Research output per year

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Personal profile


Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com


Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.


Related Links:

Research interests


Systems Pharmacology


- Malaria

- Human African Trypanosomiasis

Infectious Diseases

Drug Discovery

Community service

2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com

Clinical activities

Community Pharmacist, Tambassis Pharmacy, Brunswick

Research area keywords

  • Malaria
  • Metabolism
  • Parasitology
  • Pharmaceutics
  • Pharmacology
  • Systems Pharmacology
  • Tropical Medicine
  • Metabolomics
  • Proteomics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Research Output

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Zhou, Q. T., Lin, Y-W., Hancock, R. E. W., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., 2020, (Accepted/In press) In : Antimicrobial Agents and Chemotherapy. 64, 1, e01587-19.

Research output: Contribution to journalArticleResearchpeer-review

Multi-omic characterization of the mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum

Birrell, G. W., Challis, M. P., de Paoli, A., Anderson, D., Devine, S. M., Heffernan, G. D., Jacobus, D. P., Edstein, M. D., Siddiqui, G. & Creek, D. J., 1 Feb 2020, In : Molecular and Cellular Proteomics. 19, 2, p. 308-325 18 p.

Research output: Contribution to journalArticleResearchpeer-review

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Comparative metabolomics reveals key pathways associated with the synergistic killing of colistin and sulbactam combination against multidrug-resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Creek, D. J., Barlow, C. K., Yu, H. H., Zhou, Z., Zhang, J. & Li, J., 4 Jul 2019, In : Frontiers in Pharmacology. 10, 11 p., 754.

Research output: Contribution to journalArticleResearchpeer-review

Open Access


  • 1 Membership of an advisory panel/policy group/ board

Metabolomics Society (External organisation)

Darren Creek (Member)
1 Oct 201330 Sep 2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Press / Media