Projects per year
Personal profile
Biography
Danika Hill is a Laboratory Head in the Department of Immunology and Pathology, working to understand the cellular and molecular mechanisms that underpin robust responses to vaccination and infection, with a particular interest in T follicular helper cells and the Germinal Centre response. Dr Hill’s research uses multi-disciplinary human clinical cohorts approaches and cutting-edge immunological techniques (high-parameter flow cytometry, single cell RNA and immune repertoire sequencing) to study Group A Streptoccous, malaria and influenza immunity.
Dr Hill studied Biomedical Science at the University of Adelaide, and completed a PhD at the Walter and Eliza Hall Institute of Medical Research. From 2015, Danika was a Postdoc in Dr Michelle Linterman’s group at the Babraham Institute in Cambridge, before joining Monash University in 2020. Danika’s research is supported by an NHMRC CJ Martin Fellowship and a Michelson Prize from the Human Vaccines Project. Dr Hill is an emerging global leader in human immunology, as evidenced by lecturing for Monash University, Swiss Tropical & Public Health Institute, and being selected as a “Rising Star in Immunology” the Norwegian Society for Immunology.
Danika has made several important discoveries about how T follicular helper cells support the germinal centre response to influenza and malaria vaccines (e.g J Exp Med 2019, eLife 2020, eLife 2021), and how immune development in children influences vaccination outcomes (Science Translational Medicine 2020).
Supervision interests
Discovering targets of long-lived humoral immunity for Strep A vaccine design.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- T-cells
- CD4+ T cells
- Vaccine responses
- Cellular mechanisms
Collaborations and top research areas from the last five years
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How environment, competition, and location combine to control plasma cell lifespan
Tarlinton, D., Hawkins, E. & Hill, D.
1/01/25 → 31/12/27
Project: Research
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Structure-based antigen design as a novel strategy for precision mRNA vaccines
Quast, I. (Primary Chief Investigator (PCI)), Buckle, A. (Chief Investigator (CI)), La Gruta, N. (Chief Investigator (CI)), Hill, D. (Chief Investigator (CI)) & Beilharz, T. (Chief Investigator (CI))
15/05/23 → 15/05/25
Project: Research
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Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan
Robinson, M. J., Ding, Z., Dowling, M. R., Hill, D. L., Webster, R. H., McKenzie, C., Pitt, C., O'Donnell, K., Mulder, J., Brodie, E., Hodgkin, P. D., Wong, N. C., Quast, I. & Tarlinton, D. M., 11 Jul 2023, In: Immunity. 56, 7, p. 1596-1612.e4 22 p.Research output: Contribution to journal › Article › Research › peer-review
32 Citations (Scopus) -
Sec22b is a critical and nonredundant regulator of plasma cell maintenance
Bonaud, A., Gargowitsch, L., Gilbert, S. M., Rajan, E., Canales-Herrerias, P., Stockholm, D., Rahman, N. F., Collins, M. O., Taskiran, H., Hill, D. L., Alloatti, A., Alouche, N., Balor, S., Soldan, V., Gillet, D., Barbier, J., Bachelerie, F., Smith, K. G. C., Jellusova, J. & Bruhns, P. & 5 others, , 10 Jan 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 2, 12 p., e2213056120.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging
Silva-Cayetano, A., Fra-Bido, S., Robert, P. A., Innocentin, S., Burton, A. R., Watson, E. M., Lee, J. L., Webb, L. M. C., Foster, W. S., McKenzie, R. C. J., Bignon, A., Vanderleyden, I., Alterauge, D., Lemos, J. P., Carr, E. J., Hill, D. L., Cinti, I., Balabanian, K., Baumjohann, D. & Espeli, M. & 3 others, , Jul 2023, In: Nature Immunology. 24, 7, p. 1124-1137+ 39 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access32 Citations (Scopus) -
B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction
Lee, J. L., Fra-Bido, S. C., Burton, A. R., Innocentin, S., Hill, D. L. & Linterman, M. A., Sept 2022, In: Aging Cell. 21, 9, 21 p., e13692.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
Quast, I., Dvorscek, A. R., Pattaroni, C., Steiner, T. M., McKenzie, C. I., Pitt, C., O'Donnell, K., Ding, Z., Hill, D. L., Brink, R., Robinson, M. J., Zotos, D. & Tarlinton, D. M., 9 Aug 2022, In: Immunity. 55, 8, p. 1414-1430.e5 23 p.Research output: Contribution to journal › Article › Research › peer-review
55 Citations (Scopus)
Prizes
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Best Oral presentation by an ECR (Postdoc)
Hill, Danika (Recipient), 2022
Prize: Prize (including medals and awards)
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Margaret Baird Women in Immunology Award
Hill, Danika (Recipient), 2022
Prize: Prize (including medals and awards)
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Prize for best oral presentation by a ECR
Hill, Danika (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
- 1 Editorial responsibility
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Clinical & Translational Immunology (Journal)
Danika Hill (Editorial board member)
2023 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
Press/Media
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BCG Vaccine Helps Fight Infections by Boosting Immune Cell Production.
6/05/20
1 Media contribution
Press/Media: Expert Comment