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Personal profile

Biography

Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.

Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.

External positions

Head of Laboratory Research, Monash Health

2005 → …

Keywords

  • Kidney Disease
  • Inflammation
  • Fibrosis
  • Macrophage
  • Signalling pathways
  • Pre-clinical studies

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2022

Research Output 1992 2019

Macrophages: versatile players in renal inflammation and fibrosis

Tang, P. M. K., Nikolic-Paterson, D. J. & Lan, H. Y., 1 Mar 2019, In : Nature Reviews Nephrology. 15, 3, p. 144-158 15 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

Puelles, V. G., Fleck, D., Ortz, L., Papadouri, S., Strieder, T., Böhner, A. M. C., van der Wolde, J. W., Vogt, M., Saritas, T., Kuppe, C., Fuss, A., Menzel, S., Klinkhammer, B. M., Müller-Newen, G., Heymann, F., Decker, L., Braun, F., Kretz, O., Huber, T. B., Susaki, E. A. & 9 othersUeda, H. R., Boor, P., Floege, J., Kramann, R., Kurts, C., Bertram, J. F., Spehr, M., Nikolic-Paterson, D. J. & Moeller, M. J., 15 Mar 2019, (Accepted/In press) In : Kidney International. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

Han, Y., Tian, L., Ma, F., Tesch, G., Vesey, D. A., Gobe, G. C., Lohman, R. J., Morais, C., Suen, J. Y., Fairlie, D. P. & Nikolic-Paterson, D. J., 1 May 2019, In : Clinical and Experimental Pharmacology and Physiology. 46, 5, p. 456-464 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin

Ly, N. D. K., Tesch, G. H., Nikolic-Paterson, D. J. & Poronnik, P., Jan 2019, In : Nephrology. 24, 1, p. 121-126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A model of acute antibody-mediated renal allograft rejection in the sensitized rat

Chandran, S. R., Mulley, W. R., Kanellis, J., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Jun 2018, In : Experimental and Clinical Transplantation. 16, 3, p. 294-300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File