• 23 Innovation Walk, 77

    3800 Monash

    Australia

1983 …2020

Research output per year

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Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

Research area keywords

  • Nuclear Transport
  • viral disease
  • RNA viruses
  • development
  • cancer

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Open Access
File
1 Citation (Scopus)

Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics

Zhang, S., Hinde, E., Parkyn Schneider, M., Jans, D. A. & Bogoyevitch, M. A., 31 Jan 2020, In : Scientific Reports. 10, 1, 18 p., 1557.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

Yang, S. N. Y., Atkinson, S. C., Audsley, M. D., Heaton, S. M., Jans, D. A. & Borg, N. A., 9 Jan 2020, In : Cells. 9, 1, 13 p., 170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Yang, S. N. Y., Atkinson, S. C., Wang, C., Lee, A., Bogoyevitch, M. A., Borg, N. A. & Jans, D. A., May 2020, In : Antiviral Research. 177, 9 p., 104760.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Caly, L., Druce, J. D., Catton, M. G., Jans, D. A. & Wagstaff, K. M., Jun 2020, In : Antiviral Research. 178, 4 p., 104787.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
65 Citations (Scopus)

Activities

  • 1 Editorial responsibility

Biochemical Journal (Journal)

David Jans (Editorial board member)

2005 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility