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Personal profile
Biography
Danika Hill is a Group Leader in the Department of Immunology and Pathology, working to understand the cellular and molecular mechanisms that underpin robust responses to vaccination and infection, with a particular interest in T follicular helper cells and the Germinal Centre response. Dr Hill’s research uses multi-disciplinary human clinical cohorts approaches and cutting-edge immunological techniques (high-parameter flow cytometry, single cell RNA and immune repertoire sequencing) to study Group A Streptoccous, malaria and influenza immunity.
Dr Hill studied Biomedical Science at the University of Adelaide, and completed a PhD at the Walter and Eliza Hall Institute of Medical Research. From 2015, Danika was a Postdoc in Dr Michelle Linterman’s group at the Babraham Institute in Cambridge, before joining Monash University in 2020. Danika’s research is supported by an NHMRC CJ Martin Fellowship and a Michelson Prize from the Human Vaccines Project. Dr Hill is an emerging global leader in human immunology, as evidenced by lecturing for Monash University, Swiss Tropical & Public Health Institute, and being selected as a “Rising Star in Immunology” the Norwegian Society for Immunology.
Danika has made several important discoveries about how T follicular helper cells support the germinal centre response to influenza and malaria vaccines (e.g J Exp Med 2019, eLife 2020, eLife 2021), and how immune development in children influences vaccination outcomes (Science Translational Medicine 2020).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- T-cells
- CD4+ T cells
- Vaccine responses
- Cellular mechanisms
Network
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B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction
Lee, J. L., Fra-Bido, S. C., Burton, A. R., Innocentin, S., Hill, D. L. & Linterman, M. A., Sep 2022, In: Aging Cell. 21, 9, 21 p., e13692.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
Quast, I., Dvorscek, A. R., Pattaroni, C., Steiner, T. M., McKenzie, C. I., Pitt, C., O'Donnell, K., Ding, Z., Hill, D. L., Brink, R., Robinson, M. J., Zotos, D. & Tarlinton, D. M., 9 Aug 2022, In: Immunity. 55, 8, p. 1414-1430.e5 23 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response
Robinson, M. J., Dowling, M. R., Pitt, C., O'Donnell, K., Webster, R. H., Hill, D. L., Ding, Z., Dvorscek, A. R., Brodie, E. J., Hodgkin, P. D., Quast, I. & Tarlinton, D. M., 28 Oct 2022, In: Science Immunology. 7, 76, 12 p., eabm8389.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response
Denton, A. E., Dooley, J., Cinti, I., Silva-Cayetano, A., Fra-Bido, S., Innocentin, S., Hill, D. L., Carr, E. J., McKenzie, A. N. J., Liston, A. & Linterman, M. A., May 2022, In: Science Immunology. 7, 71, 17 p., eabk0018.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
T follicular helper cells and their impact on humoral responses during pathogen and vaccine challenge
Juno, J. A. & Hill, D. L., Feb 2022, In: Current Opinion in Immunology. 74, p. 112-117 6 p.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access5 Citations (Scopus)