Projects per year
Personal profile
Biography
Daniel Gough is a biochemist and cancer biologist and the head of the STAT Cancer Biology laboratory in the Centre for Cancer Research at the Monash Institute of Medical Research. Daniel's research focuses on signal transduction pathways which engage the Signal Transducer and Activator of Transcription (STAT) proteins in normal development and how these pathways impact cancer and immunity.
After completing his B.Sc (2000), B.Sc(Hons) (2001) in the Department of Pathology at the University of Melbourne, and Ph.D (2006) at the Peter MacCallum Cancer Centre, Daniel moved to New York University in the U.S.A for post doctoral training with Professor David E Levy (Dr. Louis A. Schneider Professor of Molecular Pathology and Professor of Microbiology and Associate Dean for Collaborative Science). During this time Daniel defined a mitochondrial and metabolic role for STAT3 which is necessary for cancers driven by Ras mutation. In 2012 Daniel was recruited to return to Australia to start his laboratory.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, Mechanisms of Interferon-mediated gene transcription, University of Melbourne
Award Date: 1 Jun 2006
Research area keywords
- Stat3
- Mitochondria
- Lung Cancer
- mouse models
- novel therapeutics
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing new therapies to improve Small Cell Lung Cancer patient outcomes
1/04/20 → 31/03/24
Project: Research
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Hudson-Monash Paediatric Precision Medicine Program: Phase 2
Firestein, R., Cain, J., Gough, D., Huang, A., Daly, R., Williams, B. & Rosenbluh, S.
1/09/19 → 30/08/22
Project: Research
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Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer
Gough, D., Watkins, D. N., Sutherland, K. & Shortt, J.
1/01/18 → 31/12/20
Project: Research
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Paediatric Cancer Precision Medicine Pilot Program
Firestein, R., Cain, J., Downie, P., Gough, D., Williams, B., Abud, H., Rosenbluh, S., Algar, E. & Wood, P.
1/09/17 → 30/08/19
Project: Research
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Circulating Tumour DNA (ctDNA) as a Predictor of Clinical Outcome in Non-Small Cell Lung Cancer Undergoing Targeted Therapies: A Systematic Review and Meta-Analysis
Zaman, F. Y., Subramaniam, A., Afroz, A., Samoon, Z., Gough, D., Arulananda, S. & Alamgeer, M., May 2023, In: Cancers. 15, 9, 18 p., 2425.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus) -
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
Sun, C. X., Daniel, P., Bradshaw, G., Shi, H., Loi, M., Chew, N., Parackal, S., Tsui, V., Liang, Y., Koptyra, M., Adjumain, S., Sun, C., Chong, W. C., Fernando, D., Drinkwater, C., Tourchi, M., Habarakada, D., Sooraj, D., Carvalho, D., Storm, P. B., & 36 others, 10 Apr 2023, In: Cancer Cell. 41, 4, p. 660-677.e7 26 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
Chen, J., Guanizo, A. C., Jakasekara, W. S. N., Inampudi, C., Luong, Q., Garama, D. J., Alamgeer, M., Thakur, N., DeVeer, M., Ganju, V., Watkins, D. N., Cain, J. E. & Gough, D. J., Dec 2023, In: Journal of Experimental and Clinical Cancer Research. 42, 1, 14 p., 100.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
Sparbier, C. E., Gillespie, A., Gomez, J., Kumari, N., Motazedian, A., Chan, K. L., Bell, C. C., Gilan, O., Chan, Y. C., Popp, S., Gough, D. J., Eckersley-Maslin, M. A., Dawson, S. J., Lehner, P. J., Sutherland, K. D., Ernst, P., McGeehan, G. M., Lam, E. Y. N., Burr, M. L. & Dawson, M. A., Feb 2023, In: Nature Cell Biology. 25, 2, p. 258-272 15 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium
Chen, J., Guanizo, A., Luong, Q., Jayasekara, W. S. N., Jayasinghe, D., Inampudi, C., Szczepny, A., Garama, D. J., Russell, P. A., Ganju, V., Cain, J. E., Watkins, D. N. & Gough, D. J., 3 Jan 2022, In: Oncogene. 41, 1, p. 138-145 8 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus)