Projects per year
Personal profile
Research interests
To develop and implement advanced imaging techniques and analysis methods for the study of disease.
Research overview
My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.
Research area keywords
- Imaging
- Biomarkers
- MRI
- PET
- ct
- FLECT
- Image analysis
Network
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Translational platform for epilepsy therapy and biomarker discovery
Galanopoulou, A. S., Moshe, S., Mowrey, W., Branch, C., Fleysher, R., Cui , M., Staba, R. J., Mazarati, A., Sankar, R., Agoston, D., Duncan, D., Cabeen, R., Coles, L., O'Brien, T., Toga, A. W., Bragin, A., Engel, J., Vespa, P., Harris, N., Wright, D., Jones, N., Shultz, S., Casillas-Espinosa, P., Hudson, M., Ali, I. & Braine, E.
National Institutes of Health (United States)
15/04/22 → 31/03/23
Project: Research
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The Glymphatic System: Novel Biomarker of Disease Severity and Therapeutic Target
1/03/22 → 1/03/24
Project: Research
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Targeted delivery of the NgR-Fc protein to enhance neurorepair in a model of multiple sclerosis
Petratos, S., Young, K., Lee, J. Y., Wong, N., Wright, D., Strittmatter, S. M. & Fehlings, M.
1/01/22 → 31/12/24
Project: Research
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3D printer - Stratasys Objet30 Pro:
Kwan, P., O'Brien, T., Jones, N., Casillas-Espinosa, P., Hudson, M., Wright, D., Alan, T., French, C., Chan, J. & Jayawardena, A.
1/10/21 → 31/12/22
Project: Research
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Measuring inflammation in brain and blood for predicting risk of post-traumatic epilepsy
Ali, I., Jones, N., O'Brien, T., Dedeurwaerdere, S., Wright, D. & Vivash, L.
United States Department of Defense (DOD)
30/09/21 → 30/09/24
Project: Research
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7t magnetic resonance imaging quantification of brain glutamate in acute ischaemic stroke
Nicolo, J. P., Moffat, B., Wright, D. K., Sinclair, B., Neal, A., Lui, E., Desmond, P., Glarin, R., Davis, K. A., Reddy, R., Yan, B., O’Brien, T. J. & Kwan, P., May 2021, In: Journal of Stroke. 23, 2, p. 281-284 4 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access2 Citations (Scopus) -
Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model
Pham, L., Wright, D. K., O'Brien, W. T., Bain, J., Huang, C., Sun, M., Casillas-Espinosa, P. M., Shah, A. D., Schittenhelm, R. B., Sobey, C. G., Brady, R. D., O'Brien, T. J., Mychasiuk, R., Shultz, S. R. & McDonald, S. J., Jan 2021, In: Neurobiology of Disease. 148, 11 p., 105151.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Cognitive ocular motor deficits and white matter damage chronically after sports-related concussion
Fuller Symons, G., Clough, M., Mutimer, S., Major, B. P., O'Brien, W. T., Costello, D. M., McDonald, S., Chen, B., White, O. B., Mychasiuk, R. M., Law, M., Wright, D., O'Brien, T. J., Fielding, J., Kolbe, S. & Shultz, S. R., 14 Sep 2021, In: Brain Communications. 3, 3, 12 p., fcab213.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Diffusion Imaging Reveals Sex Differences in the White Matter following Sports-Related Concussion
Wright, D. K., Symons, G. F., O’Brien, W. T., McDonald, S. J., Zamani, A., Major, B., Chen, Z., Costello, D., Brady, R. D., Sun, M., Law, M., O'Brien, T. J., Mychasiuk, R. & Shultz, S. R., Oct 2021, In: Cerebral Cortex. 31, 10, p. 4411-4419 9 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Longitudinal hippocampal volumetric changes in mice following brain infarction
Brait, V. H., Wright, D. K., Nategh, M., Oman, A., Syeda, W. T., Ermine, C. M., O’Brien, K. R., Werden, E., Churilov, L., Johnston, L. A., Thompson, L. H., Nithianantharajah, J., Jackman, K. A. & Brodtmann, A., Dec 2021, In: Scientific Reports. 11, 1, 13 p., 10269.Research output: Contribution to journal › Article › Research › peer-review
Open Access