Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
Research area keywords
- Nuclear Transport
- viral disease
- RNA viruses
- development
- cancer
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2000 2021
NHMRC Research Fellowship
National Health & Medical Research Council (NHMRC)
1/01/05 → 31/12/20
Project: Research
Imaging equipment: Fluorescent equipment for Laser Capture Microdissector system CAST Grid Stereology System
Risbridger, G., Cheema, S., Horne, M., Jans, D., Morrison, J. & Simpson, E.
National Health & Medical Research Council (NHMRC)
24/06/02 → …
Project: Research
Novel HTS platform to identify specific antiviral and anticancer agents
20/06/18 → 31/12/18
Project: Research
Research Output 1983 2019
Dynamic paraspeckle component localisation during spermatogenesis
Major, A. T., Hogarth, C. A., Young, J. C., Kurihara, Y., Jans, D. A. & Loveland, K. L., 1 Sep 2019, In : Reproduction. 158, 3, p. 267-280 14 p.Research output: Contribution to journal › Article › Research › peer-review
Editorial: Targeted subcellular delivery of anti-cancer agents
Jans, D. A. & Sobolev, A. S., 22 Jan 2019, In : Frontiers in Pharmacology. 9, 3 p., 1577.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access
File
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity
Heaton, S. M., Atkinson, S. C., Sweeney, M. N., Yang, S. N. Y., Jans, D. A. & Borg, N. A., 30 Sep 2019, In : Cells. 8, 10, 22 p., 1181.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
4
Citations
(Scopus)
Inhibitors of nuclear transport
Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.Research output: Contribution to journal › Review Article › Research › peer-review
2
Citations
(Scopus)
Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import
Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Activities 2005 2005
- 1 Editorial responsibility
Biochemical Journal (Journal)
David Jans (Editorial board member)2005 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility