• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021

Research output per year

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Research Output

2012

Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?

Caly, L., Wagstaff, K. M. & Jans, D. A., 2012, In : Antiviral Research. 95, 3, p. 202 - 206 5 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Nullbasic, a potent anti-HIV Tat mutant, induces CRM1-dependent disruption of HIV Rev trafficking

Lin, M-H., Sivakumaran, H., Apolloni, A., Wei, T., Jans, D. A. & Harrich, D., 2012, In : PLoS ONE. 7, 12, 12 p., e51466.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains

Ghildyal, R., Jans, D. A., Bardin, P. G. & Mills, J., 2012, In : Infectious Disorders - Drug Targets. 12, 2, p. 103 - 109 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Selective STAT3-{alpha} or -{beta} expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, H. W. I., Ng, D. CH., Jans, D. A. & Bogoyevitch, M. A., 2012, In : Biochemical Journal. 447, Part 1, p. 125 - 136 12 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Subcellular trafficking of pathogens: targeting for therapeutics

Moseley, G. & Jans, D., 2012, In : Infectious Disorders - Drug Targets. 12, 1, p. 2 - 3 2 p.

Research output: Contribution to journalLetterOther

2011

An AlphaScreen-based assay for high-throughput screening for specific inhibitors of nuclear import

Wagstaff, K. M., Rawlinson, S. M., Hearps, A. & Jans, D. A., 2011, In : Journal of Biomolecular Screening. 16, 2, p. 192 - 200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Distinct effects of importin alpha2 and alpha4 on Oct3/4 localization and expression in mouse embryonic stem cells

Young, J., Major, A., Miyamoto, Y., Loveland, K. & Jans, D., 2011, In : The FASEB Journal. 25, 11, p. 3958 - 3965 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Dual nuclear import mechanisms of sex determining factor SRY: Intracellular Ca2{+} as a switch

Kaur, G. & Jans, D. A., 2011, In : The FASEB Journal. 25, 2, p. 665 - 675 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Importin alpha2-interacting proteins with nuclear roles during mammalian spermatogenesis

Ly Huynh, J. D., Lieu, K., Major, A., Whiley, P. A. F., Holt, J., Loveland, K. & Jans, D., 2011, In : Biology of Reproduction. 85, 6, p. 1191 - 1202 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Mechanism of microtubule-facilitated "fast track" nuclear import

Martino Roth, D., Moseley, G., Pouton, C. & Jans, D., 2011, In : Journal of Biological Chemistry. 286, 16, p. 14335 - 14351 17 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44

Alvisi, G., Marin, O., Pari, G., Mancini, M., Avanzi, S., Loregian, A., Jans, D. & Ripalti, A., 2011, In : Virology. 417, 2, p. 259 - 267 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Preface: Central role of nuclear transport in signalling, viral infection and development

Jans, D., 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 9, p. 1561 - 1561 1 p.

Research output: Contribution to journalLetterOther

2 Citations (Scopus)

Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?

Fulcher, A. & Jans, D., 2011, In : Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1813, 12, p. 2176 - 2190 15 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Smad3 dosage determines androgen responsiveness and sets the pace of postnatal testis development

Itman, C. M., Wong, C., Hunyadi, B. L., Ernst, M. R., Jans, D. A. & Loveland, K. A. L., 2011, In : Endocrinology. 152, 5, p. 2076 - 2089 14 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 a

Wati, S., Rawlinson, S. M., Ivanov, R., Dorstyn, L., Beard, M. R., Jans, D. A., Pitson, S. M., Burrell, C. J., Li, P. & Carr, J. M., 2011, In : Journal of General Virology. 92, Pt. 4, p. 807 - 818 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2010

A monopartite sequence is essential for P45 NF-E2 nuclear translocation, transcriptional activity and platelet production

Perdomo, J., Fock, E-L., Kaur, G., Yan, F., Khachigian, L. M., Jans, D. A. & Chong, B. H., 2010, In : Journal of Thrombosis and Haemostasis. 8, 11, p. 2542 - 2553 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen

Fulcher, A. J., Dias, M. M. & Jans, D. A., 2010, In : Journal of Biological Chemistry. 285, 23, p. 17744 - 17753 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Calmodulin-dependent nuclear import of HMG-box family nuclear factors: Importance of the role of SRY in sex reversal

Kaur, G., Delluc-Clavieres, A., Poon, I. K., Forwood, J. K., Glover, D. & Jans, D. A., 2010, In : Biochemical Journal. 430, 1, p. 39 - 48 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Characterization of an Importin in alpha/beta-recognized nuclear localization signal in beta-dystroglycan

Lara-Chacon, B., Bermudez de Leon, M., Leocadio, D., Gomez, P., Fuentes-Mera, L., Martinez-Vieyra, I., Ortega, A., Jans, D. A. & Cisneros, B., 2010, In : Journal of Cellular Biochemistry. 110, 3, p. 706 - 717 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules

Moseley, G. W., Leyton, D. L., Glover, D. J., Filmer, R. P. & Jans, D. A., 2010, In : Journal of Biotechnology. 145, p. 222 - 225 3 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Lineage-specific expression of heterochromatin protein 1gamma in post-compaction, in vitro-produced bovine embryos

Heffernan, C., Whiley, P. A. F., Milionis, A., Verma, P., Holland, M., Jans, D. & D'Cruz, N. T., 2010, In : Reproduction, Fertility and Development. 22, 6, p. 1022 - 1031 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening

Yang, S. N. Y., Takeda, A. A. S., Fontes, M. R. M., Harris, J. M., Jans, D. A. & Kobe, B., 2010, In : Journal of Biological Chemistry. 285, 26, p. 19935 - 19946 12 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Protein Transduction: Cell Penetrating Peptides and their Therapeutic Applications

Wagstaff, K. & Jans, D., 2010, Frontiers in Medicinal Chemistry (5). Atta-ur-Rahman, Reitz, A. B. & Choudhary, M. I. (eds.). 5th ed. The Netherlands: Bentham Science Publishers, p. 98 - 126 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Role of interferon antagonist activity of rabies virus phosphoprotein in viral pathogenicity

Ito, N., Moseley, G. W., Blondel, D., Shimizu, K., Rowe, C. L., Ito, Y., Masatani, T., Nakagawa, K., Jans, D. A. & Sugiyama, M., 2010, In : Journal of Virology. 84, 13, p. 6699 - 6710 12 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal

Fulcher, A. J., Martino Roth, D., Fatima, S., Alvisi, G. & Jans, D. A., 2010, In : The FASEB Journal. 24, p. 1454 - 1466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

Glover, D., Leyton, D. L., Moseley, G. W. & Jans, D. A., 2010, In : Journal of Gene Medicine. 12, p. 77 - 85 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

151 Citations (Scopus)

Use of fluorescence photobleaching techniques to measure the kinetics of intracellular transport

Davies, R., Jans, D. A. & Wagstaff, K. M., 2010, Microscopy: Science, Technology, Applications and Education. Mendez-Vilas, A. & Diaz, J. (eds.). 4th ed. Spain: Formatex, p. 756 - 763 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

2009

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat

Sivakumaran, H., van der Horst, A., Fulcher, A. J., Apolloni, A., Lin, M-H., Jans, D. A. & Harrich, D., 2009, In : Journal of Virology. 83, 22, p. 11694 - 11703 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production

Rawlinson, S. M., Pryor, M. J., Wright, P. J. & Jans, D. A., 2009, In : Journal of Biological Chemistry. 284, 23, p. 15589 - 15597 9 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes

Itman, C. M., Small, C., Griswold, M., Nagaraja, A. K., Matzuk, M. M., Brown, C. W., Jans, D. A. & Loveland, K. A. L., 2009, In : Developmental Dynamics. 238, 7, p. 1688 - 1700 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response

Moseley, G. W., Lahaye, X., Martino Roth, D., Oksayan, S., Filmer, R. P., Rowe, C. L., Blondel, D. & Jans, D. A., 2009, In : Journal of Cell Science. 122, 20, p. 3652 - 3662 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly

Tannukit, S., Crabb, T. L., Hertel, K. J., Wen, X., Jans, D. A. & Paine, M. L., 2009, In : Biochemical and Biophysical Research Communications. 390, 3, p. 1044 - 1050 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Importins and beyond: Non-conventional nuclear transport mechanisms

Wagstaff, K. M. & Jans, D. A., 2009, In : Traffic. 10, 9, p. 1188 - 1198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

Interleukin-15 mediates potent antiviral responses via an interferon-dependent mechanism

Foong, Y. Y., Jans, D. A., Rolph, M. S., Gahan, M. E. & Mahalingam, S., 2009, In : Virology. 393, 2, p. 228 - 237 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Modelling consumer exposures to nutrients and additives in animal products

Tennant, D. R., Bequet, P. & Jans, D., 1 Jan 2009, In : Food Additives & Contaminants: Part A. 26, 1, p. 2-11 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus

Martino Roth, D., Harper, I. S., Pouton, C. W. & Jans, D. A., 2009, In : Journal of Cellular Biochemistry. 107, 6, p. 1160 - 1167 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells

Glover, D., Ng, S. M., Mechler, A. I., Martin, L. L. & Jans, D. A., 2009, In : The FASEB Journal. 23, 9, p. 2996 - 3006 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Nuclear drug delivery to target tumour cells

Wagstaff, K. M. & Jans, D. A., 2009, In : European Journal of Pharmacology. 625, 1-3, p. 174 - 180 7 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Nuclear transport in development and disease - The importance of importins

Jans, D. A., 2009, In : Seminars in Cell and Developmental Biology. 20, 5, p. 575 - 575 1 p.

Research output: Contribution to journalLetterOther

2 Citations (Scopus)

Nucleocytoplasmic transport as a driver of mammalian gametogenesis

Itman, C. M., Miyamoto, Y., Young, J. C., Jans, D. A. & Loveland, K. A. L., 2009, In : Seminars in Cell and Developmental Biology. 20, 5, p. 607 - 619 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Proteolytic cleavage of HIV-1 GFP-Vpr fusions at vovel sites within virions and living cells: Concerns for intracellular trafficking studies

Caly, L., Jans, D. A. & Piller, S. C., 2009, In : Journal of Fluorescence. 19, p. 567 - 573 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport

Ghildyal, R., Jordan, B., Li, D., Dagher, H., Bardin, P. G., Gern, J. E. & Jans, D. A., 2009, In : Journal of Virology. 83, 14, p. 7349 - 7352 4 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells

Alvisi, G., Martino Roth, D., Camozzi, D., Pari, G. S., Loregian, A., Ripalti, A. & Jans, D. A., 2009, In : Journal of Virology. 83, 18, p. 9567 - 9576 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism

Ghildyal, R., Ho, A., Dias, M., Soegiyono, L., Bardin, P. G., Tran, K. C., Teng, M. N. & Jans, D. A., 2009, In : Journal of Virology. 83, 11, p. 5353 - 5362 10 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
2008

Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches

Kim, W. S., Elliott, D. A., Kockx, M., Kritharides, L., Rye, K-A., Jans, D. A. & Garner, B., 2008, In : Biochemical Journal. 409, p. 701 - 709 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein

Li, D., Jans, D. A., Bardin, P. G., Meanger, J., Mills, J. & Ghildyal, R., 2008, In : Journal of Virology. 82, 17, p. 8863 - 8870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

CRM1-Dependent Nuclear Export of Dengue Virus Type 2 NS5

Pryor, M. J., Rawlinson, S. M., Wright, P. J. & Jans, D. A., 7 Oct 2008, New Treatment Strategies for Dengue and Other Flaviviral Diseases. Wiley-Academy, p. 149-163 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Dynamic changes in localization of chromobox (CBX) family members during the maternal to embryonic transition

D'Cruz, N. T., Prashadkumar, S., Wilson, K. J., Heffernan, C., Cooney, M. A., French, A. J., Jans, D. A., Verma, P. J. & Holland, M. K., 2008, In : Molecular Reproduction and Development. 75, 3, p. 477 - 488 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting

Wagstaff, K. M., Fan, J. Y., De Jesus, M., Tremethick, D. J. & Jans, D. A., 2008, In : The FASEB Journal. 22, 7, p. 2232 - 2242 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)