Personal profile

Biography

Professor David de Kretser AC, MBBS (Melb Univ), MD (Monash), FRACP, FAA, FTSE, LLD (Hon. Monash), LLD (Hon, Univ Melb) FRACOG (Hon), FRCOG (Hon), FRACGP (Hon)

David de Kretser is a reproductive endocrinologist, whose academic career at Monash University has included appointments as Professor of Anatomy, the founding Director of the Monash Institute of Medical Research and the Associate Dean for Biotechnology Development. In 2003, he was named a Sir John Monash Distinguished Professor.


Having served on the Human Reproduction Program at World Health Organisation and the Executive Council of the International Society of Andrology, including a term as its President, David has many international connections and has trained graduate students and post-doctoral fellows from over 20 countries. Some of these networks greatly facilitated some research programs.

He took time out from his scientific career to serve as the 28th Governor of Victoria from 2006 to 2011 during which he managed to find small amounts of time to keep up his research interests.


Since April 2011 David has resumed research at Monash University working at the MIMR-PHI Institute of Medical Rsearch (formerly Monash Institute of Medical Research), based at the Monash Medical Centre and also in the Department of Anatomy and Developmental Biology on the Clayton Campus of Monash.

Throughout his career David has practised as an endocrinologist with a major focus on male reproductive disorders. He believes that patients provide the triggers for research and, while some of his work is basic and molecular, there is always a translational aim. Being an experienced microscopist using both light and electron microscopes, he always tries to link structure with function.

His research programs address the causes and management of male infertility and included the development, with his colleagues, of a collection of DNA samples from men with infertility to enable the identification of new genetic causes of male infertility. These studies include the use of random mutagenesis in mice to identify genes causing spermatogenic disorders. 

His work on the hormonal regulation of reproduction identified inhibin and follistatin as novel proteins controlling FSH secretion. This work has led to a change in direction of some of his work since the activins, which raise FSH and are modulated by follistatin, turn out to be major regulators of the inflammatory and fibrotic responses. A significant part of his work today is involved in further characterising diagnostic and therapeutic applications of the activins and follistatin.

David is also a passionate advocate for the need to undertake preventive action to improve male health. For the past 12 years, with support form the Federal Government, he initiated, with colleagues from around Australia, a highly successful program of community and professional education in male reproductive health called Andrology Australia.

Throughout his career, David has built lasting collaborative programs in research with colleagues locally, nationally and internationally, recognizing that research today requires a multiplicity of technologies that are only available through research teams and not found in one person.

Keywords

  • reproductive biology
  • infertility
  • endocrinology

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Projects 2000 2019

Research Output 1981 2018

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P. 1 Jan 2018 In : Reproduction. 155, p. 15-23 14 p.

Research output: Research - peer-reviewArticle

Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Richardson, A. M., Lewis, D. P., Kita, B., Ludlow, H., Groome, N. P., Hedger, M. P., de Kretser, D. M. & Lidbury, B. A. 12 Apr 2018 In : Journal of Translational Medicine. 16, 1, 11 p., 97

Research output: Research - peer-reviewArticle

Open Access
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Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P. May 2017 In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Research - peer-reviewArticle

Activin Biology After Lung Transplantation

Westall, G. P., Snell, G. I., Loskot, M., Levvey, B., O'Hehir, R. E., Hedger, M. P. & de Kretser, D. M. May 2017 In : Transplantation Direct. 3, 6, e159

Research output: Research - peer-reviewArticle

Open Access
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Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: A cross sectional study

Lidbury, B. A., Kita, B., Lewis, D. P., Hayward, S., Ludlow, H., Hedger, M. P. & de Kretser, D. M. 16 Mar 2017 In : Journal of Translational Medicine. 15, 1, 60

Research output: Research - peer-reviewArticle

Open Access
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