Darren Creek

Personal profile

Biography

Dr Creek uses advanced metabolomics and systems pharmacology approaches to investigate microbial pathogens and facilitate the discovery of new medicines for infectious diseases including malaria and sleeping sickness (human African trypanosomiasis).

Further information can be found at www.creek-lab.com

Biography...

Darren completed his PhD in pharmaceutics at MIPS with Profs Sue and Bill Charman studying the mechanisms of action and clearance for novel antimalarial drugs, and followed this with first-hand experience of tropical disease research, working in a clinical trial for antimalarials in rural Uganda. He has post-doctoral experience in pre-clinical drug discovery at the Centre for Drug Candidate Optimisation, Monash University, and in parasite biochemistry at the Wellcome Centre for Molecular Parasitology at the University of Glasgow. Darren played a major role in the implementation of the Scottish Metabolomics Facility and developed novel analytical methods for metabolomics, including the widely-used metabolomics software, IDEOM. He was recently elected to the board of directors for the international Metabolomics Society.

Darren's current research in the Drug Delivery Disposition and Dynamics theme at MIPS continues to develop novel metabolomics techniques and apply metabolomics to parasitology and pharmacology. This work has recently provided new insights into protozoan parasite metabolism, in vitro culture medium development and mechanisms of action and resistance for drugs against malaria and trypanosomiasis.

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Projects 2010 2023

6 Active
8 Finished

Host and Pathogen contributors to Artemisinin Resistance

Creek, D. & Fowkes, F. J. I.

1/01/19 → 31/12/21

Project: Research

Unravelling the role of type I Interferon family in human infectious and inflammatory diseases

Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

New aminobenzimidazole antimalarial agents with a novel mechanism of action

Creek, D., Scammells, P., Ralph, S. A., Norton, R. & Devine, S.

1/01/19 → 31/12/21

Project: Research

Probing antimicrobial drug resistance by multimodal molecular analysis

Wood, B., Heraud, P., McNaughton, D., Peleg, A., Doerig, C., Goodacre, R. & Creek, D.

9/05/18 → 31/12/20

Project: Research

Enhancing anti-parasitic drug discovery with metabolomics

Creek, D.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/21

Project: Research

Research Output 2005 2019

71 Article
3 Letter
2 Chapter (Book)
2 Poster
2 More
- 1 Abstract
- 1 Editorial

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 othersPrice, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.