David Walker

Assoc Professor

1986 …2019
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Research Output 1986 2019

2019

Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction

Ranzil, S., Ellery, S., Walker, D. W., Vaillancourt, C., Alfaidy, N., Bonnin, A., Borg, A., Wallace, E. M., Ebeling, P. R., Erwich, J. J. & Murthi, P., 23 May 2019, (Accepted/In press) In : Placenta. 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse

Ellery, S. J., Goss, M. G., Brew, N., Dickinson, H., Hale, N., LaRosa, D. A., Walker, D. W. & Wong, F. Y., 15 Jan 2019, In : Neurotherapeutics. 16, 1, p. 231-243 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Knowledge gaps and emerging research areas in intrauterine growth restriction-associated brain injury

Fleiss, B., Wong, F., Brownfoot, F., Shearer, I. K., Baud, O., Walker, D. W., Gressens, P. & Tolcos, M., 1 Jan 2019, In : Frontiers in Endocrinology. 10, MAR, 24 p., 188.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

The relationship between the placental serotonin pathway and fetal growth restriction

Ranzil, S., Walker, D. W., Borg, A. J., Wallace, E. M., Ebeling, P. R. & Murthi, P., 1 Jun 2019, In : Biochimie. 161, p. 80-87 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Subplate: A Potential Driver of Cortical Folding?

Rana, S., Shishegar, R., Quezada, S., Johnston, L., Walker, D. & Tolcos, M., 4 Feb 2019, (Accepted/In press) In : Cerebral Cortex. 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Unicorn babies: Understanding circulating and cerebral creatine levels of the preterm infant. An observational study protocol

Berry, M. J., Schlegel, M., Kowalski, G. M., Bruce, C. R., Callahan, D. L., Davies-Tuck, M. L., Dickinson, H., Goodson, A., Slocombe, A., Snow, R. J., Walker, D. W. & Ellery, S. J., 1 Jan 2019, In : Frontiers in Physiology. 10, MAR, 8 p., 142.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
2018

Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?

Ellery, S. J., Kelleher, M., Grigsby, P., Burd, I., Derks, J. B., Hirst, J., Miller, S. L., Sherman, L. S., Tolcos, M. & Walker, D. W., 1 Dec 2018, In : Journal of Physiology. 596, 23, p. 5593-5609 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Development of the cerebral cortex and the effect of the intrauterine environment

Quezada, S., Castillo-Melendez, M., Walker, D. W. & Tolcos, M., 1 Dec 2018, In : The Journal of Physiology. 596, 23, p. 5665-5674 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia

Brew, N., Nakamura, S., Hale, N., Azhan, A., Davies, G. I., Nitsos, I., Miller, S. L., Walker, D. W. & Wong, F. Y., 1 Sep 2018, In : Pediatric Research. 84, 3, p. 442-450 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep

Hutchinson, D. S., Brew, N., Vu, T., Merlin, J., Hale, N., Walker, D. W. & Wong, F. Y., 1 Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Waking up too early – the consequences of preterm birth on sleep development

Bennet, L., Walker, D. W. & Horne, R. S. C., 1 Dec 2018, In : Journal of Physiology. 596, 23, p. 5687-5708 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

Altered placental tryptophan metabolic pathway in human fetal growth restriction

Murthi, P., Wallace, E. M. & Walker, D. W., 1 Apr 2017, In : Placenta. 52, p. 62-70 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Automatic segmentation of fetal brain using diffusion-weighted imaging cues

Shishegar, R., Joshi, A. A., Tolcos, M., Walker, D. W. & Johnston, L. A., 19 Jun 2017, IEEE International Symposium on Biomedical Imaging. IEEE, Institute of Electrical and Electronics Engineers, p. 804-807 4 p. 7950640

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Blocked, delayed, or obstructed: What causes poor white matter development in intrauterine growth restricted infants?

Tolcos, M., Petratos, S., Hirst, J. J., Wong, F., Spencer, S. J., Azhan, A., Emery, B. & Walker, D. W., 1 Jul 2017, In : Progress in Neurobiology. 154, p. 62-77 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation

Cumberland, A. L., Palliser, H. K., Walker, D. W. & Hirst, J. J., 1 Apr 2017, In : Cerebellum. 16, 2, p. 306-313 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep

Nakamura, S., Walker, D. W. & Wong, F. Y., 15 Feb 2017, In : Journal of Physiology. 595, 4, p. 1289-1303 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs

Nakamura, S., Walker, D. W. & Wong, F. Y., 1 Sep 2017, In : The Journal of Physiology. 595, 17, p. 6007-6021 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Creatine biosynthesis and transport by the term human placenta

Ellery, S. J., Della Gatta, P. A., Bruce, C. R., Kowalski, G. M., Davies-Tuck, M., Mockler, J. C., Murthi, P., Walker, D. W., Snow, R. J. & Dickinson, H., 1 Apr 2017, In : Placenta. 52, p. 86-93 8 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo transcriptome assembly for the spiny mouse (Acomys cahirinus)

Mamrot, J., Legaie, R., Ellery, S. J., Wilson, T., Seemann, T., Powell, D. R., Gardner, D. K., Walker, D. W., Temple-Smith, P., Papenfuss, A. T. & Dickinson, H., 1 Dec 2017, In : Scientific Reports. 7, 1, 15 p., 8996.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Description of a method for inducing fetal growth restriction in the spiny mouse

Dickinson, H., Ellery, S., Davies-Tuck, M., Tolcos, M., Nitsos, I., Walker, D. W. & Miller, S. L., Oct 2017, In : Journal of Developmental Origins of Health and Disease. 8, 5, p. 550-555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Does maternal-fetal transfer of creatine occur in pregnant sheep?

Baharom, S., De Matteo, R., Ellery, S., Della Gatta, P., Bruce, C. R., Kowalski, G. M., Hale, N., Dickinson, H., Harding, R., Walker, D. & Snow, R. J., 2017, In : American Journal of Physiology - Endocrinology and Metabolism. 313, 1, p. E75-E83

Research output: Contribution to journalArticleResearchpeer-review

Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal Guinea pig model

Cumberland, A. L., Palliser, H. K., Rani, P., Walker, D. W. & Hirst, J. J., 1 Oct 2017, In : Journal of Developmental Origins of Health and Disease. 8, 5, p. 584-596 13 p.

Research output: Contribution to journalArticleResearchpeer-review

First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus)

Bellofiore, N., Ellery, S. J., Mamrot, J., Walker, D. W., Temple-Smith, P. & Dickinson, H., 1 Jan 2017, In : American Journal of Obstetrics and Gynecology. 216, 1, p. 40.e1-40.e11

Research output: Contribution to journalArticleResearchpeer-review

Ganaxolone: A new treatment for neonatal seizures

Yawno, T., Miller, S. L., Bennet, L., Wong, F., Hirst, J. J., Fahey, M. & Walker, D. W., 22 Aug 2017, In : Frontiers in Cellular Neuroscience. 11, 7 p., 246.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero

Cumberland, A. L., Palliser, H. K., Crombie, G. K., Walker, D. W. & Hirst, J. J., 1 May 2017, In : International Journal of Developmental Neuroscience. 58, p. 50-58 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal dysfunction in early adulthood following birth asphyxia in male spiny mice, and its amelioration by maternal creatine supplementation during pregnancy

Ellery, S. J., Larosa, D. A., Cullen-Mcewen, L. A., Brown, R. D., Snow, R. J., Walker, D. W., Kett, M. M. & Dickinson, H., 1 Apr 2017, In : Pediatric Research. 81, 4, p. 646-653 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Understanding the Full Spectrum of organ injury following intrapartum asphyxia

LaRosa, D. A., Ellery, S. J., Walker, D. W. & Dickinson, H., 17 Feb 2017, In : Frontiers in Pediatrics. 5, 11 p., 16.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
2016

Creatine for women: a review of the relationship between creatine and the reproductive cycle and female-specific benefits of creatine therapy

Ellery, S. J., Walker, D. W. & Dickinson, H., 1 Aug 2016, In : Amino Acids. 48, 8, p. 1807-1817 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Dietary creatine supplementation during pregnancy: a study on the effects of creatine supplementation on creatine homeostasis and renal excretory function in spiny mice

Ellery, S. J., LaRosa, D. A., Kett, M. M., Della Gatta, P. A., Snow, R. J., Walker, D. W. & Dickinson, H., 1 Aug 2016, In : Amino Acids. 48, 8, p. 1819-1830 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine treatment during acute hypoxia is neuroprotective in the developing sheep brain

Brew, N., Azhan, A., den Heijer, I., Boomgardt, M., Davies, G. I., Nitsos, I., Miller, S. L., Walker, A. M., Walker, D. W. & Wong, F. Y., 1 Mar 2016, In : Neuroscience. 316, p. 82-93 12 p.

Research output: Contribution to journalArticleResearchpeer-review

How Systemic Inquiry Releases Citizen Knowledge to Reform Schools: Community Scorecard Case Studies

Walker, D. W., 1 Aug 2016, In : Systemic Practice and Action Research. 29, 4, p. 313-334 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of neurosteroid-mediated protection following stress during fetal life

Hirst, J. J., Cumberland, A. L., Shaw, J. C., Bennett, G. A., Kelleher, M. A., Walker, D. W. & Palliser, H. K., 1 Jun 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 160, p. 181-188 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Maternal creatine in pregnancy: a retrospective cohort study

Dickinson, H., Davies-Tuck, M., Ellery, S. J., Grieger, J. A., Wallace, E. M., Snow, R. J., Walker, D. W. & Clifton, V. L., 1 Oct 2016, In : BJOG: an International Journal of Obstetrics and Gynaecology. 123, 11, p. 1830-1838 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: A study of structure and function of hind limb muscle in the spiny mouse

Larosa, D. A., Ellery, S. J., Snow, R. J., Walker, D. W. & DIckinson, H., 1 Dec 2016, In : Pediatric Research. 80, 6, p. 852-860 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal creatine supplementation during pregnancy prevents long-term changes in diaphragm muscle structure and function after birth asphyxia

LaRosa, D. A., Ellery, S. J., Parkington, H. C., Snow, R. J., Walker, D. W. & Dickinson, H., 1 Mar 2016, In : PLoS ONE. 11, 3, 17 p., e0149840.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Models of perinatal compromises in the guinea pig: Their use in showing the role of neurosteroids in pregnancy and the newborn

Palliser, H. K., Bennett, G. A., Kelleher, M. A., Cumberland, A. L., Walker, D. W. & Hirst, J. J., 1 Nov 2016, Neuromethods. Walker, D. W. (ed.). New York NY USA: Humana Press, Vol. 109. p. 221-243 23 p. (Neuromethods; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Ontogenetic Change in the Regional Distribution of Dehydroepiandrosterone-Synthesizing Enzyme and the Glucocorticoid Receptor in the Brain of the Spiny Mouse (Acomys cahirinus)

Quinn, T. A., Ratnayake, U., Dickinson, H., Castillo-Melendez, M. & Walker, D. W., 1 Feb 2016, In : Developmental Neuroscience. 38, 1, p. 54-73 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Prenatal and Postnatal Determinants of Development

Walker, D. W. (ed.), 2016, New York NY USA: Humana Press. 364 p. (Neuromethods: Springer protocols; vol. 109)

Research output: Book/ReportEdited BookOtherpeer-review

Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies

Murthi, P., Yong, H. E. J., Nguyen, T. P. H., Ellery, S., Singh, H., Abdul Rahman, R., Dickinson, H., Walker, D. W., Davies-Tuck, M., Wallace, E. M. & Ebeling, P. R., 18 Feb 2016, In : Frontiers in Physiology. 7, p. 1-7 7 p., 43.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Segmentation of the fetal brain cortical plate using diffusion-weighted imaging cues

Shishegar, R., Rana, S., Walker, D. W. & Johnston, L. A., 2016. 3 p.

Research output: Contribution to conferenceAbstractOther

Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring

Bennett, G. A., Palliser, H. K., Walker, D. & Hirst, J., 1 Aug 2016, In : Psychoneuroendocrinology. 70, p. 47-57 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sulcal curve extraction using Laplace Beltrami eigenfunction level sets

Shishegar, R., Tolcos, M., Walker, D. W. & Johnston, L. A., 2016, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: EMBC 2016. Patton, J. (ed.). USA: IEEE, Institute of Electrical and Electronics Engineers, p. 4043-4046 4 p. 7591614

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

The feto-placental unit, and potential roles of dehydroepiandrosterone (DHEA) in prenatal and postnatal brain development: A re-examination using the spiny mouse

Quinn, T. A., Ratnayake, U., Dickinson, H., Castillo-Melendez, M. & Walker, D. W., 1 Jun 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 160, p. 204-213 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2015

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T. J., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 17 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Confirmed dioestrus in pseudopregnant mice using vaginal exfoliative cytology improves embryo transfer implantation rate

Mamrot, J., Pangestu, M., Walker, D. W., Gardner, D. K. & Dickinson, H., 2015, In : Reproductive BioMedicine Online. 31, 4 (Art. ID : 1396), p. 538 - 543 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs

Palliser, H. K., Kelleher, M. A., Tolcos, M., Walker, D. W. & Hirst, J., 2015, In : Journal of Developmental Origins of Health and Disease. 6, 4, p. 350 - 361 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal creatine homeostasis is altered during gestation in the spiny mouse: Is this a metabolic adaptation to pregnancy?

Ellery, S. J., LaRosa, D. A., Kett, M. M., Della Gatta, P., Snow, R., Walker, D. W. & Dickinson, H., 14 Apr 2015, In : BMC Pregnancy and Childbirth. 15, 1, 9 p., 92.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prenatal stress alters hippocampal neuroglia and increases anxiety in childhood

Bennett, G. A., Palliser, H. K., Shaw, J. C., Walker, D. W. & Hirst, J., 2015, In : Developmental Neuroscience. 37, 6, p. 533 - 545 13 p.

Research output: Contribution to journalArticleResearchpeer-review