David de Kretser

Emeritus Prof

1981 …2019
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Research Output 1981 2018

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2018

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P., 1 Jan 2018, In : Reproduction. 155, p. 15-23 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 othersLorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journalArticleResearchpeer-review

Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Richardson, A. M., Lewis, D. P., Kita, B., Ludlow, H., Groome, N. P., Hedger, M. P., de Kretser, D. M. & Lidbury, B. A., 12 Apr 2018, In : Journal of Translational Medicine. 16, 1, 11 p., 97.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P., May 2017, In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin Biology After Lung Transplantation

Westall, G. P., Snell, G. I., Loskot, M., Levvey, B., O'Hehir, R. E., Hedger, M. P. & de Kretser, D. M., May 2017, In : Transplantation Direct. 3, 6, 6 p., e159.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: A cross sectional study

Lidbury, B. A., Kita, B., Lewis, D. P., Hayward, S., Ludlow, H., Hedger, M. P. & de Kretser, D. M., 16 Mar 2017, In : Journal of Translational Medicine. 15, 1, 10 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P., 15 Jul 2017, In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin and the breast implant capsule

Frenkiel, B. A., Temple-Smith, P., Kretser, D. D. & Southwick, G. J., 2017, In : Plastic and Reconstructive Surgery - Global Open. 5, 3, 9 p., 1258.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Follistatin attenuates radiation-induced fibrosis in a murine model

Forrester, H. B., De Kretser, D. M., Leong, T., Hagekyriakou, J. & Sprung, C. N., 1 Mar 2017, In : PLoS ONE. 12, 3, 13 p., e0173788.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes

Maresch, C. C., Stute, D. C., Ludlow, H., Hammes, H. P., de Kretser, D. M., Hedger, M. P. & Linn, T., 5 May 2017, In : Molecular and Cellular Endocrinology. 446, p. 91-101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of EAO in mice: responses to 2 elevated circulating levels of the activin-binding protein, follistatin

Nicholas, N., Muir, J. A., Hayward, S., Chen, J. L., Stanton, P. G., Gregorevic, P., de Kretser, D. M., Loveland, K. L., Bhushan, S., Meinhardt, A., Fijak, M. & Hedger, M. P., 1 Sep 2017, In : Reproduction. 154, 3, p. 293-305 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice

Nicolas, N., Michel, V., Bhushan, S., Wahle, E., Hayward, S., Ludlow, H., De Kretser, D. M., Loveland, K., Schuppe, H. C., Meinhardt, A., Hedger, M. P. & Fijak, M., 13 Feb 2017, In : Scientific Reports. 7, 42391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Activins in reproductive biology and beyond

Wijayarathna, J. M. & de Kretser, D., 2016, In : Human Reproduction Update. 22, 3, p. 342 - 357 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility

Hetherington, L., Schneider, E. K., DeKretser, D., Muller, C. H., Hondermarck, H., Velkov, T. & Baker, M. A., 1 Dec 2016, In : Molecular & Cellular Proteomics. 15, 12, p. 3685-3693 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation

de Kretser, D. M., Bensley, J. G., Phillips, D. J., Levvey, B., Snell, G. I., Lin, E., Hedger, M. P. & O'Hehir, R. E., 2016, In : PLoS ONE. 11, 1, 16 p., e140948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A., 1 Sep 2016, In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

Holdsworth-Carson, S. J., Craythorn, R. G., Winnall, W. R., Dhaliwal, K., Genovese, R., Nowell, C. J., Rogers, P. A. W., de Kretser, D. M., Hedger, M. P. & Girling, J. E., 2015, In : Reproduction, Fertility and Development. 27, 7, p. 985 - 999 15 p.

Research output: Contribution to journalArticleResearchpeer-review

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

Liu, Y., DeBoer, K. D., de Kretser, D. M., O'Donnell, L., O'Connor, A. E., Merriner, D. J., Okuda, H., Whittle, B., Jans, D. A., Efthymiadis, A., McLachlan, R. I., Ormandy, C. J., Goodnow, C. C., Jamsai, D. & O'Bryan, M. K., 2015, In : PLoS Genetics. 11, 3, 20 p., e1005090.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology

Hardy, C. L., King, S. J., Mifsud, N. A., Hedger, M. P., Phillips, D. J., Mackay, F., de Kretser, D. M., Wilson, J. W., Rolland, J. M. & O'Hehir, R. E., Jul 2015, In : Immunology and Cell Biology. 93, 6, p. 567-574 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection

Linko, R. T., Hedger, M. P., Pettila, V., Ruokonen, E. T., Ludlow, H. & de Kretser, D. M., 2014, In : BMC Infectious Diseases. 14, 1 (Art. ID: 253), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens

Winnall, W. R., Wu, H., Sarraj, M., Rogers, P. A., de Kretser, D. M., Girling, J. E. & Hedger, M. P., 2013, In : Reproduction, Fertility and Development. 25, 3, p. 570 - 580 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts

Forrester, H. B., Ivashkevich, A., McKay, M. J., Leong, T., de Kretser, D. M. & Sprung, C. N., 2013, In : PLoS ONE. 8, 10 , 9 p., e77119.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Loss of the nuclear receptor corepressor SLIRP compromises male fertility

Colley, S. M., Wintle, L., Searles, R., Russell, V., Firman, R. C., Smith, S. J., DeBoer, K. D., Merriner, D. J., Genevieve, B., Bentel, J. M., Stuckey, B., Phillips, M. R., Simmons, L., de Kretser, D. M., O'Bryan, M. K. & Leedman, P., 2013, In : PLoS ONE. 8, 8 (Art. ID: e70700), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Male reproductive health disorders among Aboriginal and Torres Strait Islander men: a hidden problem?

Adams, M. J., Collins, V. R., Dunne, M. P., de Kretser, D. M. & Holden, C. A., 2013, In : Medical Journal of Australia. 198, 1, p. 33 - 38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenotypic assessment of male fertility status in transgenic animal models

de Kretser, D. M. & O'Donnell, L., 2013, In : Methods in Molecular Biology. 927, p. 531-548 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study

de Kretser, D. M., Bensley, J. G. A., Pettila, V., Hedger, M. P., Hayward, S., Allan, C. A., McLachlan, R. I., Ludlow, H. & Phillips, D. J., 2013, In : Critical Care. 17, 5 (Art # R263), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

An essential role for katanin p80 and microtubule severing in male gamete production

O'Donnell, L., Rhodes, D., Smith, S. J., Merriner, D. J., Clark, B. J., Borg, C. L., Whittle, B., O'Connor, A. E., Smith, L. B., McNally, F. J., de Kretser, D. M., Goodnow, C. C., Ormandy, C. J., Jamsai, D. & O'Bryan, M. K., 2012, In : PLoS Genetics. 8, 5 (Art. ID: e1002698), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus

Craythorn, R., Winnall, W., Lederman, F., Gold, E., O'Connor, A., de Kretser, D., Hedger, M., Rogers, P. & Girling, J., 2012, In : Reproductive BioMedicine Online. 24, 3, p. 364 - 374 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair

de Kretser, D., O'Hehir, R., Hardy, C. & Hedger, M., 2012, In : Molecular and Cellular Endocrinology. 359, 1-2, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice

Youngson, N., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J., Khanna, K. K., de Kretser, D. & Whitelaw, E., 2011, In : Mammalian Genome. 22, 3-4, p. 235 - 248 14 p.

Research output: Contribution to journalArticleResearchpeer-review

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription

Zamudio, N., Scott, H., Wolski, K., Lo, J. C., Law, C., Leong, D., Kinkel, S., Chong, S., Jolley, D., Smyth, G., de Kretser, D., Whitelaw, E. & O'Bryan, M., 2011, In : PLoS ONE. 6, 3, 12 p., e18276.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

TGF-β down under 2011-the experts interviewed!

de Kretser, D. & Henrik-Heldin, C., Oct 2011, In : Growth Factors. 29, 5, p. 161-162 2 p.

Research output: Contribution to journalArticleOtherpeer-review

The regulation and functions of activin and follistatin in inflammation and immunity

Hedger, M., Winnall, W., Phillips, D. J. & de Kretser, D., 2011, In : Vitamins and Hormones-Advances in Research and Applications. 85, p. 255 - 297 43 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Determinants of male health: The interaction of biological and social factors

de Kretser, D. M., 2010, In : Asian Journal of Andrology. 12, 3, p. 291 - 297 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Determinants of male reproductive health disorders: The men in Australia telephone survey (MATeS)

Holden, C., McLachlan, R. I., Pitts, M., Cumming, R., Wittert, G., Ehsani, J., de Kretser, D. & Handelsman, D., 2010, In : BMC Public Health. 10, Art. No: 96, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimization of the expression of recombinant human activin A in the yeast Pichia pastoris

Fredericks, D., Clay, R., Warner, T., O'Connor, A., de Kretser, D. & Hearn, M. T. W., 2010, In : Biotechnology Progress. 26, 2, p. 372 - 383 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Activin and related proteins in inflammation: Not just interested bystanders

Phillips, D. J., de Kretser, D. M. & Hedger, M. P., 2009, In : Cytokine and Growth Factor Reviews. 20, 2, p. 153 - 164 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples

Ludlow, H., Phillips, D. J., Myers, M., McLachlan, R. I., de Kretser, D. M., Allan, C. A., Anderson, R. A., Groome, N. P., Hyvonen, M., Duncan, W. C. & Muttukrishna, S., 2009, In : Clinical Endocrinology. 71, 6, p. 867 - 873 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Evidence that androgens regulate early developmental events, prior to sexual differentiation

Goldman, D. R., de Kretser, D. M. & Morrison, J. R., 2008, In : Endocrinology. 149, 1, p. 5 - 14 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms

Lin, S-Y., Craythorn, R. G., O'Connor, A., Matzuk, M. M., Girling, J. E., Morrison, J. R. & de Kretser, D. M., 2008, In : Molecular Endocrinology. 22, epub ahead of print, p. 415 - 429 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice

Barakat, B. M., O'Connor, A., Gold, E. J., de Kretser, D. M. & Loveland, K. A. L., 2008, In : Reproduction. 136, 3, p. 345 - 359 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids

Foulds, L. M., Boysen, R. I., Crane, M., Yang, Y., Muir, J. A., Smith, A. I., de Kretser, D. M., Hearn, M. T. W. & Hedger, M. P., 2008, In : Biology of Reproduction. 79, 3, p. 525 - 536 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian Men

Jamsai, D., Reilly, A., Smith, S. J., Gibbs, G. M., Baker, H. W. G., McLachlan, R. I., de Kretser, D. M. & O'Bryan, M. K., 2008, In : Human Reproduction. 23, 9, p. 2151 - 2159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Sox8 is a critical regulator of adult sertoli cell function and male fertility

O'Bryan, M. K., Takada, S., Borg, C. L., Scott, G., Harada, S., Ray, M. K., Dai, Q., Wilhelm, D., de Kretser, D. M., Eddy, E. M., Koopman, P. A. & Mishina, Y., 2008, In : Developmental Biology. 316, 2, p. 359 - 370 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Temporal expression of activin in acute burn wounds-From inflammatory cells to fibroblasts

McLean, C. A., Cleland, H. J., Moncrieff, N. J., Barton, R. J., de Kretser, D. M. & Phillips, D. J., 2008, In : Burns : Journal of the International Society for Burn Injuries. 34, p. 50 - 55 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia

Jones, K. L., Mansell, A. S., Patella, S., Scott, B. M., Hedger, M. P., de Kretser, D. M. & Phillips, D. J., 2007, In : Proceedings of the National Academy of Sciences. 104, 41, p. 16239 - 16244 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm

Gibbs, G. M., Bianco, D. M., Jamsai, D., Herlihy, A., Ristevski, S., Aitken, R. J., de Kretser, D. M. & O'Bryan, M. K., 2007, In : Biology of Reproduction. 77, 1, p. 108 - 114 7 p.

Research output: Contribution to journalArticleResearchpeer-review