Darren Creek

Assoc Professor


Research activity per year

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Personal profile


Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com


Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.


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Research interests


Systems Pharmacology


- Malaria

- Human African Trypanosomiasis

Infectious Diseases

Drug Discovery

Community service

2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com

Clinical activities

Community Pharmacist, Tambassis Pharmacy, Brunswick

Research area keywords

  • Malaria
  • Metabolism
  • Parasitology
  • Pharmaceutics
  • Pharmacology
  • Systems Pharmacology
  • Tropical Medicine
  • Metabolomics
  • Proteomics


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