Projects per year
Personal profile
Biography
Daniel Gough is a biochemist and cancer biologist and the head of the STAT Cancer Biology laboratory in the Centre for Cancer Research at the Monash Institute of Medical Research. Daniel's research focuses on signal transduction pathways which engage the Signal Transducer and Activator of Transcription (STAT) proteins in normal development and how these pathways impact cancer and immunity.
After completing his B.Sc (2000), B.Sc(Hons) (2001) in the Department of Pathology at the University of Melbourne, and Ph.D (2006) at the Peter MacCallum Cancer Centre, Daniel moved to New York University in the U.S.A for post doctoral training with Professor David E Levy (Dr. Louis A. Schneider Professor of Molecular Pathology and Professor of Microbiology and Associate Dean for Collaborative Science). During this time Daniel defined a mitochondrial and metabolic role for STAT3 which is necessary for cancers driven by Ras mutation. In 2012 Daniel was recruited to return to Australia to start his laboratory.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, University of Melbourne
Award Date: 1 Jun 2006
Research area keywords
- Stat3
- Mitochondria
- Lung Cancer
- mouse models
- novel therapeutics
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing new therapies to improve Small Cell Lung Cancer patient outcomes
1/04/20 → 31/03/24
Project: Research
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Hudson-Monash Paediatric Precision Medicine Program: Phase 2
Firestein, R., Cain, J., Gough, D., Huang, A., Daly, R., Williams, B. & Rosenbluh, S.
1/09/19 → 30/08/22
Project: Research
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Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer
Gough, D., Watkins, D. N., Sutherland, K. & Shortt, J.
1/01/18 → 31/12/20
Project: Research
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Paediatric Cancer Precision Medicine Pilot Program
Firestein, R., Cain, J., Downie, P., Gough, D., Williams, B., Abud, H., Rosenbluh, S., Algar, E. & Wood, P.
1/09/17 → 30/08/19
Project: Research
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Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium
Chen, J., Guanizo, A., Luong, Q., Jayasekara, W. S. N., Jayasinghe, D., Inampudi, C., Szczepny, A., Garama, D. J., Russell, P. A., Ganju, V., Cain, J. E., Watkins, D. N. & Gough, D. J., 3 Jan 2022, In: Oncogene. 41, 1, p. 138-145 8 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
Dowling, J. K., Afzal, R., Gearing, L. J., Cervantes-Silva, M. P., Annett, S., Davis, G. M., De Santi, C., Assmann, N., Dettmer, K., Gough, D. J., Bantug, G. R., Hamid, F. I., Nally, F. K., Duffy, C. P., Gorman, A. L., Liddicoat, A. M., Lavelle, E. C., Hess, C., Oefner, P. J., Finlay, D. K. & 6 others, , Dec 2021, In: Nature Communications. 12, 1, 14 p., 1460.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity
Schaschkow, A., Pang, L., Vandenbempt, V., Elvira, B., Litwak, S. A., Vekeriotaite, B., Maillard, E., Vermeersch, M., Paula, F. M. M., Pinget, M., Perez-Morga, D., Gough, D. J. & Gurzov, E. N., 1 Sep 2021, In: Diabetes. 70, 9, p. 2026-2041 16 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease
Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., D'Costa, K., Deswaerte, V., Dev, A., Sievert, W., Gough, D. J., Bhathal, P. S., Ferrero, R. L. & Jenkins, B. J., Jun 2020, In: American Journal of Pathology. 190, 6, p. 1256-1270 15 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation
Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P. & Jenkins, B. J., Jun 2020, In: Cytokine. 130, 6 p., 155059.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)