Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

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Projects 2000 2019

Research Output 1998 2018

Open Access
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c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production

Caly, L., Li, H-M., Bogoyevitch, M. A. & Jans, D. A. 29 Jan 2017 In : Biochemical and Biophysical Research Communications. 483, 1, p. 64-68 5 p.

Research output: Research - peer-reviewArticle

Open Access
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Interactome of the inhibitory isoform of the nuclear transporter Importin 13

Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A. 1 Mar 2017 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.

Research output: Research - peer-reviewArticle

Mice lacking Hbp1 function are viable and fertile

Spiller, C. M., Wilhelm, D., Jans, D. A., Bowles, J. & Koopman, P. 1 Jan 2017 In : PLoS ONE. 12, 1, 19 p., e0170576

Research output: Research - peer-reviewArticle

Open Access
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