Projects per year
Personal profile
Biography
Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.
Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Head of Laboratory Research, Monash Health
2005 → …
Research area keywords
- Kidney Disease
- Inflammation
- Fibrosis
- Macrophage
- Signalling pathways
- Pre-clinical studies
Collaborations and top research areas from the last five years
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Engineering bone marrow-derived stromal cells to express anti-fibrotic cargo as a treatment for chronic kidney disease
Samuel, C. (Primary Chief Investigator (PCI)), Ricardo, S. (Chief Investigator (CI)), Kerr, P. (Chief Investigator (CI)), Li, T. (Chief Investigator (CI)), Jenkin, G. (Chief Investigator (CI)), Hudson, P. (Chief Investigator (CI)), Polo, J. (Associate Investigator (AI)), Widdop, R. (Associate Investigator (AI)), Nikolic-Paterson, D. (Associate Investigator (AI)) & Teo, L. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Dissecting the cystogenic pathway driving Polycystic Kidney Disease.
Cottle, D. (Primary Chief Investigator (PCI)), Smyth, I. (Chief Investigator (CI)), Combes, A. (Chief Investigator (CI)), Nikolic-Paterson, D. (Chief Investigator (CI)) & Rosenbluh, S. (Chief Investigator (CI))
1/03/21 → 28/02/26
Project: Research
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Improving short- and long-term outcomes in cardiac bypass surgery by preventing acute kidney injury.
Nikolic-Paterson, D., Ma, F., Smith, J., Grynberg, K., Mulley, W., Robertson, T. & Combes, A.
1/06/22 → 31/05/24
Project: Research
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Assessing human kidney organoids as a replacement for mouse models of renal fibrosis
Combes, A. (Primary Chief Investigator (PCI)), Nikolic-Paterson, D. (Chief Investigator (CI)), Moreau, J. (Associate Investigator (AI)), Nunez Nescolarde, A. (Associate Investigator (AI)) & Lam, R. (Associate Investigator (AI))
30/06/21 → 1/08/24
Project: Research
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Therapeutic targeting of cellular senescence to prevent progression of chronic kidney disease
Tesch, G., Nikolic-Paterson, D. & Ma, F.
3/05/21 → 31/03/22
Project: Research
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Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury
Tesch, G. H., Ma, F. Y., Ozols, E. & Nikolic-Paterson, D. J., 6 Mar 2024, In: Clinical Science. 138, 5, p. 309-326 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis
de Zoysa, N., Haruhara, K., Nikolic-Paterson, D. J., Kerr, P. G., Ling, J., Gazzard, S. E., Puelles, V. G., Bertram, J. F. & Cullen-McEwen, L. A., 2024, In: Frontiers in Medicine. 11, 14 p., 1343161.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4
Zhao, W., Nikolic-Paterson, D. J., Li, K., Li, Y., Wang, Y., Chen, X., Duan, Z., Zhang, Y., Liu, P., Lu, S., Fu, R. & Tian, L., 25 Apr 2024, In: Chemico-Biological Interactions. 393, 12 p., 110944.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
Yang, J., Zhuang, H., Li, J., Nunez-Nescolarde, A. B., Luo, N., Chen, H., Li, A., Qu, X., Wang, Q., Fan, J., Bai, X., Ye, Z., Gu, B., Meng, Y., Zhang, X., Wu, D., Sia, Y., Jiang, X., Chen, W. & Combes, A. N. & 2 others, , 16 Apr 2024, In: The Journal of Clinical Investigation. 134, 10, p. 8023–8038 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Corrigendum: c-Jun amino terminal kinase signaling promotes aristolochic acid-induced acute kidney injury, (Front. Physiol, (2021), 12, (599114), 10.3389/fphys.2021.599114)
Yang, F., Ozols, E., Ma, F. Y., Leong, K. G., Tesch, G. H., Jiang, X. & Nikolic-Paterson, D. J., 4 Jan 2023, In: Frontiers in Physiology. 13, 1 p., 1123475.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access