Projects per year
Personal profile
Biography
Our team strives to make meaningful discoveries in fundamental neuroscience that contribute to improving the lives of people living with conditions that affect the nervous stem. Our current interests fall under three broad categories:
- Identifying mechanisms that regulate the cell production dynamics of neuroglia in development, aging and in response to Central Nervous System injury.
- Discovering new therapeutic targets that enhance CNS repair responses relevant to Multiple Sclerosis and Motor Neuron Disease.
- Using human induced pluripotent stem cells to engineer complex 3D Central Nervous System tissue, that can be used to model human development and disease processes.
Dr Gonsalvez completed his PhD at the University of Melbourne in 2013, after which he took on a role of Senior Tutor in the Department of Anatomy and Neuroscience. In 2014, he joined the Neurotrophin and Myelin Lab in Melbourne Brain Centre, and in 2016, was awarded prestigious National Health and Medical Research Council of Australia (NHMRC) Early Career Fellowship. In 2020, Dr Gonsalvez established an independent laboratory at Monash, and commenced an Australian Research Council (ARC) Discovery Early Career Fellowship Award (DECRA). He is now Head of the Neuroglia in Development and Disease Laboratory in the Biomedicine Discovery Institute at Monash. In addition, Dr Gonsalvez is Deputy Director of the Centre for Human Anatomy Education, and Director of the Glasgow Scholarship program. As a passionate anatomy educator, he plays a major role pre-clinical anatomy education for medical students.
Key Lab techniques / areas of specialty:
- Advanced microscopy and image analysis: TEM, Confocal, Spinning Disk, Live Cell.
- Molecular Biology (nanofiber in vitro myelin assays)
- Design Based Stereology
- iPSC models of Disease
- Mathematical modelling of growth dynamics
- Human Neuroanatomy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Wnt Signalling in Oligodendroglia: A missing link in MS neuroinflammation
Gonsalvez, D., Barton, S., Rutar, M., Mills, S. & Govier-Cole, A.
1/01/23 → 31/12/26
Project: Research
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Are Oligodendrocytes the Missing Link in Amyotrophic Lateral Sclerosis
Barton, S. & Gonsalvez, D.
6/02/22 → 6/02/26
Project: Research
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Glial Plasticity: How experience and aging change brain structure
Australian Research Council (ARC)
6/01/20 → 30/06/23
Project: Research
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Are Viva Voce Examinations an Authentic Assessment Method in Undergraduate Anatomical Education?
Fox, B., Mathangasinghe, Y., Gonsalvez, D. & Stephens, G. C., Sept 2024, In: Anatomy & Cell Biology. 57, S3, p. S183 1 p., A-0593.Research output: Contribution to journal › Meeting Abstract › peer-review
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Can We Mitigate the Effect of Examiner Bias Prior to Conducting Viva Voce Examination?
Mathangasinghe, Y., Fox, B., Stephens, G. C. & Gonsalvez, D., Sept 2024, In: Anatomy & Cell Biology. 57, S3, p. S182 1 p., A-0577.Research output: Contribution to journal › Meeting Abstract › peer-review
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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration
Liu, X., Xin, D. E., Zhong, X., Zhao, C., Li, Z., Zhang, L., Dourson, A. J., Lee, L., Mishra, S., Bayat, A. E., Nicholson, E., Seibel, W. L., Yan, B., Mason, J., Turner, B. J., Gonsalvez, D. G., Ong, W., Chew, S. Y., Ghosh, B., Yoon, S. O., & 14 others , 9 May 2024, In: Cell. 187, 10, p. 2465-2484.e22 43 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Using human iPSC-derived organoids to model demyelination, oligodendrocyte dysfunction and microglial toxicity in Multiple Sclerosis
Ramesan, S., Mason, J., Rutar, M., Swanson, M. E. V., Turner, B. J., Gonsalvez, D. & Barton, S., Jul 2023, In: GLIA. 71, S1, p. E756 1 p., T14-049B.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
Activity-dependent remodeling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment
Xiao, J., Nicholson, M., Wood, R. J., Fletcher, J., Gonsalvez, D., Hannan, A. J. & Murray, S., Aug 2022, In: Journal of Neurochemistry. 162, S1, p. 35 1 p., S18-04.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access