Projects per year
Personal profile
Biography
Dave Spanswick graduated from University of East Anglia, UK in 1986 (B.Sc).
He then obtained his PhD at University of Birmingham, studying neurophysiology. He remained in Birmingham as a Post-doctoral research fellow in Steve Logans group before moving to work in Canada with Leo Renauds group and Japan with Syogoro Nishi, Hideho Higashi, Hiroe Inokuchi and Megumu Yoshimura. He subsequently returned to the UK as a lecturer in the Department of Biomedical Sciences, University of Aberdeen before taking a sabbatical at the Department of Pharmacology, University of Cambridge and Parke-Davis.
He was appointed a senior lecturer, University of Warwick in 2000 and Professor of Molecular Neuroscience at Warwick Medical School in 2004. He arrived at the Department of Physiology, Monash University in October 2011.
Community service
1. Referee for Journals: Nature, Journal of Neuroscience, Neuropharmacology, Journal of Physiology; Journal of Neurophysiology; Neuroscience Letters; Brain Research; Nature Neuroscience, Neuroscience; J. Neurosci., Methods; Cell Metabolism; Neuropharmacology; Trends in Endocrinology and Metabolism; Biological Psychiatry
2. Referee for Grant Awarding Agencies: The Wellcome Trust; British Heart Foundation; BBSRC; MRC; Canadian Institutes for Health Research (CIHR); NIH; NHS
3. PhD External Examiner: University of Manchester, University of Cambridge, Imperial College, London, University of Ottawa
4. PhD Co-supervisor for Students at University of Ottawa Canada
Monash teaching commitment
PHY3012: Integrative Neuroscience
Research area keywords
- Metabolic Neuroscience
- pain signalling
- Electrophysiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of novel allosteric modulators for the treatment of chronic pain
Imlach, W. (Primary Chief Investigator (PCI)), Scammells, P. (Chief Investigator (CI)), Valant, C. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Spanswick, D. (Chief Investigator (CI)), Miller, S. (Chief Investigator (CI)), Malik, R. (Associate Investigator (AI)), Taverner, M. (Associate Investigator (AI)) & Tung Ng, K. (Associate Investigator (AI))
1/12/25 → 30/11/27
Project: Research
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Understanding how neural circuit activity is controlled by adenosine
Imlach, W. (Primary Chief Investigator (PCI)), Christopoulos, A. (Chief Investigator (CI)), De Koninck, Y. (Partner Investigator (PI)) & Spanswick, D. (Partner Investigator (PI))
ARC - Australian Research Council, Monash University – Internal Department Contribution
29/03/25 → 28/03/28
Project: Research
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Targeting chronic pain: non-pharmacological manipulation of endogenous adenosine
Spanswick, D. (Primary Chief Investigator (PCI)), Wong, Y. (Chief Investigator (CI)), De Koninck, Y. (Chief Investigator (CI)) & Imlach, W. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Alcohol and Striatal Adaptation
Lawrence, A. J. (Primary Chief Investigator (PCI)), Langmead, C. (Chief Investigator (CI)) & Spanswick, D. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/17 → 31/12/20
Project: Research
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Deconstructing the neural circuits regulating appetite
Andrews, Z. (Primary Chief Investigator (PCI)), Oldfield, B. (Chief Investigator (CI)) & Spanswick, D. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University
20/04/15 → 31/12/18
Project: Research
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The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system
Simonds, S. E., Pryor, J. T., Lam, B. Y. H., Dowsett, G. K., Mustafa, T., Munder, A., Elysee, K., Balland, E., Cowley, L. O., Yeo, G. S. H., Lawrence, A., Spanswick, D. C. & Cowley, M. A., 18 Feb 2025, In: Cell Reports Medicine. 6, 2, 18 p., 101936.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum
Reichenbach, A., Clarke, R. E., Stark, R., Lockie, S. H., Mequinion, M., Dempsey, H., Rawlinson, S., Reed, F., Sepehrizadeh, T., Deveer, M., Munder, A. C., Nunez-Iglesias, J., Spanswick, D. C., Mynatt, R., Kravitz, A. V., Dayas, C. V., Brown, R. & Andrews, Z. B., Jan 2022, In: eLife. 11, 24 p., e72668.Research output: Contribution to journal › Article › Research › peer-review
Open Access45 Link opens in a new tab Citations (Scopus) -
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
Wall, M. J., Hill, E., Huckstepp, R., Barkan, K., Deganutti, G., Leuenberger, M., Preti, B., Winfield, I., Carvalho, S., Suchankova, A., Wei, H., Safitri, D., Huang, X., Imlach, W., La Mache, C., Dean, E., Hume, C., Hayward, S., Oliver, J. & Zhao, F.-Y. & 5 others, , Dec 2022, In: Nature Communications. 13, 1, 22 p., 4150.Research output: Contribution to journal › Article › Research › peer-review
Open Access45 Link opens in a new tab Citations (Scopus) -
Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models
Belgi, A., Burnley, J. V., Macraild, C. A., Chhabra, S., Elnahriry, K. A., Robinson, S. D., Gooding, S. G., Tae, H. S., Bartels, P., Sadeghi, M., Zhao, F. Y., Wei, H., Spanswick, D., Adams, D. J., Norton, R. S. & Robinson, A. J., 16 Mar 2021, In: Journal of Medicinal Chemistry. 64, 6, p. 3222–3233 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile19 Link opens in a new tab Citations (Scopus) -
Neuron-specific responses to acetylcholine within the spinal dorsal horn circuits of rodent and primate
Sykes, M. J., Kekesi, O. S., Wong, Y. T., Zhao, F. Y., Spanswick, D. & Imlach, W. L., 15 Oct 2021, In: Neuropharmacology. 198, 12 p., 108755.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus)
Prizes
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Canadian Heart & Stroke Foundation Research Fellowship
Spanswick, D. (Recipient), 1993
Prize: Prize (including medals and awards)
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Royal Society Travel Scholarship
Spanswick, D. (Recipient), 1995
Prize: Prize (including medals and awards)
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Royal Society Travel Scholarship
Spanswick, D. (Recipient), 1993
Prize: Prize (including medals and awards)
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Royal Society Travel Scholarship
Spanswick, D. (Recipient), 1998
Prize: Prize (including medals and awards)