Projects per year
Personal profile
Biography
Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).
Further information can be found at www.creek-lab.com
Biography...
Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
Related Links:
Research interests
Metabolomics
Systems Pharmacology
Parasitology
- Malaria
- Human African Trypanosomiasis
Infectious Diseases
Drug Discovery
Community service
2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com
Clinical activities
Community Pharmacist, Tambassis Pharmacy, Brunswick
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Malaria
- Metabolism
- Parasitology
- Pharmaceutics
- Pharmacology
- Systems Pharmacology
- Tropical Medicine
- Metabolomics
- Proteomics
Network
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The mesenchymal stromal cell paradox – living cell therapy or dying therapeutic cell?
Heng, T., Mueller, S., Poon, I., Naderer, T., Creek, D. & Nagy, A.
1/01/22 → 31/12/24
Project: Research
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Understanding the crosstalk between salivary amylase, oral and gut microbiome, as well as host metabolome in intestinal inflammation and their association with obesity and overweight in Malaysia
Chun Wie, C., Rahman, S., Siew Hua, G., Su, T. T., Ayub, Q. & Creek, D.
1/11/20 → 31/10/23
Project: Research
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Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Systems biology-augmented, stem cell-derived, multi-tissue panel for rapid screening of approved drugs as potential COVID-19 treatments
Vasan, S., Godde, N., O'Brien, C., Balasubramanian, N. S., Beale, D., Athan, E., Blasdell, K., Chandra, R., Wilson, L., Kumar, A., Creek, D., Trevaskis, N. & Kirkpatrick, C.
8/01/21 → 8/01/22
Project: Research
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New aminobenzimidazole antimalarial agents with a novel mechanism of action
Creek, D., Scammells, P., Ralph, S. A., Norton, R. & Devine, S.
1/01/19 → 31/12/21
Project: Research
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Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination
Han, M-L., Nang, S. C., Lin, Y-W., Zhu, Y., Yu, H. H., Wickremasinghe, H., Barlow, C. K., Creek, D. J., Crawford, S., Rao, G., Dai, C., Barr, J. J., Chan, K., Turner Schooley, R., Velkov, T. & Li, J., 2022, In: Computational and Structural Biotechnology Journal. 20, p. 485-495 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema
Ishaq, M., Bandara, N., Morgan, S., Nowell, C., Mehdi, A. M., Lyu, R., McCarthy, D., Anderson, D., Creek, D. J., Achen, M. G., Shayan, R. & Karnezis, T., Mar 2022, In: International Journal of Obesity. 46, 3, p. 502-514 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells
Siddiqui, G., Giannangelo, C., De Paoli, A., Schuh, A. K., Heimsch, K. C., Anderson, D., Brown, T. G., Macraild, C. A., Wu, J., Wang, X., Dong, Y., Vennerstrom, J. L., Becker, K. & Creek, D. J., 14 Jan 2022, In: ACS Infectious Diseases. 8, 1, p. 210-226 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition
Bennett, M. K., Li, M., Tea, M. N., Pitman, M. R., Toubia, J., Wang, P. P. S., Anderson, D., Creek, D. J., Orlowski, R. Z., Gliddon, B. L., Powell, J. A., Wallington-Beddoe, C. T. & Pitson, S. M., Jan 2022, In: Neoplasia. 24, 1, p. 1-11 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
Pitman, M. R., Lewis, A. C., Davies, L. T., Moretti, P. A. B., Anderson, D., Creek, D. J., Powell, J. A. & Pitson, S. M., Dec 2022, In: Scientific Reports. 12, 1, 12 p., 454.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
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Metabolomics Society (External organisation)
Darren Creek (Member)
1 Oct 2013 → 30 Sep 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Medicines for Malaria Venture (MMV) (External organisation)
Jonathan Vennerstrom (Inventor), Yuxiang Dong (Inventor), Susan Ann Charman (Inventor), Sergio Wittlin (Inventor), Jacques Chollet (Inventor), Darren J. Creek (Inventor), Xiaofang Wang (Inventor), Kamaraj Sriraghavan (Inventor), Lin Zhou (Inventor), Hugues Matile (Inventor) & William N. Charman (Inventor)
29 Nov 2011Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press / Media
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A$9.8 million fight against superbugs
Jian Li, William Neil Charman, Jiangning Song, Anthony Wayne Purcell, Paul John Hertzog, Darren John Creek, Roger Leigh Nation, Jurgen Bullita & John Dallas Boyce
24/04/14
1 Media contribution
Press/Media: Public Engagement Activities