20062019
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Research Output 2006 2019

4 Citations (Scopus)

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Bone marrow transplant from Gpr21-/- mice inhibits the ex vivo migration of mouse immune cells

Riddy, D., 2018.

Research output: Contribution to conferencePosterOther

4 Citations (Scopus)

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma

Sandham, D. A., Barker, L., Brown, L., Brown, Z., Budd, D., Charlton, S. J., Chatterjee, D., Cox, B. J., Dubois, G., Duggan, N., Hall, E., Hatto, J., Maas, J., Manini, J., Profit, R., Riddy, D., Ritchie, C., Sohal, B., Shaw, D., Stringer, R. & 8 others, Sykes, D. A., Thomas, M. B., Turner, K. L., Watson, S. J., West, R., Willard, E., Williams, G. & Willis, J., 11 May 2017, In : A C S Medicinal Chemistry Letters. 8, 5, p. 582-586 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy

Sykes, D. A., Bradley, M. E., Riddy, D. M., Willard, E., Reilly, J., Miah, A., Bauer, C., Watson, S. J., Sandham, D. A., Dubois, G. & Charlton, S. J., 1 May 2016, In : Molecular Pharmacology. 89, 5, p. 593-605 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Isoform-specific bias of histamine H3 receptor agonists

Riddy, D., Cook, A. E., Diepenhorst, N., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R., Charman, W., Sexton, P. M., Christopoulos, A. & Langmead, C., 2016.

Research output: Contribution to conferencePosterOtherpeer-review

21 Citations (Scopus)

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization

Sykes, D. A., Riddy, D. M., Stamp, C., Bradley, M. E., McGuiness, N., Sattikar, A., Guerini, D., Rodrigues, I., Glaenzel, A., Dowling, M. R., Mullershausen, F. & Charlton, S. J., 2014, In : British Journal of Pharmacology. 171, 21, p. 4797-4807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

QAW039, a slowly dissociating CRTh2 antagonist with potential for improved clinical efficacy

Sykes, D. A., Bradley, M. E., Riddy, D., Willard, E., Powell-Herlaar, E., Sandham, D. A., Watson, S. J., Bauer, C., Dubois, G. & Charlton, S. J., 2014. 1 p.

Research output: Contribution to conferenceAbstractOther

Open Access

QAW039, a slowly dissociating CRTh2 antagonist with potential for improved clinical efficacy

Sykes, D. A., Bradley, M. E., Riddy, D., Willard, E., Powell-Herlaar, E., Watson, S. J., Bauer, C., Sandham, D. A., Dubois, G. & Charlton, S. J., 2014. 2 p.

Research output: Contribution to conferencePosterOther

Open Access
File

The emerging importance of receptor kinetics in drug discovery: what goes (k)on must come (k)off

Riddy, D., 2014. 1 p.

Research output: Contribution to conferenceAbstractOther

Use of hemi-equilibrium to determine the dissociation kinetics of histamine H3 receptor antagonists.

Bosnyak, S., Riddy, D., Cook, A. E., Diepenhorst, N., Sexton, P. M., Christopoulos, A. & Langmead, C., 2014. 1 p.

Research output: Contribution to conferencePosterOtherpeer-review

2012

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalisation

Riddy, D., 2012.

Research output: Contribution to conferencePosterOtherpeer-review

9 Citations (Scopus)

Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays

Riddy, D. M., Stamp, C., Sykes, D. A., Charlton, S. J. & Dowling, M. R., Oct 2012, In : British Journal of Pharmacology. 167, 4, p. 868-880 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

S1P3 agonist potency estimates for β-arrestin coupling correlate with binding affinity

Riddy, D., 2010.

Research output: Contribution to conferencePosterOtherpeer-review

2006
20 Citations (Scopus)

A prospective study of isolated human hepatocyte function following liver resection for colorectal liver metastases: The effects of prior exposure to chemotherapy

Hewes, J. C., Riddy, D., Morris, R. W., Woodrooffe, A. J., Davidson, B. R. & Fuller, B., Aug 2006, In : Journal of Hepatology. 45, 2, p. 263-270 8 p.

Research output: Contribution to journalArticleResearchpeer-review