Projects per year
Personal profile
Biography
Daniel Gough is a biochemist and cancer biologist and the head of the STAT Cancer Biology laboratory in the Centre for Cancer Research at the Monash Institute of Medical Research. Daniel's research focuses on signal transduction pathways which engage the Signal Transducer and Activator of Transcription (STAT) proteins in normal development and how these pathways are altered in childhood cancers.
After completing his B.Sc (2000), B.Sc(Hons) (2001) in the Department of Pathology at the University of Melbourne, and Ph.D (2006) at the Peter MacCallum Cancer Centre, Daniel moved to New York University in the U.S.A for post doctoral training with Professor David E Levy (Dr. Louis A. Schneider Professor of Molecular Pathology and Professor of Microbiology and Associate Dean for Collaborative Science). During this time Daniel defined a mitochondrial and metabolic role for STAT3 which is necessary for cancers driven by Ras mutation. In 2012 Daniel was recruited to return to Australia to start his laboratory.
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Projects 2010 2020
Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer
Gough, D., Watkins, D. N., Sutherland, K. & Shortt, J.
1/01/18 → 31/12/20
Project: Research
Paediatric Cancer Precision Medicine Pilot Program
Firestein, R., Cain, J., Downie, P., Gough, D., Williams, B., Abud, H., Rosenbluh, S., Algar, E. & Wood, P.
1/09/17 → 30/08/19
Project: Research
Targeting mitochondrial STAT3 in gastric cancer
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
Defining the potential of targeting STAT3 as a treatment for CMYC driven tumours
Gough, D. & Unknown, ..
1/01/14 → 31/12/15
Project: Research
Research Output 2003 2019
Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map
Huynh, J., Chand, A., Gough, D. & Ernst, M., 1 Feb 2019, In : Nature Reviews Cancer. 19, 2, p. 82-96 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2
Liu, Y. D., Yu, L., Ying, L., Balic, J., Gao, H., Deng, N. T., West, A., Yan, F., Ji, C. B., Gough, D., Tan, P., Jenkins, B. J. & Li, J. K., 15 Jun 2019, In : International Journal of Cancer. 144, 12, p. 3056-3069 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
A phase IIa study of HA-irinotecan, formulation of hyaluronic acid and irinotecan targeting CD44 in extensive-stage small cell lung cancer
Alamgeer, M., Neil Watkins, D., Banakh, I., Kumar, B., Gough, D. J., Markman, B. & Ganju, V., 1 Apr 2018, In : Investigational New Drugs. 36, 2, p. 288-298 11 p.Research output: Contribution to journal › Article › Research › peer-review
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, 7 Mar 2018, In : Oncogene. 38, 10, p. 1661-1675 15 p.Research output: Contribution to journal › Article › Research › peer-review
Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine
Sandow, J. J., Rainczuk, A., Infusini, G., Makanji, M., Bilandzic, M., Wilson, A. L., Fairweather, N., Stanton, P. G., Garama, D., Gough, D., Jobling, T. W., Webb, A. I. & Stephens, A. N., 1 May 2018, In : Proteomics - Clinical Applications. 12, 3, 10 p., 1700135.Research output: Contribution to journal › Article › Research › peer-review