20032022
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Research Output 2003 2019

  • 25 Article
  • 3 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate
2019

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., Livis, T., Bhathal, P. S., Gough, D. J. & Jenkins, B. J., 15 Oct 2019, In : Cancer Research. 79, 20, p. 5272-5287 16 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

Huynh, J., Chand, A., Gough, D. & Ernst, M., 1 Feb 2019, In : Nature Reviews Cancer. 19, 2, p. 82-96 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

Liu, Y. D., Yu, L., Ying, L., Balic, J., Gao, H., Deng, N. T., West, A., Yan, F., Ji, C. B., Gough, D., Tan, P., Jenkins, B. J. & Li, J. K., 15 Jun 2019, In : International Journal of Cancer. 144, 12, p. 3056-3069 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018
8 Citations (Scopus)

A phase IIa study of HA-irinotecan, formulation of hyaluronic acid and irinotecan targeting CD44 in extensive-stage small cell lung cancer

Alamgeer, M., Neil Watkins, D., Banakh, I., Kumar, B., Gough, D. J., Markman, B. & Ganju, V., 1 Apr 2018, In : Investigational New Drugs. 36, 2, p. 288-298 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2018, In : Oncogene. 38, 10, p. 1661-1675 15 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine

Sandow, J. J., Rainczuk, A., Infusini, G., Makanji, M., Bilandzic, M., Wilson, A. L., Fairweather, N., Stanton, P. G., Garama, D., Gough, D., Jobling, T. W., Webb, A. I. & Stephens, A. N., 1 May 2018, In : Proteomics - Clinical Applications. 12, 3, 10 p., 1700135.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice

Darzi, S., Deane, J. A., Nold, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K. S., Vashi, A. V., Werkmeister, J. A. & Gargett, C. E., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 6554.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

STAT3: a multifaceted oncoprotein

Guanizo, A. C., Fernando, C. D., Garama, D. J. & Gough, D. J., 4 Mar 2018, In : Growth Factors. 36, 1-2, p. 1-14 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017
21 Citations (Scopus)

Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

Greenall, S. A., Lim, Y. C., Mitchell, C. B., Ensbey, K. S., Stringer, B. W., Wilding, A. L., O'Neill, G. M., McDonald, K. L., Gough, D. J., Day, B. W. & Johns, T. G., 1 Jan 2017, In : Oncogenesis. 6, 5, 13 p., e336.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

JNK activation of BIM promotes hepatic oxidative stress, steatosis, and insulin resistance in obesity

Litwak, S. A., Pang, L., Galic, S., Igoillo-Esteve, M., Stanley, W. J., Turatsinze, J. V., Loh, K., Thomas, H. E., Sharma, A., Trepo, E., Moreno, C., Gough, D. J., Eizirik, D. L., De Haan, J. B. & Gurzov, E. N., 1 Dec 2017, In : Diabetes. 66, 12, p. 2973-2986 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

Lee, W. T., Sun, X., Tsai, T-S., Johnson, J. L., Gould, J. A., Garama, D. J., Gough, D. J., McKenzie, M., Trounce, I. A. & St John, J. C., 1 Jan 2017, In : Cell Death Discovery. 3, 11 p., 17062.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016
14 Citations (Scopus)

Cre-dependent DNA recombination activates a STING-dependent innate immune response

Pépin, G., Ferrand, J., Höning, K., Jayasekara, W. S. N., Cain, J. E., Behlke, M. A., Gough, D. J., Williams, B. R. G., Hornung, V. & Gantier, M. P., 20 Jun 2016, In : Nucleic Acids Research. 44, 11, p. 5356-5364 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

Mitochondrial STAT3: Powering up a potent factor

Garama, D. J., White, C. L., Balic, J. J. & Gough, D. J., 1 Nov 2016, In : Cytokine. 87, p. 20-25 6 p.

Research output: Contribution to journalArticleOther

33 Citations (Scopus)

The JAK/STAT pathway in obesity and diabetes

Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E. & Gough, D. J., 1 Aug 2016, In : FEBS Journal. p. 3002-3015 14 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2015
17 Citations (Scopus)

A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3

Garama, D. J., Harris, T. J., White, C. L., Rossello, F. J., Abdul-Hay, M., Gough, D. J. & Levy, D. E., 2015, In : Molecular and Cellular Biology. 35, 21, p. 3646 - 3656 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

Lee, W., Johnson, J. L., Gough, D. J., Donoghue, J. F., Cagnone, G., Vaghjiani, V., Brown, K. A., Johns, T. G. & St John, J. C., 2015, In : Cell Death and Disease. 6, 2 (Art. No: e1664), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014
24 Citations (Scopus)

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation

Gough, D. J., Marié, I. J., Lobry, C., Aifantis, I. & Levy, D. E., 2 Oct 2014, In : Blood. 124, 14, p. 2252-2261 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
58 Citations (Scopus)

The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and ras-mediated transformation

Gough, D. J., Koetz, L. & Levy, D. E., 29 Nov 2013, In : PLoS ONE. 8, 11, e83395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012
204 Citations (Scopus)

Constitutive type I interferon modulates homeostatic balance through tonic signaling

Gough, D. J., Messina, N. L., Clarke, C. J. P., Johnstone, R. W. & Levy, D. E., 2012, In : Immunity. 36, 2, p. 166 - 174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nongenomic functions of STAT3

Gough, D. J., Seghal, P. B. & Levy, D. E., 2012, Jak-Stat Signaling: From Basics to Disease. Decker, T. & Muller, M. (eds.). Wien: Springer, p. 91 - 98 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

27 Citations (Scopus)

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function

Lee, J. E., Yang, Y-M., Liang, F-X., Gough, D. J., Levy, D. E. & Seghal, P. B., 2012, In : American Journal of Physiology - Cell Physiology. 302, 5, p. C804 - C820 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
138 Citations (Scopus)

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

Demaria, M., Diorgi, C., Lebiedzinska, M., Esposito, G., D'Angeli, L., Bartoli, A., Gough, D. J., Turkson, J., Levy, D. E., Watson, C. J., Wieckowski, M. R., Provero, P., Pinton, P. & Poli, V., 2010, In : Aging. 2, 11, p. 823-842 20 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

Functional crosstalk between type I and II interferon through the regulated expression of STAT1

Gough, D. J., Messina, N. L., Hii, L., Gould, J. A., Sabapathy, K., Robertson, A. P. S., Trapani, J. A., Levy, D. E., Hertzog, P. J., Clarke, C. J. P. & Johnstone, R. W., 2010, In : PLoS Biology. 8, 4 (e1000361), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
414 Citations (Scopus)

Mitochondrial STAT3 supports RasDependent oncogenic transformation

Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C. & Levy, D. E., 2009, In : Science. 324, 5935, p. 1713 - 1716 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
193 Citations (Scopus)

IFNgamma signaling-does it mean JAK-STAT?

Gough, D. J., Levy, D. E., Johnstone, R. W. & Clarke, C. J. P., 2008, In : Cytokine and Growth Factor Reviews. 19, 5-6, p. 383 - 394 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The role of p202 in regulating hematopoietic cell proliferation and differentiation

Ludlow, L. E., Purton, L. E., Klarmann, K., Gough, D. J., Hii, L. L. P., Trapani, J. A., Keller, J., Clarke, C. J. P. & Johnstone, R. W., 2008, In : Journal of Interferon and Cytokine Research. 28, 1, p. 5 - 11 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of p202 in regulating hematopoietic cell proliferation and differentiation (Journal of Interferon and Cytokine Research 28, 1, (5-11))

Ludlow, L. E., Purton, L. E., Klarmann, K., Gough, D. J., Hii, L. L., Trapani, J. A., Keller, J. R., Clarke, C. J. P. & Johnstone, R. W., 1 Feb 2008, In : Journal of Interferon and Cytokine Research. 28, 2, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2007
44 Citations (Scopus)

A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes

Gough, D. J., Sabapathy, K., Ko, E. Y-N., Arthur, H. A., Schreiber, R. D., Trapani, J. A., Clarke, C. J. P. & Johnstone, R. W., 2007, In : Journal of Biological Chemistry. 282, 2, p. 938 - 946 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
19 Citations (Scopus)

Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16

Clarke, C. J. P., Apostolidis, V. A., Hii, L. L. P., Gough, D. J., Trapani, J. A. & Johnstone, R. W., 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 80 - 93 14 p.

Research output: Contribution to journalArticleResearchpeer-review