Personal profile

Biography

Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com

Biography...

Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.

 

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Research interests

Metabolomics

Systems Pharmacology

Parasitology

- Malaria

- Human African Trypanosomiasis

Infectious Diseases

Drug Discovery

Community service

2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com

Clinical activities

Community Pharmacist, Tambassis Pharmacy, Brunswick

Keywords

  • Malaria
  • Metabolism
  • Parasitology
  • Pharmaceutics
  • Pharmacology
  • Systems Pharmacology
  • Tropical Medicine
  • Metabolomics
  • Proteomics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2021

Research Output 2005 2017

Metabolomics-based elucidation of active metabolic pathways in erythrocytes and HSC-derived reticulocytes

Srivastava, A., Evans, K. J., Sexton, A. E., Schofield, L. D. & Creek, D. J. 7 Apr 2017 In : Journal of Proteome Research. 16, 4, p. 1492-1505 14 p.

Research output: Contribution to journalArticle

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

Counihan, N. A., Chisholm, S. A., Bullen, H. E., Srivastava, A., Sanders, P. R., Jonsdottir, T. K., Weiss, G. E., Ghosh, S., Crabb, B. S., Creek, D. J., Gilson, P. R. & De Koning-Ward, T. F. 2 Mar 2017 In : eLife. 6, 31 p., e23217

Research output: Contribution to journalArticle

File

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

Mahamad Maifiah, M. H., Creek, D. J., Nation, R. L., Forrest, A., Tsuji, B. T., Velkov, T. & Li, J. 30 Mar 2017 In : Scientific Reports. 7, 12 p., 45527

Research output: Contribution to journalArticle

Open Access
File

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis

Bhuiyan, M. S., Ellett, F., Murray, G. L., Kostoulias, X., Cerqueira, G. M., Schulze, K. E., Mahamad Maifiah, M. H., Li, J., Creek, D. J., Lieschke, G. J. & Peleg, A. Y. 23 Aug 2016 In : Proceedings of the National Academy of Sciences. 113, 34, p. 9599-9604 6 p., 1523116113

Research output: Contribution to journalArticle

Open Access

Activities 2013 2013

  • 1 Membership of an advisory panel/policy group/ board

Metabolomics Society (External organisation)

Creek, D. J. (Member)
1 Oct 201330 Sep 2015

Activity: Membership of an advisory panel/policy group/ board