Projects per year
Personal profile
Biography
David Shackleford leads the Biopharmaceutics section of the Centre for Drug Candidate Optimisation (CDCO). He completed his studies at the University of South Australia before moving to Melbourne to undertake a post-doctoral position with Professor Christopher Porter and Professor Susan Charman in the Department of Pharmaceutics, Monash University. David specialises in pharmacokinetics and drug metabolism within the area of ADME lead optimisation. In 2003, he joined the CDCO. David's role focusses on activities as they relate to the classification of novel compounds PK/ADME properties. Outside of work he enjoys various interests including racing bicycles, flying gliders, building model aircraft and swing dancing.
Research interests
Pharmacokinetics, drug metabolism and ADME lead optimisation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Collaborative Study Program Agreement with The University of Auckland (Wilson) for Lead Optimisation Studies
30/03/23 → 31/12/23
Project: Research
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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Gummer, J. P. A., Olasz, B., Nambiar, S., Hope, D. E., Casey, T. H., Lee, Y. C. G., Leslie, C., Nealon, G., Shackleford, D. M., Powell, A. K., Grimaldi, M., Balaguer, P., Zemek, R. M., Bosco, A., Piggott, M. J., Vrielink, A., & 2 others, 21 Jan 2022, In: iScience. 25, 1, 27 p., 103571.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses
Devi, S., Alexandre, Y. O., Loi, J. K., Gillis, R., Ghazanfari, N., Creed, S. J., Holz, L. E., Shackleford, D., Mackay, L. K., Heath, W. R., Sloan, E. K. & Mueller, S. N., 8 Jun 2021, In: Immunity. 54, 6, p. 1219-1230.e7 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access35 Citations (Scopus) -
Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients
Gillis, R. D., Botteri, E., Chang, A., Ziegler, A. I., Chung, N. C., Pon, C. K., Shackleford, D. M., Andreassen, B. K., Halls, M. L., Baker, J. G. & Sloan, E. K., 1 Apr 2021, In: European Journal of Cancer. 147, p. 106-116 11 p.Research output: Contribution to journal › Article › Research › peer-review
21 Citations (Scopus) -
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
Shackleford, D. M., Chiu, F. C. K., Katneni, K., Blundell, S., McLaren, J., Wang, X., Zhou, L., Sriraghavan, K., Alker, A. M., Hunziker, D., Scheurer, C., Zhao, Q., Dong, Y., Möhrle, J. J., Abla, N., Matile, H., Wittlin, S., Vennerstrom, J. L. & Charman, S. A., 8 Jun 2021, In: ACS Infectious Diseases. 7, 7, p. 1885–1893 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease
Wong, S. W., Vivash, L., Mudududdla, R., Nguyen, N., Hermans, S. J., Shackleford, D. M., Field, J., Xue, L., Aprico, A., Hancock, N. C., Haskali, M., Stashko, M. A., Frye, S. V., Wang, X., Binder, M. D., Ackermann, U., Parker, M. W., Kilpatrick, T. J. & Baell, J. B., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 11 p., 113822.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Centre for Drug Candidate Optimisation
David Shackleford (Member)
30 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries