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Research Output 2002 2019

2019

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O’Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. & Brierley, S. M., 19 Sep 2019, In : JCI Insight. 4, 18, 42 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Anderson, B., Poole, D. P., Aurelio, L., Ng, G. Z., Fleischmann, M., Kasperkiewicz, P., Morissette, C., Drag, M., van Driel, I. R., Schmidt, B. L., Vanner, S. J., Bunnett, N. & Edgington-Mitchell, L., 16 Sep 2019, In : Scientific Reports. 9, 12 p., 13295.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Zhao, P., Pattison, L. A., Jensen, D. D., Jimenez-Vargas, N. N., Latorre, R., Lieu, T., Jaramillo, J. O., Lopez-Lopez, C., Poole, D. P., Vanner, S. J., Schmidt, B. L. & Bunnett, N. W., 5 Jul 2019, In : Journal of Biological Chemistry. 294, 27, p. 10649-10662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model

Vu, N. M., Rajasekhar, P., Poole, D. P., Khor, S. Y., Truong Phuoc, N., Nowell, C., Quinn, J. F., Whittaker, M., Veldhuis, N. & Davis, T. P., 29 Mar 2019, In : ACS Applied Nano Materials. 2, 4, p. 1844-1856 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Co-expression of μ and δ opioid receptors by mouse colonic nociceptors

Guerrero-Alba, R., Valdez-Morales, E. E., Jiménez-Vargas, N. N., Bron, R., Poole, D., Reed, D., Castro, J., Campaniello, M., Hughes, P. A., Brierley, S. M., Bunnett, N., Lomax, A. E. & Vanner, S., 1 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2622-2634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Schneider, E. K., McQuade, R. M., Carbone, V. C., Reyes-Ortega, F., Wilson, J. W., Button, B., Saito, A., Poole, D. P., Hoyer, D. & Li, J., 1 Jan 2018, In : ERJ Open Research. 4, 1, 10 p., 00127-2017.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

G-CSF receptor blockade ameliorates arthritic pain and disease

Lee, M. C., McCubbin, J. A., Christensen, A. D., Poole, D. P., Rajasekhar, P., Lieu, T., Bunnett, N. W., Garcia-Caraballo, S., Erickson, A., Brierley, S. M., Saleh, R., Achuthan, A., Fleetwood, A. J., Anderson, R. L., Hamilton, J. A. & Cook, A. D., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3565-3575 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes

Rajasekhar, P., Poole, D. P. & Veldhuis, N. A., 2017, Ion Channels DownUnder. Geraghty, D. P. & Rash, L. D. (eds.). Cambridge MA USA: Academic Press, Vol. 79. p. 117-139 23 p. (Advances in Pharmacology; vol. 79). (Advances in Pharmacology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Schofield, L., Ioannidis, L. J., Karl, S., Robinson, L. J., Tan, Q. Y., Poole, D. P., Betuela, I., Hill, D. L., Siba, P. M., Hansen, D. S., Mueller, I. & Eriksson, E. M., 15 Jun 2017, In : BMC Medicine. 15, 1, 15 p., 114.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

Lay, J., Carbone, S. E., Dicello, J. J., Bunnett, N., Canals, M. & Poole, D. P., 1 Aug 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 2, p. G252-G266 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of food components that activate TRPA1 receptors on mucosal ion transport in the Mouse intestine

Fothergill, L. J., Callaghan, B., Rivera, L. R., Lieu, T. M., Poole, D. P., Cho, H. J., Bravo, D. M. & Furness, J. B., 1 Oct 2016, In : Nutrients. 8, 10, 11 p., 623.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., 9 Feb 2016, In : Science Signaling. 9, 414, p. 1-13 13 p., ra16.

Research output: Contribution to journalArticleResearchpeer-review

File

Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the golgi apparatus to the plasma membrane

Jensen, D. D., Zhao, P., Jimenez-Vargas, N. N., Lieu, T., Gerges, M., Yeatman, H. R., Canals, M., Vanner, S. J., Poole, D. P. & Bunnett, N. W., 20 May 2016, In : Journal of Biological Chemistry. 291, 21, p. 11285-11299 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging

Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. & Canals, M., 2015, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols. Filizola, M. (ed.). 2 ed. New York NY USA: Springer, Vol. 1335. p. 131-161 31 p. (Methods in Molecular Biology; vol. 1335, no. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting of transient receptor potential channels in digestive disease

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P. & Bunnett, N. W., 2015, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Szallasi, A. (ed.). London UK: Elsevier, p. 385-403 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

Thompson, G. L., Canals, M. & Poole, D. P., 2014, In : Frontiers in Pharmacology. 5, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Jensen, D. D., Halls, M. L., Murphy, J. E., Canals, M., Cattaruzza, F., Poole, D. P., Lieu, T. M., Koon, H-W., Pothoulakis, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20283 - 20294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: Evidence for a neurolymphocrine system

Poole, D. P., Lee, M., Tso, P., Bunnett, N. W., Yo, S. J., Lieu, T. M., Shiu, A., Wang, J-C., Nomura, D. & Aponte, G. W., 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 8, p. G686 - G698 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice

Lieu, T. M., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M., McIntyre, P., Bron, R., Wilson, Y., Krappitz, M., Haerteis, S., Korbmacher, C., Steinhoff, M. S., Nassini, R., Materazzi, S., Geppetti, P., Corvera, C. U. & Bunnett, N. W., 2014, In : Gastroenterology. 147, 6, p. 1417 - 1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Zhao, P., Canals, M., Murphy, J. E., Klingler, D., Eriksson, E. M., Pelayo, J-C., Hardt, M., Bunnett, N. W. & Poole, D. P., 2013, In : Journal of Biological Chemistry. 288, 36, p. 25689 - 25700 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Arresting inflammation: Contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Cattaruzza, F., Poole, D. P. & Bunnett, N. W., 2013, In : Biochemical Society Transactions. 41, 1, p. 137 - 143 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Poole, D. P., Amadesi, S., Veldhuis, N. A., Abogadie, F. C., Lieu, T. M., Darby, W., Liedtke, W., Lew, M. J., McIntyre, P. B. & Bunnett, N. W., 2013, In : Journal of Biological Chemistry. 288, 8, p. 5790 - 5802 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The bile acid receptor TGR5 does not interact with b-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Jensen, D. D., Godfrey, C. B., Niklas, C., Canals, M., Kocan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., Lambert, N., Bunnett, N. W. & Corvera, C. U., 2013, In : Journal of Biological Chemistry. 288, 32, p. 22942 - 22960 19 p.

Research output: Contribution to journalArticleResearchpeer-review

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

Alemi, F., Poole, D. P., Chiu, J. V., Schoonjans, K., Cattaruzza, F., Grider, J. R., Bunnett, N. W. & Corvera, C. U., 2013, In : Gastroenterology. 144, 1, p. 145 - 154 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The TGR5 receptor mediates bile acid-induced itch and analgesia

Alemi, F., Kwon, E., Poole, D. P., Lieu, T. M., Lyo, V., Cattaruzza, F., Cevikbas, F., Steinhoff, M., Nassini, R., Materazzi, S., Guerrero-Alba, R., Valdez-Morales, E., Cottrell, G. S., Schoonjans, K., Geppetti, P., Vanner, S., Bunnett, N. W. & Corvera, C. U., 2013, In : Journal of Clinical Investigation. 123, 4, p. 1513 - 1530 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Enteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology

Poole, D. P. & Furness, J. B., 2012, Physiology of the Gastrointestinal Tract. Johnson, L. R., Ghishan, F. K., Kaunitz, J. D., Merchant, J. L., Said, H. M. & Wood, J. D. (eds.). 5th ed. London UK: Elsevier, Vol. 1. p. 557-581 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Knock out of neuronal nitric oxide synthase exacerbates intestinal ischemia/reperfusion injury in mice

Rivera, L. R., Pontell, L., Cho, H. J., Castelucci, P., Thacker, M., Poole, D. P., Frugier, T. & Furness, J. B., 2012, In : Cell and Tissue Research. 349, 2, p. 565-576 12 p.

Research output: Contribution to journalArticleResearchpeer-review

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor

Veldhuis, N. A., Lew, M. J., Abogadie, F. C., Poole, D. P., Jennings, E. A., Ivanusic, J. J., Eilers, H., Bunnett, N. W. & McIntyre, P. B., 2012, In : Journal of Biological Chemistry. 287, 28, p. 21765 - 21772 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nonruminant nutrition symposium: Involvement of gut neural and endocrine systems in pathological disorders of the digestive tract

Furness, J. B. & Poole, D. P., Apr 2012, In : Journal of Animal Science. 90, 4, p. 1203-1212 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2011

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Pelayo, J-C., Poole, D. P., Steinhoff, M., Cottrell, G. S. & Bunnett, N. W., 2011, In : The Journal of Physiology. 589, 21, p. 5213 - 5230 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice

Poole, D., Pelayo, J-C., Scherrer, G., Evans, C., Kieffer, B. & Bunnett, N., 2011, In : Gastroenterology. 141, 3, p. 982 - 991 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The involvement of nitric oxide synthase neurons in enteric neuropathies

Rivera, L. R., Poole, D. P., Thacker, M. & Furness, J. B., 2011, In : Neurogastroenterology and Motility. 23, 11, p. 980 - 988 9 p.

Research output: Contribution to journalArticleResearchpeer-review