Daniela Loessner

Assoc Professor

Accepting PhD Students

PhD projects

The effect of functionalisation of hydrogel materials with bioactive factors on biomechanical properties and cell functions. Organoid modelling of the tumour immune microenvironment.


Research output per year

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Personal profile


Daniela has a joint appointment across the Faculties of Engineering and Medicine at Monash University. She has Bachelor of Science and Master of Science degrees and a PhD in Natural Sciences (Dr rer nat) from the Faculty of Chemistry, Technical University of Munich, Germany. She has over 17 years of academic experience, working as a research scientist and group leader in 5 countries (Germany, Australia, Switzerland, USA, UK). She was Deputy Director in the Centre for Regenerative Medicine at Queensland University of Technology, before she joined the Barts Cancer Institute at Queen Mary University of London as a Reader in Bioengineering and Cancer.

Daniela’s scientific achievements, technologies and leadership have been recognised by a number of national and international awards. She is the recipient of the 2019 Joint E.K. Frey – E.Werle and Henner Graeff Promotion Prize, a 2015 Monash University Engineering Women’s Leadership Award, a 2013 Oral Presentation Award at the Victorian Comprehensive Cancer Centre Congress, Queensland University of Technology Mid-Career and Early Career Researcher Awards and four Carla Patterson Publication Awards. She was selected to attend the 2017 Women and Power Executive Leadership Program at the Harvard Kennedy School.

Research interests

Daniela’s research interests are to understand the role of the extracellular and cellular microenvironment in modulating cancer progression and therapy response applying tissue-engineered technologies. Using her multidisciplinary expertise in cell biology, biomedical engineering and translational research, her team develops 3D platforms by integrating patient-specific and biomechanical characteristics of the tumour microenvironment to test biological therapies.

Daniela’s work and research have been recognised nationally and internationally with peer-reviewed publications (Nature Protocols, Biomaterials, Cancer Research, Advanced Drug Delivery Reviews, Trends in Biotechnology), presentations and invited participation in international symposia.

Education/Academic qualification

Natural Sciences, PhD, Technische Universitat Munchen (Technical University of Munich)

Award Date: 25 Oct 2007

External positions

Honorary contract, Queen Mary University of London and Barts

2 Mar 2020 → …

Research area keywords

  • 3D cell culture models
  • Tissue engineering
  • Biomaterials
  • Cancer Biology
  • Mechanobiology

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Research Output

3D approaches to model the tumor microenvironment of pancreatic cancer

Tomás-Bort, E., Kieler, M., Sharma, S., Candido, J. B. & Loessner, D., 2020, In : Theranostics. 10, 11, p. 5074-5089 16 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
1 Citation (Scopus)

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns

Loessner, D., Rockstroh, A., Shokoohmand, A., Holzapfel, B. M., Wagner, F., Baldwin, J., Boxberg, M., Schmalfeldt, B., Lengyel, E., Clements, J. A. & Hutmacher, D. W., Jan 2019, In : Biomaterials. 190-191, p. 63-75 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma

Wagner, F., Holzapfel, B. M., Martine, L. C., McGovern, J., Lahr, C. A., Boxberg, M., Prodinger, P. M., Grässel, S., Loessner, D. & Hutmacher, D. W., 15 Apr 2019, In : Acta Biomaterialia. 89, p. 372-381 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Cell recovery of hydrogel-encapsulated cells for molecular analysis

Peerani, E., Candido, J. B. & Loessner, D., 2019, Theranostics: Methods and Protocols. Batra, J. & Srinivasan, S. (eds.). New York NY USA: Springer, p. 3-21 19 p. (Methods in Molecular Biology; vol. 2054).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo

Quent, V. M. C., Taubenberger, A. V., Reichert, J. C., Martine, L. C., Clements, J. A., Hutmacher, D. W. & Loessner, D., Feb 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 2, p. 494-504 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)