Projects per year
Personal profile
Biography
Dr David Metz is a paediatric nephrologist, paediatric clinical pharmacologist and clinician-researcher. His PhD investigated methods to increase precision in mycophenolic acid dosing in kidney transplantation, through clinical trial and pharmacometric analysis. His research continues in this field, alongside active translation into clinical care. He is also medical lead of the Monash Children’s Clinical Trial Centre at Monash Health, which is involved in both commercial and investigator-initiated therapeutic trials to increase access to, and improve safety and effectiveness of, therapeutic drugs used in children.
Research interests
Individualised dosing of immunosuppressants and other critical dose drugs.
Paediatric clinical pharmacology and optimal usage of therapeutic drugs to increase safety and effectiveness in children.
Clinical activities
Paediatric nephrologist, clinical lead in haemodialysis and therapeutic plasma exchange.
Education/Academic qualification
Transplant Immunosuppression; Clinical Pharmacology, PhD, Optimising immunosuppressant dosing in kidney transplantation: better outcomes through quantitative pharmacology, University of Melbourne
2014 → 8 Jul 2021
Award Date: 8 Jul 2021
Bachelor of Medicine, Bachelor of Surgery, MBBS
External positions
Medical Lead, Monash Children's Clinical Trial Centre, Monash Children's Hospital
Paediatric Nephrologist, Royal Children's Hospital Melbourne
Research area keywords
- Pharmacokinetics
- Kidney Transplant
- Pharmacology
- Optimisation of Dosing
- Paediatrics
- Nephrology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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RSV MAT-015: A non-randomized, open label, multi-country, cohort study to describe the safety of study participants who received RSVPreF3 maternal vaccination (any dose) or controls from previous RSV MAT studies (RSV MAT-001, RSV MAT-004, RSV MAT-010, RSV MAT-011, RSV MAT-009, RSV MAT-012 and RSV MAT-039) during any pregnancy conceived post vaccination/control
Metz, D. (Primary Chief Investigator (PCI))
22/03/23 → 21/03/28
Project: Research
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Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action
Lorentzos, M. S., Metz, D., Moore, A. S., Fawcett, L. K., Bray, P., Attwood, L., Munns, C. F. & Davidson, A., 19 Feb 2024, In: The Medical Journal of Australia. 220, 3, p. 121-125 5 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access2 Citations (Scopus) -
Pharmacokinetics of anakinra in extremely premature infants
Green, E. A., Metz, D., Galinsky, R., Kirkpatrick, C. M., Gunn, A. J., Hunt, R. W., Atkinson, R., Szuka, E., Clark, M., Berger, P. J., Nold-Petry, C. A. & Nold, M. F., 26 Mar 2023, In: Journal of Paediatrics and Child Health. 59, S1, p. 21 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
Anakinra Pilot – a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants
Green, E. A., Metz, D., Galinsky, R., Atkinson, R., Skuza, E. M., Clark, M., Gunn, A. J., Kirkpatrick, C. M., Hunt, R. W., Berger, P. J., Nold-Petry, C. A. & Nold, M. F., 27 Oct 2022, In: Frontiers in Immunology. 13, 14 p., 1022104.Research output: Contribution to journal › Article › Other › peer-review
Open Access21 Citations (Scopus) -
Important lack of difference in tacrolimus and mycophenolic acid pharmacokinetics between Aboriginal and Caucasian kidney transplant recipients
Barraclough, K. A., Metz, D., Staatz, C. E., Gorham, G., Carroll, R., Majoni, S. W., Cherian, S., Swaminathan, R. & Holford, N., Sept 2022, In: Nephrology. 27, 9, p. 771-779 9 p.Research output: Contribution to journal › Article › Research › peer-review
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Mycophenolic acid area under the curve assessment after mycophenolate mofetil dose reduction in kidney transplant recipients
Malaweera, A., Metz, D., Mulley, W. & Lee, D., Jun 2022, p. 108. 1 p.Research output: Contribution to conference › Poster › peer-review
Prizes
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Australian Clinical Trials Education Centre (A-CTEC) Symposium
Metz, D. (Organiser)
19 Oct 2023Activity: Participating in or organising an event types › Contribution to conference
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HD Academy
Metz, D. (Invited speaker)
18 Feb 2023Activity: Participating in or organising an event types › Contribution to conference
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World Conference on Pharmacometrics
Metz, D. (Speaker)
2022Activity: Participating in or organising an event types › Contribution to conference
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Annual Scientific Meeting of the Australian-and-New-Zealand-Society-of-Nephrology 2021
Metz, D. (Invited speaker)
2021Activity: Participating in or organising an event types › Contribution to conference
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Royal Australasian College of Physicians (RACP) (External organisation)
Metz, D. (Member)
2020 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Press/Media
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Featured top downloaded paper of week from journal Transplantation: 1st author manuscript
5/05/22
1 item of Media coverage
Press/Media: Blogs, Podcasts and Social Media › Social Media Mentions