David Wright

Dr

20022024
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Personal profile

Research interests

To develop and implement advanced imaging techniques and analysis methods for the study of disease.

Research overview

My most significant contributions to brain imaging research are in the development, application and analysis of advanced MRI techniques for the study of disease, in particular, traumatic brain injury (TBI). During my PhD I investigated the potential of neuroimaging, blood, and behavioural biomarkers to provide reliable and objective insight into the pathophysiological changes that occur following TBI. Significant contributions included evidence supporting a relationship between TBI and the later development of a motor neuron disease-like process and the identification of novel MRI metrics sensitive to the axonal injury commonly seen in TBI. Furthermore, I showed that these MRI metrics, together with blood-based proteomics, were also sensitive to the subtle pathophysiological changes that occur following mild TBI. Importantly, I identified brain abnormalities beyond the resolution of neurocognitive deficits that are typically used to define recovery, which has important implications in the clinical management of mTBI, including guiding return-to-play decisions post-concussion.

Research area keywords

  • Imaging
  • Biomarkers
  • MRI
  • PET
  • ct
  • FLECT
  • Image analysis

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Projects 2018 2024

Research Output 2002 2020

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Tan, X. L., Zheng, P., Wright, D. K., Sun, M., Brady, R. D., Liu, S., McDonald, S. J., Mychasiuk, R., Cenap, S., Jones, N. C., O’Brien, T. J. & Shultz, S. R., 2020, In : Brain Injury. 34, 1, p. 131–139 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Advanced MRI analysis to detect white matter brain injury in growth restricted newborn lambs

Malhotra, A., Sepehrizadeh, T., Dhollander, T., Wright, D., Castillo-Melendez, M., Sutherland, A. E., Pham, Y., Ditchfield, M., Polglase, G. R., de Veer, M., Jenkin, G., Pannek, K., Shishegar, R. & Miller, S. L., 1 Jan 2019, In : NeuroImage: Clinical. 24, 9 p., 101991.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R., Smith, G., Brady, R. D., Wright, D., Johnston, L., Harris, N. G., Manninen, E., Salo, R., Branch, C., Duncan, D., Cabeen, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Shultz, S. R., Andrade, P., Puhakka, N., Staba, R. J., O'Brien, T. J. & 3 others, Toga, A. W., Pitkänen, A. & Gröhn, O., 1 Feb 2019, In : Epilepsy Research. 150, p. 46-57 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Internal Subdivisions of the Marmoset Claustrum Complex: Identification by Myeloarchitectural Features and High Field Strength Imaging

Pham, X., Wright, D. K., Atapour, N., Chan, J. M-H., Watkins, K. J., Worthy, K. H., Rosa, M., Reichelt, A. & Reser, D. H., Nov 2019, In : Frontiers in Neuroanatomy. 13, 13 p., 96.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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