20062019
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Research Output 2006 2019

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2019
4 Citations (Scopus)

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
4 Citations (Scopus)

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
6 Citations (Scopus)

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma

Sandham, D. A., Barker, L., Brown, L., Brown, Z., Budd, D., Charlton, S. J., Chatterjee, D., Cox, B. J., Dubois, G., Duggan, N., Hall, E., Hatto, J., Maas, J., Manini, J., Profit, R., Riddy, D., Ritchie, C., Sohal, B., Shaw, D., Stringer, R. & 8 others, Sykes, D. A., Thomas, M. B., Turner, K. L., Watson, S. J., West, R., Willard, E., Williams, G. & Willis, J., 11 May 2017, In : A C S Medicinal Chemistry Letters. 8, 5, p. 582-586 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
25 Citations (Scopus)

Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy

Sykes, D. A., Bradley, M. E., Riddy, D. M., Willard, E., Reilly, J., Miah, A., Bauer, C., Watson, S. J., Sandham, D. A., Dubois, G. & Charlton, S. J., 1 May 2016, In : Molecular Pharmacology. 89, 5, p. 593-605 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
21 Citations (Scopus)

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization

Sykes, D. A., Riddy, D. M., Stamp, C., Bradley, M. E., McGuiness, N., Sattikar, A., Guerini, D., Rodrigues, I., Glaenzel, A., Dowling, M. R., Mullershausen, F. & Charlton, S. J., 2014, In : British Journal of Pharmacology. 171, 21, p. 4797-4807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
9 Citations (Scopus)

Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays

Riddy, D. M., Stamp, C., Sykes, D. A., Charlton, S. J. & Dowling, M. R., Oct 2012, In : British Journal of Pharmacology. 167, 4, p. 868-880 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
20 Citations (Scopus)

A prospective study of isolated human hepatocyte function following liver resection for colorectal liver metastases: The effects of prior exposure to chemotherapy

Hewes, J. C., Riddy, D., Morris, R. W., Woodrooffe, A. J., Davidson, B. R. & Fuller, B., Aug 2006, In : Journal of Hepatology. 45, 2, p. 263-270 8 p.

Research output: Contribution to journalArticleResearchpeer-review