1992 …2022

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.

Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.

External positions

Head of Laboratory Research, Monash Health

2005 → …

Research area keywords

  • Kidney Disease
  • Inflammation
  • Fibrosis
  • Macrophage
  • Signalling pathways
  • Pre-clinical studies

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Li, J., Sun, Y. B. Y., Chen, W., Fan, J., Li, S., Qu, X., Chen, Q., Chen, R., Zhu, D., Zhang, J., Wu, Z., Chi, H., Crawford, S., Oorschot, V., Puelles, V. G., Kerr, P. G., Ren, Y., Nilsson, S. K., Christian, M., Tang, H. & 4 others, Chen, W., Bertram, J. F., Nikolic-Paterson, D. J. & Yu, X., 5 Feb 2020, In : EMBO Reports. 21, 2, 20 p., e48781.

Research output: Contribution to journalArticleResearchpeer-review

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Jiang, M., Fan, J., Qu, X., Li, S., Nilsson, S. K., Sun, Y. B. Y., Chen, Y., Yu, D., Liu, D., Liu, B-C., Tang, M., Chen, W., Ren, Y., Nikolic-Paterson, D. J., Jiang, X., Li, J. & Yu, X., 9 Aug 2019, In : Frontiers in Pharmacology. 10, 17 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Pullen, N., Jesson, M. I., Schlerman, F. J. & Nikolic-Paterson, D. J., 1 Dec 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1439-F1449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Establishing equivalent diabetes in male and female Nos3-deficient mice results in a comparable onset of diabetic kidney injury

Tian, L., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Sep 2019, In : Physiological Reports. 7, 18, 8 p., e14197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Macrophages: versatile players in renal inflammation and fibrosis

Tang, P. M. K., Nikolic-Paterson, D. J. & Lan, H. Y., 1 Mar 2019, In : Nature Reviews Nephrology. 15, 3, p. 144-158 15 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

26 Citations (Scopus)