1985 …2024

Research output per year

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Research Output

2007

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Huntington, N. D., Puthalakath, H., Gunn, P., Naik, E., Michalak, E. M., Smyth, M. J., Tabarias, H., Degli-Esposti, M. A., Dewson, G., Willis, S. N., Motoyama, N., Huang, D. C. S., Nutt, S. L., Tarlinton, D. M. & Strasser, A., 1 Aug 2007, In : Nature Immunology. 8, 8, p. 856-863 8 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation

Huntington, N. D., Tabarias, H., Fairfax, K., Brady, J., Hayakawa, Y., Degli-Esposti, M. A., Smyth, M. J., Tarlinton, D. M. & Nutt, S. L., 15 Apr 2007, In : Journal of Immunology. 178, 8, p. 4764-4770 7 p.

Research output: Contribution to journalArticleResearchpeer-review

184 Citations (Scopus)

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

Fischer, S. F., Bouillet, P., O'Donnell, K., Light, A., Tarlinton, D. M. & Strasser, A., 1 Dec 2007, In : Blood. 110, 12, p. 3978-3984 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
75 Citations (Scopus)
2006

B-cell memory: Are subsets necessary?

Tarlinton, D., 15 Oct 2006, In : Nature Reviews Immunology. 6, 10, p. 785-790 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

109 Citations (Scopus)

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

Huntington, N. D., Xu, Y., Puthalakath, H., Light, A., Willis, S. N., Strasser, A. & Tarlinton, D. M., 1 Feb 2006, In : Nature Immunology. 7, 2, p. 190-198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phenotype to the Idd11 locus on chromosome 4 [1]

Brodnicki, T. C., O'Donnell, K., Quirk, F. & Tarlinton, D. M., 15 Jan 2006, In : Journal of Immunology. 176, 2, p. 701-702 2 p.

Research output: Contribution to journalLetterOtherpeer-review

7 Citations (Scopus)
2005

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger"

Corbett, A., Caminschi, I., McKenzie, B., Brady, J. L., Wright, M. D., Mottram, P. L., Hogarth, P. M., Hodder, A. N., Zhan, Y., Tarlinton, D. M., Shortman, K. & Lew, A. M., 2005, In : European Journal of Immunology. 35, 10, p. 2815 - 2825 11 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

Huntington, N. D., Xu, Y., Nutt, S. L. & Tarlinton, D. M., 2 May 2005, In : Journal of Experimental Medicine. 201, 9, p. 1421-1433 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

Differential requirement for OBF-1 during antibody-secreting cell differentiation

Corcoran, L. M., Hasbold, J., Dietrich, W., Hawkins, E., Kallies, A., Nutt, S. L., Tarlinton, D. M., Matthias, P. & Hodgkin, P. D., 2 May 2005, In : Journal of Experimental Medicine. 201, 9, p. 1385-1396 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization

Blink, E. J., Light, A., Kallies, A., Nutt, S. L., Hodgkin, P. D. & Tarlinton, D., 2005, In : Journal of Experimental Medicine. 201, 4, p. 545 - 554 10 p.

Research output: Contribution to journalArticleResearchpeer-review

186 Citations (Scopus)

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity

Beavitt, S-J. E., Harder, K. W., Kemp, J. M., Jones, J., Quilici, C., Casagranda, F., Lam, E., Turner, D., Brennan, S., Sly, P. D., Tarlinton, D. M., Anderson, G. P. & Hibbs, M. L., 2005, In : Journal of Immunology. 175, p. 1867 - 1875 9 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Lyn tyrosine kinase: Accentuating the positive and the negative

Xu, Y., Harder, K. W., Huntington, N. D., Hibbs, M. L. & Tarlinton, D. M., 1 Jan 2005, In : Immunity. 22, 1, p. 9-18 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
218 Citations (Scopus)

The development of functional B lymphocytes in conditional PU.1 knock-out mice

Polli, M., Dakic, A., Light, A., Wu, L., Tarlinton, D. M. & Nutt, S. L., 15 Sep 2005, In : Blood. 106, 6, p. 2083-2090 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)
2004

CD45: Direct and indirect government of immune regulation

Huntington, N. D. & Tarlinton, D. M., 15 Jul 2004, In : Immunology Letters. 94, 3, p. 167-174 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)

Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation

Hasbold, J., Corcoran, L. M., Tarlinton, D. M., Tangye, S. G. & Hodgkin, P. D., 1 Jan 2004, In : Nature Immunology. 5, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleResearchpeer-review

151 Citations (Scopus)

Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1

Harder, K. W., Quilici, C., Naik, E., Inglese, M., Kountouri, N., Turner, A., Zlatic, K., Tarlinton, D. M. & Hibbs, M. L., 15 Dec 2004, In : Blood. 104, 13, p. 3901-3910 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
78 Citations (Scopus)

Plasma cell ontogeny defined by quantitative changes in Blimp-1 expression

Kallies, A., Hasbold, J., Tarlinton, D. M., Dietrich, W., Corcoran, L. M., Hodgkin, P. D. & Nutt, S. L., 18 Oct 2004, In : Journal of Experimental Medicine. 200, 8, p. 967-977 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
315 Citations (Scopus)

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

Brender, C., Columbus, R., Metcalf, D., Handman, E., Starr, R., Huntington, N., Tarlinton, D., Ødum, N., Nicholson, S. E., Nicola, N. A., Hilton, D. J. & Alexander, W. S., 1 Jul 2004, In : Molecular and Cellular Biology. 24, 13, p. 6094-6103 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
52 Citations (Scopus)

Targeting plasma cells in autoimmune diseases

Tarlinton, D. M. & Hodgkin, P. D., 7 Jun 2004, In : Journal of Experimental Medicine. 199, 11, p. 1451-1454 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
22 Citations (Scopus)
2003

Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses

Tarlinton, D., Light, A., Metcalf, D., Harvey, R. P. & Robb, L., 15 Apr 2003, In : Journal of Immunology. 170, 8, p. 4002-4010 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Generation and analysis of Siah2 mutant mice

Frew, I. J., Hammond, V. E., Dickins, R. A., Quinn, J. M. W., Walkley, C. R., Sims, N. A., Schnall, R., Della, N. G., Holloway, A. J., Digby, M. R., Janes, P. W., Tarlinton, D. M., Purton, L. E., Gillespie, M. T. & Bowtell, D. D. L., 2003, In : Molecular and Cellular Biology. 23, 24, p. 9150 - 9161 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

Enders, A., Bouillet, P., Puthalakath, H., Xu, Y., Tarlinton, D. M. & Strasser, A., 6 Oct 2003, In : Journal of Experimental Medicine. 198, 7, p. 1119-1126 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
222 Citations (Scopus)
2002

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

Hibbs, M. L., Harder, K. W., Armes, J., Kountouri, N., Quilici, C., Casagranda, F., Dunn, A. R. & Tarlinton, D. M., 16 Dec 2002, In : Journal of Experimental Medicine. 196, 12, p. 1593-1604 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
120 Citations (Scopus)

The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses

Tarrant, J. M., Groom, J., Metcalf, D., Li, R., Borobokas, B., Wright, M. D., Tarlinton, D. & Robb, L., 9 Jul 2002, In : Molecular and Cellular Biology. 22, 14, p. 5006-5018 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent

Xu, Y., Beavitt, S. J. E., Harder, K. W., Hibbs, M. L. & Tarlinton, D. M., 15 Dec 2002, In : Journal of Immunology. 169, 12, p. 6910-6918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

Pohl, T., Gugasyan, R., Grumont, R. J., Strasser, A., Metcalf, D., Tarlinton, D., Sha, W., Baltimore, D. & Gerondakis, S., 2 Apr 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4514-4519 6 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

Croker, B. A., Tarlinton, D. M., Cluse, L. A., Tuxen, A. J., Light, A., Yang, F. C., Williams, D. A. & Roberts, A. W., 1 Apr 2002, In : Journal of Immunology. 168, 7, p. 3376-3386 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
91 Citations (Scopus)
2001

Defective gp130-mediated Signal Transducer and Activator of Transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., Heath, J. K. & Dunn, A. R., 16 Jul 2001, In : Journal of Experimental Medicine. 194, 2, p. 189-203 15 p.

Research output: Contribution to journalArticleResearchpeer-review

195 Citations (Scopus)
2000

Affinity maturation in the B-cell response to antigen

Tarlinton, D., Light, A., Smith, K. & Nossal, G. J. V., 1 Jan 2000, In : Immunologist. 8, 1-2, p. 9-11 3 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

bcl-2 Transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

Smith, K. G. C., Light, A., O'Reilly, L. A., Ang, S. M., Strasser, A. & Tarlinton, D., 2000, In : Journal of Experimental Medicine. 191, 3, p. 475 - 484 10 p.

Research output: Contribution to journalArticleResearchpeer-review

150 Citations (Scopus)

Dissecting affinity maturation: A model explaining selection of antibody-forming cells and memory B cells in the germinal centre

Tarlinton, D. M. & Smith, K. G. C., 1 Jan 2000, In : Immunology Today. 21, 9, p. 436-441 6 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

111 Citations (Scopus)

Erratum: Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAm-1 in specialized endothelial cells of the viscera (Developmental Biology (2000) 224:232 (152-167))

Wang, C. C., Biben, C., Robb, L., Nassir, F., Barnett, L., Davidson, N. O., Koentgen, F., Tarlinton, D. & Harvey, R. P., 15 Nov 2000, In : Developmental Biology. 227, 2, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera

Wang, C. C., Biben, C., Robb, L., Nassir, F., Barnett, L., Davidson, N. O., Koentgen, F., Tarlinton, D. & Harvey, R. P., 15 Aug 2000, In : Developmental Biology. 224, 2, p. 152-167 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
51 Citations (Scopus)

Single cell sorting and cloning

Battye, F. L., Light, A. & Tarlinton, D. M., 21 Sep 2000, In : Journal of Immunological Methods. 243, 1-2, p. 25-32 8 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
1999

Genetic evidence for Lyn as a negative regulator of IL-4 signaling

Janas, M. L., Hodgkin, P., Hibbs, M. & Tarlinton, D., 20 Oct 1999, In : Journal of Immunology. 163, 8, p. 4192-4198 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)
1998

Germinal centers: Form and function

Tarlinton, D., 1 Jan 1998, In : Current Opinion in Immunology. 10, 3, p. 245-251 7 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Germinal centers: Getting there is half the fun

Tarlinton, D., 22 Oct 1998, In : Current Biology. 8, 21

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inhibition of the B cell by CD22: A requirement for Lyn

Smith, K. G. C., Tarlinton, D. M., Doody, G. M., Hibbs, M. L. & Fearon, D. T., 2 Mar 1998, In : Journal of Experimental Medicine. 187, 5, p. 807-811 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
202 Citations (Scopus)

Kinetics of establishing the memory B cell population as revealed by CD38 expression

Ridderstad, A. & Tarlinton, D. M., 15 May 1998, In : Journal of Immunology. 160, 10, p. 4688-4695 8 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)
1997

Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis

Nandurkar, H. H., Robb, L. G., Tarlinton, D. M., Barnett, L., Kontgen, F. & Begley, C. G., 1997, In : Blood. 90, 6, p. 2148 - 2159 12 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)

Affinity maturation of the primary response by V gene diversification

Tarlinton, D. M., Light, A., Nossal, G. J. V. & Smith, K. G. C., 1 Dec 1997, In : Current topics in microbiology and immunology. 229, p. 71-84 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)

Antigen presentation by memory B cells: The sting is in the tail

Tarlinton, D., 18 Apr 1997, In : Science. 276, 5311, p. 374-375 2 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Apoptosis and the B cell response to antigen

Tarlinton, D. M. & Smith, K. G. C., 1 Jan 1997, In : International Reviews of Immunology. 15, 1-2, p. 53-71 19 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

B cell memory in xid mice is Long-Lived despite reduced memory b cell frequency

Ridderstad, A. & Tarlinton, D. M., 1 Jan 1997, In : Scandinavian Journal of Immunology. 45, 6, p. 655-659 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Continued differentiation during a lymphopoiesis requires signals in addition to cell survival

Tarlinton, D. M., Corcoran, L. M. & Strasser, A., 22 Oct 1997, In : International Immunology. 9, 10, p. 1481-1494 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo

O'Reilly, L. A., Harris, A. W., Tarlinton, D. M., Corcoran, L. M. & Strasser, A., 1 Dec 1997, In : Journal of Immunology. 159, 5, p. 2301-2311 11 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Germinal centers: A second childhood for lymphocytes

Tarlinton, D., 1 Jan 1997, In : Current Biology. 7, 3

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Mice lacking both the nfκb1 and c-rel genes develop normally but exhibit an impaired production of immunoglobulins and profound defects in proliferation of B and T lymphocytes

Pohl, T., Strasser, A., Tarlinton, D., Metcalf, D. & Gerondakis, S., 1 Jan 1997, In : Immunobiology. 197, 2-4, p. 143-144 2 p.

Research output: Contribution to journalArticleResearchpeer-review

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

Smith, K. G. C., Light, A., Nossal, G. V. J. & Tarlinton, D., 1997, In : The EMBO Journal. 16, 11, p. 2996 - 3006 11 p.

Research output: Contribution to journalArticleResearchpeer-review

293 Citations (Scopus)
1996

Chapter 2 The B-cell in immunity

Tarlinton, D., 1 Dec 1996, In : Principles of Medical Biology. 6, C, p. 21-46 26 p.

Research output: Contribution to journalArticleResearchpeer-review