Projects per year
Personal profile
Biography
David Shackleford leads the Biopharmaceutics section of the Centre for Drug Candidate Optimisation (CDCO). He completed his studies at the University of South Australia before moving to Melbourne to undertake a post-doctoral position with Professor Christopher Porter and Professor Susan Charman in the Department of Pharmaceutics, Monash University. David specialises in pharmacokinetics and drug metabolism within the area of ADME lead optimisation. In 2003, he joined the CDCO. David's role focusses on activities as they relate to the classification of novel compounds PK/ADME properties. Outside of work he enjoys various interests including racing bicycles, flying gliders, building model aircraft and swing dancing.
Research interests
Pharmacokinetics, drug metabolism and ADME lead optimisation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Discovery of New Antimalarials with a Novel Mechanism of Action and Irresistible Target
Giannangelo, C., Dillon, A., Shackleford, D., Edstein, M., Creek, D., Charman, S., Burrows, J. N., Stupple, P., Gilson, P., Niles, J., Delves, M. & Wittlin, S.
1/01/25 → 31/12/27
Project: Research
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Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure
Ritchie, R., Figtree, G., Qin, C. H., May, L., Nicholls, S., Taylor, A., Yang, J. Y. H., Shackleford, D., Schiattarella, G., Pinto, A., Drummond, G., Horowitz, J. D., Bubb, K., Ng, H. H., Vecchio, L., Nelson, A., Kirkpatrick, C., McDonald, C., Febbraio, M., Vinh, A., Odiba, J., Brown, H. & Stupple, P.
1/02/23 → 31/01/26
Project: Research
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Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction
Ritchie, R., Stupple, P., Qin, C. H., May, L., Vecchio, L., Figtree, G. A., Shackleford, D., Chong, J. J. H., Charman, S. & McDonald, C.
1/01/23 → 31/12/25
Project: Research
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Pharmacokinetic assessment and optimisation of a new therapy for PKD
Smyth, I., Cottle, D., Powell, A., Shackleford, D., Baell, J. & Zhao, Y.
Project: Research
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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
Jörg, M., van der Westhuizen, E. T., Lu, Y., Christopher Choy, K. H., Shackleford, D. M., Khajehali, E., Tobin, A. B., Thal, D. M., Capuano, B., Christopoulos, A., Valant, C. & Scammells, P. J., 5 Oct 2023, In: European Journal of Medicinal Chemistry. 258, 20 p., 115588.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1
Braillard, S., Keenan, M., Breese, K. J., Heppell, J., Abbott, M., Islam, R., Shackleford, D. M., Katneni, K., Crighton, E., Chen, G., Patil, R., Lee, G., White, K. L., Carvalho, S., Wall, R. J., Chemi, G., Zuccotto, F., González, S., Marco, M., Deakyne, J., & 18 others, 13 Dec 2023, In: Science Translational Medicine. 15, 726, 15 p., eadh9902.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus
Martin, A. J., Shackleford, D. M., Charman, S. A., Wagstaff, K. M., Porter, C. J. H. & Jans, D. A., Jul 2023, In: Pharmaceutics. 15, 7, 17 p., 1974.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen
Francisco, A. F., Chen, G., Wang, W., Sykes, M. L., Escudié, F., Scandale, I., Olmo, F., Shackleford, D. M., Zulfiqar, B., Kratz, J. M., Pham, T., Saunders, J., Hu, M., Avery, V. M., Charman, S. A., Kelly, J. M. & Chatelain, E., 27 Sept 2023, In: Frontiers in Tropical Diseases. 4, 11 p., 1254061.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Gummer, J. P. A., Olasz, B., Nambiar, S., Hope, D. E., Casey, T. H., Lee, Y. C. G., Leslie, C., Nealon, G., Shackleford, D. M., Powell, A. K., Grimaldi, M., Balaguer, P., Zemek, R. M., Bosco, A., Piggott, M. J., Vrielink, A., & 2 others, 21 Jan 2022, In: iScience. 25, 1, 27 p., 103571.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Centre for Drug Candidate Optimisation
David Shackleford (Member)
30 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries