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Personal profile

Research interests

To develop and implement advanced imaging techniques and analysis methods for the study of disease.

Research overview

My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.

Keywords

  • Imaging
  • Biomarkers
  • MRI
  • PET
  • ct
  • FLECT
  • Image analysis

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Projects 2018 2020

Biomarkers of Brain Concussion

Shultz, S., O'Brien, T. J., Kosofsky, B., Germaine, J., Smith, R., Fielding, J., Clough, M. J. & Wright, D. K.

14/11/187/01/20

Project: Research

Research Output 2002 2018

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Meconi, A., Wortman, R. C., Wright, D. K., Neale, K. J., Clarkson, M., Shultz, S. R. & Christie, B. R., 1 May 2018, In : PLoS ONE. 13, 5, 24 p., e0197187.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Telomere length and advanced diffusion MRI as biomarkers for repetitive mild traumatic brain injury in adolescent rats

Wright, D. K., O'Brien, T. J., Mychasiuk, R. & Shultz, S. R., 2018, In : NeuroImage: Clinical. 18, p. 315-324 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Tan, X. L., Sun, M., Brady, R. D., Liu, S., Llanos, R. M., Cheung, S., Wright, D. K., Casillas-Espinosa, P. M., Sashindranath, M., O'Brien, T. J., McDonald, S. J., Turner, B. J. & Shultz, S., 14 Jun 2018, (Accepted/In press) In : Journal of Neurotrauma. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

Wright, D. K., Johnston, L. A., Kershaw, J., Ordidge, R., O'Brien, T. J. & Shultz, S. R., 1 Jul 2017, In : Journal of Neurotrauma. 34, 13, p. 2109-2118 10 p.

Research output: Contribution to journalArticleResearchpeer-review