Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
Keywords
- Nuclear Transport
- viral disease
- RNA viruses
- development
- cancer
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Projects 2000 2020
Novel HTS platform to identify specific DDX3X antiviral and anticancer agents
20/06/18 → 31/12/18
Project: Research
A Safe, Orally Administered Agent for Dengue
Jans, D. A., Charman, S. A., Dow, G., Low, J., Porter, C. J., Vasudevan, S. & Wagstaff, K. M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Protein Kinase Regulatory Switches: Decision-Making in the Nucleus
Australian Research Council (ARC)
1/01/16 → 31/12/18
Project: Research
Protein kinase regulatory switches: decision-making in the nucleus
Jans, D. A., Bogoyevitch, M. A., Mantovani, R. & Remenyi, A.
Australian Research Council (ARC)
1/01/16 → 31/12/18
Project: Research
Epigenetic regulation by PKC-theta in human breast cancer stem cells
Rao, S., Jans, D. A., Forwood, J. K., Dahlstrom, J. E. & Yip, D.
1/01/16 → 31/12/19
Project: Other
Research Output 1998 2018
Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting
Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G. 1 Aug 2018 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.Research output: Contribution to journal › Article
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening
Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A. 1 Mar 2018 In : Antiviral Research. 151, p. 8-19 12 p.Research output: Contribution to journal › Article
Open Access
File
Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection
Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M. 1 Jan 2018 (Accepted/In press) In : Cellular Microbiology.Research output: Contribution to journal › Article
Nucleocytoplasmic trafficking of dengue non-structural protein 5 as a target for antivirals
Jans, D. A. & Martin, A. J. 1 Jan 2018 Dengue and Zika: Control and Antiviral Treatment Strategies. Hilgenfeld, R. & Vasudevan, S. G. (eds.). Singapore: Springer, p. 199-213 15 p. (Advances in Experimental Medicine and Biology; vol. 1062)Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book)
Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v
Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A. 10 Jan 2018 In : Scientific Reports. 8, 1, 17 p., 358Research output: Contribution to journal › Article
Open Access
File
Activities 2005 2005
- 1 Editorial responsibility
Biochemical Journal (Journal)
Jans, D. A. (Editorial board member)2005 → …
Activity: Editorial responsibility