• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021

Research output per year

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Research Output

2020

Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics

Zhang, S., Hinde, E., Parkyn Schneider, M., Jans, D. A. & Bogoyevitch, M. A., 31 Jan 2020, In : Scientific Reports. 10, 1, 18 p., 1557.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

Yang, S. N. Y., Atkinson, S. C., Audsley, M. D., Heaton, S. M., Jans, D. A. & Borg, N. A., 9 Jan 2020, In : Cells. 9, 1, 13 p., 170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Yang, S. N. Y., Atkinson, S. C., Wang, C., Lee, A., Bogoyevitch, M. A., Borg, N. A. & Jans, D. A., 3 Mar 2020, (Accepted/In press) In : Antiviral Research.

Research output: Contribution to journalArticleResearchpeer-review

2019

Dengue Non-structural Protein 5 Polymerase Complexes With Promyelocytic Leukemia Protein (PML) Isoforms III and IV to Disrupt PML-Nuclear Bodies in Infected Cells

Giovannoni, F., Ladelfa, M. F., Monte, M., Jans, D. A., Hemmerich, P. & García, C., 13 Aug 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 14 p., 284.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dynamic paraspeckle component localisation during spermatogenesis

Major, A. T., Hogarth, C. A., Young, J. C., Kurihara, Y., Jans, D. A. & Loveland, K. L., 1 Sep 2019, In : Reproduction. 158, 3, p. 267-280 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Editorial: Targeted subcellular delivery of anti-cancer agents

Jans, D. A. & Sobolev, A. S., 22 Jan 2019, In : Frontiers in Pharmacology. 9, 3 p., 1577.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Heaton, S. M., Atkinson, S. C., Sweeney, M. N., Yang, S. N. Y., Jans, D. A. & Borg, N. A., 30 Sep 2019, In : Cells. 8, 10, 22 p., 1181.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

DeBono, A., Thomas, D. R., Lundberg, L., Pinkham, C., Cao, Y., Graham, J. D., Clarke, C. L., Wagstaff, K. M., Shechter, S., Kehn-Hall, K. & Jans, D. A., 22 Feb 2019, In : Scientific Reports. 9, 1, 19 p., 2634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells

Tano, V., Jans, D. A. & Bogoyevitch, M. A., 11 Jun 2019, In : Biochemical and Biophysical Research Communications. 513, 4, p. 1076-1082 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

Hu, M., Schulze, K. E., Ghildyal, R., Henstridge, D. C., Kolanowski, J. L., New, E. J., Hong, Y., Hsu, A. C., Hansbro, P. M., Wark, P. A., Bogoyevitch, M. A. & Jans, D. A., 27 Jun 2019, In : eLife. 8, 30 p., e42448.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

Ng, I. H. W., Chan, K. W. K., Tan, M. J. A., Gwee, C. P., Smith, K. M., Jeffress, S. J., Saw, W. G., Swarbrick, C. M. D., Watanabe, S., Jans, D. A., Grüber, G., Forwood, J. K. & Vasudevan, S. G., 14 Jun 2019, In : ACS Infectious Diseases. 5, 6, p. 932-948 17 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2018

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M., Aug 2018, In : Cellular Microbiology. 20, 8, 13 p., e12848.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Nucleocytoplasmic trafficking of dengue non-structural protein 5 as a target for antivirals

Jans, D. A. & Martin, A. J., 1 Jan 2018, Dengue and Zika: Control and Antiviral Treatment Strategies. Hilgenfeld, R. & Vasudevan, S. G. (eds.). Singapore: Springer, p. 199-213 15 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function

Liu, X., Lin, W., Davies, R. G., Wagstaff, K. M., Tao, T. & Jans, D. A., 31 Aug 2018, In : Biochemical Journal. 475, 16, p. 2699-2712 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v

Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A., 10 Jan 2018, In : Scientific Reports. 8, 1, 17 p., 358.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Trawler Web: An online de novo motif discovery tool for next-generation sequencing datasets

Dang, L. T., Tondl, M., Chiu, M. H. H., Revote, J., Paten, B., Tano, V., Tokolyi, A., Besse, F., Quaife-Ryan, G., Cumming, H., Drvodelic, M. J., Eichenlaub, M. P., Hallab, J. C., Stolper, J. S., Rossello, F. J., Bogoyevitch, M. A., Jans, D. A., Nim, H. T., Porrello, E. R., Hudson, J. E. & 1 others, Ramialison, M., 5 Apr 2018, In : BMC Genomics. 19, 1, 9 p., 238.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
2017

c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production

Caly, L., Li, H-M., Bogoyevitch, M. A. & Jans, D. A., 29 Jan 2017, In : Biochemical and Biophysical Research Communications. 483, 1, p. 64-68 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins

Major, A. T., Miyamoto, Y., Lo, C. Y., Jans, D. A. & Loveland, K. L., 27 Feb 2017, In : Scientific Reports. 7, 18 p., 43323.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Interactome of the inhibitory isoform of the nuclear transporter Importin 13

Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A., 1 Mar 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Mice lacking Hbp1 function are viable and fertile

Spiller, C. M., Wilhelm, D., Jans, D. A., Bowles, J. & Koopman, P., 1 Jan 2017, In : PLoS ONE. 12, 1, 19 p., e0170576.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production

Hu, M., Li, H-M., Bogoyevitch, M. A. & Jans, D. A., 5 Aug 2017, In : Biochemical and Biophysical Research Communications. 489, 4, p. 460-465 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2017, In : Scientific Reports. 7, 1, 16 p., 17705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection

Wang, C., Yang, S. N. Y., Smith, K., Forwood, J. K. & Jans, D. A., 2 Dec 2017, In : Biochemical and Biophysical Research Communications. 493, 4, p. 1555-1559 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins

McLinton, E. C., Wagstaff, K. M., Lee, A., Moseley, G. W., Marsh, G. A., Wang, L-F., Jans, D. A., Lieu, K. G. & Netter, H. J., 1 Apr 2017, In : Journal of General Virology. 98, 4, p. 563-576 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2016

CORRIGENDUM: Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

Gotz, V., Magar, L., Dornfeld, D., Giese, S., Pohlmann, A., Hoper, D., Kong, B-W., Jans, D. A., Beer, M., Haller, O. A. & Schwemmle, M., 2016, In : Scientific Reports. 6, Article # 25428, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Dynamic nucleolar targeting of dengue virus polymerase NS5 in response to extracellular pH

Fraser, J. E., Rawlinson, S. M., Heaton, S. M. & Jans, D. A., Jun 2016, In : Journal of Virology. 90, 12, p. 5797-5807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein: Impaired trafficking in a clinical isolate

Caly, L., Kassouf, V. T., Moseley, G. W., Diefenbach, R. J., Cunningham, A. L. & Jans, D. A., 11 Jan 2016, In : Biochemical and Biophysical Research Communications. 470, 3, p. 735-740 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Host Factors Modulating RSV Infection Use of Small Interfering RNAs to Probe Functional Importance: Use of Small Interfering RNAs to Probe Functional Importance

Caly, L., Li, H-M. & Jans, D. A., 2016, Human Respiratory Syncytial Virus: Methods and Protocols. Tripp, R. A. & Jorquera, P. A. (eds.). New York: Humana Press, Vol. 1442. p. 93-117 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

4 Citations (Scopus)

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

Gotz, V., Magar, L., Dornfeld, D., Giese, S., Pohlmann, A., Hoper, D., Kong, B-W., Jans, D. A., Beer, M., Haller, O. & Schwemmle, M., 18 Mar 2016, In : Scientific Reports. 6, 14 p., 23138.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
28 Citations (Scopus)

Nuclear trafficking of the Rabies virus interferon antagonist P-protein is regulated by an importin-binding nuclear localization sequence in the C-terminal domain

Rowe, C. L., Wagstaff, K. M., Oksayan, S., Glover, D. J., Jans, D. A. & Moseley, G. W., 3 Mar 2016, In : PLoS ONE. 11, 3, 18 p., 0150477.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness

Hinde, E., Pandzic, E., Yang, Z., Ng, I. H. W., Jans, D. A., Bogoyevitch, M. A., Gratton, E. & Gaus, K., 24 Mar 2016, In : Nature Communications. 7, 14 p., 11047.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Quantitative analysis of the microtubule interaction of rabies virus P3 protein: Roles in immune evasion and pathogenesis

Brice, A., Whelan, D. R., Ito, N., Shimizu, K., Wiltzer-Bach, L., Lo, C. Y., Blondel, D., Jans, D. A., Bell, T. D. M. & Moseley, G. W., 21 Sep 2016, In : Scientific Reports. 6, 12 p., 33493.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection

Walker, E., Jensen, L., Croft, S., Wei, K., Fulcher, A. J., Jans, D. A. & Ghildyal, R., Dec 2016, In : Journal of Virology. 90, 24, p. 11032-11042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

Roles of nuclear trafficking in infection by cytoplasmic negative-strand RNA viruses: Paramyxoviruses and beyond

Audsley, M. D., Jans, D. A. & Moseley, G. W., 13 Oct 2016, In : Journal of General Virology. 97, 10, p. 2463-2481 19 p., 000575.

Research output: Contribution to journalReview ArticleOtherpeer-review

6 Citations (Scopus)

Secret life of importin-β solenoid flexibility as the key to transport through the nuclear pore

Alvisi, G. & Jans, D. A., 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 6, p. 703-704 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lundberg, L., Pinkham, C., de la Fuente, C., Brahms, A., Shafagati, N., Wagstaff, K. M., Jans, D. A., Tamir, S. & Kehn-Hall, K., 30 Nov 2016, In : PLoS Neglected Tropical Diseases. 10, 11, 24 p., e0005122.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

The C-terminal 18 amino acid region of Dengue virus NS5 regulates its subcellular localization and contains a conserved arginine residue essential for infectious virus production

Tay, M. Y. F., Smith, K., Ng, I. H. W., Chan, K. W. K., Zhao, Y., Ooi, E. E., Lescar, J., Luo, D., Jans, D. A., Forwood, J. K. & Vasudevan, S. G., 13 Sep 2016, In : PLoS Pathogens. 12, 9, 34 p., 1005886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)

The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with their inclusion in the proposed genus Jeilongvirus

Audsley, M. D., Marsh, G. A., Lieu, K. G., Tachedjian, M., Joubert, D. A., Wang, L-F., Jans, D. A. & Moseley, G. W., Mar 2016, In : Journal of General Virology. 97, 3, p. 581-592 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

Fulcher, A. J., Sivakumaran, H., Jin, H., Rawle, D. J., Harrich, D. & Jans, D. A., 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 2, p. 254-262 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods

Chandrasekaran, R., Lee, A. S. W., Yap, L. W., Jans, D. A., Wagstaff, K. M. & Cheng, W., 7 Jan 2016, In : Nanoscale. 8, 1, p. 187-196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2015

Basis of cargo recognition by importin αs: the power of structure

Alvisi, G. & Jans, D. A., 2015, In : Structure. 23, 2, p. 251 - 252 2 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Open Access
4 Citations (Scopus)