Projects per year
Personal profile
Biography
David Shackleford leads the Biopharmaceutics section of the Centre for Drug Candidate Optimisation (CDCO). He completed his studies at the University of South Australia before moving to Melbourne to undertake a post-doctoral position with Professor Christopher Porter and Professor Susan Charman in the Department of Pharmaceutics, Monash University. David specialises in pharmacokinetics and drug metabolism within the area of ADME lead optimisation. In 2003, he joined the CDCO. David's role focusses on activities as they relate to the classification of novel compounds PK/ADME properties. Outside of work he enjoys various interests including racing bicycles, flying gliders, building model aircraft and swing dancing.
Research interests
Pharmacokinetics, drug metabolism and ADME lead optimisation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Discovery of New Antimalarials with a Novel Mechanism of Action and Irresistible Target
Giannangelo, C. (Primary Chief Investigator (PCI)), Dillon, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Edstein, M. (Chief Investigator (CI)), Creek, D. (Associate Investigator (AI)), Charman, S. (Associate Investigator (AI)), Burrows, J. N. (Associate Investigator (AI)), Stupple, P. (Associate Investigator (AI)), Gilson, P. (Associate Investigator (AI)), Niles, J. (Associate Investigator (AI)), Delves, M. (Associate Investigator (AI)) & Wittlin, S. (Associate Investigator (AI))
1/01/25 → 31/12/27
Project: Research
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Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure
Ritchie, R. (Primary Chief Investigator (PCI)), Figtree, G. A. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)), Taylor, A. (Chief Investigator (CI)), Yang, J. Y. H. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Schiattarella, G. (Chief Investigator (CI)), Pinto, A. (Chief Investigator (CI)), Drummond, G. (Chief Investigator (CI)), Horowitz, J. D. (Chief Investigator (CI)), Bubb, K. (Chief Investigator (CI)), Vecchio, L. (Associate Investigator (AI)), Nelson, A. (Associate Investigator (AI)), Kirkpatrick, C. (Associate Investigator (AI)), McDonald, C. (Associate Investigator (AI)), Febbraio, M. (Associate Investigator (AI)), Vinh, A. (Associate Investigator (AI)), Odiba, J. (Associate Investigator (AI)), Brown, H. (Associate Investigator (AI)) & Stupple, P. (Chief Investigator (CI))
1/02/23 → 31/07/26
Project: Research
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Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction
Ritchie, R. (Primary Chief Investigator (PCI)), Stupple, P. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Vecchio, L. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Chong, J. J. H. (Chief Investigator (CI)), Charman, S. (Associate Investigator (AI)) & McDonald, C. (Associate Investigator (AI))
1/01/23 → 31/12/25
Project: Research
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Pharmacokinetic assessment and optimisation of a new therapy for PKD
Smyth, I. (Primary Chief Investigator (PCI)), Cottle, D. (Chief Investigator (CI)), Powell, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Baell, J. (Chief Investigator (CI)) & Zhao, Y. (Chief Investigator (CI))
1/07/22 → 30/06/23
Project: Research
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A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia
Dangerfield, J., DeBono, A., Keller, A. N., Josephs, T. M., Shackleford, D. M., Gregory, K. J., Leach, K. & Capuano, B., Oct 2025, In: Acta Pharmaceutica Sinica B. 15, 10, p. 5387-5399 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
Nie, Z., Bonnert, R., Tsien, J., Deng, X., Higgs, C., El Mazouni, F., Zhang, X., Li, R., Ho, N., Feher, V., Paulsen, J., Shackleford, D. M., Katneni, K., Chen, G., Ng, A. C. F., McInerney, M., Wang, W., Saunders, J., Collins, D. & Yan, D. & 24 others, , 9 Jan 2025, In: Journal of Medicinal Chemistry. 68, 1, p. 590–637 48 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Lawong, A., Gahalawat, S., Ray, S., Ho, N., Han, Y., Ward, K. E., Deng, X., Chen, Z., Kumar, A., Xing, C., Hosangadi, V., Fairhurst, K. J., Tashiro, K., Liszczak, G., Shackleford, D. M., Katneni, K., Chen, G., Saunders, J., Crighton, E. & Casas, A. & 14 others, , 15 Aug 2024, In: Cell Chemical Biology. 31, 8, p. 1503-1517.e19 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Single-Dose Drug Development Candidate for Schistosomiasis
Leas, D. A., Keiser, J., Charman, S. A., Shackleford, D. M., Jones, J. O., Campbell, M., Chen, G., Katneni, K., Patil, R., Hu, M., Pham, T., Häberli, C., Schulze, T. T., Neville, A. J., Wang, X., Dong, Y., Davis, P. H. & Vennerstrom, J. L., 8 Nov 2024, In: ACS Infectious Diseases. 10, 11, p. 3963-3972 10 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
The effects of single and multiple resistance mechanisms on bacterial response to meropenem
Fuhs, D. T., Cortés-Lara, S., Tait, J. R., Rogers, K. E., López-Causapé, C., Lee, W. L., Shackleford, D. M., Nation, R. L., Oliver, A. & Landersdorfer, C. B., Oct 2024, In: Clinical Microbiology and Infection. 30, 10, p. 1276-1283 8 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Centre for Drug Candidate Optimisation
Shackleford, D. (Member)
30 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries