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Personal profile

Biography

Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com

Biography...

Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.

 

Related Links:

Research interests

Metabolomics

Systems Pharmacology

Parasitology

- Malaria

- Human African Trypanosomiasis

Infectious Diseases

Drug Discovery

Community service

2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com

Clinical activities

Community Pharmacist, Tambassis Pharmacy, Brunswick

Keywords

  • Malaria
  • Metabolism
  • Parasitology
  • Pharmaceutics
  • Pharmacology
  • Systems Pharmacology
  • Tropical Medicine
  • Metabolomics
  • Proteomics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2023

Research Output 2005 2019

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

Wang, M., Gustafsson, O. J. R., Siddiqui, G., Javed, I., Kelly, H. G., Blin, T., Yin, H., Kent, S. J., Creek, D. J., Kempe, K., Ke, P. C. & Davis, T. P., 21 Jun 2018, In : Nanoscale. 10, 23, p. 10863-10875 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Schneider-Futschik, E. K., Hu, X., Zhou, Q. T., Lin, Y-W., Anderson, D., Creek, D. J., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, In : Computational and Structural Biotechnology Journal. 16, p. 587-599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Li, M., Yu, H. H., Zhou, Z., Creek, D. J., Zhang, J. & Li, J., 16 Nov 2018, In : Frontiers in Microbiology. 9, 12 p., 2776.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2013 2013

  • 1 Membership of an advisory panel/policy group/ board

Metabolomics Society (External organisation)

Darren Creek (Member)
1 Oct 201330 Sep 2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Press / Media

A$9.8 million fight against superbugs

Jian Li, William Charman, Jiangning Song, Anthony Purcell, Paul Hertzog, Darren Creek, Roger Nation, Jurgen Bullita & John Boyce

24/04/14

1 media contribution

Press/Media: Public Engagement Activities