David Thal

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20062022
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Research Output 2006 2018

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2018

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structure of the adenosine-bound human adenosine A1 receptor-Gi complex

Draper-Joyce, C. J., Khoshouei, M., Thal, D. M., Liang, Y. L., Nguyen, A. T. N., Furness, S. G. B., Venugopal, H., Baltos, J. A., Plitzko, J. M., Danev, R., Baumeister, W., May, L. T., Wootten, D., Sexton, P. M., Glukhova, A. & Christopoulos, A., 20 Jun 2018, In : Nature. 558, 7711, p. 559-565 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Burger, W. A. C., Sexton, P. M., Christopoulos, A. & Thal, D. M., 1 Oct 2018, In : Journal of General Physiology. 150, 10, p. 1360-1372 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Liang, Y-L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L. J., Christopoulos, A., Kobilka, B., Wootten, D., Skiniotis, G. & Sexton, P., 1 Jun 2017, In : Nature. 546, 7656, p. 118-123 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

2016

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Thal, D. M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C. C., Bures, M. G., Evans, D. A., Weis, W. I., Bachhawat, P., Kobilka, T. S., Sexton, P. M., Kobilka, B. K. & Christopoulos, A., 17 Mar 2016, In : Nature. 531, 7594, p. 335-340 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Cluster cytometry for high-capacity bioanalysis

Edwards, B. S., Zhu, J., Chen, J., Carter, M. B., Thal, D. M., Tesmer, J. J. G., Graves, S. W. & Sklar, L. A., May 2012, In : Cytometry Part A. 81 A, 5, p. 419-429 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Paroxetine is a direct inhibitor of G protein-coupled receptor kinase 2 and increases myocardial contractility

Thal, D., Homan, K. T., Chen, J., Wu, E., Hinkle, P. M., Huang, Z. M., Chuprun, J. K., Song, J., Gao, E., Cheung, J., Sklar, L. A., Koch, W. & Tesmer, J. J. G., 2012, In : ACS Chemical Biology. 7, 11, p. 1830 - 1839 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An autoinhibitory helix in the C-terminal region of phospholipase C-B mediates Gaq activation

Lyon, A. M., Tesmer, V. M., Dhamsania, V. D., Thal, D., Gutierrez, J., Chowdhury, S., Suddala, K. C., Northup, J. K. & Tesmer, J. J. G., 2011, In : Nature Structural and Molecular Biology. 18, 9, p. 999 - 1006 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors

Thal, D., Yeow, R. Y., Schoenau, C., Huber, J. & Tesmer, J. J. G., 2011, In : Molecular Pharmacology. 80, 2, p. 294 - 303 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Assembly of high order Gaq-effector complexes with RGS proteins

Shankaranarayanan, A., Thal, D., Tesmer, V. M., Roman, D. L., Neubig, R., Kozasa, T. & Tesmer, J. J. G., 2008, In : Journal of Biological Chemistry. 283, 50, p. 34923 - 34934 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members

Gu, S., He, J., Ho, W. T., Ramineni, S., Thal, D. M., Natesh, R., Tesmer, J. J. G., Hepler, J. R. & Heximer, S. P., 9 Nov 2007, In : Journal of Biological Chemistry. 282, 45, p. 33064-33075 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase

Hanes, J. W., Thal, D. M. & Johnson, K. A., 24 Nov 2006, In : Journal of Biological Chemistry. 281, 47, p. 36241-36248 8 p.

Research output: Contribution to journalArticleResearchpeer-review