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Research Output 1992 2019

2019

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

Hortle, E., Starrs, L., Brown, F., Jane, S., Curtis, D., McMorran, B. J., Foote, S. J. & Burgio, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 6356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

Shields, B. J., Slape, C. I., Vo, N., Jackson, J. T., Pliego-Zamora, A., Ranasinghe, H., Shi, W., Curtis, D. J. & McCormack, M. P., 1 Jan 2019, In : Leukemia. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Acute myeloid leukaemia relapsing after allogeneic haemopoietic stem cell transplantation: prognostic factors and impact of initial therapy of relapse

Lim, A. B. M., Curley, C., Fong, C. Y., Bilmon, I., Beligaswatte, A., Purtill, D., Getta, B., Johnston, A. M., Armytage, T., Collins, M., Mason, K., Fielding, K., Greenwood, M., Gibson, J., Hertzberg, M., Wright, M., Lewis, I., Moore, J., Curtis, D., Szer, J. & 2 othersKennedy, G. & Ritchie, D., 1 Mar 2018, In : Internal Medicine Journal. 48, 3, p. 276-285 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel role for Lyl1 in primitive erythropoiesis

Chiu, S. K., Saw, J. M. Y., Huang, Y., Sonderegger, S. E., Wong, N. C. L., Powell, D. R., Beck, D., Pimanda, J., Tremblay, C. & Curtis, D. J., 11 Oct 2018, In : Development. 145, 19, 9 p., dev162990.

Research output: Contribution to journalArticleResearchpeer-review

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J., 21 May 2018, In : Disease Models and Mechanisms. 11, 5, 8 p., dmm034678.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of Tfrc-mutant mice with microcytic phenotypes

Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M. & Curtis, D. J., 14 Aug 2018, In : Blood Advances. 2, 5, p. 1914-1922 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome

Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Al-Sharea, A., Lee, M. K. S., Flynn, M. C., Stolz, C. J., Guirguis, A. A., Lancaster, G. I., Chin-Dusting, J., Curtis, D. J. & Murphy, A. J., 23 Mar 2018, In : Haematologica: the hematology journal. 103, 4, p. 597-606 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair, A. P., Walker, P., Kalff, A., Bergin, K., Hocking, J., Avery, S., Curtis, D. J., Patil, S., Das, T., Klarica, D., Morgan, S., Muirhead, J., Gorniak, M. B., Reynolds, J. & Spencer, A., 1 Jun 2017, In : Bone Marrow Transplantation. 52, 6, p. 839-845 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J., 1 Aug 2017, In : Disease Models and Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J., Sep 2017, In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens, S., Peirs, S., Loocke, W. V., Wang, J., Takawy, M., Matthijssens, F., Sonderegger, S. E., Haigh, K., Nguyen, T., Vandamme, N., Costa, M., Carmichael, C., Van Nieuwerburgh, F., Deforce, D., Kleifeld, O., Curtis, D. J., Berx, G., Van Vlierberghe, P. & Haigh, J. J., 23 Feb 2017, In : Blood. 129, 8, p. 981-990 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Specification of neurotransmitter identity by Tal1 in thalamic nuclei

Lee, B., Lee, M., Song, S., Loi, L. D., Lam, D. T., Yoon, J., Baek, K., Curtis, D. J. & Jeong, Y., 1 Oct 2017, In : Developmental Dynamics. 246, 10, p. 749-758 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted therapies for T-cell acute lymphoblastic leukaemia (T-ALL): what makes T-ALL TYK?

Curtis, D. J., 1 Apr 2017, In : British Journal of Haematology. 177, 2, p. 169-170 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2016

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis, A., Slape, C. I., Failla, L. M., Saw, J. M. Y., Tremblay, C., Powell, D. R., Rossello, F. J., Wei, A., Strasser, A. & Curtis, D. J., 2016, In : Cell Death and Differentiation. 23, 6, p. 1049 - 1059 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation

Pham, T., Patil, S., Fleming, S. A., Avery, S., Walker, P. A., Wei, A., Curtis, D. J., Stuart, G., Klarica, D., O'Brien, M., Morris, K., Das, T. P., Bollard, G. M., Muirhead, J., Coutsouvelis, J. & Spencer, A., 2015, In : Transfusion. 55, 11, p. 2709 - 2713 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Monosomal karyotype predicts inferior survival independently of a complex karyotype in patients with myelodysplastic syndromes

McQuilten, Z., Sundararajan, V., Andrianopoulos, N., Curtis, D. J., Wood, E. M., Campbell, L. J. & Wall, M., 2015, In : Cancer. 121, 17, p. 2892 - 2899 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming quiescence by targeting p21 (Cdkn1a) sensitizes pre-leukemic stem cells to chemotherapy

Tremblay, C., Saw, J. M. Y., Chiu, S. K. & Curtis, D. J., 1 Sep 2015, p. S45. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Goossens, S., Radaelli, E., Blanchet, O., Durinck, K., Van der Meulen, J., Peirs, S., Taghon, T., Tremblay, C., Costa, M., Ghahremani, M. F., De Medts, J., Bartunkova, S., Haigh, K., Schwab, C., Farla, N., Pieters, T., Matthijssens, F., Roy, N. V., Best, J. A., Deswarte, K. & 24 othersBogaert, P., Carmichael, C., Rickard, A. S., Suryani, S., Bracken, L. S., Alserihi, R., Cante-Barrett, K., Haenebalcke, L., Clappier, E., Rondou, P., Slowicka, K., Huylebroeck, D., Goldrath, A. W., Janzen, V., McCormack, M., Lock, R. B., Curtis, D. J., Harrison, C., Berx, G., Speleman, F. P., Meijerink, J. P. P., Soulier, J., Van Vlierberghe, P. & Haigh, J. J., 2015, In : Nature Communications. 6, p. 1 - 12 12 p., 5794.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Safe and effective use of outpatient non-myeloablative allogeneic stem cell transplantation for myeloma

Campbell, P., Walker, P. A., Avery, S., Curtis, D. J., Schwarer, A., Wei, A., Kalff, A., Muirhead, J. L. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 5, p. e213 - e213 3 p.

Research output: Contribution to journalLetterOther

The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia

Tremblay, C. & Curtis, D. J., 2014, In : Current Opinion in Hematology. 21, 4, p. 320 - 325 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Underestimation of myelodysplastic syndrome incidence by cancer registries: results from a population-based data linkage study

McQuilten, Z., Wood, E. M., Polizzotto, M. N., Campbell, L., Wall, M., Curtis, D. J., Farrugia, H., McNeil, J. J. & Sundararajan, V., 2014, In : Cancer. 120, 11, p. 1686 - 1694 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level

Brown, F., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., Whitelaw, N. C., Whitelaw, E., Kile, B., Jane, S. M. & Curtis, D. J., 2013, In : Blood Cells, Molecules, and Diseases. 50, 2, p. 86-92 7 p.

Research output: Contribution to journalArticleResearchpeer-review

LIM-domain-only proteins in cancer

Matthews, J. M., Lester, K., Joseph, S. & Curtis, D. J., 2013, In : Nature Reviews Cancer. 13, 2, p. 111 - 122 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

McCormack, M., Shields, B., Jackson, J., Nasa, C., Shi, W., Slater, N. J., Tremblay, C., Rabbitts, T. H. & Curtis, D. J., 2013, In : Blood. 122, 12, p. 2093 - 2103 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

Saw, J. M. Y., Curtis, D. J., Hussey, D. J., Dobrovic, A., Aplan, P. D. & Slape, C. I., 2013, In : Leukemia Research. 37, 12, p. 1668 - 1673 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Slape, C. I., Saw, J. M. Y., Jowett, J. B., Aplan, P. D., Strasser, A., Jane, S. M. & Curtis, D. J., 2012, In : Blood. 120, 12, p. 2475 - 2483 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation

Nguyen, N-Y. N., Maxwell, M. J., Ooms, L., Davies, E. M., Hilton, A. A., Collinge, J. E., Hilton, D. J., Kile, B. T., Mitchell, C. A., Hibbs, M. L., Jane, S. M. & Curtis, D. J., 2011, In : Blood. 117, 20, p. 5362-5371 10 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

2010

Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common Ibeta-chain heteroreceptor

Kanellakis, P., Pomilio, G., Agrotis, A., Gao, X., Du, X-J., Curtis, D. J. & Bobik, A., 2010, In : British Journal of Pharmacology. 160, 8, p. 2085 - 2096 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

McCormack, M., Young, L., Vasudevan, S., de Graaf, C., Codrington, R., Rabbitts, T., Jane, S. & Curtis, D., 2010, In : Science. 327, 12, p. 879 - 883 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia

Curtis, D. J. & McCormack, M. P., 2010, In : Clinical Cancer Research. 16, 23, p. 5618 - 5623 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors

Dey, S., Curtis, D., Jane, S. & Brandt, S., 2010, In : Molecular and Cellular Biology. 30, 9, p. 2181 - 2192 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The thymus under siege: Lmo2 induces precancerous stem cells in a mouse model of T-ALL

McCormack, M. P. & Curtis, D. J., 2010, In : Cell Cycle. 9, 12, p. 2267 - 2268 2 p.

Research output: Contribution to journalLetterOther

2009

Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival

Souroullas, G., Salmon, J. M., Sablitzky, F., Curtis, D. J. & Goodell, M. A., 2009, In : Cell Stem Cell. 4, 2, p. 180 - 186 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., Fernandez, K. M., McCormack, M. P., Cooke, B. M., Foote, S. J., Crabb, B. S., Curtis, D. J., Hilton, D. J., Kile, B. T. & Jane, S. M., 2009, In : Blood. 113, 14, p. 3352 - 3362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q., Rank, G., Tan, Y., Moritz, R., Simpson, R., Cerruti, L., Curtis, D. & Jane, S., 2009, In : Nature Structural and Molecular Biology. 16, 3, p. 304 - 311 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The generation and properties of human macrophage populations from hemopoietic stem cells

Way, K., Dinh, H., Keene, M. R., White, K. E., Clanchy, F. IL., Lusby, P. E., Roiniotis, J., Cook, A. D., Cassady, A. I., Curtis, D. J. & Hamilton, J. A., 2009, In : Journal of leukocyte biology. 85, 5, p. 766 - 778 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms

Siggins, S., Nguyen, N-Y., McCormack, M., Vasudevan, S., Vilani, R., Jane, S., Wainwright, B. & Curtis, D., 2009, In : Blood. 114, 5, p. 995 - 1004 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet

Tonkin, J. N., Knight, B., Curtis, D. J., Abraham, L. J. & Yeoh, G. C., 2008, In : Stem Cell Research. 1, 3, p. 195 - 204 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclosporin, methotrexate and prednisolone for graft-versus-host disease prophylaxis in allogeneic peripheral blood progenitor cell transplants

Hoyt, R., Ritchie, D., Roberts, A. W., MacGregor, L., Curtis, D. J., Szer, J. & Grigg, A. P., 2008, In : Bone Marrow Transplantation. 41, 7, p. 651 - 658 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3

Croom, H. A., Izon, D. J., Chong, M. MW., Curtis, D. J., Roberts, A. W., Kay, T. W., Hilton, D. J., Alexander, W. & Starr, R. J., 2008, In : Molecular Immunology. 45, 10, p. 2888 - 2896 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

Salmon, J., Slater, N., Hall, M., McCormack, M., Jane, S. & Curtis, D., 2007, In : Blood. 110, 10, p. 3573 - 3581 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S. L., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P., Jane, S. M. & Curtis, D. J., 2006, In : Blood. 108, 7, p. 2248-2256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: Implications for mutation detection in peripheral blood

Stevenson, W. S., Hoyt, R., Bell, A., Guipponi, M., Juneja, S., Grigg, A. P., Curtis, D. J., Scott, H. S., Szer, J., Alexander, W. S., Tuckfield, A. & Roberts, A. W., 1 Aug 2006, In : Pathology. 38, 4, p. 336-342 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Granulocyte colony-stimulating factor and stem cell factor improve endogenous repair after myocardial infarction

Kanellakis, P., Slater, N. J., Du, X. J., Bobik, A. & Curtis, D. J., 1 Apr 2006, In : Cardiovascular Research. 70, 1, p. 117-125 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Functional but Abnormal Adult Erythropoiesis in the Absence of the Stem Cell Leukemia Gene

Hall, M., Slater, N., Begley, C., Salmon, J., Stekelenburg, L. J., McCormack, M., Jane, S. & Curtis, D., 2005, In : Molecular and Cellular Biology. 25, 15, p. 6355 - 6362 8 p.

Research output: Contribution to journalArticleResearchpeer-review