David de Kretser

Emeritus Prof

1981 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1981 2018

2018

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P. 1 Jan 2018 In : Reproduction. 155, p. 15-23 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K. , Croucher, D. R. , McCloy, R. A. , Vaghjiani, V. , Gonzalez-Rajal, A. , Hastings, J. F. , Chin, V. T. , Szczepny, A. , Kostyrko, K. , Marquez, C. , Jayasekara, W. S. N. , Alamgeer, M. , Boolell, V. , Han, J. Z. R. , Waugh, T. , Lee, H. C. , Oakes, S. R. , Kumar, B. , Harrison, C. A. , Hedger, M. P. & 13 others Lorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N. 25 Jul 2018 In : Science Translational Medicine. 10, 451, 13 p., eaat3504

Research output: Contribution to journalArticleResearchpeer-review

Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Richardson, A. M., Lewis, D. P., Kita, B., Ludlow, H., Groome, N. P., Hedger, M. P., de Kretser, D. M. & Lidbury, B. A. 12 Apr 2018 In : Journal of Translational Medicine. 16, 1, 11 p., 97

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P. May 2017 In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin Biology After Lung Transplantation

Westall, G. P., Snell, G. I., Loskot, M., Levvey, B., O'Hehir, R. E., Hedger, M. P. & de Kretser, D. M. May 2017 In : Transplantation Direct. 3, 6, 6 p., e159

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: A cross sectional study

Lidbury, B. A., Kita, B., Lewis, D. P., Hayward, S., Ludlow, H., Hedger, M. P. & de Kretser, D. M. 16 Mar 2017 In : Journal of Translational Medicine. 15, 1, 10 p., 60

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P. 15 Jul 2017 In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin and the breast implant capsule

Frenkiel, B. A., Temple-Smith, P., Kretser, D. D. & Southwick, G. J. 2017 In : Plastic and Reconstructive Surgery - Global Open. 5, 3, 9 p., 1258

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Follistatin attenuates radiation-induced fibrosis in a murine model

Forrester, H. B., De Kretser, D. M., Leong, T., Hagekyriakou, J. & Sprung, C. N. 1 Mar 2017 In : PLoS ONE. 12, 3, 13 p., e0173788

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes

Maresch, C. C., Stute, D. C., Ludlow, H., Hammes, H. P., de Kretser, D. M., Hedger, M. P. & Linn, T. 5 May 2017 In : Molecular and Cellular Endocrinology. 446, p. 91-101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of EAO in mice: responses to 2 elevated circulating levels of the activin-binding protein, follistatin

Nicholas, N., Muir, J. A., Hayward, S., Chen, J. L., Stanton, P. G., Gregorevic, P., de Kretser, D. M., Loveland, K. L., Bhushan, S., Meinhardt, A., Fijak, M. & Hedger, M. P. 1 Sep 2017 In : Reproduction. 154, 3, p. 293-305 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice

Nicolas, N., Michel, V., Bhushan, S., Wahle, E., Hayward, S., Ludlow, H., De Kretser, D. M., Loveland, K., Schuppe, H. C., Meinhardt, A., Hedger, M. P. & Fijak, M. 13 Feb 2017 In : Scientific Reports. 7, 42391

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Activins in reproductive biology and beyond

Wijayarathna, J. M. & de Kretser, D. 2016 In : Human Reproduction Update. 22, 3, p. 342 - 357 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility

Hetherington, L., Schneider, E. K., DeKretser, D., Muller, C. H., Hondermarck, H., Velkov, T. & Baker, M. A. 1 Dec 2016 In : Molecular & Cellular Proteomics. 15, 12, p. 3685-3693 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endocrinology: Adult & Pediatric

Jameson, J. L. (ed.), De Groot, L. J. (ed.), de Kretser, D. M. (ed.), Giudice, L. C. (ed.), Grossman, A. B. (ed.), Melmed, S. (ed.), Potts Jr., J. T. (ed.) & Weir, G. C. (ed.) 2016 7th ed. Philadelphia PA USA: Elsevier.

Research output: Book/ReportEdited BookOtherpeer-review

Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone)

de Kretser, D. M., Hedger, M. P. & Burger, H. G. 2016 Endocrinology: Adult & Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 1 and 2, p. 2037 - 2050 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Spermatogenesis

de Kretser, D. M., Loveland, K. A. L. & O'Bryan, M. K. 2016 Endocrinology: Adult & Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 1 and 2, p. 2325 - 2353 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation

de Kretser, D. M., Bensley, J. G., Phillips, D. J., Levvey, B., Snell, G. I., Lin, E., Hedger, M. P. & O'Hehir, R. E. 2016 In : PLoS ONE. 11, 1, 16 p., e140948

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A. 1 Sep 2016 In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

Holdsworth-Carson, S. J., Craythorn, R. G., Winnall, W. R., Dhaliwal, K., Genovese, R., Nowell, C. J., Rogers, P. A. W., de Kretser, D. M., Hedger, M. P. & Girling, J. E. 2015 In : Reproduction, Fertility and Development. 27, 7, p. 985 - 999 15 p.

Research output: Contribution to journalArticleResearchpeer-review

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

Liu, Y., DeBoer, K. D., de Kretser, D. M., O'Donnell, L., O'Connor, A. E., Merriner, D. J., Okuda, H., Whittle, B., Jans, D. A., Efthymiadis, A., McLachlan, R. I., Ormandy, C. J., Goodnow, C. C., Jamsai, D. & O'Bryan, M. K. 2015 In : PLoS Genetics. 11, 3, 20 p., e1005090

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology

Hardy, C. L., King, S. J., Mifsud, N. A., Hedger, M. P., Phillips, D. J., Mackay, F., de Kretser, D. M., Wilson, J. W., Rolland, J. M. & O'Hehir, R. E. Jul 2015 In : Immunology and Cell Biology. 93, 6, p. 567-574 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

Lessons learned in Andrology: Keep your options open and do not hesitate to follow leads and change directions

de Kretser, D. M. 2014 In : Andrology. 2, 4, p. 481 - 483 3 p.

Research output: Contribution to journalLetterOther

Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection

Linko, R. T., Hedger, M. P., Pettila, V., Ruokonen, E. T., Ludlow, H. & de Kretser, D. M. 2014 In : BMC Infectious Diseases. 14, 1 (Art. ID: 253), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Endocrinology of the Male Reproductive System

de Kretser, D. M. & O'Donnell, L. 2013 Endocrinology of Male Reproduction. Beck-Peccoz, P., Chrousos, G. & De Groot, L. J. (eds.). 1st ed. USA: Endotext, p. 1 - 64 64 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens

Winnall, W. R., Wu, H., Sarraj, M., Rogers, P. A., de Kretser, D. M., Girling, J. E. & Hedger, M. P. 2013 In : Reproduction, Fertility and Development. 25, 3, p. 570 - 580 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts

Forrester, H. B., Ivashkevich, A., McKay, M. J., Leong, T., de Kretser, D. M. & Sprung, C. N. 2013 In : PLoS ONE. 8, 10 , 9 p., e77119

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Open Access
File

Loss of the nuclear receptor corepressor SLIRP compromises male fertility

Colley, S. M., Wintle, L., Searles, R., Russell, V., Firman, R. C., Smith, S. J., DeBoer, K. D., Merriner, D. J., Genevieve, B., Bentel, J. M., Stuckey, B., Phillips, M. R., Simmons, L., de Kretser, D. M., O'Bryan, M. K. & Leedman, P. 2013 In : PLoS ONE. 8, 8 (Art. ID: e70700), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Male reproductive health disorders among Aboriginal and Torres Strait Islander men: a hidden problem?

Adams, M. J., Collins, V. R., Dunne, M. P., de Kretser, D. M. & Holden, C. A. 2013 In : Medical Journal of Australia. 198, 1, p. 33 - 38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenotypic assessment of male fertility status in transgenic animal models

de Kretser, D. M. & O'Donnell, L. 2013 In : Methods in Molecular Biology. 927, p. 531-548 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study

de Kretser, D. M., Bensley, J. G. A., Pettila, V., Hedger, M. P., Hayward, S., Allan, C. A., McLachlan, R. I., Ludlow, H. & Phillips, D. J. 2013 In : Critical Care. 17, 5 (Art # R263), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

An essential role for katanin p80 and microtubule severing in male gamete production

O'Donnell, L., Rhodes, D., Smith, S. J., Merriner, D. J., Clark, B. J., Borg, C. L., Whittle, B., O'Connor, A. E., Smith, L. B., McNally, F. J., de Kretser, D. M., Goodnow, C. C., Ormandy, C. J., Jamsai, D. & O'Bryan, M. K. 2012 In : PLoS Genetics. 8, 5 (Art. ID: e1002698), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus

Craythorn, R., Winnall, W., Lederman, F., Gold, E., O'Connor, A., de Kretser, D., Hedger, M., Rogers, P. & Girling, J. 2012 In : Reproductive BioMedicine Online. 24, 3, p. 364 - 374 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair

de Kretser, D., O'Hehir, R., Hardy, C. & Hedger, M. 2012 In : Molecular and Cellular Endocrinology. 359, 1-2, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice

Youngson, N., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J., Khanna, K. K., de Kretser, D. & Whitelaw, E. 2011 In : Mammalian Genome. 22, 3-4, p. 235 - 248 14 p.

Research output: Contribution to journalArticleResearchpeer-review

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription

Zamudio, N., Scott, H., Wolski, K., Lo, J. C., Law, C., Leong, D., Kinkel, S., Chong, S., Jolley, D., Smyth, G., de Kretser, D., Whitelaw, E. & O'Bryan, M. 2011 In : PLoS ONE. 6, 3, 12 p., e18276

Research output: Contribution to journalArticleResearchpeer-review

Open Access

TGF-β down under 2011-the experts interviewed!

de Kretser, D. & Henrik-Heldin, C. Oct 2011 In : Growth Factors. 29, 5, p. 161-162 2 p.

Research output: Contribution to journalArticleOtherpeer-review

The regulation and functions of activin and follistatin in inflammation and immunity

Hedger, M., Winnall, W., Phillips, D. J. & de Kretser, D. 2011 In : Vitamins and Hormones-Advances in Research and Applications. 85, p. 255 - 297 43 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Attention to men's health

de Kretser, D. Dec 2010 In : Health Sociology Review. 19, 4, p. 401 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

Determinants of male health: The interaction of biological and social factors

de Kretser, D. M. 2010 In : Asian Journal of Andrology. 12, 3, p. 291 - 297 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Determinants of male reproductive health disorders: The men in Australia telephone survey (MATeS)

Holden, C., McLachlan, R. I., Pitts, M., Cumming, R., Wittert, G., Ehsani, J., de Kretser, D. & Handelsman, D. 2010 In : BMC Public Health. 10, Art. No: 96, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimization of the expression of recombinant human activin A in the yeast Pichia pastoris

Fredericks, D., Clay, R., Warner, T., O'Connor, A., de Kretser, D. & Hearn, M. T. W. 2010 In : Biotechnology Progress. 26, 2, p. 372 - 383 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Activin and related proteins in inflammation: Not just interested bystanders

Phillips, D. J., de Kretser, D. M. & Hedger, M. P. 2009 In : Cytokine and Growth Factor Reviews. 20, 2, p. 153 - 164 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples

Ludlow, H., Phillips, D. J., Myers, M., McLachlan, R. I., de Kretser, D. M., Allan, C. A., Anderson, R. A., Groome, N. P., Hyvonen, M., Duncan, W. C. & Muttukrishna, S. 2009 In : Clinical Endocrinology. 71, 6, p. 867 - 873 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Evidence that androgens regulate early developmental events, prior to sexual differentiation

Goldman, D. R., de Kretser, D. M. & Morrison, J. R. 2008 In : Endocrinology. 149, 1, p. 5 - 14 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms

Lin, S-Y., Craythorn, R. G., O'Connor, A., Matzuk, M. M., Girling, J. E., Morrison, J. R. & de Kretser, D. M. 2008 In : Molecular Endocrinology. 22, epub ahead of print, p. 415 - 429 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice

Barakat, B. M., O'Connor, A., Gold, E. J., de Kretser, D. M. & Loveland, K. A. L. 2008 In : Reproduction. 136, 3, p. 345 - 359 15 p.

Research output: Contribution to journalArticleResearchpeer-review