Personal profile

Biography

Dr David Pook is a Medical Oncologist working with the Prostate Cancer Research Program in the Department of Anatomy and Developmental Biology. Dr Pook's research work is directed towards developing a better understanding of castrate resistant prostate cancer. He is also a lead investigator in the VCA funded CAPTIV prostate cancer research program.

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Projects 2011 2024

• 3 Finished
• 20 Active

Projects per year

A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

Pook, D.

6/11/19 → 5/11/24

Project: Research

A Phase 3, Randomized, Double-blind Study to Compare the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination with Lenvatinib (E7080/MK-7902) Versus Pembrolizumab and Placebo as First Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma in Cisplatin-ineligible Participants Whose Tumors Express PD-L1, and in Participants Ineligible for Any Platinum-containing Chemotherapy Regardless of PD-L1 Expression (LEAP-011)

Pook, D.

24/10/19 → 23/10/24

Project: Research

A Multicenter, Open-label, Phase 1 Trial of bacTRL-IL-12 in Adult Subjects with Advanced, Treatment-Refractory Solid Tumors

Pook, D.

26/09/19 → 25/09/24

Project: Research

A Phase 2 Trial of Nivolumab plus Ipilimumab, Ipilimumab Alone, or Cabazitaxel in Men with Metastatic Castration-Resistant Prostate Cancer

Pook, D.

4/09/19 → 3/09/24

Project: Research

A phase 3 randomised, placebo-controlled, double-blind study of Niraparib in combination with Abiraterone acetate and Prednisone versus Abiraterone acetate and Prednisone for treatment of subjects with metastatic prostate cancer [MAGNITUDE].

Pook, D. & Baker, E.

29/07/19 → 31/12/24

Project: Research

Research Output 2008 2019

• 16 Article
• 1 Meeting Abstract
• 1 Letter

Research Output per year

26 Citations (Scopus)

Enzalutamide with standard first-line therapy in metastatic prostate cancer

Davis, I. D., Martin, A. J., Stockler, M. R., Begbie, S., Chi, K. N., Chowdhury, S., Coskinas, X., Frydenberg, M., Hague, W. E., Horvath, L. G., Joshua, A. M., Lawrence, N. J., Marx, G., McCaffrey, J., McDermott, R., McJannett, M., North, S. A., Parnis, F., Parulekar, W., Pook, D. W. & 13 others, Reaume, M. N., Sandhu, S. K., Tan, A., Tan, T. H., Thomson, A., Tu, E., Vera-Badillo, F., Williams, S. G., Yip, S., Zhang, A. Y., Zielinski, R. R., Sweeney, C. J. & for the ENZAMET Trial Investigators and the Australian and New Zealand Urogenital and Prostate Cancer Trials Group, 11 Jul 2019, In : New England Journal of Medicine. 381, 2, p. 121-131 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer

Porter, L. H., Lawrence, M. G., Wang, H., Clark, A. K., Bakshi, A., Obinata, D., Goode, D., Papargiris, M., Clouston, D., Ryan, A., Norden, S., Corey, E., Nelson, P. S., Isaacs, J. T., Grummet, J., Kourambas, J., Sandhu, S., Murphy, D. G., Pook, D., Frydenberg, M. & 2 others, Taylor, R. A. & Risbridger, G. P., 1 Aug 2019, In : Prostate. 79, 11, p. 1326-1337 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Prognostic Utility of a Whole-blood Androgen Receptor-based Gene Signature in Metastatic Castration-resistant Prostate Cancer

Kwan, E. M., Fettke, H., Docanto, M. M., To, S. Q., Bukczynska, P., Mant, A., Pook, D., Ng, N., Graham, L. J. K., Mangiola, S., Segelov, E., Mahon, K., Davis, I. D., Parente, P., Pezaro, C., Todenhöfer, T., Horvath, L. G. & Azad, A. A., 15 May 2019, (Accepted/In press) In : European Urology Focus. 8 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Timing of brain metastases development in metastatic renal cell cancer patients treated with targeted therapies and survival outcomes: An Australian multicenter study

Ha, F. J., Spain, L., Dowling, A., Kwan, E. M., Pezaro, C., Day, D., Chia, P. L., Tran, B., Pook, D. & Weickhardt, A. J., 30 Jan 2019, (Accepted/In press) In : Asia-Pacific Journal of Clinical Oncology. 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC)

Kwan, E. M., To, S. Q. G., Fettke, H. C., Docanto, M., Bukczynska, P., Mant, A. M., Pook, D. W., Ng, N., Graham, L. J. K., Segelov, E., Mahon, K. L., Davis, I., Parente, P., Pezaro, C., Horvath, L. G. & Azad, A., 1 Mar 2019, In : Journal of Clinical Oncology. 37, 7 Suppl, p. 188 1 p.

Research output: Contribution to journal › Meeting Abstract › Other › peer-review