Positive allosteric mechanisms of adenosine A₁ receptor-mediated analgesia

Draper-Joyce, C. J., Bhola, R., Wang, J., Bhattarai, A., Nguyen, A. T. N., Cowie-Kent, I., O’Sullivan, K., Chia, L. Y., Venugopal, H., Valant, C., Thal, D. M., Wootten, D., Panel, N., Carlsson, J., Christie, M. J., White, P. J., Scammells, P., May, L. T., Sexton, P. M., Danev, R. & 4 others, Miao, Y., Glukhova, A., Imlach, W. L. & Christopoulos, A., 23 Sep 2021, In: Nature. 597, p. 571–576 25 p.

Research output: Contribution to journal › Article › Research › peer-review

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Mobbs, J. I., Belousoff, M. J., Harikumar, K. G., Piper, S. J., Xu, X., Furness, S. G. B., Venugopal, H., Christopoulos, A., Danev, R., Wootten, D., Thal, D. M., Miller, L. J. & Sexton, P. M., 4 Jun 2021, In: PLoS Biology. 19, 6, 28 p., e3001295.

Research output: Contribution to journal › Article › Research › peer-review

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Abbracchio, M. P., Alexander, W., Al-hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., Beaulieu, J. M. & 135 others, Bernstein, K. E., Bettler, B., Birdsall, N. J. M., Blaho, V., Boulay, F., Bousquet, C., Bräuner-Osborne, H., Burnstock, G., Caló, G., Castaño, J. P., Catt, K. J., Ceruti, S., Chazot, P., Chiang, N., Chini, B., Chun, J., Cianciulli, A., Civelli, O., Clapp, L. H., Couture, R., Csaba, Z., Dahlgren, C., Dent, G., Singh, K. D., Douglas, S. D., Dournaud, P., Eguchi, S., Escher, E., Filardo, E. J., Fong, T., Fumagalli, M., Gainetdinov, R. R., Gasparo, M. D., Gerard, C., Gershengorn, M., Gobeil, F., Goodfriend, T. L., Goudet, C., Gregory, K. J., Gundlach, A. L., Hamann, J., Hanson, J., Hauger, R. L., Hay, D. L., Heinemann, A., Hollenberg, M. D., Holliday, N. D., Horiuchi, M., Hoyer, D., Hunyady, L., Husain, A., IJzerman, A. P., Inagami, T., Jacobson, K. A., Jensen, R. T., Jockers, R., Jonnalagadda, D., Karnik, S., Kaupmann, K., Kemp, J., Kennedy, C., Kihara, Y., Kitazawa, T., Kozielewicz, P., Kreienkamp, H. J., Kukkonen, J. P., Langenhan, T., Leach, K., Lecca, D., Lee, J. D., Leeman, S. E., Leprince, J., Li, X. X., Williams, T. L., Lolait, S. J., Lupp, A., Macrae, R., Maguire, J., Mazella, J., McArdle, C. A., Melmed, S., Michel, M. C., Miller, L. J., Mitolo, V., Mouillac, B., Müller, C. E., Murphy, P., Nahon, J. L., Ngo, T., Norel, X., Nyimanu, D., O’Carroll, A. M., Offermanns, S., Panaro, M. A., Parmentier, M., Pertwee, R. G., Pin, J. P., Prossnitz, E. R., Quinn, M., Ramachandran, R., Ray, M., Reinscheid, R. K., Rondard, P., Rovati, G. E., Ruzza, C., Sanger, G. J., Schöneberg, T., Schulte, G., Schulz, S., Segaloff, D. L., Serhan, C. N., Stoddart, L. A., Sugimoto, Y., Summers, R., Tan, V. P., Thal, D., Thomas, W., Timmermans, P. B. M. W. M., Tirupula, K., Tulipano, G., Unal, H., Unger, T., Valant, C., Vanderheyden, P., Vaudry, D., Vaudry, H., Vilardaga, J. P., Walker, C. S., Wang, J. M., Ward, D. T., Wester, H. J., Willars, G. B., Woodruff, T. M., Yao, C. & Ye, R. D., Oct 2021, In: British Journal of Pharmacology. 178, S1, p. S27-S156 130 p.

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Crystal structure of the M₅ muscarinic acetylcholine receptor

Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.

Research output: Contribution to journal › Article › Research › peer-review

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In: Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journal › Article › Research › peer-review