Projects per year
Personal profile
Biography
Nuclear transport is central to processes such as signal transduction, oncogenesis and differentiation, where changes in transcription within the nucleus are effected by transcription factors which access the nucleus through the cellular nuclear transport system. This is also critical in viral infection, where viruses hijack host transport mechanisms to effect nuclear targeting of critical viral proteins, as well as to prevent the host anti-viral response.
Our work focusses on cancer and viruses of medical significance such as Dengue, to define the role of nuclear transport in disease, and how this can be exploited for therapeutic intervention through novel antiviral/anti-cancer agents.
Keywords
- Nuclear Transport
- viral disease
- RNA viruses
- development
- cancer
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Projects 2000 2021
A Safe, Orally Administered Agent for Dengue
Jans, D., Charman, S., Dow, G., Low, J., Porter, C., Vasudevan, S. & Wagstaff, K.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Epigenetic regulation by PKC-theta in human breast cancer stem cells
Rao, S., Jans, D., Forwood, J. K., Dahlstrom, J. E. & Yip, D.
1/01/16 → 31/12/19
Project: Other
NHMRC Research Fellowship
National Health & Medical Research Council (NHMRC)
1/01/05 → 31/12/20
Project: Research
Imaging equipment: Fluorescent equipment for Laser Capture Microdissector system CAST Grid Stereology System
Risbridger, G., Cheema, S., Horne, M., Jans, D., Morrison, J. & Simpson, E.
National Health & Medical Research Council (NHMRC)
24/06/02 → …
Project: Research
Research Output 1998 2019
Inhibitors of nuclear transport
Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.Research output: Contribution to journal › Review Article › Research › peer-review
Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity
DeBono, A., Thomas, D. R., Lundberg, L., Pinkham, C., Cao, Y., Graham, J. D., Clarke, C. L., Wagstaff, K. M., Shechter, S., Kehn-Hall, K. & Jans, D. A., 22 Feb 2019, In : Scientific Reports. 9, 1, 19 p., 2634.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting
Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.Research output: Contribution to journal › Article › Research › peer-review
Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)
Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Activities 2005 2005
- 1 Editorial responsibility
Biochemical Journal (Journal)
David Jans (Editorial board member)2005 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility