Projects per year
Personal profile
Biography
Field of Research. Chronic kidney disease affects 1 in 10 adult Australians, although many are not aware of this insidious disease. Progression to end-stage kidney disease requires treatment by dialysis or transplantation. Dr Nikolic-Paterson’s research focuses identifying the underlying mechanisms of inflammation and fibrosis that are involved in both kidney disease and kidney transplant rejection. In particular, his work focuses on signalling pathways in leukocytes, intrinsic kidney cells and fibroblasts. Using a combination of approaches in human and experimental kidney disease, including conditional gene deletion, cell culture studies and selective kinase inhibitors, a number of therapeutic targets have been identified which are relevant not only to progressive kidney disease, but also chronic fibrotic diseases in the lung, liver and heart. This work has led to a number of clinical trials in lung and kidney disease, including a current study of ASK1 blockade in patients with diabetic kidney disease. This has been achieved through collaborations with researchers both within Australia and overseas, and with a number of commercial companies.
Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Head of Laboratory Research, Monash Health
2005 → …
Research area keywords
- Kidney Disease
- Inflammation
- Fibrosis
- Macrophage
- Signalling pathways
- Pre-clinical studies
Network
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Engineering bone marrow-derived stromal cells to express anti-fibrotic cargo as a treatment for chronic kidney disease
Samuel, C., Ricardo, S., Kerr, P., Li, T., Jenkin, G., Hudson, P., Polo, J., Widdop, R., Nikolic-Paterson, D. & Teo, L.
1/01/23 → 31/12/26
Project: Research
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Improving short- and long-term outcomes in cardiac bypass surgery by preventing acute kidney injury.
Nikolic-Paterson, D., Ma, F., Smith, J., Grynberg, K., Mulley, W., Robertson, T. & Combes, A.
1/06/22 → 31/05/24
Project: Research
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Assessing human kidney organoids as a replacement for mouse models of renal fibrosis
Combes, A., Nikolic-Paterson, D., Moreau, J., Nunez Nescolarde, A. & Lam, R.
30/06/21 → 1/08/24
Project: Research
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Dissecting the cystogenic pathway driving Polycystic Kidney Disease.
Cottle, D., Smyth, I., Combes, A., Nikolic-Paterson, D. & Rosenbluh, S.
1/03/21 → 29/02/24
Project: Research
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Therapeutic targeting of cellular senescence to prevent progression of chronic kidney disease
Tesch, G., Nikolic-Paterson, D. & Ma, F.
3/05/21 → 31/03/22
Project: Research
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ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death
Ogier, J. M., Gao, Y., Dunne, E. M., Wilson, M. A., Ranganathan, S. C., Tesch, G. H., Nikolic Paterson, D. J., Dabdoub, A., Burt, R. A., Nayagam, B. A. & Lockhart, P. J., May 2022, In: Journal of Molecular Medicine. 100, 5, p. 797-813 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Editorial: Immune Landscape of Kidney Pathology
Tang, P. M. K., Chen, H., Tang, Y., Nikolic-Paterson, D. J. & Lan, H. Y., 25 Jan 2022, In: Frontiers in Physiology. 12, 4 p., 827537.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access1 Citation (Scopus) -
Human Kidney Organoids and Tubuloids as Models of Complex Kidney Disease
Nunez-Nescolarde, A. B., Nikolic-Paterson, D. J. & Combes, A. N., 1 May 2022, In: American Journal of Pathology. 192, 5, p. 738-749 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access5 Citations (Scopus) -
Mice with Established Diabetes Show Increased Susceptibility to Renal Ischemia/Reperfusion Injury: Protection by Blockade of Jnk or Syk Signaling Pathways
Grynberg, K., Tian, L., Tesch, G., Ozols, E., Mulley, W. R., Nikolic-Paterson, D. J. & Ma, F. Y., Mar 2022, In: American Journal of Pathology. 192, 3, p. 441-453 13 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Mizoribine halts kidney fibrosis in childhood IgA nephropathy: association with modulation of M2-type macrophages
Ikezumi, Y., Yoshikane, M., Kondoh, T., Matsumoto, Y., Kumagai, N., Kaneko, M., Hasegawa, H., Yamada, T., Suzuki, T. & Nikolic-Paterson, D. J., 2022, (Accepted/In press) In: Pediatric Nephrology. 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access