• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021

Research output per year

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Research Output

70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY

Kaur, G., Lieu, K. G. & Jans, D. A., 2013, In : Journal of Biological Chemistry. 288, 6, p. 4148 - 4157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

Trapani, J. A., Sutton, V. R., Thia, K. Y. T., Li, Y. Q., Froelich, C. J., Jans, D. A., Sandrin, M. S. & Browne, K. A., 2003, In : Journal of Cell Biology. 106, 2, p. 223 - 233 11 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

A consensus cAMP-dependent protein kinase (PK-A) site in place of the CcN motif casein kinase II site of simian virus 40 large T-antigen confers PK-A-mediated regulation of nuclear import

Xiao, C. Y., Hübner, S., Elliot, R. M., Caon, A. & Jans, D. A., 15 Mar 1996, In : Journal of Biological Chemistry. 271, 11, p. 6451-6457 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Adenoviruses synergize with nuclear localization signals to enhance nuclear delivery and photodynamic action of internalizable conjugates containing chlorin e 6

Akhlynina, T. V., Jans, D. A., Statsyuk, N. V., Balashova, I. Y., Toth, G., Pavo, I., Rosenkranz, A. A., Naroditsky, B. S. & Sobolev, A. S., 18 May 1999, In : International Journal of Cancer. 81, 5, p. 734-740 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
52 Citations (Scopus)

A functional bipartite nuclear localisation signal in the cytokine interleukin-5

Jans, D. A., Briggs, L. J., Gustin, S. E., Jans, P., Ford, S. & Young, I. G., 14 Apr 1997, In : FEBS Letters. 406, 3, p. 315-320 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)

A low affinity vasopressin v2-receptor in inherited nephrogenic diabetes insipidus

Luzius, H., Jans, D. A., Grünbaum, E. G., Moritz, A., Rascher, W. & Fahrenholz, F., 1 Jan 1992, In : Journal of Receptors and Signal Transduction. 12, 3, p. 351-368 18 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

A mechanistic role for polypeptide hormone receptor lateral mobility in signal transduction

Jans, D. A. & Pavo, I., 1 Jun 1995, In : Amino Acids. 9, 2, p. 93-109 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins

Martino Roth, D., Moseley, G. W., Glover, D., Pouton, C. W. & Jans, D. A., 2007, In : Traffic. 8, 6, p. 673-686 14 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Ammonium chloride affects receptor number and lateral mobility of the vasopressin V2-type receptor in the plasma membrane of LLC-PK1 renal epithelial cells: Role of the cytoskeleton

Jans, D. A., Peters, R., Jans, P. & Fahrenholz, F., 1 Jan 1990, In : Experimental Cell Research. 191, 1, p. 121-128 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A monopartite sequence is essential for P45 NF-E2 nuclear translocation, transcriptional activity and platelet production

Perdomo, J., Fock, E-L., Kaur, G., Yan, F., Khachigian, L. M., Jans, D. A. & Chong, B. H., 2010, In : Journal of Thrombosis and Haemostasis. 8, 11, p. 2542 - 2553 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

An acidic or basic amino acid at position 26 of the b subunit of Escherichia coli F1F0-ATPase impairs membrane proton permeability: Suppression of the uncF469 nonsense mutation

Jans, D. A., Hatch, L., Fimmel, A. L., Gibson, F. & Cox, G. B., 1 Dec 1984, In : Journal of Bacteriology. 160, 2, p. 764-770 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

An additional acidic residue in the membrane portion of the b-subunit of the energy-transducing adenosine triphosphatase of Escherichia coli affects both assembly and function.

Jans, D. A., Fimmel, A. L., Hatch, L., Gibson, F. & Cox, G. B., 1 Jan 1984, In : The Biochemical journal. 221, 1, p. 43-51 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

An AlphaScreen-based assay for high-throughput screening for specific inhibitors of nuclear import

Wagstaff, K. M., Rawlinson, S. M., Hearps, A. & Jans, D. A., 2011, In : Journal of Biomolecular Screening. 16, 2, p. 192 - 200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches

Kim, W. S., Elliott, D. A., Kockx, M., Kritharides, L., Rye, K-A., Jans, D. A. & Garner, B., 2008, In : Biochemical Journal. 409, p. 701 - 709 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

An efficient system for high-level expression and easy purification of authentic recombinant proteins

Catanzariti, A-M., Soboleva, T. A., Jans, D. A., Board, P. G. & Baker, R. T., 2004, In : Protein Science. 13, 5, p. 1331 - 1339 9 p.

Research output: Contribution to journalArticleResearchpeer-review

185 Citations (Scopus)

An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import

Xiao, C. Y. & Jans, D. A., 9 Oct 1998, In : FEBS Letters. 436, 3, p. 313-317 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus

Alvisi, G., Musiani, D., Jans, D. A. & Ripalti, A., 2007, In : Biochemistry. 46, 32, p. 9155 - 9163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

An inverse relationship between receptor internalization and the fraction of laterally mobile receptors for the vasopressin renal-type V2-receptor. An active role for receptor immobilization in down-regulation?

Jans, D. A., Peters, R. & Fahrenholz, F., 12 Nov 1990, In : FEBS Letters. 274, 1-2, p. 223-226 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

A novel LLC-PK1 renal epithelial cell mutant impaired in in vivo down-regulation of cAMP-mediated hormonal response

Jans, D. A., Resink, T. J. & Hemmings, B. A., 1 Jan 1991, In : Archives of Biochemistry and Biophysics. 285, 2, p. 377-381 5 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel microtubule-associated protein-2 (map-2) isoform in brain and testis with nuclear localisation

Loveland, K. L., Rames, E., Herszfeld, D., Chu, B., de Kretser, D. M., Briggs, L. J. & Jans, D., 1998, p. 5 - 5. 1 p.

Research output: Contribution to conferenceAbstract

A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein

Oksayan, S., Wiltzer, L., Rowe, C. L., Blondel, D., Jans, D. A. & Moseley, G. W., 2012, In : Journal of Biological Chemistry. 287, 33, p. 28112 - 28121 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

A novel system to quantitate nuclear-cytoplasmic flux in vivo: Kinetics of signal-dependent nuclear protein export

Efthymiadis, A., Dottorini, T. & Jans, D. A., 15 Jul 1998, In : Archives of Biochemistry and Biophysics. 355, 2, p. 254-261 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies

Janssen, K., Hofmann, T. G., Jans, D. A., Hay, R. T., Schulze-Osthoff, K. & Fischer, U., 2007, In : Oncogene. 26, p. 1557 - 1566 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells

Poon, I. K. H., Oro, C., Dias, M. M., Zhang, J. & Jans, D. A., 2005, In : Cancer Research. 65, 16, p. 7059 - 7064 6 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies

Elliott, D., Kim, W. S., Jans, D. A. & Garner, B., 2007, In : Neuroscience Letters. 416, 2, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44

Alvisi, G., Jans, D. A., Guo, J., Pinna, L. A. & Ripalti, A., 2005, In : Traffic. 6, 11, p. 1002 - 1013 12 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat

Sivakumaran, H., van der Horst, A., Fulcher, A. J., Apolloni, A., Lin, M-H., Jans, D. A. & Harrich, D., 2009, In : Journal of Virology. 83, 22, p. 11694 - 11703 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-β and the viral helicase, NS3

Johansson, M., Brooks, A. J., Jans, D. A. & Vasudevan, S. G., 1 Jan 2001, In : Journal of General Virology. 82, 4, p. 735-745 11 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal

Argentaro, A., Sim, H., Kelly, S., Preiss, S., Clayton, A., Jans, D. A. & Harley, V. R., 2003, In : Journal of Biological Chemistry. 278, 36, p. 33839 - 33847 9 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein

Li, D., Jans, D. A., Bardin, P. G., Meanger, J., Mills, J. & Ghildyal, R., 2008, In : Journal of Virology. 82, 17, p. 8863 - 8870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

A system to select for mutant LLC-PK1 cells affected in camp mediated hormonal response using a photoactivatable analogue of vasopressin

Luzius, H., Jans, D. A. & Fahrenholz, F., 1 Jan 1990, In : Journal of Receptors and Signal Transduction. 10, 1-2, p. 61-80 20 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Atomic force microscopy imaging of DNA-cationic liposome complexes optimised for gene transfection into neuronal cells

Wangerek, L. A., Dahl, H. H. M., Senden, T. J., Carlin, J. B., Jans, D. A., Dunstan, D. E., Ioannou, P. A., Williamson, R. & Forrest, S. M., 1 Jan 2001, In : Journal of Gene Medicine. 3, 1, p. 72-81 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin [2]

Poon, I. K. H., Oro, C., Dias, M. M., Zhang, J. -P. & Jans, D. A., 2005, In : Journal of Virology. 79, 2, p. 1339 - 1341 3 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Basis of cargo recognition by importin αs: the power of structure

Alvisi, G. & Jans, D. A., 2015, In : Structure. 23, 2, p. 251 - 252 2 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Open Access
4 Citations (Scopus)

Bcl-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis

Jans, D. A., Sutton, V. R., Jans, P., Froelich, C. J. & Trapani, J. A., 12 Feb 1999, In : Journal of Biological Chemistry. 274, 7, p. 3953-3961 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
41 Citations (Scopus)

Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen

Fulcher, A. J., Dias, M. M. & Jans, D. A., 2010, In : Journal of Biological Chemistry. 285, 23, p. 17744 - 17753 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Biophysical characterization of interactions involving importin-alpha during nuclear import

Catimel, B., Teh, T., Fontes, M. RM., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. & Kobe, B., 2001, In : Journal of Biological Chemistry. 276, 36, p. 34189 - 34198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Biophysical Characterization of Interactions Involving Importin-α during Nuclear Import

Catimel, B., Teh, T., Fontes, M. R. M., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. C. & Kobe, B., 7 Sep 2001, In : Journal of Biological Chemistry. 276, 36, p. 34189-34198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
128 Citations (Scopus)

Biotinyl analogues of vasopressin as biologically active probes for vasopressin receptor expression in cultured cells

Jans, D. A., Bergmann, L., Peters, R. & Fahrenholz, F., 10 Sep 1990, In : Journal of Biological Chemistry. 265, 24, p. 14599-14605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Bovine ephemeral fever rhabdovirus alpha1 protein has viroporin-like properties and binds importin alpha1 and importin 7

Joubert, A., Blasdell, K. R., Audsley, M. D., Trinidad, L., Monaghan, P., Dave, K. A., Lieu, K. G., Amos-Ritchie, R., Jans, D. A., Moseley, G. W., Gorman, J. J. & Walker, P. J., 2014, In : Journal of Virology. 88, 3, p. 1591 - 1603 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Calmodulin-dependent nuclear import of HMG-box family nuclear factors: Importance of the role of SRY in sex reversal

Kaur, G., Delluc-Clavieres, A., Poon, I. K., Forwood, J. K., Glover, D. & Jans, D. A., 2010, In : Biochemical Journal. 430, 1, p. 39 - 48 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

cAMP-dependent protein kinase activation affects vasopressin V2-receptor number and internalization in LLC-PK1 renal epithelial cells

Jans, D. A. & Hemmings, B. A., 9 Apr 1991, In : FEBS Letters. 281, 1-2, p. 267-271 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
7 Citations (Scopus)

Central role of the respiratory syncytial virus matrix protein in infection

Ghildyal, R., Ho, A. & Jans, D. A., 2006, In : FEMS Microbiology Reviews. 30, 5, p. 692 - 705 14 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Changing subcellular localization of nuclear transport factors during human spermatogenesis

Whiley, P. A. F., Miyamoto, Y., McLachlan, R. I., Jans, D. & Loveland, K., 2012, In : International Journal of Andrology. 35, 2, p. 158 - 169 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets

Vasudevan, S. G., Johansson, M., Brooks, A. J., Llewellyn, L. E. & Jans, D. A., 1 Mar 2001, In : Il Farmaco. 56, 1-2, p. 33-36 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Characterization of an Importin in alpha/beta-recognized nuclear localization signal in beta-dystroglycan

Lara-Chacon, B., Bermudez de Leon, M., Leocadio, D., Gomez, P., Fuentes-Mera, L., Martinez-Vieyra, I., Ortega, A., Jans, D. A. & Cisneros, B., 2010, In : Journal of Cellular Biochemistry. 110, 3, p. 706 - 717 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Characterization of two mutants of the LLC‐PK1 porcine kidney cell line affected in the catalytic subunit of the cAMP‐dependent protein kinase

BOTTERELL, S. H., JANS, D. A. & HEMMINGS, B. A., 1 Jan 1987, In : European Journal of Biochemistry. 164, 1, p. 39-44 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production

Caly, L., Li, H-M., Bogoyevitch, M. A. & Jans, D. A., 29 Jan 2017, In : Biochemical and Biophysical Research Communications. 483, 1, p. 64-68 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)