19982021
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Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

Keywords

  • Nuclear Transport
  • viral disease
  • RNA viruses
  • development
  • cancer

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Projects 2000 2021

Research Output 1998 2019

Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

DeBono, A., Thomas, D. R., Lundberg, L., Pinkham, C., Cao, Y., Graham, J. D., Clarke, C. L., Wagstaff, K. M., Shechter, S., Kehn-Hall, K. & Jans, D. A., 22 Feb 2019, In : Scientific Reports. 9, 1, 19 p., 2634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Activities 2005 2005

  • 1 Editorial responsibility

Biochemical Journal (Journal)

David Jans (Editorial board member)
2005 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility