19982020
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Personal profile

Biography

Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.

Keywords

  • Nuclear Transport
  • viral disease
  • RNA viruses
  • development
  • cancer

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2020

Research Output 1998 2018

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., 1 Jan 2018, (Accepted/In press) In : Cellular Microbiology. 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M., Aug 2018, In : Cellular Microbiology. 20, 8, 13 p., e12848.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2005 2005

  • 1 Editorial responsibility

Biochemical Journal (Journal)

David Jans (Editorial board member)
2005 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility