Projects per year
Personal profile
Biography
Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).
Further information can be found at www.creek-lab.com
Biography...
Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
Related Links:
Research interests
Metabolomics
Systems Pharmacology
Parasitology
- Malaria
- Human African Trypanosomiasis
Infectious Diseases
Drug Discovery
Community service
2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com
Clinical activities
Community Pharmacist, Tambassis Pharmacy, Brunswick
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Malaria
- Metabolism
- Parasitology
- Pharmaceutics
- Pharmacology
- Systems Pharmacology
- Tropical Medicine
- Metabolomics
- Proteomics
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A Novel Drug Treatment for Fibrotic Disease
Flynn, B. (Primary Chief Investigator (PCI)), Pitson, S. (Chief Investigator (CI)) & Creek, D. (Chief Investigator (CI))
20/06/25 → 19/06/26
Project: Research
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The molecular basis of rapid cellular replication in the malaria parasite
Creek, D. (Primary Chief Investigator (PCI)) & Wilson, D. W. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University – Internal School Contribution
1/05/25 → 30/04/28
Project: Research
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Discovery of New Antimalarials with a Novel Mechanism of Action and Irresistible Target
Giannangelo, C. (Primary Chief Investigator (PCI)), Dillon, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Edstein, M. (Chief Investigator (CI)), Creek, D. (Associate Investigator (AI)), Charman, S. (Associate Investigator (AI)), Burrows, J. N. (Associate Investigator (AI)), Stupple, P. (Associate Investigator (AI)), Gilson, P. (Associate Investigator (AI)), Niles, J. (Associate Investigator (AI)), Delves, M. (Associate Investigator (AI)) & Wittlin, S. (Associate Investigator (AI))
1/01/25 → 31/12/27
Project: Research
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Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism
Xie, S. (Primary Chief Investigator (PCI)), Creek, D. (Sponsor) & Owens, N. (Sponsor)
ARC - Australian Research Council, Monash University – Internal School Contribution
25/09/23 → 24/09/26
Project: Research
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Drug Target Identification Platform
Creek, D. (Primary Chief Investigator (PCI)), Avery, V. M. (Chief Investigator (CI)), Pitson, S. M. (Chief Investigator (CI)), George, A. J. (Chief Investigator (CI)), Olechnowicz, S. (Chief Investigator (CI)), Baell, J. (Chief Investigator (CI)), Schittenhelm, R. (Chief Investigator (CI)), Li, J. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Stupple, P. (Chief Investigator (CI)), Drinkwater, C. (Chief Investigator (CI)), Flynn, B. (Chief Investigator (CI)), Brouwer, K. (Chief Investigator (CI)), Arndt, G. (Chief Investigator (CI)) & Newman, S. (Chief Investigator (CI))
Department of Health and Aged Care (Australia)
30/06/23 → 6/12/28
Project: Research
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Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii
Han, M.-L. (Leading Author), Alsaadi, Y., Zhao, J., Zhu, Y., Lu, J., Jiang, X., Ma, W., Patil, N. A., Dunstan, R. A., Le Brun, A. P., Wickremasinghe, H., Hu, X., Wu, Y., Yu, H. H., Wang, J., Barlow, C. K., Bergen, P. J., Shen, H.-H., Lithgow, T. & Creek, D. J. & 2 others, , 23 Jul 2024, In: Cell Reports. 43, 7, 21 p., 114410.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
Giannangelo, C., Challis, M. P., Siddiqui, G., Edgar, R., Malcolm, T. R., Webb, C. T., Drinkwater, N., Vinh, N., Macraild, C., Counihan, N., Duffy, S., Wittlin, S., Devine, S. M., Avery, V. M., De Koning-Ward, T., Scammells, P., McGowan, S. & Creek, D. J., 8 Jul 2024, In: eLife. 13, 32 p., RP92990.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Correction to: The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate (The EMBO Journal, (2024), 10.1038/s44318-024-00100-w)
Bhattacharjee, P., Wang, D., Anderson, D., Buckler, J. N., de Geus, E., Yan, F., Polekhina, G., Schittenhelm, R., Creek, D. J., Harris, L. D. & Sadler, A. J., 2024, In: EMBO Journal. 43, 1 p., 3084.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
High-fat feeding drives the intestinal production and assembly of C16:0 ceramides in chylomicrons
Mah, M. S. M., Cao, E., Anderson, D., Escott, A., Tegegne, S., Gracia, G., Schmitz, J., Brodesser, S., Zaph, C., Creek, D. J., Hong, J., Windsor, J. A., Phillips, A. R., Trevaskis, N. L., Febbraio, M. A. & Turpin-Nolan, S. M., 23 Aug 2024, In: Science Advances. 10, 34, 14 p., eadp2254.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa
Tait, J. R., Anderson, D., Nation, R. L., Creek, D. J. & Landersdorfer, C. B., Apr 2024, In: Antimicrobial Agents and Chemotherapy. 68, 4, p. 1-14 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Prizes
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Australian Synchrotron
Siddiqui, G. (Recipient), Creek, D. (Recipient) & Wood, B. (Recipient), 2021
Prize: Prize (including medals and awards)
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Faculty Seed Grant, Monash Uni Faculty of Pharmacy and Pharmaceuticals Sciences
Siddiqui, G. (Recipient), Creek, D. (Recipient) & Devine, S. (Recipient), 2017
Prize: Prize (including medals and awards)
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Metabolomics Society (External organisation)
Creek, D. (Member)
1 Oct 2013 → 30 Sept 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Medicines for Malaria Venture (MMV) (External organisation)
Vennerstrom, J. (Inventor), Dong, Y. (Inventor), Charman, S. A. (Inventor), Wittlin, S. (Inventor), Chollet, J. (Inventor), Creek, D. J. (Inventor), Wang, X. (Inventor), Sriraghavan, K. (Inventor), Zhou, L. (Inventor), Matile, H. (Inventor) & Charman, W. N. (Inventor)
29 Nov 2011Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press/Media
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A$9.8 million fight against superbugs
Li, J., Charman, W. N., Song, J., Purcell, A. W., Hertzog, P. J., Creek, D. J., Nation, R. L., Bullita, J. & Boyce, J. D.
24/04/14
1 Media contribution
Press/Media: Public Engagement Activities