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Role of JUN/AP-1 in acute and chronic kidney injury. Mechanisms of acute kidney injury in high risk individuals. Novel roles for macrophages in renal fibrosis.

1992 …2020

Research output per year

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Research Output

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2004

Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies

Masaki, T., Stambe, C., Hill, P. A., Dowling, J. P., Atkins, R. C. & Nikolic-Paterson, D. J., 2004, In : Journal of the American Society of Nephrology. 15, 7, p. 1835 - 1843 9 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: A mechanism for activation of latent TGF-β 1

Naito, T., Masaki, T., Nikolic-Paterson, D. J., Tanji, C., Yorioka, N. & Kohno, N., 1 Feb 2004, In : American Journal of Physiology-Renal Physiology. 286, 2 55-2, p. F278-F287

Research output: Contribution to journalArticleResearchpeer-review

118 Citations (Scopus)

Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-1

Naito, T., Masaki, T., Nikolic-Paterson, D. J., Tanji, C., Yorioka, N. & Kohno, N., 2004, In : American Journal of Physiology-Renal Physiology. 286, p. 278 - 287 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Macrophage accumulation and renal fibrosis are independent of macrophage migration inhibitory factor in mouse obstructive nephropathy

Rice, E. K., Nikolic-Paterson, D. J., David, J. R., Bucala, R., Metz, C. N., Atkins, R. C. & Tesch, G. H., 2004, In : Nephrology. 9, 5, p. 278 - 287 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Macrophage-mediated renal injury is dependent on signaling via the JNK pathway

Ikezumi, Y., Hurst, L. A., Atkins, R. C. & Nikolic-Paterson, D. J., 2004, In : Journal of the American Society of Nephrology. 15, 7, p. 1775 - 1784 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury

Chow, F. Y., Ozols, E., Nikolic-Paterson, D. J., Atkins, R. C. & Tesch, G. H., 2004, In : Kidney International. 65, 1, p. 116 - 128 13 p.

Research output: Contribution to journalArticleResearchpeer-review

354 Citations (Scopus)

Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis

Chow, F. Y., Nikolic-Paterson, D. J., Atkins, R. C. & Tesch, G. H., 2004, In : Nephrology Dialysis Transplantation. 19, 12, p. 2987 - 2996 10 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

p38 Mitogen-Activated Protein Kinase Activation and Cell Localization in Human Glomerulonephritis: Correlation with Renal Injury

Stambe, C., Nikolic-Paterson, D. J., Hill, P. A., Dowling, J. P. & Atkins, R. C., 2004, In : Journal of the American Society of Nephrology. 15, 2, p. 326 - 336 11 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Renal processing of serum proteins in an albumin-deficient environment: an in vivo study of glomerulonephritis in the Nagase analbuminaemic rat

Osicka, T. M., Strong, K. J., Nikolic-Paterson, D. J., Atkins, R. C., Jerums, G. & Comper, W. D., 2004, In : Nephrology Dialysis Transplantation. 19, 2, p. 320 - 328 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The role of p38α mitogen-activated protein kinase activation in renal fibrosis

Stambe, C., Atkins, R. C., Tesch, G. H., Masaki, T., Schreiner, G. F. & Nikolic-Paterson, D. J., 2004, In : Journal of the American Society of Nephrology. 15, 2, p. 370 - 379 10 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)
2005

Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses

O'Bryan, M. K., Gerdprasert, O., Nikolic-Paterson, D. J., Meinhardt, A., Muir, J. A., Foulds, L. M., Phillips, D. J., de Kretser, D. M. & Hedger, M. P., 2005, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 288, 6, p. R1744 - R1755 12 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice

Chow, F. Y., Nikolic-Paterson, D. J., Ozols, E., Atkins, R. C. & Tesch, G. H., 2005, In : Journal of the American Society of Nephrology. 16, 6, p. 1711 - 1722 12 p.

Research output: Contribution to journalArticleResearchpeer-review

195 Citations (Scopus)

Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy

De Haan-Klein, J. B., Stefanovic, N., Nikolic-Paterson, D. J., Scurr, L. L., Croft, K. D., Mori, T. A., Hertzog, P. J., Kola, I., Atkins, R. C. & Tesch, G. H., 2005, In : American Journal of Physiology-Renal Physiology. 289, 3, p. F544 - F551 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Mechanism of hypoalbuminemia in rodents

Koltun, M., Nikolovski, J., Strong, K., Nikolic-Paterson, D. J. & Comper, W. D., 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 4, p. H1604 - H1610 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis

Ikezumi, Y., Suzuki, T., Hayafuji, S., Okubo, S., Nikolic-Paterson, D. J., Kawachi, H., Shimizu, F. & Uchiyama, M., 2005, In : Nephrology Dialysis Transplantation. 20, 12, p. 2704 - 2713 10 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
2006

Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney

Hilliard, L. M., Osicka, T. M., Clavant, S. P., Robinson, P. J., Nikolic-Paterson, D. J. & Comper, W. D., 2006, In : Journal of Laboratory and Clinical Medicine. 147, 1, p. 36 - 44 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Histological differences in new-onset IgA nephropathy between children and adults

Ikezumi, Y., Suzuki, T., Imai, N., Ueno, M., Narita, I., Kawachi, H., Shimizu, F., Nikolic-Paterson, D. J. & Uchiyama, M., 2006, In : Nephrology Dialysis Transplantation. 21, 12, p. 3466 - 3474 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats

Lam, E., Funder, J. W., Nikolic-Paterson, D. J., Fuller, P. J. & Young, M. J., 2006, In : Endocrinology. 147, 7, p. 3623 - 3629 7 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

Chow, F., Nikolic-Paterson, D. J., Ozols, E., Atkins, R. C., Rollins, B. J. & Tesch, G. H., 2006, In : Kidney International. 69, 1, p. 73 - 80 8 p.

Research output: Contribution to journalArticleResearchpeer-review

304 Citations (Scopus)

Recent Insights into experimental mouse models of diabetic nephropathy

Tesch, G. H. & Nikolic-Paterson, D. J., 2006, In : Nephron Experimental Nephrology. 104, 2, p. 57 - 62 6 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2007

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis

Ma, F., Flanc, R., Tesch, G. H., Han, Y., Atkins, R. C., Bennett, B. L., Friedman, G. C., Fan, J-H. & Nikolic-Paterson, D. J., 2007, In : Journal of the American Society of Nephrology. 18, 2, p. 472 - 484 13 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis

Flanc, R., Ma, F., Tesch, G. H., Han, Y., Atkins, R. C., Bennett, B. L., Friedman, G. C., Fan, J-H. & Nikolic-Paterson, D. J., 2007, In : Kidney International. 72, 6, p. 698 - 708 11 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Human peritoneal mesothelial cells isolated from spent dialysate fluid maintain contaminating macrophages via production of macrophage colony stimulating factor

Tee, M. M., Tesch, G. H., Nikolic-Paterson, D. J. & Brown, F. G., 2007, In : Nephrology. 12, 2, p. 160 - 165 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

Ma, F., Tesch, G. H., Flavell, R. A., Davis, R. & Nikolic-Paterson, D. J., 2007, In : American Journal of Physiology-Renal Physiology. 293, 5, p. 1556 - 1563 8 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

Chow, F. YF., Nikolic-Paterson, D. J., Ma, F., Ozols, E., Rollins, B. J. & Tesch, G. H., 2007, In : Diabetologia. 50, 2, p. 471 - 480 10 p.

Research output: Contribution to journalArticleResearchpeer-review

168 Citations (Scopus)

Transcriptional analysis of early lineage commitment in human embryonic stem cells

Laslett, A. L., Grimmond, S. M., Gardiner, B., Stamp, L., Lin, S. A., Hawes, S. M., Wormald, S., Nikolic-Paterson, D. J., Haylock, D. N. & Pera, M. F., 2007, In : BMC Developmental Biology. 7, 12, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)
2008

Activated macrophages down-regulate podocyte nephrin and podocin expression via stress-activated protein kinases

Ikezumi, Y., Suzuki, T., Karasawa, T., Kawachi, H., Nikolic-Paterson, D. J. & Uchiyama, M., 2008, In : Biochemical and Biophysical Research Communications. 376, 4, p. 706 - 711 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury

Fukuda, K., Tesch, G. H. & Nikolic-Paterson, D. J., 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 710 - 716 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Disease-dependent mechanisms of albuminuria

Comper, W. D., Hilliard, L. M., Nikolic-Paterson, D. J. & Russo, L. M., 2008, In : American Journal of Physiology-Renal Physiology. 295, 6, p. F1589 - F1600 12 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

Extracellular signal-regulated kinase-dependent interstitial macrophage proliferation in the obstructed mouse kidney

Han, Y., Masaki, T., Hurst, L. A., Ikezumi, Y., Trzaskos, J. M., Atkins, R. C. & Nikolic-Paterson, D. J., 2008, In : Nephrology. 13, 5, p. 411 - 418 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Indoleamine 2,3-dioxygenase in transplantation

Mulley, W. & Nikolic-Paterson, D. J., 2008, In : Nephrology. 13, 3, p. 204 - 211 8 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

In vivo visualization of albumin degradation in the proximal tubule

Slattery, C., Lee, A., Zhang, Y., Kelly, D. J., Thorn, P., Nikolic-Paterson, D. J., Tesch, G. H. & Poronnik, P., 2008, In : Kidney International. 74, 11, p. 1480 - 1486 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

Fukuda, K., Tesch, G. H., Yap, F., Forbes, J. M., Flavell, R. A., Davis, R. & Nikolic-Paterson, D. J., 2008, In : Laboratory Investigation. 88, 4, p. 398 - 407 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

Tokuyama, H., Kelly, D. J., Cox, A., Zhang, Y., Thai, K., Nikolic-Paterson, D. J. & Gilbert, R. E., 2008, In : Nephron Experimental Nephrology. 109, 1, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy

Ikezumi, Y., Suzuki, T., Karasawa, T., Kawachi, H., Nikolic-Paterson, D. J. & Uchiyama, M., 2008, In : Pediatric Nephrology. 23, 4, p. 645 - 650 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2009

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

Lim, A. K. H., Nikolic-Paterson, D. J., Ma, F., Ozols, E., Thomas, M. C., Flavell, R. A., Davis, R. J. & Tesch, G. H., 2009, In : Diabetologia. 52, 2, p. 347 - 358 12 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

The role of stress-activated protein kinase signaling in renal pathophysiology

Ma, F., Liu, J. & Nikolic-Paterson, D. J., 2009, In : Brazilian Journal of Medical and Biological Research. 42, 1, p. 29 - 37 9 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)
2010

CD4+ T cells: a potential player in renal fibrosis.

Nikolic-Paterson, D. J., 2010, In : Kidney International. 78, 4, p. 333 - 335 3 p.

Research output: Contribution to journalArticleOther

19 Citations (Scopus)

Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat Thy-1 mesangial proliferative glomerulonephritis

Ikezumi, Y., Suzuki, T., Karasawa, T., Hasegawa, H., Kawachi, H., Nikolic-Paterson, D. J. & Uchiyama, M., 2010, In : American Journal of Nephrology. 31, 3, p. 273 - 282 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

JNK signalling in human and experimental renal ischaemia/reperfusion injury

Kanellis, J., Ma, F., Kandane, R. K., Dowling, J., Polkinghorne, K., Bennett, B., Friedman, G. & Nikolic-Paterson, D., 2010, In : Nephrology Dialysis Transplantation. 25, 9, p. 2898 - 2908 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells

Mariasegaram, M., Tesch, G. H., Verhardt, S. L., Hurst, L. A., Lan, H. & Nikolic-Paterson, D. J., 2010, In : Biochemical and Biophysical Research Communications. 393, 4, p. 855 - 859 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
34 Citations (Scopus)

Macrophage signaling pathways: A novel target in renal disease

Ma, F., Ikezumi, Y. & Nikolic-Paterson, D. J., 2010, In : Seminars in Nephrology. 30, 3, p. 334 - 344 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Resveratrol inhibits renal fibrosis in the obstructed kidney: Potential role in deacetylation of Smad3

Li, J., Qu, X., Ricardo, S. D., Bertram, J. F. & Nikolic-Paterson, D. J., 2010, In : American Journal of Pathology. 177, 3, p. 1065 - 1071 7 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)
2011

A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice

Leng, L., Chen, L., Fan, J., Greven, D., Arjona, A., Du, X., Austin, D., Kashgarian, M., Yin, Z., Huang, X., Lan, H. Y., Lolis, E., Nikolic-Paterson, D. & Bucala, R., 2011, In : Journal of Immunology. 186, 1, p. 527 - 538 12 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

Han, Y., Ma, F., Tesch, G., Manthey, C. & Nikolic-Paterson, D., 2011, In : Laboratory Investigation. 91, 7, p. 978 - 991 14 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats

Lim, A., Ma, F., Nikolic-Paterson, D., Ozols, E., Young, M., Bennett, B., Friedman, G. & Tesch, G., 2011, In : American Journal of Nephrology. 34, 4, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion

Ikezumi, Y., Suzuki, T., Karasawa, T., Hasegawa, H., Yamada, T., Imai, N., Narita, I., Kawachi, H., Polkinghorne, K., Nikolic-Paterson, D. & Uchiyama, M., 2011, In : Histopathology. 58, 2, p. 198 - 210 13 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Mast cells mediate acute kidney injury through the production of TNF

Summers, S. A., Chan, J., Gan, P-Y., Dewage, L., Nozaki, Y., Steinmetz, O., Nikolic-Paterson, D., Kitching, A. & Holdsworth, S., 2011, In : Journal of the American Society of Nephrology. 22, 12, p. 2226 - 2236 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)