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Role of JUN/AP-1 in acute and chronic kidney injury. Mechanisms of acute kidney injury in high risk individuals. Novel roles for macrophages in renal fibrosis.

1992 …2022

Research activity per year

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Personal profile

Biography

Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.

Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Head of Laboratory Research, Monash Health

2005 → …

Research area keywords

  • Kidney Disease
  • Inflammation
  • Fibrosis
  • Macrophage
  • Signalling pathways
  • Pre-clinical studies

Network

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