Research Output per year
Personal profile
Biography
David Shackleford leads the Biopharmaceutics section of the Centre for Drug Candidate Optimisation (CDCO). He completed his studies at the University of South Australia before moving to Melbourne to undertake a post-doctoral position with Professor Christopher Porter and Professor Susan Charman in the Department of Pharmaceutics, Monash University. David specialises in pharmacokinetics and drug metabolism within the area of ADME lead optimisation. In 2003, he joined the CDCO. David's role focusses on activities as they relate to the classification of novel compounds PK/ADME properties. Outside of work he enjoys various interests including racing bicycles, flying gliders, building model aircraft and swing dancing.
Research interests
Pharmacokinetics, drug metabolism and ADME lead optimisation.
Network
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Research Output 2001 2019
Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists
Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations
Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 2018, In : ACS Omega. 3, 8, p. 9227-9240 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Muscarinic M5 receptors modulate ethanol seeking in rats
Berizzi, A. E., Perry, C. J., Shackleford, D. M., Lindsley, C. W., Jones, C. K., Chen, N. A., Sexton, P. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 1 Jun 2018, In : Neuropsychopharmacology. 43, 7, p. 1510-1517 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Progress in antischistosomal N,N′-diaryl urea SAR
Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., 1 Feb 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 244-248 5 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2011 2011
- 1 Submissions to industry or govt committees, commissions and inquiries
Centre for Drug Candidate Optimisation
David Shackleford (Member)30 Nov 2011
Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries