environments and develop into the leading cause of death from hospital-acquired antibiotic associated intestinal infection.

Clostridium difficile has become so successful at exploiting our modern hospital practices that it is now found in every hospital in the world that uses antibiotics. And not only is the bactrium surviving medical science's best attempts to kill it, it is actually becoming more deadly.

"I'm interested in this bacterium because it has adapted so well to our modern hospital environments. It is really a product of our times," Dena says.

"It was not known to cause problems before antibiotics, but the introduction of antibiotics changed things and it found a new niche to occupy. As a consequence it has become a significant problem in hospitals worldwide.

"It has also changed genetically and now causes more severe disease. Where people would normally be treated and recover, now we have people who are far sicker, and more people are dying because they cannot recover from these infections.

"The reason for this is that the bacteria quickly adapt to the environment they are in - in this case hospitals - resulting in newer versions of the bacteria that are far better at causing disease. In other words, superbugs. I am interested in how that process happens."

Researchers in Dena's lab, the Clostridial Genetics Laboratory, are trying to understand how Clostridium difficile causes disease, and in particular why these new versions of the bacterium have become more potent.

Part of the bug's success lies in the use of antibiotics in hospitals. Not only have the bacteria developed increasing resistance to antibiotic treatments, but the devastating effect some drugs have on the good bacteria that protect our bodies is creating a space that harmful bacteria can exploit.

Dena's team have enjoyed some success in better understanding the bug through genetic manipulation. She was the lead author of a study published in the prestigious journal Nature, which shed new light on the essential role specific toxins play in causing disease, a discovery that disproved prevailing opinion.

More recently, Dena's team have discovered new genetic factors responsible for creating the increased virulence of the bacteria in research that has recently been accepted for publication in another prestigious journal.

Dena is now using this knowledge to develop new therapeutic strategies capable of tackling the ever-changing super bug. She heads an ARC Linkage project in collaboration with industry partners who are developing strategies for handling these infections.

But there are no promises of an easy fix.

"We think of these bacteria as lacking complexity, but when we see what they can do we see that they are incredibly complex and can change at a frighteningly fast rate," Dena says.

External positions

President, The Australian Society for Microbiology

20182020

Research area keywords

  • Gastrointestinal infections
  • Host-pathogen interactions
  • Antibiotic resistance in bacteria
  • Mobile DNA and lateral gene transfer
  • Therapeutics for gut infections

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2001 2021

Research Output 1992 2019

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke

Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In : Aging Cell. 18, 5, 13 p., e12980.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain

Wehrhahn, M. C., Keighley, C., Kurtovic, J., Knight, D. R., Hong, S., Hutton, M. L., Lyras, D., Wang, Q., Leong, R., Borody, T., Edye, M. & Riley, T. V., 1 Feb 2019, In : Anaerobe. 55, p. 117-123 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

Tague, A. J., Putsathit, P., Hutton, M. L., Hammer, K. A., Wales, S. M., Knight, D. R., Riley, T. V., Lyras, D., Keller, P. A. & Pyne, S. G., 15 May 2019, In : European Journal of Medicinal Chemistry. 170, p. 203-224 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., 12 Aug 2019, (Accepted/In press) In : Nature Microbiology. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Clostridial genetics: Genetic manipulation of the pathogenic Clostridia

Kuehne, S., Rood, J. I. & Lyras, D., Jun 2019, In : Microbiology spectrum. 7, 3, 16 p., GPP3-0040-2018.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2017 2017

  • 1 Membership of industry collaboration/ network

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)
1 Mar 2017

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network