Projects per year
Personal profile
Biography
Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).
Further information can be found at www.creek-lab.com
Biography...
Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
Related Links:
Research interests
Metabolomics
Systems Pharmacology
Parasitology
- Malaria
- Human African Trypanosomiasis
Infectious Diseases
Drug Discovery
Community service
2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com
Clinical activities
Community Pharmacist, Tambassis Pharmacy, Brunswick
Keywords
- Malaria
- Metabolism
- Parasitology
- Pharmaceutics
- Pharmacology
- Systems Pharmacology
- Tropical Medicine
- Metabolomics
- Proteomics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2010 2023
New aminobenzimidazole antimalarial agents with a novel mechanism of action
Creek, D., Scammells, P., Ralph, S. A., Norton, R. & Devine, S.
1/01/19 → 31/12/21
Project: Research
Host and Pathogen contributors to Artemisinin Resistance
Creek, D. & Fowkes, F. J. I.
1/01/19 → 31/12/21
Project: Research
Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/23
Project: Research
Probing antimicrobial drug resistance by multimodal molecular analysis
Wood, B., Heraud, P., McNaughton, D., Peleg, A., Doerig, C., Goodacre, R. & Creek, D.
9/05/18 → 31/12/20
Project: Research
Enhancing anti-parasitic drug discovery with metabolomics
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/21
Project: Research
Research Output 2005 2019
3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity
Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.Research output: Contribution to journal › Article › Research › peer-review
Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa
Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria
Giannangelo, C., Fowkes, F. J. I., Simpson, J. A., Charman, S. A. & Creek, D. J., 1 Jul 2019, In : Trends in Parasitology. 35, 7, p. 529-543 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access
File
Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa
Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.Research output: Contribution to journal › Article › Research › peer-review
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, e0006450.Research output: Contribution to journal › Article › Research › peer-review
Activities 2013 2013
- 1 Membership of an advisory panel/policy group/ board
Metabolomics Society (External organisation)
Darren Creek (Member)1 Oct 2013 → 30 Sep 2015
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Press / Media
A$9.8 million fight against superbugs
Jian Li, William Charman, Jiangning Song, Anthony Purcell, Paul Hertzog, Darren Creek, Roger Nation, Jurgen Bullita & John Boyce
24/04/14
1 media contribution
Press/Media: Public Engagement Activities