Projects per year
Personal profile
Research interests
To develop and implement advanced imaging techniques and analysis methods for the study of disease.
Research overview
My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Imaging
- Biomarkers
- MRI
- PET
- ct
- FLECT
- Image analysis
Collaborations and top research areas from the last five years
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The Glymphatic System: Novel Biomarker of Disease Severity and Therapeutic Target
1/03/22 → 1/03/24
Project: Research
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Cellular therapeutics for neurorepair in multiple sclerosis
Petratos, S., Young, K., Lee, J. Y., Wong, N., Wright, D., Strittmatter, S. M. & Fehlings, M.
1/01/22 → 31/12/24
Project: Research
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Next Generation Imaging Biomarkers for Mild Traumatic Brain Injury
1/01/20 → 31/12/24
Project: Research
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Translational platform for epilepsy therapy and biomarker discovery
Galanopoulou, A. S., Moshe, S., Mowrey, W., Branch, C., Fleysher, R., Cui , M., Staba, R. J., Mazarati, A., Sankar, R., Agoston, D., Duncan, D., Cabeen, R., Coles, L., O'Brien, T., Toga, A. W., Bragin, A., Engel, J., Vespa, P., Harris, N., Wright, D., Jones, N., Shultz, S., Casillas-Espinosa, P., Hudson, M., Ali, I. & Braine, E.
NIH - National Institutes of Health (United States of America)
15/04/22 → 31/03/23
Project: Research
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3D printer - Stratasys Objet30 Pro:
Kwan, P., O'Brien, T., Jones, N., Casillas-Espinosa, P., Hudson, M., Wright, D., Alan, T., French, C., Chan, J. & Jayawardena, A.
1/10/21 → 31/12/22
Project: Research
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Acute effects of single and repeated mild traumatic brain injury on levels of neurometabolites, lipids, and mitochondrial function in male rats
Allen, J., Pham, L., Bond, S. T., O’Brien, W. T., Spitz, G., Shultz, S. R., Drew, B. G., Wright, D. K. & McDonald, S. J., 29 Jun 2023, In: Frontiers in Molecular Neuroscience. 16, 13 p., 1208697.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Author Correction: Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects (Nature Communications, (2023), 14, 1, (3403), 10.1038/s41467-023-39040-0)
Ayers, K. L., Eggers, S., Rollo, B. N., Smith, K. R., Davidson, N. M., Siddall, N. A., Zhao, L., Bowles, J., Weiss, K., Zanni, G., Burglen, L., Ben-Shachar, S., Rosensaft, J., Raas-Rothschild, A., Jørgensen, A., Schittenhelm, R. B., Huang, C., Robevska, G., van den Bergen, J., Casagranda, F., & 23 others , Dec 2023, In: Nature Communications. 14, 1, 1 p., 3566.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy
Ali, I., Silva, J., Casillas-Espinosa, P. M., Braine, E., Yamakawa, G. R., Hudson, M. R., Brady, R. D., Major, B., Thergarajan, P., Haskali, M. B., Wright, D. K., Jupp, B., Vivash, L., Shultz, S. R., Mychasiuk, R., Kwan, P., Jones, N. C., Fukushima, K., Sachdev, P., Cheng, J. Y., & 1 others , 2023, (Accepted/In press) In: Epilepsia. 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, S., Cabeen, R., Harris, N. G., Gröhn, O., Wright, D. K., Garner, R., Bennett, A., Alba, C., Martinez, A., Ndode-Ekane, X. E., Andrade, P., Paananen, T., Ciszek, R., Immonen, R., Manninen, E., Puhakka, N., Tohka, J., Heiskanen, M., Ali, I., Shultz, S. R., & 13 others , Sept 2023, In: Epilepsy Research. 195, 6 p., 107201.Research output: Contribution to journal › Article › Research › peer-review
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Initial Severity of Injury Has Little Effect on the Temporal Profile of Long-Term Deficits in Locomotion, Anxiety, and Cognitive Function after Diffuse Traumatic Brain Injury
Corrigan, F., Arulsamy, A., Shultz, S. R., Wright, D. K. & Collins-Praino, L. E., 1 Jan 2023, In: Neurotrauma Reports. 4, 1, p. 41-50 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Activities
- 1 Contribution to conference
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Australian Synchrotron Users Meeting (ANSTO) [Virtual]
Anton Maksimento (Speaker), David Reser (Speaker), Daniel Hausermann (Speaker), Michael De Veer (Speaker), Olga Panagiotopoulou (Speaker), Charles Huveneers (Speaker), David Wright (Speaker) & Christopher Hall (Speaker)
2021Activity: Participating in or organising an event types › Contribution to conference
Equipment
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Biomedical Imaging (MBI)
Kylie Reid (Manager), Robert Brkljaca (Manager), Christoph Hagemeyer (Other) & David Wright (Other)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility