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Personal profile

Biography

Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.

Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.

External positions

Head of Laboratory Research, Monash Health

2005 → …

Keywords

  • Kidney Disease
  • Inflammation
  • Fibrosis
  • Macrophage
  • Signalling pathways
  • Pre-clinical studies

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2022

Research Output 1992 2019

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin

Ly, N. D. K., Tesch, G. H., Nikolic-Paterson, D. J. & Poronnik, P., Jan 2019, In : Nephrology. 24, 1, p. 121-126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A model of acute antibody-mediated renal allograft rejection in the sensitized rat

Chandran, S. R., Mulley, W. R., Kanellis, J., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Jun 2018, In : Experimental and Clinical Transplantation. 16, 3, p. 294-300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis

Han, Y., Ma, F. Y., Di Paolo, J. & Nikolic-Paterson, D. J., 1 Jan 2018, In : International Journal of Immunopathology and Pharmacology. 32, 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

Liles, J. T., Corkey, B. K., Notte, G. T., Budas, G. R., Lansdon, E. B., Hinojosa-Kirschenbaum, F., Badal, S. S., Lee, M., Schultz, B. E., Wise, S., Pendem, S., Graupe, M., Castonguay, L., Koch, K. A., Wong, M. H., Papalia, G. A., French, D. M., Sullivan, T., Huntzicker, E. G., Ma, F. Y. & 5 othersNikolic-Paterson, D. J., Altuhaifi, T., Yang, H., Fogo, A. B. & Breckenridge, D. G., 1 Oct 2018, In : Journal of Clinical Investigation. 128, 10, p. 4485-4500 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Amos, L. A., Ma, F. Y., Tesch, G. H., Liles, J. T., Breckenridge, D. G., Nikolic-Paterson, D. J. & Han, Y., 1 Sep 2018, In : Journal of Cellular and Molecular Medicine. 22, 9, p. 4522-4533 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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