Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C., Capuano, B., Choy, C., Thal, D., Miao, Y., Christopoulos, A., Felder, C. & Pantellis, C.
1/01/23 → 31/12/26
Project: Research
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Discovery of a lead molecule for development into a non-hormonal male contraceptive
Mobbs, J., Ventura, S., Thal, D. & Bennetts, F.
1/01/23 → 31/12/23
Project: Research
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D., Valant, C., Carbone, S., Mobbs, J., Thal, D., Scammells, P., King, S. K., Imlach, W., Hamilton, J. A. & Veldhuis, N.
1/01/23 → 31/12/26
Project: Research
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alpha1-adrenoceptor protein structures and selective tools: towards novel treatments for heart failure and Alzheimer’s disease
Scott, D. J., Abdul Ridha, A., Chalmers, D., Draper-Joyce, C., Gooley, P., Adlard, P. A., Lankadeva, Y. R., Betrie, A. H., Graham, B. & Thal, D.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/22 → 31/12/25
Project: Research
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Using protein structure and dynamics to facilitate drug discovery
1/01/21 → 31/12/25
Project: Research
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Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs (Nature Chemical Biology, (2023), 10.1038/s41589-022-01247-5)
Powers, A. S., Pham, V., Burger, W. A. C., Thompson, G., Laloudakis, Y., Barnes, N. W., Sexton, P. M., Paul, S. M., Christopoulos, A., Thal, D. M., Felder, C. C., Valant, C. & Dror, R. O., Apr 2023, In: Nature Chemical Biology. 19, 4, p. 529-529 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Biased Profile of Xanomeline at the Recombinant Human M4Muscarinic Acetylcholine Receptor
McDonald, J. K., Van Der Westhuizen, E. T., Pham, V., Thompson, G., Felder, C. C., Paul, S. M., Thal, D. M., Christopoulos, A. & Valant, C., 20 Apr 2022, In: ACS Chemical Neuroscience. 13, 8, p. 1206-1218 13 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., 2022, (Accepted/In press) In: British Journal of Pharmacology.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Harris, J. A., Faust, B., Gondin, A. B., Dämgen, M. A., Suomivuori, C. M., Veldhuis, N. A., Cheng, Y., Dror, R. O., Thal, D. M. & Manglik, A., Jan 2022, In: Nature Chemical Biology. 18, 1, p. 109–115 7 p.Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus) -
The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the -Opioid Receptor
Deo, O., Alvi, S., Pham, V., Christopoulos, A., Thal, D. M., Jörg, M., Capuano, B., Valant, C. & Scammells, P. J., 13 Sep 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12367–12385 19 p.Research output: Contribution to journal › Article › Research › peer-review