Projects per year
Personal profile
Research interests
- Enteric Neurobiology
- Gastrointestinal Physiology
- Neuroimmune interactions
- Hirschsprung Disease
- Molecular Mechanisms of Pain
- Transient Receptor Potential Channels
- Opioid Receptors
Supervision interests
Currently Recruiting PhD Students
Biography
CURRENT POSITIONS
Co-director of the Integrated Neurogenic Mechanisms Laboratory, Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences (with Dr Nik Veldhuis and Dr Simona Carbone).
Secretary, Australasian Neurogastroenterology and Motility Association (ANGMA) https://www.angma.org.au/
Associate Editor, American Journal of Physiology- Gastrointestinal Liver Physiology https://journals.physiology.org/journal/ajpgi
Secretary, Society For Neuroscience (SFN), Melbourne Chapter
BROAD RESEARCH PROGRAM
1. Defining the cellular environment of the gut.
It is now appreciated that complex interactions between diverse cell types are essential for normal gastrointestinal processes. These interactions may be disrupted in disease, leading to altered gut function. Our research characterizes key cell types in the gut in health and disease including resident macrophages and glial cells. We examine how these cells communicate with each other and interact with the enteric nervous system (ENS) to influence key physiological processes.
2. G Protein-Coupled Receptor (GPCR) expression and signaling in the ENS.
Although GPCRs are a major target of currently approved therapeutics, our current understanding of GPCR biology in the ENS is limited. Our research program examines GPCR expression, trafficking and signaling specifically in enteric neurons. Our current focus is on opioid and muscarinic receptors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- enteric nervous system
- Gastrointestinal tract
- GPCR biology
- Transient Receptor Potential Ion Channels
Network
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D., Valant, C., Carbone, S., Mobbs, J., Thal, D., Scammells, P., King, S. K., Imlach, W., Hamilton, J. A. & Veldhuis, N.
1/01/23 → 31/12/26
Project: Research
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Caveospheres: A versatile peptide delivery system
Johnston, A., Veldhuis, N., Poole, D. & Foley, M. A.
15/09/20 → 14/09/23
Project: Research
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NHMRC Equipment Grant - FLIPR Tetra high-throughput cellular screening system
Sexton, P., Christopoulos, A., Leach, K., Gregory, K., Veldhuis, N., Poole, D. & Langmead, C.
1/01/18 → 31/12/18
Project: Research
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Spatial and temporal dimensions of mu-opioid receptor signalling: implications for the development of tolerance
Halls, M., Canals, M. & Poole, D.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 30/06/21
Project: Research
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Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain
Jiménez-Vargas, N. N., Gong, J., Wisdom, M. J., Jensen, D. D., Latorre, R., Hegron, A., Teng, S. L., Di Cello, J., Rajasekhar, P., Veldhuis, N. A., Carbone, S., Yu, Y., Lopez, C. L., Polanco, J. J., Canals, M., Reed, D., Lomax, A. E., Schmidt, B. L., Leong, K. W., Vanner, S., & 3 others , 30 Jun 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 26, p. 15281-15292 12 p.Research output: Contribution to journal › Article › Research › peer-review
48 Citations (Scopus) -
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
DiCello, J. J., Carbone, S. E., Saito, A., Rajasekhar, P., Ceredig, R. A., Pham, V., Valant, C., Christopoulos, A., Veldhuis, N. A., Canals, M., Massotte, D. & Poole, D. P., Mar 2020, In: Cellular and Molecular Gastroenterology and Hepatology. 9, 3, p. 465-483 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile16 Citations (Scopus) -
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability
Peng, S., Grace, M., Gondin, AB., Retamal, J. S., Dill, L., Darby, W. G., Bunnett, N., Abogadie, F. C., Carbone, S., Tigani, T., Davis, T. P., Poole, D. P., Veldhuis, N. & McIntyre, P., Aug 2020, In: Laboratory Investigation. 100, 8, p. 1057–1067 11 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Inflammation without pain: Immune-derived opioids hold the key
Carbone, S. & Poole, D. P., 1 Feb 2020, In: Neurogastroenterology & Motility. 32, 2, 5 p., e13787.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
Agonist-dependent development of delta opioid receptor tolerance in the colon
DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In: Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.Research output: Contribution to journal › Article › Research › peer-review
7 Citations (Scopus)
Press/Media
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Opioid receptors inside cells important for pain relief
Michelle Halls, Nigel Bunnett & Daniel Poole
22/06/20 → 23/06/20
2 items of Media coverage
Press/Media: Article/Feature
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Opioid receptors inside cells important for pain relief
23/06/20
1 item of Media coverage
Press/Media: Article/Feature
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Delta opioid receptor identified as promising therapeutic target for inflammatory pain relief
15/06/20
1 item of Media coverage
Press/Media: Article/Feature