• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2021
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Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

Research area keywords

  • Nuclear Transport
  • viral disease
  • RNA viruses
  • development
  • cancer

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2021

Research Output 1983 2019

Dynamic paraspeckle component localization during spermatogenesis

Major, A. T., Hogarth, C. A., Young, J. C., Kurihara, Y., Jans, D. A. & Loveland, K., Jul 2019, (Accepted/In press) In : Reproduction.

Research output: Contribution to journalArticleResearchpeer-review

Editorial: Targeted subcellular delivery of anti-cancer agents

Jans, D. A. & Sobolev, A. S., 22 Jan 2019, In : Frontiers in Pharmacology. 9, 3 p., 1577.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Heaton, S. M., Atkinson, S. C., Sweeney, M. N., Yang, S. N. Y., Jans, D. A. & Borg, N. A., 30 Sep 2019, In : Cells. 8, 10, 22 p., 1181.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2005 2005

  • 1 Editorial responsibility

Biochemical Journal (Journal)

David Jans (Editorial board member)
2005 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility