Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

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Projects 2000 2019

Research Output 1998 2018

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G. 1 Aug 2018 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticle

Open Access
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Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M. 1 Jan 2018 (Accepted/In press) In : Cellular Microbiology.

Research output: Contribution to journalArticle

Open Access
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Trawler Web: An online de novo motif discovery tool for next-generation sequencing datasets

Dang, L. T. , Tondl, M. , Chiu, M. H. H. , Revote, J. , Paten, B. , Tano, V. , Tokolyi, A. , Besse, F. , Quaife-Ryan, G. , Cumming, H. , Drvodelic, M. J. , Eichenlaub, M. P. , Hallab, J. C. , Stolper, J. S. , Rossello, F. J. , Bogoyevitch, M. A. , Jans, D. A. , Nim, H. T. , Porrello, E. R. , Hudson, J. E. & 1 others Ramialison, M. 5 Apr 2018 In : BMC Genomics. 19, 1, 9 p., 238

Research output: Contribution to journalArticle

Open Access
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