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Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.


  • Nuclear Transport
  • viral disease
  • RNA viruses
  • development
  • cancer

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Projects 2000 2020

Research Output 1998 2018

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G. 1 Aug 2018 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A. 1 Mar 2018 In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A. 1 Jan 2018 (Accepted/In press) In : Cellular Microbiology. 13 p., e12953

Research output: Contribution to journalArticleResearchpeer-review

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M. Aug 2018 In : Cellular Microbiology. 20, 8, 13 p., e12848

Research output: Contribution to journalArticleResearchpeer-review

Nucleocytoplasmic trafficking of dengue non-structural protein 5 as a target for antivirals

Jans, D. A. & Martin, A. J. 1 Jan 2018 Dengue and Zika: Control and Antiviral Treatment Strategies. Hilgenfeld, R. & Vasudevan, S. G. (eds.). Singapore: Springer, p. 199-213 15 p. (Advances in Experimental Medicine and Biology; vol. 1062)

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Activities 2005 2005

  • 1 Editorial responsibility

Biochemical Journal (Journal)

Jans, D. A. (Editorial board member)
2005 → …

Activity: Editorial responsibility