David Thal

Senior Research Fellow, Drug Discovery Biology

https://orcid.org/0000-0002-0325-2524

EmailDavid.Thal@monash.edu

Research activity per year

If you made any changes in Pure these will be visible here soon.

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

1 Finished
3 Active

Using protein structure and dynamics to facilitate drug discovery
Thal, D.
1/01/21 → 31/12/25
Project: Research
Engineering new tools to aid structure determination of membrane proteins
Thal, D., Veldhuis, N., Wang, H. & Scott, D. J.
9/10/19 → 8/10/22
Project: Research
Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
Thal, D., Gooley, P. R. & Dror, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/21
Project: Research
Molecular insight into allosteric modulation of G protein-coupled receptors
Thal, D.
Australian Research Council (ARC)
1/01/17 → 31/12/19
Project: Research

19 Article
1 Review Article

Crystal structure of the M₅ muscarinic acetylcholine receptor
Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

4 Citations (Scopus)
Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex
Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

138 Citations (Scopus)
Recent advances in the determination of G protein-coupled receptor structures
Thal, D. M., Vuckovic, Z., Draper-Joyce, C. J., Liang, Y-L., Glukhova, A., Christopoulos, A. & Sexton, P. M., 1 Aug 2018, In : Current Opinion in Structural Biology. 51, p. 28-34 7 p.
Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)
Structural insights into G-protein-coupled receptor allostery
Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A., 5 Jul 2018, In : Nature. 559, 7712, p. 45-53 9 p.
Research output: Contribution to journal › Review Article › Research › peer-review

98 Citations (Scopus)
Structure of the adenosine-bound human adenosine A₁ receptor-G_i complex
Draper-Joyce, C. J., Khoshouei, M., Thal, D. M., Liang, Y. L., Nguyen, A. T. N., Furness, S. G. B., Venugopal, H., Baltos, J. A., Plitzko, J. M., Danev, R., Baumeister, W., May, L. T., Wootten, D., Sexton, P. M., Glukhova, A. & Christopoulos, A., 20 Jun 2018, In : Nature. 558, 7711, p. 559-565 7 p.
Research output: Contribution to journal › Article › Research › peer-review

120 Citations (Scopus)