• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021

Research output per year

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Research Output

2005

Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS

Hu, W., Kemp, B. E. & Jans, D. A., 2005, In : Journal of Cellular Biochemistry. 95, 4, p. 782 - 793 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme

Soboleva, T., Jans, D. A., Johnson-Saliba, M. & Baker, R. T., 2005, In : Journal of Biological Chemistry. 280, 1, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha

Ghildyal, R., Ho, A., Wagstaff, K. M., Dias, M. M., Barton, C. L., Jans, P., Bardin, P. & Jans, D. A., 2005, In : Biochemistry. 44, 38, p. 12887 - 12895 9 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Quantitative analysis of protein-protein interactions by native page/fluorimaging

Wagstaff, K. M., Dias, M. M., Alvisi, G. & Jans, D. A., 2005, In : Journal of Fluorescence. 15, 4, p. 469 - 473 5 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?

Hogarth, C., Itman, C. M., Jans, D. A. & Loveland, K. A. L., 2005, In : BioEssays. 27, 10, p. 1011 - 1025 15 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Regulation of nuclear transport: central role in development and transformation?

Poon, I. K. H. & Jans, D. A., 2005, In : Traffic. 6, 3, p. 173 - 186 14 p.

Research output: Contribution to journalArticleResearchpeer-review

279 Citations (Scopus)

Tetraspanins in viral infections: a fundamental role in viral biology?

Martin, F., Martino Roth, D., Jans, D. A., Pouton, C. W., Partridge, L. J., Monk, P. N. & Moseley, G. W., 2005, In : Journal of Virology. 79, 17, p. 10839 - 10851 13 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Towards safe, non-viral therapeutic gene expression in humans

Glover, D. J., Lipps, H. J. & Jans, D. A., 2005, In : Nature Reviews Genetics. 6, 4, p. 299 - 310 12 p.

Research output: Contribution to journalArticleResearchpeer-review

444 Citations (Scopus)
2004

An efficient system for high-level expression and easy purification of authentic recombinant proteins

Catanzariti, A-M., Soboleva, T. A., Jans, D. A., Board, P. G. & Baker, R. T., 2004, In : Protein Science. 13, 5, p. 1331 - 1339 9 p.

Research output: Contribution to journalArticleResearchpeer-review

185 Citations (Scopus)

The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus

Oro, C. & Jans, D. A., 2004, In : Current Drug Targets. 5, 2, p. 179 - 190 12 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors

Johnson, H. M., Subramaniam, P. S., Olsnes, S. & Jans, D. A., 2004, In : BioEssays. 26, 9, p. 993 - 1004 12 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)
2003

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

Trapani, J. A., Sutton, V. R., Thia, K. Y. T., Li, Y. Q., Froelich, C. J., Jans, D. A., Sandrin, M. S. & Browne, K. A., 2003, In : Journal of Cell Biology. 106, 2, p. 223 - 233 11 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal

Argentaro, A., Sim, H., Kelly, S., Preiss, S., Clayton, A., Jans, D. A. & Harley, V. R., 2003, In : Journal of Biological Chemistry. 278, 36, p. 33839 - 33847 9 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Defective importin recognition and nuclear import of the sex-determining factory SRY are associated with XY sex-reversing mutations

Harley, V. R., Layfield, S., Mitchell, C. L., Forwood, J. K., John, A. P., Briggs, L. J., McDowall, S. G. & Jans, D. A., 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 12, p. 7045 - 7050 6 p.

Research output: Contribution to journalArticleResearchpeer-review

130 Citations (Scopus)

Inhibition of nuclear import mediated by the Rev-Arginine Rich Motif by RNA molecules

Fineberg, K. M., Fineberg, T., Graessmann, A., Luedtke, N. W., Tor, Y., Lixin, R., Jans, D. A. & Loyter, A., 2003, In : Biochemistry. 42, 9, p. 2625 - 2633 9 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways

Keough, R. A., MacMillan, E. M., Lutwyche, J. K., Gardner, J. M., Tavner, F. J., Jans, D. A., Henderson, B. R. & Gonda, T. J., 2003, In : Experimental Cell Research. 289, 1, p. 108 - 123 16 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Nuclear Import of the pre-integration complex (PIC): the Achilles heel of HIV?

Piller, S. C., Caly, L. & Jans, D. A., 2003, In : Current Drug Targets. 4, 5, p. 409 - 429 21 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles

Jans, D. A., Thomas, R. J. & Gillespie, M. T., 2003, Vitamins and Hormones. Litwack, G. (ed.). 66 ed. San Diego USA: Academic Press, p. 345 - 384 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

42 Citations (Scopus)

Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation

Schedlich, L. J., Nilsen, T., John, A. P., Jans, D. A. & Baxter, R. C., 2003, In : Endocrinology. 144, 5, p. 1984 - 1993 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity

Rosenkranz, A. A., Lunin, V. G., Gulak, P. V., Sergienko, O. V., Shumiantseva, M. A., Voronina, O. L., Gilyazova, D. G., John, A. P., Kofner, A. A., Mironov, A. F., Jans, D. A. & Sobolev, A. S., 2003, In : The FASEB Journal. 17, 9, p. 1121 - 1123 3 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-

Fontes, M. R. M., Teh, T., Toth, G., John, A. P., Pavo, I., Jans, D. A. & Kobe, B., 2003, In : Biochemical Journal. 375, 2, p. 339 - 349 11 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Role of prodomain in importin-mediated nuclear localization and activation of caspase-2

Baliga, B. C., Colussi, P. A., Read, S. H., Dias, M. M., Jans, D. A. & Kumar, S., 14 Feb 2003, In : Journal of Biological Chemistry. 278, 7, p. 4899-4905 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
79 Citations (Scopus)

Structural basis for the specificity of bipartite nuclear localisation sequence binding by importin-

Fontes, M. R. M., Teh, T., Jans, D. A., Brinkworth, R. I. & Kobe, B., 2003, In : Journal of Biological Chemistry. 278, 30, p. 27981 - 27987 7 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

The HIV-1 Tat transactivator protein: a therapeutic target?

Fulcher, A. J. & Jans, D. A., 2003, In : IUBMB Life. 55, 12, p. 669 - 680 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2002

EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response

Henderson, M. J., Russell, A. J., Hird, S., Munoz, M., Clancy, J. L., Lehrbach, G. M., Calanni, S. T., Jans, D. A., Sutherland, R. L. & Watts, C. K. W., 2002, In : Journal of Biological Chemistry. 277, 19, p. 26468 - 26478 11 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Nuclear import pathway of the telomere elongation suppressor TRFI: inhibition by importin

Forwood, J. K. & Jans, D. A., 2002, In : Biochemistry. 41, 30, p. 9333 - 9340 8 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules

Lam, M. H. C., Thomas, R. J., Loveland, K. L., Schilders, S., Min, G., Martin, T. J., Gillespie, M. T. & Jans, D. A., 2002, In : Molecular Endocrinology. 16, 2, p. 390 - 401 12 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Role of prodomain in importin-medicated nuclear localization and activation of Capase-2*

Baliga, B. C., Colussi, P. A., Read, S. H., Dias, M. & Jans, D. A., 2002, In : Journal of Biological Chemistry. 278, 7, p. 4899 - 4905 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin

Hübner, S., Jans, D. A., Xiao, C. Y., John, A. P. & Drenckhahn, D., 15 Jan 2002, In : Biochemical Journal. 361, 2, p. 287-296 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Targeting of nonkaryophilic cell-permeable peptides into the nuclei of intact cells by covalently attached nuclear localization signals

Hariton-Gazal, E., Feder, R., Mor, A., Graessmann, A., Brack-Werner, R., Jans, D. A., Gilon, C. & Loyter, A., 2002, In : Biochemistry. 41, 29, p. 9208 - 9214 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

The interdomain region of dengue NS5 protein interacts with NS3 and host proteins

Brooks, A. J., Johansson, M., Criswell, E., Jans, D. A. & Vasudevan, S. G., 1 Dec 2002, In : Dengue Bulletin. 26, p. 155-161 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin 1 and Improtin Recognized Nuclear Localization Signals

Brooks, A. J., Johansson, M., John, A. V., Xu, Y., Jans, D. A. & Vasuvedan, S. B., 2002, In : Journal of Biological Chemistry. 277, 39, p. 36399 - 36407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin β1 and importin α/β-recognized nuclear localization signals

Brooks, A. J., Johansson, M., John, A. V., Xu, Y., Jans, D. A. & Vasudevan, S. G., 27 Sep 2002, In : Journal of Biological Chemistry. 277, 39, p. 36399-36407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
101 Citations (Scopus)

Using nuclear targeting signals to enhance non-viral gene transfer

Chan, C-K. & Jans, D. A., 2002, In : Immunology and Cell Biology. 80, 2, p. 119 - 130 12 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)
2001

A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-β and the viral helicase, NS3

Johansson, M., Brooks, A. J., Jans, D. A. & Vasudevan, S. G., 1 Jan 2001, In : Journal of General Virology. 82, 4, p. 735-745 11 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Atomic force microscopy imaging of DNA-cationic liposome complexes optimised for gene transfection into neuronal cells

Wangerek, L. A., Dahl, H. H. M., Senden, T. J., Carlin, J. B., Jans, D. A., Dunstan, D. E., Ioannou, P. A., Williamson, R. & Forrest, S. M., 1 Jan 2001, In : Journal of Gene Medicine. 3, 1, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Biophysical characterization of interactions involving importin-alpha during nuclear import

Catimel, B., Teh, T., Fontes, M. RM., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. & Kobe, B., 2001, In : Journal of Biological Chemistry. 276, 36, p. 34189 - 34198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Biophysical Characterization of Interactions Involving Importin-α during Nuclear Import

Catimel, B., Teh, T., Fontes, M. R. M., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. C. & Kobe, B., 7 Sep 2001, In : Journal of Biological Chemistry. 276, 36, p. 34189-34198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
128 Citations (Scopus)

Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets

Vasudevan, S. G., Johansson, M., Brooks, A. J., Llewellyn, L. E. & Jans, D. A., 1 Mar 2001, In : Il Farmaco. 56, 1-2, p. 33-36 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Compound Effects of Point Mutations Causing Campomelic Dysplasia/Autosomal Sex Reversal upon SOX9 Structure, Nuclear Transport, DNA Binding, and Transcriptional Activation

Preiss, S., Argentaro, A., Clayton, A., John, A., Jans, D. A., Ogata, T., Nagai, T., Barroso, I., Schafer, A. J. & Harley, V. R., 27 Jul 2001, In : Journal of Biological Chemistry. 276, 30, p. 27864-27872 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Dynamics of leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein

Lam, M. H. C., Henderson, B., Gillespie, M. T. & Jans, D. A., 20 Nov 2001, In : Traffic. 2, 11, p. 812-819 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway

Chan, C-K. & Jans, D. A., 2001, In : Gene Therapy. 8, 2, p. 166 - 171 6 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Gene therapy: optimising DNA delivery to the nucleus

Johnson-Saliba, M. & Jans, D. A., 2001, In : Current Drug Targets. 2, 4, p. 371 - 399 29 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Molecular dissection of the importin β1-recognized nuclear targeting signal of parathyroid hormone-related protein

Lam, M. H. C., Hu, W., Xiao, C. Y., Gillespie, M. T. & Jans, D. A., 1 Jan 2001, In : Biochemical and Biophysical Research Communications. 282, 2, p. 629-634 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Novel properties of the nucleolar targeting signal of human angiogenin

Lixin, R., Efthymiadis, A., Henderson, B. & Jans, D. A., 14 Oct 2001, In : Biochemical and Biophysical Research Communications. 284, 1, p. 185-193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16

Briggs, L. J., Johnstone, R. W., Elliot, R. M., Xiao, C. Y., Dawson, M., Trapani, J. A. & Jans, D. A., 1 Jan 2001, In : Biochemical Journal. 353, 1, p. 69-77 9 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Nuclear import of Creb and AP-1 transcription factors requires importin-β1 and Ran but is independent of importin-α

Forwood, J. K., Lam, M. H. C. & Jans, D. A., 1 May 2001, In : Biochemistry. 40, 17, p. 5208-5217 10 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1

Bird, C., Blink, E. J., Hirst, C. E., Buzza, M. S., Steele, P. M., Sun, J. H., Jans, D. A. & Bird, P. I., 2001, In : Molecular and Cellular Biology. 21, 16, p. 5396 - 5407 12 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Roles of cytoskeletal and junctional plaque proteins in nuclear signaling

Hübner, S., Jans, D. A. & Drenckhahn, D., 1 Jan 2001, In : International Review of Cytology. 208, p. 207-265 59 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin b1

Forwood, J. K., Harley, V. & Jans, D. A., 2001, In : Journal of Biological Chemistry. 276, 49, p. 46575 - 46582 8 p.

Research output: Contribution to journalArticleResearchpeer-review