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Personal profile

Biography

Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.

Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.

External positions

Head of Laboratory Research, Monash Health

2005 → …

Keywords

  • Kidney Disease
  • Inflammation
  • Fibrosis
  • Macrophage
  • Signalling pathways
  • Pre-clinical studies

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2022

Research Output 1992 2018

Matrix metalloproteinase-12 (MMP-12) deficiency attenuates experimental crescentic anti-GBM glomerulonephritis

Abraham, A. P., Ma, F. Y., Mulley, W. R., Nikolic-Paterson, D. J. & Tesch, G. H., Feb 2018, In : Nephrology. 23, 2, p. 183-189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of spleen tyrosine kinase reduces renal allograft injury in a rat model of acute antibody-mediated rejection in sensitized recipients

Ramessur Chandran, S., Han, Y., Tesch, G. H., Di Paolo, J., Mulley, W. R., Kanellis, J., Ma, F. Y. & Nikolic-Paterson, D. J., 1 Aug 2017, In : Transplantation. 101, 8, p. e240-e248 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury

Wang, Y. Y., Jiang, H., Pan, J., Huang, X. R., Wang, Y. C., Huang, H. F., To, K. F., Nikolic-Paterson, D. J., Lan, H. Y. & Chen, J. H., 1 Jul 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2053-2067 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney

Ma, F. Y., Blease, K. & Nikolic-Paterson, D. J., 1 Feb 2016, In : Life Sciences. 146, p. 192-200 9 p.

Research output: Contribution to journalArticleResearchpeer-review