Projects per year
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Using protein structure and dynamics to facilitate drug discovery
1/01/21 → 31/12/25
Project: Research
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Engineering new tools to aid structure determination of membrane proteins
Thal, D., Veldhuis, N., Wang, H. & Scott, D. J.
9/10/19 → 8/10/22
Project: Research
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Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
Thal, D., Gooley, P. R. & Dror, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 30/09/22
Project: Research
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Molecular insight into allosteric modulation of G protein-coupled receptors
Australian Research Council (ARC)
1/01/17 → 31/12/19
Project: Research
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Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
Draper-Joyce, C. J., Bhola, R., Wang, J., Bhattarai, A., Nguyen, A. T. N., Cowie-Kent, I., O’Sullivan, K., Chia, L. Y., Venugopal, H., Valant, C., Thal, D. M., Wootten, D., Panel, N., Carlsson, J., Christie, M. J., White, P. J., Scammells, P., May, L. T., Sexton, P. M., Danev, R. & 4 others, , 23 Sep 2021, In: Nature. 597, p. 571–576 25 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Mobbs, J. I., Belousoff, M. J., Harikumar, K. G., Piper, S. J., Xu, X., Furness, S. G. B., Venugopal, H., Christopoulos, A., Danev, R., Wootten, D., Thal, D. M., Miller, L. J. & Sexton, P. M., 4 Jun 2021, In: PLoS Biology. 19, 6, 28 p., e3001295.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Abbracchio, M. P., Alexander, W., Al-hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., Beaulieu, J. M. & 135 others, , Oct 2021, In: British Journal of Pharmacology. 178, S1, p. S27-S156 130 p.Research output: Contribution to journal › Article › Other › peer-review
Open AccessFile113 Citations (Scopus) -
Crystal structure of the M5 muscarinic acetylcholine receptor
Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile17 Citations (Scopus) -
Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex
Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In: Nature. 555, 7694, p. 121-125 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile182 Citations (Scopus)