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Research Output 2005 2019

2019

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 othersPrice, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, e0006450.

Research output: Contribution to journalArticleResearchpeer-review

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

Wang, M., Gustafsson, O. J. R., Siddiqui, G., Javed, I., Kelly, H. G., Blin, T., Yin, H., Kent, S. J., Creek, D. J., Kempe, K., Ke, P. C. & Davis, T. P., 21 Jun 2018, In : Nanoscale. 10, 23, p. 10863-10875 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Schneider-Futschik, E. K., Hu, X., Zhou, Q. T., Lin, Y-W., Anderson, D., Creek, D. J., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, In : Computational and Structural Biotechnology Journal. 16, p. 587-599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Li, M., Yu, H. H., Zhou, Z., Creek, D. J., Zhang, J. & Li, J., 16 Nov 2018, In : Frontiers in Microbiology. 9, 12 p., 2776.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

Tjhin, E. T., Spry, C., Sewell, A. L., Hoegl, A., Barnard, L., Sexton, A. E., Siddiqui, G., Howieson, V. M., Maier, A. G., Creek, D. J., Strauss, E., Marquez, R., Auclair, K. & Saliba, K. J., 1 Apr 2018, In : PLoS Pathogens. 14, 4, 30 p., e1006918.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity

Giannangelo, C., Stingelin, L., Yang, T., Tilley, L., Charman, S. A. & Creek, D. J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01566-17.

Research output: Contribution to journalArticleResearchpeer-review

Repurposing cancer drugs – a new perspective for antimalarial drug discovery?

John von Freyend, S., Adderley, J. D., Jackson, S., Burns, A. L., Ruether, A., Sexton, A., Creek, D., Wood, B., Wilson, D. & Doerig, C., 3 Jul 2018.

Research output: Contribution to conferencePosterOther

Synergistic killing of polymyxin B in combination with the antineoplastic drug mitotane against polymyxin-susceptible and -resistant Acinetobacter baumannii: A metabolomic study

Tran, T. B., Bergen, P. J., Creek, D. J., Velkov, T. & Li, J., 16 Apr 2018, In : Frontiers in Pharmacology. 9, 14 p., 359.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

Alzahrani, K. J. H., Ali, J. A. M., Eze, A. A., Looi, W. L., Tagoe, D. N. A., Creek, D. J., Barrett, M. P. & De Koning, H. P., 1 Aug 2017, In : International Journal for Parasitology: Drugs and Drug Resistance. 7, 2, p. 206-226 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia

Murray, G. L., Tsyganov, K., Kostoulias, X. P., Bulach, D. M., Powell, D., Creek, D. J., Boyce, J. D., Paulsen, I. T. & Peleg, A. Y., 15 Feb 2017, In : Journal of Infectious Diseases. 215, 1, p. S52-S57

Research output: Contribution to journalArticleResearchpeer-review

Metabolomics-based elucidation of active metabolic pathways in erythrocytes and HSC-derived reticulocytes

Srivastava, A., Evans, K. J., Sexton, A. E., Schofield, L. D. & Creek, D. J., 7 Apr 2017, In : Journal of Proteome Research. 16, 4, p. 1492-1505 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin-resistant Plasmodium falciparum

Siddiqui, G., Srivastava, A., Russell, A. S. & Creek, D. J., 1 May 2017, In : Journal of Infectious Diseases. 215, 9, p. 1435-1444 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles

Wang, M., Siddiqui, G., Gustafsson, O. J. R., Käkinen, A., Javed, I., Voelcker, N. H., Creek, D. J., Ke, P. C. & Davis, T. P., 27 Sep 2017, In : Small. 13, 36, 1701528.

Research output: Contribution to journalArticleResearchpeer-review

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

Counihan, N. A., Chisholm, S. A., Bullen, H. E., Srivastava, A., Sanders, P. R., Jonsdottir, T. K., Weiss, G. E., Ghosh, S., Crabb, B. S., Creek, D. J., Gilson, P. R. & De Koning-Ward, T. F., 2 Mar 2017, In : eLife. 6, 31 p., e23217.

Research output: Contribution to journalArticleResearchpeer-review

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Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

Mwenechanya, R., Kovářová, J., Dickens, N. J., Manikhandan, M., Herzyk, P., Vincent, I. M., Weidt, S. K., Burgess, K. E., Burchmore, R. J. S., Pountain, A. W., Smith, T. K., Creek, D. J., Kim, D-H., Lepesheva, G. I. & Barrett, M. P., 16 Jun 2017, In : PLoS Neglected Tropical Diseases. 11, 6, 21 p., e0005649.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

Mahamad Maifiah, M. H., Creek, D. J., Nation, R. L., Forrest, A., Tsuji, B. T., Velkov, T. & Li, J., 30 Mar 2017, In : Scientific Reports. 7, 12 p., 45527.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis

Bhuiyan, M. S., Ellett, F., Murray, G. L., Kostoulias, X., Cerqueira, G. M., Schulze, K. E., Mahamad Maifiah, M. H., Li, J., Creek, D. J., Lieschke, G. J. & Peleg, A. Y., 23 Aug 2016, In : Proceedings of the National Academy of Sciences. 113, 34, p. 9599-9604 6 p., 1523116113.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

An oncogenic role for sphingosine kinase 2

Neubauer, H. A., Pham, D. H., Zebol, J. R., Moretti, P. A. B., Peterson, A. L., Leclercq, T. M., Chan, H., Powell, J. A., Pitman, M. R., Samuel, M. S., Bonder, C. S., Creek, D. J., Gliddon, B. L. & Pitson, S. M., 2016, In : Oncotarget. 7, 40, p. 64886-64899 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

Tran, T. B., Cheah, S-E., Yu, H. H., Bergen, P. J., Nation, R. L., Creek, D. J., Purcell, A., Forrest, A., Doi, Y., Song, J., Velkov, T. & Li, J., 1 Jun 2016, In : Journal of Antibiotics. 69, 6, p. 415-421 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strains

Yang, T., Xie, S. C., Cao, P., Giannangelo, C., McCaw, J., Creek, D. J., Charman, S. A., Klonis, N. & Tilley, L., 1 Aug 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4501-4510 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic dysregulation induced in Plasmodium falciparum by dihydroartemisinin and other front-line antimalarial drugs

Cobbold, S. A., Chua, H. H., Nijagal, B., Creek, D. J., Ralph, S. A. & McConville, M. J., 15 Jan 2016, In : Journal of Infectious Diseases. 213, 2, p. 276-286 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J., 1 Jul 2016, In : Metabolomics. 12, 7, 14 p., 126.

Research output: Contribution to journalArticleResearchpeer-review

Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action

Creek, D. J., Chua, H. H., Cobbold, S. A., Nijagal, B., MacRae, J. I., Dickerman, B. K., Gilson, P. R., Ralph, S. A. & McConville, M. J., 1 Nov 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6650-6663 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Optimized method for untargeted metabolomics analysis of MDA-MB-231 breast cancer cells

Peterson, A. L., Walker, A. K., Sloan, E. K. & Creek, D. J., 1 Dec 2016, In : Metabolites. 6, 4, 16 p., 30.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria

Tchaparian, E., Sambol, N. C., Arinaitwe, E., McCormack, S. A., Bigira, V., Wanzira, H., Muhindo, M., Creek, D. J., Sukumar, N., Blessborn, D., Tappero, J. W., Kakuru, A., Bergqvist, Y., Aweeka, F. T. & Parikh, S., 15 Oct 2016, In : Journal of Infectious Diseases. 214, 8, p. 1243-1251 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stage-specific changes in Plasmodium metabolism required for differentiation and adaptation to different host and vector environments

Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P., Creek, D. J., McConville, M. J. & Waters, A. P., 27 Dec 2016, In : PLoS Pathogens. 12, 12, e1006094.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Strategies for extending metabolomics studies with stable isotope labelling and fluxomics

Srivastava, A., Kowalski, G. M., Callahan, D. L., Meikle, P. J. & Creek, D. J., 1 Dec 2016, In : Metabolites. 6, 4, 13 p., 32.

Research output: Contribution to journalArticleOtherpeer-review

The Role of Metabolomics in Antiparasitic Drug Discovery

Giannangelo, C. R., Ellis, K. M., Sexton, A. E., Stoessel, D. & Creek, D. J., 5 Aug 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Müller, S., Cerdan, R. & Radulescu, O. (eds.). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, p. 321-342 22 p. (Drug Discovery in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Open Access
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2015

An attenuated total reflection (ATR) and Raman spectroscopic investigation into the effects of chloroquine on Plasmodium falciparum-infected red blood cells

Kozicki, M., Creek, D. J., Sexton, A., Morahan, B. J., Weselucha-Birczynska, A. & Wood, B. R., 2015, In : The Analyst. 140, 7, p. 2236 - 2246 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool

Trochine, A., Creek, D. J., Faral Tello, M. P., Barrett, M. P. & Robello, C., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 5, p. 2921 - 2925 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P., McConville, M. J. & Waters, A. P., 2015, In : PLoS Pathogens. 11, 6, p. 1-22 22 p., e1004882.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolomics continues to expand: highlights from the 2015 metabolomics conference

Fiehn, O., Putri, S. P., Saito, K., Salek, R. M. & Creek, D. J., 13 Aug 2015, In : Metabolomics. 11, 5, p. 1036-1040 5 p.

Research output: Contribution to journalArticleOtherpeer-review

Population pharmacokinetics of piperaquine in Young Ugandan Children treated with dihydroartemisinin-piperaquine for uncomplicated malaria

Sambol, N. C., Yan, L., Creek, D. J., McCormack, S. A., Arinaitwe, E., Bigira, V., Wanzira, H., Kakuru, A., Tappero, J. W., Lindegardh, N., Tarning, J., Nosten, F., Aweeka, F. T. & Parikh, S., 1 Jul 2015, In : Clinical Pharmacology and Therapeutics. 98, 1, p. 87-95 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione

Alkhaldi, A. A. M., Creek, D. J., Ibrahim, H., Kim, D-H., Quashie, N. B., Burgess, K., Changtam, C., Barrett, M. P., Suksamrarn, A. & De Koning, H. P., 2015, In : Molecular Pharmacology. 87, 3, p. 451 - 464 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Creek, D. J., Mazet, M., Achcar, F., Anderson, J. S., Kim, D-H., Kamour, R., Morand, P., Millerioux, Y., Biran, M., Kerkhoven, E. J., Chokkathukalam, A., Weidt, S. K., Burgess, K., Breitling, R., Watson, D. G., Bringaud, F. & Barrett, M. P., 2015, In : PLoS Pathogens. 11, 3, 25 p., e1004689.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Butikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., De Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 othersGinger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Maser, P., Michels, P. A. M., Nayak, A., Nes, W. D., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

What role can metabolomics play in the discovery and development of new medicines for infectious diseases?

Kim, D-H. & Creek, D. J., 2015, In : Bioanalysis. 7, 6, p. 629 - 631 3 p.

Research output: Contribution to journalLetterOther

2014

BCKDH: The missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei

Oppenheim, R. D., Creek, D. J., MacRae, J. I., Modrzynska, K. K., Pino, P., Limenitakis, J., Polonais, V., Seeber, F., Barrett, M. P., Billker, O., McConville, M. J. & Soldati-Favre, D., 2014, In : PLoS Pathogens. 10, 7, 18 p., e1004263.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

Trochine, A., Creek, D. J., Faral Tello, M. P., Barrett, M. P. & Robello, C., 2014, In : PLoS Neglected Tropical Diseases. 8, 5, 15 p., e2844.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Determination of antiprotozoal drug mechanisms by metabolomics approaches

Creek, D. J. & Barrett, M. P., 2014, In : Parasitology. 141, 1, p. 83 - 92 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Metabolite identification: Are you sure? And how do your peers gauge your confidence?

Creek, D. J., Dunn, W. B., Fiehn, O., Griffin, J. L., Hall, R. D., Lei, Z., Mistrik, R., Neumann, S., Schymanski, E. L., Sumner, L. W., Trengove, R. D. & Wolfender, J-L., 2014, In : Metabolomics. 10, 3, p. 350 - 353 4 p.

Research output: Contribution to journalLetterOther

Stable isotope-labeling studies in metabolomics: New insights into structure and dynamics of metabolic networks

Chokkathukalam, A., Kim, D-H., Barrett, M. P., Breitling, R. & Creek, D. J., 2014, In : Bioanalysis. 6, 4, p. 511 - 524 14 p.

Research output: Contribution to journalArticleResearchpeer-review