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Personal profile

Research interests

To develop and implement advanced imaging techniques and analysis methods for the study of disease.

Research overview

My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.

Keywords

  • Imaging
  • Biomarkers
  • MRI
  • PET
  • ct
  • FLECT
  • Image analysis

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Projects 2018 2022

Biomarkers of Brain Concussion

Shultz, S., O'Brien, T., Kosofsky, B., Germaine, J., Smith, R., Fielding, J., Clough, M. & Wright, D.

14/11/187/01/20

Project: Research

Research Output 2002 2019

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R., Smith, G., Brady, R. D., Wright, D., Johnston, L., Harris, N. G., Manninen, E., Salo, R., Branch, C., Duncan, D., Cabeen, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Shultz, S. R., Andrade, P., Puhakka, N., Staba, R. J., O'Brien, T. J. & 3 othersToga, A. W., Pitkänen, A. & Gröhn, O., 1 Feb 2019, In : Epilepsy Research. 150, p. 46-57 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Tan, X. L., Sun, M., Brady, R. D., Liu, S., Llanos, R. M., Cheung, S., Wright, D. K., Casillas-Espinosa, P. M., Sashindranath, M., O'Brien, T. J., McDonald, S. J., Turner, B. J. & Shultz, S., 1 Jan 2019, In : Journal of Neurotrauma. 36, 1, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Wortman, R. C., Meconi, A., Neale, K. J., Brady, R. D., McDonald, S. J., Christie, B. R., Wright, D. K. & Shultz, S. R., 1 Dec 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1588-1598 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Meconi, A., Wortman, R. C., Wright, D. K., Neale, K. J., Clarkson, M., Shultz, S. R. & Christie, B. R., 1 May 2018, In : PLoS ONE. 13, 5, 24 p., e0197187.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File