Projects per year
Personal profile
Biography
Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).
Further information can be found at www.creek-lab.com
Biography...
Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.
Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.
Related Links:
Research interests
Metabolomics
Systems Pharmacology
Parasitology
- Malaria
- Human African Trypanosomiasis
Infectious Diseases
Drug Discovery
Community service
2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com
Clinical activities
Community Pharmacist, Tambassis Pharmacy, Brunswick
Research area keywords
- Malaria
- Metabolism
- Parasitology
- Pharmaceutics
- Pharmacology
- Systems Pharmacology
- Tropical Medicine
- Metabolomics
- Proteomics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.
National Health & Medical Research Council (NHMRC)
1/01/20 → 31/12/24
Project: Research
Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/23
Project: Research
New aminobenzimidazole antimalarial agents with a novel mechanism of action
Creek, D., Scammells, P., Ralph, S. A., Norton, R. & Devine, S.
1/01/19 → 31/12/21
Project: Research
Host and Pathogen contributors to Artemisinin Resistance
Creek, D. & Fowkes, F. J. I.
1/01/19 → 31/12/21
Project: Research
Probing antimicrobial drug resistance by multimodal molecular analysis
Wood, B., Heraud, P., McNaughton, D., Peleg, A., Doerig, C., Goodacre, R. & Creek, D.
1/01/18 → 31/12/20
Project: Research
Research Output
Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa
Hussein, M., Han, M-L., Zhu, Y., Zhou, Q. T., Lin, Y-W., Hancock, R. E. W., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., 2020, (Accepted/In press) In : Antimicrobial Agents and Chemotherapy. 64, 1, e01587-19.Research output: Contribution to journal › Article › Research › peer-review
Multi-omic characterization of the mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum
Birrell, G. W., Challis, M. P., de Paoli, A., Anderson, D., Devine, S. M., Heffernan, G. D., Jacobus, D. P., Edstein, M. D., Siddiqui, G. & Creek, D. J., 1 Feb 2020, In : Molecular and Cellular Proteomics. 19, 2, p. 308-325 18 p.Research output: Contribution to journal › Article › Research › peer-review
3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity
Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, , 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.Research output: Contribution to journal › Article › Research › peer-review
1
Citation
(Scopus)
Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa
Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
4
Citations
(Scopus)
Comparative metabolomics reveals key pathways associated with the synergistic killing of colistin and sulbactam combination against multidrug-resistant Acinetobacter baumannii
Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Creek, D. J., Barlow, C. K., Yu, H. H., Zhou, Z., Zhang, J. & Li, J., 4 Jul 2019, In : Frontiers in Pharmacology. 10, 11 p., 754.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Activities
- 1 Membership of an advisory panel/policy group/ board
Metabolomics Society (External organisation)
Darren Creek (Member)1 Oct 2013 → 30 Sep 2015
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Press / Media
A$9.8 million fight against superbugs
Jian Li, William Neil Charman, Jiangning Song, Anthony Wayne Purcell, Paul John Hertzog, Darren John Creek, Roger Leigh Nation, Jurgen Bullita & John Dallas Boyce
24/04/14
1 Media contribution
Press/Media: Public Engagement Activities