Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
Research area keywords
- Nuclear Transport
- viral disease
- RNA viruses
- development
- cancer
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Ivermectin as an anti-viral against SARS-CoV-2
Wagstaff, K., Jans, D., Druce, J., Caly, L. & Denholm, J. T.
1/06/20 → 28/02/21
Project: Research
NHMRC Research Fellowship
National Health & Medical Research Council (NHMRC)
1/01/05 → 31/12/20
Project: Research
Imaging equipment: Fluorescent equipment for Laser Capture Microdissector system CAST Grid Stereology System
Risbridger, G., Cheema, S., Horne, M., Jans, D., Morrison, J. & Simpson, E.
National Health & Medical Research Council (NHMRC)
24/06/02 → …
Project: Research
Research Output
Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses
Jans, D. & Wagstaff, K., Jun 2020, In : Antiviral Research. 178, 3 p., 104805.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access
File
1
Citation
(Scopus)
Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics
Zhang, S., Hinde, E., Parkyn Schneider, M., Jans, D. A. & Bogoyevitch, M. A., 31 Jan 2020, In : Scientific Reports. 10, 1, 18 p., 1557.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X
Yang, S. N. Y., Atkinson, S. C., Audsley, M. D., Heaton, S. M., Jans, D. A. & Borg, N. A., 9 Jan 2020, In : Cells. 9, 1, 13 p., 170.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer
Yang, S. N. Y., Atkinson, S. C., Wang, C., Lee, A., Bogoyevitch, M. A., Borg, N. A. & Jans, D. A., May 2020, In : Antiviral Research. 177, 9 p., 104760.Research output: Contribution to journal › Article › Research › peer-review
12
Citations
(Scopus)
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Caly, L., Druce, J. D., Catton, M. G., Jans, D. A. & Wagstaff, K. M., Jun 2020, In : Antiviral Research. 178, 4 p., 104787.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
65
Citations
(Scopus)
Activities
- 1 Editorial responsibility
Biochemical Journal (Journal)
David Jans (Editorial board member)
2005 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility