Projects per year
Personal profile
Biography
Dr. Goode is a Senior Lecturer and head of the Cancer Bioinformatics and Tumour Evolution group in the Monash University Dept of Biochemistry & Molecular Biology and the Monash Biomedicine Discovery Institute.
His research applies bioinformatics, molecular evolution and population genetics to large cancer genomics data sets to study how tumours evolve and adapt. Areas of active interest include how changes in gene regulation and microenvironmental factors lead to phenotypic plasticity and therapy resistance in cancer cells.
Dr Goode's group have strong track records in prostate cancer and brain cancer, but have worked across a range of solid tumours. We take an evolutionary lens to cancer 'omics to study all stages of tumour evolution, through in-depth analysis of large genome, RNA sequencing and spatial profiling data sets from cancer patients and laboratory models of cancer. Increasingly, we incorporate machine learning and computational modeling to address questions of translational importance.
Dr Goode has published 59 peer-reviewed articles, with an H-index of 24 (Web of Science) and senior author publications in Genome Biology, PNAS and eLife, among others. He has held a Mid-Career Fellowship from the Victorian Cancer Agency (2018-2023) and a Peter Dohery Early Career Fellowship from the NHMRC (2013-2016).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cancer
- Bioinformatics
- Genomics
- Transcriptomics
- Evolution
- Oncology
- Drug Resistance
- Prostate Cancer
- Brain Cancer
- Single Cell Genomics
- Spatial Transcriptomics
Collaborations and top research areas from the last five years
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Boosting conventional radiotherapy with microbeams to advance cancer treatment outcomes
Martin, O. (Primary Chief Investigator (PCI)), Goode, D. (Associate Investigator (AI)), Djonov, V. (Chief Investigator (CI)), Tehei, M. (Chief Investigator (CI)), Kok, D. (Chief Investigator (CI)), Ryan, S. (Chief Investigator (CI)), Engels, E. (Chief Investigator (CI)), Anderson, R. (Associate Investigator (AI)), Lerch, M. (Associate Investigator (AI)), Hausermann, D. (Associate Investigator (AI)), Corde, S. (Associate Investigator (AI)), Klein, M. (Associate Investigator (AI)), MacManus, M. (Associate Investigator (AI)) & Park, S. (Associate Investigator (AI))
3/02/25 → 31/12/28
Project: Research
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Early Bipolar Androgen Therapy for Advanced Prostate Cancer
Lawrence, M. (Primary Chief Investigator (PCI)), Selth, L. A. (Chief Investigator (CI)), Crumbaker, M. (Chief Investigator (CI)), Joshua, A. M. (Chief Investigator (CI)), Denmeade, S. (Chief Investigator (CI)), Taylor, R. (Associate Investigator (AI)), Ryan, A. (Associate Investigator (AI)), Lau, X. (Associate Investigator (AI)), Butler, L. M. (Associate Investigator (AI)), Goode, D. (Associate Investigator (AI)), Mills, I. G. (Associate Investigator (AI)) & Quezada Urban, R. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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“GLIMMER” - Glioma Liquid biopsy and Multiomic-Monitoring Enabled Research platform
Whittle, J. R. (Primary Chief Investigator (PCI)), Jenkins, M. R. (Chief Investigator (CI)), Freytag, S. (Chief Investigator (CI)), Best, S. A. (Chief Investigator (CI)), Morokoff, A. (Chief Investigator (CI)), Goode, D. (Chief Investigator (CI)), Wong, S. Q. (Chief Investigator (CI)), Grimmond, S. (Chief Investigator (CI)), Fox, S. B. (Chief Investigator (CI)), Dawson, S.-J. (Chief Investigator (CI)), Gately, L. (Chief Investigator (CI)), Drummond, K. J. (Chief Investigator (CI)), Eisenstat, D. D. (Chief Investigator (CI)) & Palmer, L. M. (Chief Investigator (CI))
1/01/22 → 31/10/27
Project: Research
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PMR-116, a Novel Inhibitor of Ribosome Biogenesis with Antitumor Activity in Preclinical Models of Prostate Cancer
Furic, L. (Primary Chief Investigator (PCI)), Lawrence, M. (Chief Investigator (CI)), Hofman, M. S. (Chief Investigator (CI)), Sandhu, S. (Chief Investigator (CI)), Risbridger, G. (Chief Investigator (CI)), Trigos, A. (Chief Investigator (CI)), Goode, D. (Chief Investigator (CI)), Azad, A. (Chief Investigator (CI)), Haddach, M. (Chief Investigator (CI)) & Hannan, K. M. (Chief Investigator (CI))
9/01/22 → 31/08/25
Project: Research
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ComBATing lethal prostate cancer with combination Bipolar Androgen Therapy
Lawrence, M. (Primary Chief Investigator (PCI)), Joshua, A. (Chief Investigator (CI)), Ramm, S. (Chief Investigator (CI)), Risbridger, G. (Associate Investigator (AI)), Clark, A. (Associate Investigator (AI)), Goode, D. (Associate Investigator (AI)), Simpson, K. J. (Associate Investigator (AI)), Brennen, W. N. (Associate Investigator (AI)), Corey, E. (Associate Investigator (AI)) & Nelson, P. S. (Associate Investigator (AI))
1/01/22 → 31/12/24
Project: Research
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Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma
Wang, M., Qin, L., Thia, K., Nguyen, T., MacDonald, S., Belobrov, S., Kranz, S., Goode, D., Trapani, J. A., Wiesenfeld, D. & Neeson, P. J., 2 Oct 2024, In: Journal for ImmunoTherapy of Cancer. 12, 10, 14 p., e009617.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Co-targeting BET, CBP, and p300 inhibits neuroendocrine signalling in androgen receptor-null prostate cancer
Choo, N. (Leading Author), Keerthikumar, S., Ramm, S., Ashikari, D., Teng, L., Niranjan, B., Hedwards, S., Porter, L. H., Goode, D. L., Simpson, K. J., Taylor, R. A., Risbridger, G. P. & Lawrence, M. G. (Leading Author), Jun 2024, In: Journal of Pathology. 263, 2, p. 242–256 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Defining the challenges and opportunities for using patient-derived models in prostate cancer research
Brennen, W. N. (Leading Author), Le Magnen, C. (Leading Author), Karkampouna, S., Anselmino, N., Bock, N., Choo, N., Clark, A. K., Coleman, I. M., Dolgos, R., Ferguson, A. M., Goode, D. L., Krutihof-de Julio, M., Navone, N. M., Nelson, P. S., O'Neill, E., Porter, L. H., Ranasinghe, W., Sunada, T., Williams, E. D. & Butler, L. M. & 5 others, , 15 May 2024, In: The Prostate. 84, 7, p. 623-635 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins
Trigos, A. S., Bongiovanni, F., Zhang, Y., Zethoven, M., Tothill, R., Pearson, R., Papenfuss, A. T. & Goode, D. L., 29 Apr 2024, In: Genome Biology. 25, 1, 25 p., 110.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Plasma ctDNA enables early detection of temozolomide resistance mutations in glioma
Jones, J. J., Jones, K. L., Wong, S. Q., Whittle, J., Goode, D., Nguyen, H., Iaria, J., Stylli, S., Towner, J., Pieters, T., Gaillard, F., Kaye, A. H., Drummond, K. J. & Morokoff, A. P., Jan 2024, In: Neuro-Oncology Advances. 6, 1, 10 p., vdae041.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)