• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021

Research output per year

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Research Output

2008

HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages

Dowling, D., Nasr-Esfahani, S., Tan, C. H., O'Brien, K., Howard, J. L., Jans, D. A., Purcell, D. FJ., Stoltzfus, C. M. & Sonza, S., 2008, In : Retrovirology. 5, 18, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

Caly, L., Saksena, N. K., Piller, S. & Jans, D. A., 2008, In : Retrovirology. 5, 1, p. 67 - 73 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Interaction with PI3-kinase contributes to the cytotoxic activity of Apoptin

Maddika, S., Wiechec, E., Ande, S. R., Poon, I. K., Fischer, U., Wesselborg, S., Jans, D. A., Schulze-Osthoff, K. & Los, M., 2008, In : Oncogene. 27, p. 3060 - 3065 5 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Interferon gamma is recognised by importin alpha/beta: Enhanced nuclear localising and transactivation activities of an interferon gamma mimetic

Fulcher, A., Ahmed, C. M. I., Noon-Song, E. N., Kwan, R. Y. Q., Subramaniam, P. S., Johnson, H. M. & Jans, D. A., 2008, In : FEBS Letters. 582, 11, p. 1569 - 1574 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis

Elliott, D., Kim, W. S., Jans, D. A. & Garner, B., 2008, In : Biochimica et Biophysica Acta. General Subjects. 1780, p. 145 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Regulated nucleocytoplasmic trafficking of viral gene products: A therapeutic target?

Alvisi, G., Rawlinson, S. M., Ghildyal, R., Ripalti, A. & Jans, D. A., 2008, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1784, p. 213 - 227 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells

Sinigalia, E., Alvisi, G., Mercorelli, B., Coen, D. M., Pari, G. S., Jans, D. A., Ripalti, A., Palu, G. & Loregian, A., 2008, In : Journal of Virology. 82, 24, p. 12574 - 12579 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module

Kuusisto, H. V., Wagstaff, K. M., Alvisi, G. & Jans, D. A., 2008, In : International Journal of Cancer. 123, 12, p. 2965 - 2969 5 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
36 Citations (Scopus)
2007

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins

Martino Roth, D., Moseley, G. W., Glover, D., Pouton, C. W. & Jans, D. A., 2007, In : Traffic. 8, 6, p. 673-686 14 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus

Alvisi, G., Musiani, D., Jans, D. A. & Ripalti, A., 2007, In : Biochemistry. 46, 32, p. 9155 - 9163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies

Janssen, K., Hofmann, T. G., Jans, D. A., Hay, R. T., Schulze-Osthoff, K. & Fischer, U., 2007, In : Oncogene. 26, p. 1557 - 1566 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies

Elliott, D., Kim, W. S., Jans, D. A. & Garner, B., 2007, In : Neuroscience Letters. 416, 2, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Dynein light chain association sequences can facilitate nuclear protein import

Moseley, G. W., Martino Roth, D., De Jesus, M., Leyton, D. L., Filmer, R., Pouton, C. W. & Jans, D. A., 2007, In : Molecular Biology of the Cell. 18, 8, p. 3204 - 3213 10 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Getting to the heart of a tumour cell

Jans, D. A. & Wagstaff, K. M., 2007, In : Pharma Focus Asia. 0, 5, p. 21 - 24 4 p.

Research output: Contribution to journalArticleOther

Histone-mediated transduction as an efficient means for gene delivery

Wagstaff, K. M., Glover, D., Tremethick, D. J. & Jans, D. A., 2007, In : Molecular Therapy. 15, 4, p. 721 - 731 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Nuclear import properties of the sex-determining factor SRY

Forwood, J. K., Kaur, G. & Jans, D. A., 2007, Protein Targeting Protocols (Methods in Molecular Biology). van der Giezen, M. (ed.). 2nd ed. Totowa NJ USA: Humana Press, p. 83 - 97 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

4 Citations (Scopus)

Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection

Pryor, M. J., Rawlinson, S. M., Butcher, R. E., Barton, C., Waterhouse, T. A., Vasudevan, S. G., Bardin, P. G., Wright, P. J., Jans, D. A. & Davidson, A. D., 2007, In : Traffic. 8, 7, p. 795 - 807 13 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis

Conway-Campbell, B. L., Wooh, J. W., Brooks, A. J., Gordon, D., Brown, R. J., Lichanska, A. M., Chin, H. S., Barton, C., Boyle, G. M., Parsons, P. G., Jans, D. A. & Waters, M. J., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 33, p. 13331 - 13336 6 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Nucleocytoplasmic distribution of rabies virus P-protein is regulated by phosphorylation adjacent to C-terminal nuclear import and export signals

Moseley, G. W., Filmer, R., De Jesus, M. & Jans, D. A., 2007, In : Biochemistry. 46, 43, p. 12053 - 12061 9 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer

Wagstaff, K. M. & Jans, D. A., 2007, In : Biochemical Journal. 406, 2, p. 185 - 202 18 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Overcoming Barriers to Achieve Safe, Sustained and Efficient Non-Viral Gene Therapy

Glover, D., Glouchkova, L., Lipps, H. J. & Jans, D. A., 2007, In : Advances in Gene, Molecular and Cell Therapy. 1, 2, p. 126 - 140 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulating the functions of the HIV-1 matrix protein

Hearps, A. C. & Jans, D. A., 2007, In : AIDS Research and Human Retroviruses. 23, 3, p. 341 - 346 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Regulation of nuclear import during differentiation: The IMP alpha gene family and spermatogenesis

Holt, J., Ly Huynh, J. D., Efthymiadis, A., Hime, G. R., Loveland, K. A. L. & Jans, D. A., 2007, In : Current Genomics. 8, 5, p. 323 - 334 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Subcellular distribution of importins correlates with germ cell maturation

Hogarth, C. A., Jans, D. A. & Loveland, K. A. L., 2007, In : Developmental Dynamics. 236, 8, p. 2311 - 2320 10 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Targeted delivery to the nucleus

Pouton, C. W., Wagstaff, K. M., Martino Roth, D., Moseley, G. W. & Jans, D. A., 2007, In : Advanced Drug Delivery Reviews. 59, 8, p. 698 - 717 20 p.

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)

The biarsenical dye lumiotrademark exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells

Hearps, A. C., Pryor, M. J., Kuusisto, H. V., Rawlinson, S. M., Piller, S. & Jans, D. A., 2007, In : Journal of Fluorescence. 17, 6, p. 593 - 597 5 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2006

Central role of the respiratory syncytial virus matrix protein in infection

Ghildyal, R., Ho, A. & Jans, D. A., 2006, In : FEMS Microbiology Reviews. 30, 5, p. 692 - 705 14 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

CRM1-dependent nuclear export of dengue virus type 2 NS5

Pryor, M. J., Rawlinson, S. M., Wright, P. J. & Jans, D. A., 2006, New Treatment Strategies for Dengue and Other Flaviviral Diseases. Bock, G. & Goode, J. (eds.). 277 ed. Chichester UK: John Wiley & Sons, p. 149 - 163 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

10 Citations (Scopus)

Dengue virus RNA polymerase NS5: a potential therapeutic target?

Rawlinson, S. M., Pryor, M. J., Wright, P. J. & Jans, D. A., 2006, In : Current Drug Targets. 7, 12, p. 1623 - 1638 16 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis

Loveland, K. A. L., Hogarth, C., Szczepny, A., Mithra Prabhu, S. & Jans, D. A., 2006, In : Biology of Reproduction. 74, 28 September 2005, p. 67 - 74 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

HIV-1 integrase is capable of targeting DNA to the nucleus via an Importin alpha/beta-dependent mechanism

Hearps, A. C. & Jans, D. A., 2006, In : Biochemical Journal. 398, 3, p. 475 - 484 10 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus

Alvisi, G., Jans, D. A. & Ripalti, A., 2006, In : Biochemistry. 45, 22, p. 6866 - 6872 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Human cytomegalovirus DNA polymerase catalytic subunit pUL54 possesses independently acting nuclear localization and ppUL44 binding motifs

Alvisi, G., Ripalti, A., Ngankeu, A., Giannandrea, M., Caraffi, S. G., Dias, M. & Jans, D. A., 2006, In : Traffic. 7, 10, p. 1322 - 1332 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Importin alpha mRNAs have distinct expression profiles during spermatogenesis

Hogarth, C. A., Calanni, S. T., Jans, D. A. & Loveland, K. A. L., 2006, In : Developmental Dynamics. 235, 1, p. 253 - 262 10 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method

Wagstaff, K. M. & Jans, D. A., 2006, In : Analytical Biochemistry. 348, 1, p. 49 - 56 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates

Huebner, S., Eam, J. E., Huebner, A. & Jans, D. A., 2006, In : Experimental Cell Research. 312, 2, p. 171 - 183 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Protein transduction: cell penetrating peptides and their therapeutic applications

Wagstaff, K. M. & Jans, D. A., 2006, In : Current Medicinal Chemistry. 13, 12, p. 1371 - 1387 17 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Quantitative analysis of DNA-protein interactions using double-labeled native gel electrophoresis and fluorescence-based imaging

Forwood, J. K. & Jans, D. A., 2006, In : Electrophoresis. 27, 16, p. 3166 - 3170 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Quantitative analysis of localization and nuclear aggregate formation induced by GFP-lamin A mutant proteins in living HeLa cells

Hubner, S., Eam, J. E., Wagstaff, K. M. & Jans, D. A., 2006, In : Journal of Cellular Biochemistry. 98, 4, p. 810 - 826 17 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins

Goffin, L., Vodala, S., Fraser, C., Ryan, J., Timms, M., Meusburger, S., Catimel, B., Nice, E. C., Silver, P. A., Xiao, C-Y., Jans, D. A. & Gething, M-J. H., 2006, In : Molecular Biology of the Cell. 17, 12, p. 5309 - 5323 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Tumor-specific nuclear targeting: promises for anti-cancer therapy?

Alvisi, G., Poon, I. K. H. & Jans, D. A., 2006, In : Drug Resistance Updates. 9, 1-2, p. 40 - 50 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2005

Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells

Poon, I. K. H., Oro, C., Dias, M. M., Zhang, J. & Jans, D. A., 2005, In : Cancer Research. 65, 16, p. 7059 - 7064 6 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44

Alvisi, G., Jans, D. A., Guo, J., Pinna, L. A. & Ripalti, A., 2005, In : Traffic. 6, 11, p. 1002 - 1013 12 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin [2]

Poon, I. K. H., Oro, C., Dias, M. M., Zhang, J. -P. & Jans, D. A., 2005, In : Journal of Virology. 79, 2, p. 1339 - 1341 3 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Drivers of germ cell maturation

Loveland, K. L., Hogarth, C., Mendis, S. H. S., Efthymiadis, A., Ly Huynh, J. D., Itman, C. M., Meachem, S., Brown, C. W. & Jans, D. A., 2005, In : Annals of the New York Academy of Sciences. 1061, p. 173 - 182 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort

Caly, L., Wang, B., Mikhail, M., Gill, M. J., Beckthold, B., Salemi, M., Jans, D. A., Piller, S. C. & Saksena, N. K., 2005, In : AIDS Research and Human Retroviruses. 21, 8, p. 728 - 733 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

FRAP analysis of nucleocytoplasmic dynamics of the vitamin D receptor splice variant VDRB1: preferential targeting to nuclear speckles

Sunn, K. L., Eisman, J. A., Gardiner, E. M. & Jans, D. A., 2005, In : Biochemical Journal. 388, 2, p. 509 - 514 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association

Young, D. B., Jonnalagadda, J., Gatei, M., Jans, D. A., Meyn, S. & Khanna, K. K., 2005, In : Journal of Biological Chemistry. 280, 30, p. 27587 - 27594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: Modulation by the serpin inhibitor PI-9

Blink, E. J., Jiansheng, Z., Hu, W., Calanni, S. T., Trapani, J. A., Bird, P. I. & Jans, D. A., 2005, In : Journal of Cellular Biochemistry. 95, 3, p. 598 - 610 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)