Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Nuclear Transport
- viral disease
- RNA viruses
- development
- cancer
Network
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Imaging equipment: Fluorescent equipment for Laser Capture Microdissector system CAST Grid Stereology System
Risbridger, G., Cheema, S., Horne, M., Jans, D., Morrison, J. & Simpson, E.
National Health and Medical Research Council (NHMRC) (Australia)
24/06/02 → …
Project: Research
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Ivermectin as an anti-viral against SARS-CoV-2
Wagstaff, K., Jans, D., Druce, J. D., Caly, L. & Denholm, J. T.
1/06/20 → 28/02/21
Project: Research
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Novel HTS platform to identify specific antiviral and anticancer agents
20/06/18 → 31/12/18
Project: Research
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Adenovirus terminal protein contains a bipartite nuclear localisation signal essential for its import into the nucleus
Al-Wassiti, H. A., Thomas, D. R., Wagstaff, K. M., Fabb, S. A., Jans, D. A., Johnston, A. P. & Pouton, C. W., 1 Apr 2021, In: International Journal of Molecular Sciences. 22, 7, 18 p., 3310.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Implication of the nuclear trafficking of rabies virus P3 protein in viral pathogenicity
Brice, A. M., Watts, E., Hirst, B., Jans, D. A., Ito, N. & Moseley, G. W., Dec 2021, In: Traffic. 22, 12, p. 482-489 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response
Gajewska, K. A., Lescesen, H., Ramialison, M., Wagstaff, K. M. & Jans, D. A., Dec 2021, In: Nature Communications. 12, 1, 13 p., 5904.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Phenotypic divergence of p proteins of australian bat lyssavirus lineages circulating in microbats and flying foxes
Deffrasnes, C., Luo, M. X., Wiltzer-Bach, L., David, C. T., Lieu, K. G., Wang, L-F., Jans, D. A., Marsh, G. A. & Moseley, G. W., May 2021, In: Viruses. 13, 5, 12 p., 831.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Structural basis for nuclear import selectivity of pioneer transcription factor SOX2
Jagga, B., Edwards, M., Pagin, M., Wagstaff, K. M., Aragão, D., Roman, N., Nanson, J. D., Raidal, S. R., Dominado, N., Stewart, M., Jans, D. A., Hime, G. R., Nicolis, S. K., Basler, C. F. & Forwood, J. K., 4 Jan 2021, In: Nature Communications. 12, 1, 11 p., 28.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus)
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MONASH UNIVERSITY (Organisational unit)
Leon Caly (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Johanna Fraser (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
31 Oct 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Biochemical Journal (Journal)
David Jans (Editorial board member)
2005 → …Activity: Publication peer-review and editorial work types › Editorial responsibility