Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
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Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2000 2019
A Safe, Orally Administered Agent for Dengue
Jans, D. A., Charman, S. A., Dow, G., Low, J., Porter, C. J., Vasudevan, S. & Wagstaff, K. M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Protein kinase regulatory switches: decision-making in the nucleus
Jans, D. A., Bogoyevitch, M. A., Mantovani, R. & Remenyi, A.
Australian Research Council (ARC)
1/01/16 → 31/12/18
Project: Research
Protein Kinase Regulatory Switches: Decision-Making in the Nucleus
Australian Research Council (ARC)
1/01/16 → 31/12/18
Project: Research
Epigenetic regulation by PKC-theta in human breast cancer stem cells
Rao, S., Jans, D. A., Forwood, J. K., Dahlstrom, J. E. & Yip, D.
1/01/16 → 31/12/19
Project: Other
Imaging equipment: Fluorescent equipment for Laser Capture Microdissector system CAST Grid Stereology System
Risbridger, G. P., Cheema, S., Horne, M., Jans, D. A., Morrison, J. & Simpson, E. R.
National Health & Medical Research Council (NHMRC)
24/06/02 → …
Project: Research
Research Output 1998 2018
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening
Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A. 1 Mar 2018 In : Antiviral Research. 151, p. 8-19 12 p.Research output: Research - peer-review › Article
Open Access
File
Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v
Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A. 10 Jan 2018 In : Scientific Reports. 8, 1, 17 p., 358Research output: Research - peer-review › Article
Open Access
File
c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production
Caly, L., Li, H-M., Bogoyevitch, M. A. & Jans, D. A. 29 Jan 2017 In : Biochemical and Biophysical Research Communications. 483, 1, p. 64-68 5 p.Research output: Research - peer-review › Article
Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins
Major, A. T., Miyamoto, Y., Lo, C. Y., Jans, D. A. & Loveland, K. L. 27 Feb 2017 In : Scientific Reports. 7, 18 p., 43323Research output: Research - peer-review › Article
Open Access
File
Interactome of the inhibitory isoform of the nuclear transporter Importin 13
Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A. 1 Mar 2017 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.Research output: Research - peer-review › Article