20022020

Research output per year

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Personal profile

Research interests

To develop and implement advanced imaging techniques and analysis methods for the study of disease.

Research overview

My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.

Research area keywords

  • Imaging
  • Biomarkers
  • MRI
  • PET
  • ct
  • FLECT
  • Image analysis

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Projects

Research Output

  • 47 Article
  • 1 Chapter (Book)
  • 1 Conference Paper
  • 1 Review Article

Examining the effects of anabolic–androgenic steroids on repetitive mild traumatic brain injury (RmTBI) outcomes in adolescent rats

Tabor, J., Wright, D. K., Christensen, J., Zamani, A., Collins, R., Shultz, S. R. & Mychasiuk, R., May 2020, In : Brain Sciences. 10, 5, 17 p., 258.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats

Christensen, J., Wright, D. K., Yamakawa, G. R., Shultz, S. R. & Mychasiuk, R., 10 Apr 2020, In : Scientific Reports. 10, 1, 9 p., 6254.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Tan, X. L., Zheng, P., Wright, D. K., Sun, M., Brady, R. D., Liu, S., McDonald, S. J., Mychasiuk, R., Cenap, S., Jones, N. C., O’Brien, T. J. & Shultz, S. R., 2020, In : Brain Injury. 34, 1, p. 131–139 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging

Zamani, A., Ryan, N. P., Wright, D. K., Caeyenberghs, K. & Semple, B. D., 1 Mar 2020, In : Journal of Neurotrauma. 37, 5, p. 724-738 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Neurological Consequences of Engaging in Australian Collision Sports

Symons, G. F., Clough, M., Fielding, J., O'Brien, W. T., Shepherd, C. E., Wright, D. K. & Shultz, S. R., 1 Mar 2020, In : Journal of Neurotrauma. 37, 5, p. 792-809 18 p.

Research output: Contribution to journalArticleResearchpeer-review