Daniela Loessner

Research output

Research output per year 2006 2014 2016 2018 2021 2023

• 47 Article
• 11 Review Article
• 6 Chapter (Book)

Research output per year

Research output per year

Search results

• 2023

  A tumor microenvironment model of pancreatic cancer to elucidate responses toward immunotherapy

  Kast, V., Nadernezhad, A., Pette, D., Gabrielyan, A., Fusenig, M., Honselmann, K. C., Stange, D. E., Werner, C. & Loessner, D., 1 Jun 2023, In: Advanced Healthcare Materials. 12, 14, 15 p., 2201907.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  1 Citation (Scopus)
• 2021

  3D Collagen-Nanocellulose Matrices Model the Tumour Microenvironment of Pancreatic Cancer

  Curvello, R., Kast, V., Abuwarwar, M. H., Fletcher, A. L., Garnier, G. & Loessner, D., Jul 2021, In: Frontiers in Digital Health. 3, 13 p., 704584.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

• A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells

  McGovern, J. A., Bock, N., Shafiee, A., Martine, L. C., Wagner, F., Baldwin, J. G., Landgraf, M., Lahr, C. A., Meinert, C., Williams, E. D., Pollock, P. M., Denham, J., Russell, P. J., Risbridger, G. P., Clements, J. A., Loessner, D., Holzapfel, B. M. & Hutmacher, D. W., 30 Aug 2021, In: Communications Biology. 4, 1, 14 p., 1014.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

  Osuna de la Peña, D., Trabulo, S. M. D., Collin, E., Liu, Y., Sharma, S., Tatari, M., Behrens, D., Erkan, M., Lawlor, R. T., Scarpa, A., Heeschen, C., Mata, A. & Loessner, D., 24 Aug 2021, In: Nature Communications. 12, 1, 15 p., 5623.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  28 Citations (Scopus)

• Kallikrein-related peptidase 6 is associated with the tumour microenvironment of pancreatic ductal adenocarcinoma

  Candido, J. B., Maiques, O., Boxberg, M., Kast, V., Peerani, E., Tomás-bort, E., Weichert, W., Sananes, A., Papo, N., Magdolen, V., Sanz-moreno, V. & Loessner, D., 2 Aug 2021, In: Cancers. 13, 16, 17 p., 3969.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

• Neuroblastoma invasion strategies are regulated by the extracellular matrix

  Gavin, C., Geerts, N., Cavanagh, B., Haynes, M., Reynolds, C. P., Loessner, D., Ewald, A. J. & Piskareva, O., 10 Feb 2021, In: Cancers. 13, 4, p. 1-23 23 p., 736.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

• Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells

  Soelch, S., Beaufort, N., Loessner, D., Kotzsch, M., Reuning, U., Luther, T., Kirchner, T. & Magdolen, V., 14 Dec 2021, In: Molecular Medicine. 27, 1, 17 p., 158.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Stromal cells promote matrix deposition, remodelling and an immunosuppressive tumour microenvironment in a 3d model of colon cancer

  Leonard, N. A., Reidy, E., Thompson, K., McDermott, E., Peerani, E., Bort, E. T., Balkwill, F. R., Loessner, D. & Ryan, A. E., 1 Dec 2021, In: Cancers. 13, 23, 26 p., 5998.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Tgfbi production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer

  Lecker, L. S. M., Berlato, C., Maniati, E., Delaine-Smith, R., Pearce, O. M. T., Heath, O., Nichols, S. J., Trevisan, C., Novak, M., McDermott, J., Brenton, J. D., Cutillas, P. R., Rajeeve, V., Hennino, A., Drapkin, R., Loessner, D. & Balkwill, F. R., 15 Nov 2021, In: Cancer Research. 81, 22, p. 5706-5719 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  39 Citations (Scopus)
• 2020

  Peptide-protein coassembling matrices as a biomimetic 3d model of ovarian cancer

  Hedegaard, C. L., Redondo-Gómez, C., Tan, B. Y., Ng, K. W., Loessner, D. & Mata, A., 30 Sept 2020, In: Science Advances. 6, 40, 15 p., eabb3298.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  28 Citations (Scopus)
• 2019

  A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns

  Loessner, D., Rockstroh, A., Shokoohmand, A., Holzapfel, B. M., Wagner, F., Baldwin, J., Boxberg, M., Schmalfeldt, B., Lengyel, E., Clements, J. A. & Hutmacher, D. W., Jan 2019, In: Biomaterials. 190-191, p. 63-75 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  36 Citations (Scopus)

• A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma

  Wagner, F., Holzapfel, B. M., Martine, L. C., McGovern, J., Lahr, C. A., Boxberg, M., Prodinger, P. M., Grässel, S., Loessner, D. & Hutmacher, D. W., 15 Apr 2019, In: Acta Biomaterialia. 89, p. 372-381 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  11 Citations (Scopus)
• 2018

  A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo

  Quent, V. M. C., Taubenberger, A. V., Reichert, J. C., Martine, L. C., Clements, J. A., Hutmacher, D. W. & Loessner, D., Feb 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12, 2, p. 494-504 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

• Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma

  Wagner, F., Holzapfel, B. M., McGovern, J. A., Shafiee, A., Baldwin, J. G., Martine, L. C., Lahr, C. A., Wunner, F. M., Friis, T., Bas, O., Boxberg, M., Prodinger, P. M., Shokoohmand, A., Moi, D., Mazzieri, R., Loessner, D. & Hutmacher, D. W., Jul 2018, In: Biomaterials. 171, p. 230-246 17 p.

  Research output: Contribution to journal › Article › Research › peer-review
  31 Citations (Scopus)

• Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone

  McGovern, J. A., Shafiee, A., Wagner, F., Lahr, C. A., Landgraf, M., Meinert, C., Williams, E. D., Russell, P. J., Clements, J. A., Loessner, D., Holzapfel, B. M., Risbridger, G. P. & Hutmacher, D. W., 13 Nov 2018, In: Cancers. 10, 11, 15 p., 438.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

• Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer

  Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., Yang, F., Schmitt, M., Schilling, O., Rockstroh, A., Clements, J. A. & Loessner, D., 5 Oct 2018, In: British Journal of Cancer. 119, 7, p. 823-831 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  25 Citations (Scopus)

• SpheroidSim: preliminary evaluation of a new computational tool to predict the influence of cell cycle time and phase fraction on spheroid growth

  Little, P. J., Pettet, G. J., Hutmacher, D. W. & Loessner, D., Nov 2018, In: Biotechnology Progress. 34, 6, p. 1335-1343 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
• 2017

  Endosteal-like extracellular matrix expression on melt electrospun written scaffolds

  Muerza-Cascante, M. L., Shokoohmand, A., Khosrotehrani, K., Haylock, D., Dalton, P. D., Hutmacher, D. W. & Loessner, D., 1 Apr 2017, In: Acta Biomaterialia. 52, p. 145-158 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  54 Citations (Scopus)

• Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load

  Holzapfel, N. P., Shokoohmand, A., Wagner, F., Landgraf, M., Champ, S., Holzapfel, B. M., Clements, J. A., Hutmacher, D. W. & Loessner, D., 2017, In: American Journal of Cancer Research. 7, 6, p. 1322-1336 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  34 Citations (Scopus)

• The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in ovarian tumour xenografts

  Tourell, M. C., Shokoohmand, A., Landgraf, M., Holzapfel, N. P., Poh, P. S. P., Loessner, D. & Momot, K. I., 21 Feb 2017, In: Scientific Reports. 7, 13 p., 42905.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  14 Citations (Scopus)
• 2016

  Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

  Dorn, J., Yassouridis, A., Walch, A., Diamandis, E. P., Schmitt, M., Kiechle, M., Wang, P., Drecoll, E., Schmalfeldt, B., Loessner, D., Kotzsch, M. & Magdolen, V., 2016, In: American Journal of Cancer Research. 6, 1, p. 61-70 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  9 Citations (Scopus)

• A validated preclinical animal model for primary bone tumor research

  Wagner, F., Holzapfel, B. M., Thibaudeau, L., Straub, M., Ling, M-T., Grifka, J., Loessner, D., Levesque, J. P. & Hutmacher, D. W., 1 Jun 2016, In: The Journal of Bone & Joint Surgery. 98, 11, p. 916-925 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms

  Loessner, D., Meinert, C., Kaemmerer, E., Martine, L. C., Yue, K., Levett, P. A., Klein, T. J., Melchels, F. P. W., Khademhosseini, A. & Hutmacher, D. W., 17 Mar 2016, In: Nature Protocols. 11, 4, p. 727-746 20 p.

  Research output: Contribution to journal › Article › Other › peer-review
  480 Citations (Scopus)

• Lycopene's effects on cancer cell functions within monolayer and spheroid cultures

  Holzapfel, N. P., Holzapfel, B. M., Theodoropoulos, C., Kaemmerer, E., Rausch, T., Feldthusen, J., Champ, S., Clements, J. A., Hutmacher, D. W. & Loessner, D., 2016, In: Nutrition and Cancer. 68, 2, p. 350-363 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)

• Magnetic resonance microimaging of cancer cell spheroid constructs

  Momot, K. I., Bas, O., Holzapfel, N. P. & Loessner, D., 2016, In: Biomedical Spectroscopy and Imaging. 5, 1, p. 41-54 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

• Prostate cancer-associated kallikrein-related peptidase 4 activates matrix metalloproteinase-1 and thrombospondin-1

  Fuhrman-Luck, R. A., Stansfield, S. H., Stephens, C. R., Loessner, D. & Clements, J. A., 5 Aug 2016, In: Journal of Proteome Research. 15, 8, p. 2466-2478 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  20 Citations (Scopus)
• 2015

  Biomaterial science meets computational biology

  Hutmacher, D. W., Little, J. P., Pettet, G. J. & Loessner, D., May 2015, In: Journal of Materials Science: Materials in Medicine. 26, 5, 3 p., 185.

  Research output: Contribution to journal › Article › Research › peer-review
  3 Citations (Scopus)

• Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance

  Hutmacher, D. W., Holzapfel, B. M., De-Juan-Pardo, E. M., Pereira, B. A., Ellem, S. J., Loessner, D. & Risbridger, G. P., 2015, In: Current Opinion in Biotechnology. 35, p. 127 - 132 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  29 Citations (Scopus)

• Tissue engineered humanized bone supports human hematopoiesis in vivo

  Holzapfel, B. M., Hutmacher, D. W., Nowlan, B., Barbier, V., Thibaudeau, L., Theodoropoulos, C., Hooper, J. D., Loessner, D., Clements, J. A., Russell, P. J., Pettit, A. R., Winkler, I. G. & Levesque, J. P., Aug 2015, In: Biomaterials. 61, p. 103-114 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  55 Citations (Scopus)
• 2014

  Gelatine methacrylamide-based hydrogels: an alternative three-dimensional cancer cell culture system

  Kaemmerer, E., Melchels, F. P. W., Holzapfel, B. M., Meckel, T., Hutmacher, D. W. & Loessner, D., Jun 2014, In: Acta Biomaterialia. 10, 6, p. 2551-2562 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  144 Citations (Scopus)

• Kallikrein-related peptidases in prostate cancer: from molecular function to clinical application

  Fuhrman-Luck, R. A., Loessner, D. & Clements, J. A., Oct 2014, In: eJIFCC. 25, 3, p. 269-281 13 p.

  Research output: Contribution to journal › Article › Other › peer-review

  Open Access

  File

• Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

  Shahinian, H., Loessner, D., Biniossek, M. L., Kizhakkedathu, J. N., Clements, J. A., Magdolen, V. & Schilling, O., Feb 2014, In: Molecular Oncology. 8, 1, p. 68-82 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  52 Citations (Scopus)

• Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone

  Holzapfel, B. M., Wagner, F., Loessner, D., Holzapfel, N. P., Thibaudeau, L., Crawford, R., Ling, M-T., Clements, J. A., Russell, P. J. & Hutmacher, D. W., Apr 2014, In: Biomaterials. 35, 13, p. 4108-4115 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  84 Citations (Scopus)
• 2013

  A bioengineered 3D ovarian cancer model for the assessment ofpeptidase-mediated enhancement of spheroid growth andintraperitoneal spread

  Loessner, D., Rizzi, S. C., Stok, K. S., Fuehrmann, T., Hollier, B., Magdolen, V., Hutmacher, D. W. & Clements, J. A., 1 Oct 2013, In: Biomaterials. 34, 30, p. 7389-7400 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  52 Citations (Scopus)

• A multiscale road map of cancer spheroids-incorporating experimental and mathematical modelling to understand cancer progression

  Loessner, D., Paige Little, J., Pettet, G. J. & Hutmacher, D. W., 1 Jul 2013, In: Journal of Cell Science. 126, 13, p. 2761-2771 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  23 Citations (Scopus)

• Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach

  Loessner, D., Flegg, J. A., Byrne, H. M., Clements, J. A. & Hutmacher, D. W., 2013, In: Integrative Biology. 5, 3, p. 597 - 605 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  39 Citations (Scopus)
• 2012

  Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

  Loessner, D., Quent, V. M. C., Kraemer, J., Weber, E. C., Hutmacher, D. W., Magdolen, V. & Clements, J. A., 1 Dec 2012, In: Gynecologic Oncology. 127, 3, p. 569-578 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  32 Citations (Scopus)

• Design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode

  Brown, T. D., Slotosch, A., Thibaudeau, L., Taubenberger, A., Loessner, D., Vaquette, C., Dalton, P. D. & Hutmacher, D. W., 1 Jan 2012, In: Biointerphases. 7, 1-4, p. 1-16 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  172 Citations (Scopus)
• 2011

  Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

  Lawrence, M. G., Margaryan, N. V., Loessner, D., Collins, A., Kerr, K. M., Turner, M., Seftor, E. A., Stephens, C. R., Lai, J., APC BioResource, Postovit, L-M., Clements, J. & Hendrix, M. JC., 2011, In: The Prostate. 71, 11, p. 1198 - 1209 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  90 Citations (Scopus)
• 2010

  Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells

  Loessner, D., Stok, K. S., Lutolf, M. P., Hutmacher, D. W., Clements, J. A. & Rizzi, S. C., 1 Nov 2010, In: Biomaterials. 31, 32, p. 8494-8506 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  505 Citations (Scopus)

• Discrepancies between metabolic activity and DNA content as tool to assess cell proliferation in cancer research

  Quent, V. M. C., Loessner, D., Friis, T., Reichert, J. C. & Hutmacher, D. W., 1 Apr 2010, In: Journal of Cellular and Molecular Medicine. 14, 4, p. 1003-1013 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  153 Citations (Scopus)

• Kallikrein-related peptidase 7 promotes multicellular aggregation via the α₅β₁ Integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma

  Dong, Y., Tan, O. L., Loessner, D., Stephens, C., Walpole, C., Boyle, G. M., Parsons, P. G. & Clements, J. A., 1 Apr 2010, In: Cancer Research. 70, 7, p. 2624-2633 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  79 Citations (Scopus)
• 2009

  Integrin αvβ3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription

  Lössner, D., Abou-Ajram, C., Benge, A., Aumercier, M., Schmitt, M. & Reuning, U., Aug 2009, In: Journal of Cellular Physiology. 220, 2, p. 367-375 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  28 Citations (Scopus)

• Translating tissue engineering technology platforms into cancer research

  Hutmacher, D. W., Horch, R. E., Loessner, D., Rizzi, S., Sieh, S., Reichert, J. C., Clements, J. A., Beier, J. P., Arkudas, A., Bleiziffer, O. & Kneser, U., 1 Aug 2009, In: Journal of Cellular and Molecular Medicine. 13, 8 A, p. 1417-1427 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  124 Citations (Scopus)
• 2008

  Integrin αvβ3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells

  Lössner, D., Abou-Ajram, C., Benge, A. & Reuning, U., 23 Jun 2008, In: International Journal of Biochemistry & Cell Biology. 40, 12, p. 2746-2761 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  26 Citations (Scopus)
• 2007

  The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior

  Lenski, C., Kooy, R. F., Reyniers, E., Loessner, D., Wanders, R. J. A., Winnepenninckx, B., Hellebrand, H., Engert, S., Schwartz, C. E., Meindl, A. & Ramser, J., Feb 2007, In: American Journal of Human Genetics. 80, 2, p. 372-377 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  50 Citations (Scopus)
• 2006

  Binding of small mono- and oligomeric integrin ligands to membrane-embedded integrins monitored by surface plasmon-enhanced fluorescence spectroscopy

  Lössner, D., Kessler, H., Thumshirn, G., Dahmen, C., Wiltschi, B., Tanaka, M., Knoll, W., Sinner, E. K. & Reuning, U., 1 Jul 2006, In: Analytical Chemistry. 78, 13, p. 4524-4533 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)