19982020

Research output per year

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Personal profile

Biography

Professor David Kaye is an NHMRC Principal Research Fellow and a Heart Failure/Transplant physician at the Alfred Hospital Melbourne. Prof Kaye’s research has been directed towards the characterisation of the pathophysiology of heart failure, with a particular emphasis on the identification of novel mechanisms that can be targeted for therapeutic intervention. Prof Kaye has been highly successful in the generation of intellectual property leading to commercial and clinical outcomes.

He is an Adjunct Professor at Monash University. He leads the Heart Failure Research laboratory, comprising a number of senior post-docs, RAs, PhD students and BSc(Hons) students. Prof Kaye is Chair of the Medical Advisory Boards for Opsrey Medical and Cardiora Pty Ltd, both companies which he founded based upon intellectual property he generated.

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Projects

Research Output

Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature

Savira, F., Magaye, R., Liew, D., Reid, C., Kelly, D. J., Kompa, A. R., Sangaralingham, S. J., Burnett, J. C., Kaye, D. & Wang, B. H., Jul 2020, In : British Journal of Pharmacology. 177, 13, p. 2906-2922 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, Spector, T. D., Valdes, A. M., Mackay, C. R. & Marques, F. Z., 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1

Magaye, R. R., Savira, F., Hua, Y., Xiong, X., Huang, L., Reid, C., Flynn, B., Kaye, D., Liew, D. & Wang, B. H., Aug 2020, In : Cellular Signalling. 72, 18 p., 109629.

Research output: Contribution to journalArticleResearchpeer-review

Impact of a model of care for heart failure in‐patients to reduce variation in care – a quality improvement project

Hopper, I., Easton, K., Bader, I., Campbell, J., Busija, L., Markey, P., Bergin, P. J. & Kaye, D. M., 11 Feb 2020, (Accepted/In press) In : Internal Medicine Journal. 29 p.

Research output: Contribution to journalArticleResearchpeer-review

The Emerging Role of Gut Dysbiosis in Cardio-metabolic Risk Factors for Heart Failure

Sata, Y., Marques, F. Z. & Kaye, D. M., 1 May 2020, In : Current Hypertension Reports. 22, 5, 8 p., 38.

Research output: Contribution to journalReview ArticleResearchpeer-review