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Personal profile

Biography

Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com

Biography...

Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.

 

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Research interests

Metabolomics

Systems Pharmacology

Parasitology

- Malaria

- Human African Trypanosomiasis

Infectious Diseases

Drug Discovery

Community service

2008 - Orphan education and community health education in Uganda. Let the Needy Smile: www.lettheneedysmile.com

Clinical activities

Community Pharmacist, Tambassis Pharmacy, Brunswick

Keywords

  • Malaria
  • Metabolism
  • Parasitology
  • Pharmaceutics
  • Pharmacology
  • Systems Pharmacology
  • Tropical Medicine
  • Metabolomics
  • Proteomics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2023

Research Output 2005 2019

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 othersPrice, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

Giannangelo, C., Fowkes, F. J. I., Simpson, J. A., Charman, S. A. & Creek, D. J., 1 Jul 2019, In : Trends in Parasitology. 35, 7, p. 529-543 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Steketee, P. C., Vincent, I. M., Achcar, F., Giordani, F., Kim, D. H., Creek, D. J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M. C., MacLeod, A. & Barrett, M. P., 14 May 2018, In : PLoS Neglected Tropical Diseases. 12, 5, e0006450.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2013 2013

  • 1 Membership of an advisory panel/policy group/ board

Metabolomics Society (External organisation)

Darren Creek (Member)
1 Oct 201330 Sep 2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Press / Media

A$9.8 million fight against superbugs

Jian Li, William Charman, Jiangning Song, Anthony Purcell, Paul Hertzog, Darren Creek, Roger Nation, Jurgen Bullita & John Boyce

24/04/14

1 media contribution

Press/Media: Public Engagement Activities