Projects per year
Personal profile
Biography
Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).
Further information can be found at www.creek-lab.com
Biography...
Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
Related Links:
Research interests
Metabolomics
Systems Pharmacology
Parasitology
- Malaria
- Human African Trypanosomiasis
Infectious Diseases
Drug Discovery
Community service
2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com
Clinical activities
Community Pharmacist, Tambassis Pharmacy, Brunswick
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Malaria
- Metabolism
- Parasitology
- Pharmaceutics
- Pharmacology
- Systems Pharmacology
- Tropical Medicine
- Metabolomics
- Proteomics
Collaborations and top research areas from the last five years
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Drug Target Identification Platform
Creek, D., Avery, V. M., Pitson, S. M., George, A. J., Olechnowicz, S., Baell, J., Schittenhelm, R., Li, J., Langmead, C., Stupple, P., Drinkwater, C., Flynn, B., Brouwer, K., Arndt, G. M. & Newman, S.
30/06/23 → 6/12/28
Project: Research
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Point-of-Site Malaria Detection using a Matchbox Size near Infrared Spectrometer
Mclean, A., Wood, B., Chavchich, M. & Creek, D.
Defence Science Institute (DSI)
13/03/23 → 13/03/25
Project: Research
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Discovery of new metabolic functions in Plasmodium parasites
Australian Research Council (ARC)
1/01/23 → 31/12/26
Project: Research
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The mesenchymal stromal cell paradox – living cell therapy or dying therapeutic cell?
Heng, T., Mueller, S., Poon, I., Naderer, T., Creek, D. & Nagy, A.
1/01/22 → 31/12/24
Project: Research
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Understanding the crosstalk between salivary amylase, oral and gut microbiome, as well as host metabolome in intestinal inflammation and their association with obesity and overweight in Malaysia
Chun Wie, C., Rahman, S., Siew Hua, G., Su, T. T., Ayub, Q. & Creek, D.
1/11/20 → 31/10/23
Project: Research
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The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity
Ruparelia, A. A., Salavaty, A., Barlow, C. K., Lu, Y., Sonntag, C., Hersey, L., Eramo, M. J., Krug, J., Reuter, H., Schittenhelm, R. B., Ramialison, M., Cox, A., Ryan, M. T., Creek, D. J., Englert, C. & Currie, P. D., May 2023, (Accepted/In press) In: Aging Cell. 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome
Siddiqui, G., De Paoli, A., MacRaild, C. A., Sexton, A. E., Boulet, C., Shah, A. D., Batty, M. B., Schittenhelm, R. B., Carvalho, T. G. & Creek, D. J., 7 Mar 2022, In: GigaScience. 11, 17 p., giac008.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Bio-Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity
Mehta, A., Desai, A., Rudd, D., Siddiqui, G., Nowell, C. J., Tong, Z., Creek, D. J., Tayalia, P., Gandhi, P. S. & Voelcker, N. H., 2022, (Accepted/In press) In: Advanced Biology. 6, 12, 16 p., 2200152.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites
Liffner, B., Balbin, J. M., Shami, G. J., Siddiqui, G., Strauss, J., Frölich, S., Heinemann, G. K., Edwards, E. M., Alder, A., Wichers, J. S., Creek, D. J., Tilley, L., Dixon, M. W. A., Gilberger, T. W. & Wilson, D. W., Dec 2022, In: Communications Biology. 5, 1, 17 p., 121.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia
Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., Wallington-Beddoe, C. T., Moretti, P. A. B., Anderson, D., Creek, D. J., Costabile, M., Ali, S. R., Thompson-Peach, C. A. L., Dredge, B. K., Bert, A. G., Goodall, G. J., Ekert, P. G., Brown, A. L., D'Andrea, R., Robinson, N., & 6 others , 30 Jun 2022, In: Blood. 139, 26, p. 3737-3751 15 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)
Prizes
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Australian Synchrotron
Siddiqui, Ghizal (Recipient), Creek, Darren (Recipient) & Wood, Bayden (Recipient), 2021
Prize: Prize (including medals and awards)
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Faculty Seed Grant, Monash Uni Faculty of Pharmacy and Pharmaceuticals Sciences
Siddiqui, Ghizal (Recipient), Creek, Darren (Recipient) & Devine, Shane (Recipient), 2017
Prize: Prize (including medals and awards)
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Metabolomics Society (External organisation)
Darren Creek (Member)
1 Oct 2013 → 30 Sept 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Medicines for Malaria Venture (MMV) (External organisation)
Jonathan Vennerstrom (Inventor), Yuxiang Dong (Inventor), Susan Ann Charman (Inventor), Sergio Wittlin (Inventor), Jacques Chollet (Inventor), Darren J. Creek (Inventor), Xiaofang Wang (Inventor), Kamaraj Sriraghavan (Inventor), Lin Zhou (Inventor), Hugues Matile (Inventor) & William N. Charman (Inventor)
29 Nov 2011Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press/Media
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A$9.8 million fight against superbugs
Jian Li, William Neil Charman, Jiangning Song, Anthony Wayne Purcell, Paul John Hertzog, Darren John Creek, Roger Leigh Nation, Jurgen Bullita & John Dallas Boyce
24/04/14
1 Media contribution
Press/Media: Public Engagement Activities