20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

David Shackleford leads the Biopharmaceutics section of the Centre for Drug Candidate Optimisation (CDCO). He completed his studies at the University of South Australia before moving to Melbourne to undertake a post-doctoral position with Professor Christopher Porter and Professor Susan Charman in the Department of Pharmaceutics, Monash University. David specialises in pharmacokinetics and drug metabolism within the area of ADME lead optimisation. In 2003, he joined the CDCO. David's role focusses on activities as they relate to the classification of novel compounds PK/ADME properties. Outside of work he enjoys various interests including racing bicycles, flying gliders, building model aircraft and swing dancing.

Research interests

Pharmacokinetics, drug metabolism and ADME lead optimisation.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Charman, S. A., Andreu, A., Barker, H., Blundell, S., Campbell, A., Campbell, M., Chen, G., Chiu, F. C. K., Crighton, E., Katneni, K., Morizzi, J., Patil, R., Pham, T., Ryan, E., Saunders, J., Shackleford, D. M., White, K. L., Almond, L., Dickins, M., Smith, D. A. & 3 others, Moehrle, J. J., Burrows, J. N. & Abla, N., 2 Jan 2020, In : Malaria Journal. 19, 1, 27 p., 1.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 2018, In : ACS Omega. 3, 8, p. 9227-9240 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Muscarinic M5 receptors modulate ethanol seeking in rats

Berizzi, A. E., Perry, C. J., Shackleford, D. M., Lindsley, C. W., Jones, C. K., Chen, N. A., Sexton, P. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 1 Jun 2018, In : Neuropsychopharmacology. 43, 7, p. 1510-1517 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Activities

  • 1 Submissions to industry or govt committees, commissions and inquiries

Centre for Drug Candidate Optimisation

David Shackleford (Member)

30 Nov 2011

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries