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Role of JUN/AP-1 in acute and chronic kidney injury. Mechanisms of acute kidney injury in high risk individuals. Novel roles for macrophages in renal fibrosis.

1992 …2020

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2020

Cyclophilin a promotes inflammation in acute kidney injury but not in renal fibrosis

Leong, K. G., Ozols, E., Kanellis, J., Nikolic-Paterson, D. J. & Ma, F. Y., 2 May 2020, In : International Journal of Molecular Sciences. 21, 10, 13 p., 3667.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Li, J., Sun, Y. B. Y., Chen, W., Fan, J., Li, S., Qu, X., Chen, Q., Chen, R., Zhu, D., Zhang, J., Wu, Z., Chi, H., Crawford, S., Oorschot, V., Puelles, V. G., Kerr, P. G., Ren, Y., Nilsson, S. K., Christian, M., Tang, H. & 4 others, Chen, W., Bertram, J. F., Nikolic-Paterson, D. J. & Yu, X., 5 Feb 2020, In : EMBO Reports. 21, 2, 20 p., e48781.

Research output: Contribution to journalArticleResearchpeer-review

Targeting apoptosis signal-regulating kinase 1 in acute and chronic kidney disease

Tesch, G. H., Ma, F. Y. & Nikolic-Paterson, D. J., 23 Jan 2020, (Accepted/In press) In : Anatomical Record. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2019

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Jiang, M., Fan, J., Qu, X., Li, S., Nilsson, S. K., Sun, Y. B. Y., Chen, Y., Yu, D., Liu, D., Liu, B-C., Tang, M., Chen, W., Ren, Y., Nikolic-Paterson, D. J., Jiang, X., Li, J. & Yu, X., 9 Aug 2019, In : Frontiers in Pharmacology. 10, 17 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Pullen, N., Jesson, M. I., Schlerman, F. J. & Nikolic-Paterson, D. J., 1 Dec 2019, In : American Journal of Physiology-Renal Physiology. 317, 6, p. F1439-F1449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Establishing equivalent diabetes in male and female Nos3-deficient mice results in a comparable onset of diabetic kidney injury

Tian, L., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Sep 2019, In : Physiological Reports. 7, 18, 8 p., e14197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

MTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Puelles, V. G., van der Wolde, J. W., Wanner, N., Scheppach, M. W., Cullen-McEwen, L. A., Bork, T., Lindenmeyer, M. T., Gernhold, L., Wong, M. N., Braun, F., Cohen, C. D., Kett, M. M., Kuppe, C., Kramann, R., Saritas, T., Van Roeyen, C. R., Moeller, M. J., Tribolet, L., Rebello, R., Sun, Y. B. Y. & 13 others, Li, J., Müller-Newen, G., Hughson, M. D., Hoy, W. E., Person, F., Wiech, T., Ricardo, S. D., Kerr, P. G., Denton, K. M., Furic, L., Huber, T. B., Nikolic-Paterson, D. J. & Bertram, J. F., 19 Sep 2019, In : JCI Insight. 4, 18, 18 p., e99271.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

Puelles, V. G., Fleck, D., Ortz, L., Papadouri, S., Strieder, T., Böhner, A. M. C., van der Wolde, J. W., Vogt, M., Saritas, T., Kuppe, C., Fuss, A., Menzel, S., Klinkhammer, B. M., Müller-Newen, G., Heymann, F., Decker, L., Braun, F., Kretz, O., Huber, T. B., Susaki, E. A. & 9 others, Ueda, H. R., Boor, P., Floege, J., Kramann, R., Kurts, C., Bertram, J. F., Spehr, M., Nikolic-Paterson, D. J. & Moeller, M. J., Aug 2019, In : Kidney International. 96, 2, p. 505–516 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

Han, Y., Tian, L., Ma, F., Tesch, G., Vesey, D. A., Gobe, G. C., Lohman, R. J., Morais, C., Suen, J. Y., Fairlie, D. P. & Nikolic-Paterson, D. J., 1 May 2019, In : Clinical and Experimental Pharmacology and Physiology. 46, 5, p. 456-464 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney

Ma, F. Y., Han, Y., Ozols, E., Chew, P., Vesey, D. A., Gobe, G. C., Morais, C., Lohman, R. J., Suen, J. Y., Johnson, D. W., Fairlie, D. P. & Nikolic-Paterson, D. J., Sep 2019, In : Nephrology. 24, 9, p. 983-991 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin

Ly, N. D. K., Tesch, G. H., Nikolic-Paterson, D. J. & Poronnik, P., Jan 2019, In : Nephrology. 24, 1, p. 121-126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A model of acute antibody-mediated renal allograft rejection in the sensitized rat

Chandran, S. R., Mulley, W. R., Kanellis, J., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Jun 2018, In : Experimental and Clinical Transplantation. 16, 3, p. 294-300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis

Han, Y., Ma, F. Y., Di Paolo, J. & Nikolic-Paterson, D. J., 1 Jan 2018, In : International Journal of Immunopathology and Pharmacology. 32, 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

Liles, J. T., Corkey, B. K., Notte, G. T., Budas, G. R., Lansdon, E. B., Hinojosa-Kirschenbaum, F., Badal, S. S., Lee, M., Schultz, B. E., Wise, S., Pendem, S., Graupe, M., Castonguay, L., Koch, K. A., Wong, M. H., Papalia, G. A., French, D. M., Sullivan, T., Huntzicker, E. G., Ma, F. Y. & 5 others, Nikolic-Paterson, D. J., Altuhaifi, T., Yang, H., Fogo, A. B. & Breckenridge, D. G., 1 Oct 2018, In : Journal of Clinical Investigation. 128, 10, p. 4485-4500 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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24 Citations (Scopus)

ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Amos, L. A., Ma, F. Y., Tesch, G. H., Liles, J. T., Breckenridge, D. G., Nikolic-Paterson, D. J. & Han, Y., 1 Sep 2018, In : Journal of Cellular and Molecular Medicine. 22, 9, p. 4522-4533 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney

Hou, W., Leong, K. G., Ozols, E., Tesch, G. H., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 250-260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis

Abraham, A. P., Ma, F. Y., Mulley, W. R., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Feb 2018, In : Nephrology. 23, 2, p. 183-189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease

Han, Y., Ly, N. D. K., Tesch, G. H., Poronnik, P. & Nikolic-Paterson, D. J., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 241-249 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Representing the process of inflammation as key events in adverse outcome pathways

Villeneuve, D. L., Landesmann, B., Allavena, P., Ashley, N., Bal-Price, A., Corsini, E., Halappanavar, S., Hussell, T., Laskin, D., Lawrence, T., Nikolic-Paterson, D., Pallardy, M., Paini, A., Pieters, R., Roth, R. & Tschudi-Monnet, F., 1 Jun 2018, In : Toxicological Sciences. 163, 2, p. 346-352 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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7 Citations (Scopus)
2017
6 Citations (Scopus)

Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury

Wang, Y. Y., Jiang, H., Pan, J., Huang, X. R., Wang, Y. C., Huang, H. F., To, K. F., Nikolic-Paterson, D. J., Lan, H. Y. & Chen, J. H., 1 Jul 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2053-2067 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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50 Citations (Scopus)
2016

A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney

Ma, F. Y., Blease, K. & Nikolic-Paterson, D. J., 1 Feb 2016, In : Life Sciences. 146, p. 192-200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

Meng, X-M., Wang, S., Huang, X. R., Yang, C., Xiao, J., Zhang, Y., To, K. F., Nikolic-Paterson, D. J. & Lan, H. Y., 1 Dec 2016, In : Cell Death and Disease. 7, 12, 9 p., e2495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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51 Citations (Scopus)

Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase

Ryan, J., Ma, F. Y., Han, Y., Ozols, E., Kanellis, J., Tesch, G. H. & Nikolic-Paterson, D. J., 1 Jan 2016, In : Journal of Pathology. 238, 1, p. 10-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury

Ryan, J., Kanellis, J., Blease, K., Ma, F. Y. & Nikolic-Paterson, D. J., 1 Aug 2016, In : American Journal of Pathology. 186, 8, p. 2032-2042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice

Dai, X. Y., Huang, X. R., Zhou, L., Zhang, L., Fu, P., Manthey, C., Nikolic-Paterson, D. J. & Lan, H. Y., 2016, In : Oncotarget. 7, 10, p. 10841-10856 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

Wang, S., Meng, X. M., Ng, Y. Y., Ma, F. Y., Zhou, S., Zhang, Y., Yang, C., Huang, X. R., Xiao, J., Wang, Y-Y., Ka, S. M., Tang, Y-J., Chung, A. C. K., To, K. F., Nikolic-Paterson, D. J. & Lan, H. Y., 2016, In : Oncotarget. 7, 8, p. 8809-8822 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
69 Citations (Scopus)

Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli

Puelles, V. G., van der Wolde, J. W., Schulze, K. E., Short, K. M., Wong, M. N., Bensley, J. G., Cullen-McEwen, L. A., Caruana, G., Hokke, S. N., Li, J., Firth, S. D., Harper, I. S., Nikolic-Paterson, D. J. & Bertram, J. F., 1 Oct 2016, In : Journal of the American Society of Nephrology. 27, 10, p. 3093-3104 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2015

Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury

Ikezumi, Y., Suzuki, T., Yamada, T., Hasegawa, H., Kaneko, U., Hara, M., Yanagihara, T., Nikolic-Paterson, D. J. & Saitoh, A., 2015, In : Pediatric Nephrology. 30, 6, p. 1007 - 1017 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Ma, F., Han, Y., Liles, J. T., Breckenridge, D. G. & Nikolic-Paterson, D. J., 2015, In : Diabetes. 64, 11, p. 3903 - 3913 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis

Lee, A., Slattery, C., Nikolic-Paterson, D. J., Hryciw, D. H., Wilk, S., Wilk, E., Zhang, Y., Valova, V. A., Robinson, P. J., Kelly, D. J. & Poronnik, P., 2015, In : American Journal of Physiology-Renal Physiology. 308, 7, p. 784 - 792 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance

Sun, Y. B. Y., Qu, X., Howard, V., Dai, L., Jiang, X., Ren, Y., Fu, P., Puelles, V. G., Nikolic-Paterson, D. J., Caruana, G., Bertram, J. F., Sleeman, M. W. & Li, J., Aug 2015, In : Kidney International. 88, 2, p. 286 - 298 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

Ramessur, S., Tesch, G. H., Han, Y., Woodman, N., Mulley, W., Kanellis, J., Blease, K., Ma, F. & Nikolic-Paterson, D. J., 2015, In : International Journal of Experimental Pathology. 96, 1, p. 54 - 62 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Suppression of rapidly progressive mouse glomerulonephritis with the non-steroidal mineralocorticoid receptor antagonist BR-4628

Ma, F., Han, Y., Nikolic-Paterson, D. J., Kolkhof, P. & Tesch, G. H., 2015, In : PLoS ONE. 10, 12 (Art. No: e0145666), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction

Qu, X., Jiang, M., Sun, Y. B. Y., Jiang, X., Fu, P., Ren, Y., Wang, D., Dai, L., Caruana, G., Bertram, J. F., Nikolic-Paterson, D. J. & Li, J., 2015, In : Kidney International. 88, 6, p. 1323 - 1335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2014
55 Citations (Scopus)

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Tesch, G. H., Sourris, K., Summers, S. A., McCarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A. R., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. & Forbes, J. M., 2014, In : Diabetologia. 57, 9, p. 1977 - 1985 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Induction monotherapy with sirolimus has selected beneficial effects on glomerular and tubulointersititial injury in nephrotoxic serum nephritis

Succar, L., Lai-Kwon, J. E., Nikolic-Paterson, D. J. & Rangan, G. K., 2014, In : International Journal of Nephrology and Renovascular Disease. 7, p. 303 - 313 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Inflammatory processes in renal fibrosis

Meng, X-M., Nikolic-Paterson, D. J. & Lan, H. Y., 2014, In : Nature Reviews Nephrology. 10, 9, p. 493 - 503 11 p.

Research output: Contribution to journalArticleResearchpeer-review

252 Citations (Scopus)

Macrophages promote renal fibrosis through direct and indirect mechanisms

Nikolic-Paterson, D. J., Wang, S. & Lan, H. Y., 2014, In : Kidney International Supplements. 4, 1, p. 34 - 38 5 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease

Huang, L., Nikolic-Paterson, D. J., Han, Y., Ozols, E., Ma, F., Young, M. J. & Tesch, G. H., 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2231 - 2240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Regulation of renal fibrosis by Smad3 Thr388 phosphorylation

Qu, X., Li, X., Zheng, Y., Ren, Y., Puelles Rodriguez, V. G., Caruana, G., Nikolic-Paterson, D. J. & Li, J., 2014, In : American Journal of Pathology. 184, 4, p. 944 - 952 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The role of macrophage migration inhibitory factor in autoimmune liver disease

Assis, D. N., Leng, L., Du, X., Zhang, C. K., Grieb, G., Merk, M., Baeza Garcia, A., McCrann, C. H., Chapiro, J., Meinhardt, A., Mizue, Y., Nikolic-Paterson, D. J., Bernhagen, J., Kaplan, M. M., Zhao, H., Boyer, J. L. & Bucala, R., 2014, In : Hepatology. 59, 2, p. 580 - 591 12 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
2013

Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney

Sun, Y. B. Y., Qu, X., Li, X., Nikolic-Paterson, D. J. & Li, J., 2013, In : PLoS ONE. 8, 12 (Art. ID: e84063), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Macrophages contribute to cellular but not humoral mechanisms of acute rejection in rat renal allografts

Ma, F., Woodman, N., Mulley, W., Kanellis, J. & Nikolic-Paterson, D. J., 2013, In : Transplantation. 96, 11, p. 949 - 957 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3beta acetylation

Zhang, X., Qu, X., Sun, Y. B. Y., Caruana, G., Bertram, J. F., Nikolic-Paterson, D. J. & Li, J., 2013, In : PLoS ONE. 8, 6 (e67471), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis

Han, Y., Ma, F., Tesch, G. H., Manthey, C. L. & Nikolic-Paterson, D. J., 2013, In : American Journal of Physiology-Renal Physiology. 304, 8, p. 1043 - 1053 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
2012
29 Citations (Scopus)

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis

Nozaki, Y., Nikolic-Paterson, D., Snelgrove, S., Akiba, H., Yagita, H., Holdsworth, S. & Kitching, A., 2012, In : Kidney International. 81, 9, p. 844 - 855 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)