Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of a P2X1 receptor antagonist for use as a male contraceptive
Bennetts, F. (Primary Chief Investigator (PCI)), Ventura, S. (Supervisor) & Thal, D. (Supervisor)
17/03/25 → 17/03/27
Project: Research
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D. (Primary Chief Investigator (PCI)), Valant, C. (Chief Investigator (CI)), Carbone, S. (Chief Investigator (CI)), Mobbs, J. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)), King, S. K. (Associate Investigator (AI)), Imlach, W. (Associate Investigator (AI)), Hamilton, J. A. (Associate Investigator (AI)) & Veldhuis, N. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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alpha1-adrenoceptor protein structures and selective tools: towards novel treatments for heart failure and Alzheimer’s disease
Scott, D. J. (Primary Chief Investigator (PCI)), Abdul Ridha, A. (Chief Investigator (CI)), Chalmers, D. (Chief Investigator (CI)), Draper-Joyce, C. (Associate Investigator (AI)), Gooley, P. R. (Associate Investigator (AI)), Adlard, P. A. (Associate Investigator (AI)), Lankadeva, Y. R. (Associate Investigator (AI)), Betrie, A. H. (Associate Investigator (AI)), Graham, B. (Associate Investigator (AI)) & Thal, D. (Associate Investigator (AI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/22 → 31/12/25
Project: Research
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Using protein structure and dynamics to facilitate drug discovery
Thal, D. (Primary Chief Investigator (PCI))
1/01/21 → 31/12/25
Project: Research
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Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Liu, B., Thompson, G., Jörg, M., Barnes, N., Thal, D. M., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 18 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13286–13304 19 p.Research output: Contribution to journal › Article › Research › peer-review
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Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors
Mobbs, J. I., Black, K. A., Tran, M., Burger, W. A. C., Venugopal, H., Holman, T. R., Holinstat, M., Thal, D. M. & Glukhova, A., 5 Oct 2023, In: Blood. 142, 14, p. 1233–1242 22 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
Jörg, M., van der Westhuizen, E. T., Lu, Y., Christopher Choy, K. H., Shackleford, D. M., Khajehali, E., Tobin, A. B., Thal, D. M., Capuano, B., Christopoulos, A., Valant, C. & Scammells, P. J., 5 Oct 2023, In: European Journal of Medicinal Chemistry. 258, 20 p., 115588.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Nawaratne, V., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y. L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P. & Danev, R. & 4 others, , 30 May 2023, In: eLife. 12, 52 p., e83477.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus)