Projects per year
Personal profile
Biography
Professor David Kaye is an NHMRC Principal Research Fellow and a Heart Failure/Transplant physician at the Alfred Hospital Melbourne. Prof Kaye’s research has been directed towards the characterisation of the pathophysiology of heart failure, with a particular emphasis on the identification of novel mechanisms that can be targeted for therapeutic intervention. Prof Kaye has been highly successful in the generation of intellectual property leading to commercial and clinical outcomes.
He is an Adjunct Professor at Monash University. He leads the Heart Failure Research laboratory, comprising a number of senior post-docs, RAs, PhD students and BSc(Hons) students. Prof Kaye is Chair of the Medical Advisory Boards for Opsrey Medical and Cardiora Pty Ltd, both companies which he founded based upon intellectual property he generated.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Endovascular Ablation of the Greater Splanchnic Nerve in Subjects Having Heart Failure with Preserved Ejection Fraction: First In-Human Feasibility Study
Kaye, D. & Dean, E.
18/03/20 → 31/12/21
Project: Research
Assessment of a new novel fluid monitoring device in heart failure patients.
Kaye, D. & Dean, E.
12/08/19 → 31/12/20
Project: Research
Investigation of Thrombosis in Extracorporeal Membrane Oxygenation Drainage Cannulas
Kaye, D., Gregory, S., Pellegrino, V., Soria, J., Steinseifer, U., Salamonsen, R., Nandurkar, H., Pinar, I. & Liao, S.
14/01/19 → 13/01/22
Project: Research
Research Output
Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature
Savira, F., Magaye, R., Liew, D., Reid, C., Kelly, D. J., Kompa, A. R., Sangaralingham, S. J., Burnett, J. C., Kaye, D. & Wang, B. H., Jul 2020, In : British Journal of Pharmacology. 177, 13, p. 2906-2922 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease
Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, , 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.Research output: Contribution to journal › Article › Research › peer-review
5
Citations
(Scopus)
Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1
Magaye, R. R., Savira, F., Hua, Y., Xiong, X., Huang, L., Reid, C., Flynn, B., Kaye, D., Liew, D. & Wang, B. H., Aug 2020, In : Cellular Signalling. 72, 18 p., 109629.Research output: Contribution to journal › Article › Research › peer-review
Impact of a model of care for heart failure in‐patients to reduce variation in care – a quality improvement project
Hopper, I., Easton, K., Bader, I., Campbell, J., Busija, L., Markey, P., Bergin, P. J. & Kaye, D. M., 11 Feb 2020, (Accepted/In press) In : Internal Medicine Journal. 29 p.Research output: Contribution to journal › Article › Research › peer-review
The Emerging Role of Gut Dysbiosis in Cardio-metabolic Risk Factors for Heart Failure
Sata, Y., Marques, F. Z. & Kaye, D. M., 1 May 2020, In : Current Hypertension Reports. 22, 5, 8 p., 38.Research output: Contribution to journal › Review Article › Research › peer-review