Projects per year
Personal profile
Biography
Daniel Gough is a biochemist and cancer biologist and the head of the STAT Cancer Biology laboratory in the Centre for Cancer Research at the Monash Institute of Medical Research. Daniel's research focuses on signal transduction pathways which engage the Signal Transducer and Activator of Transcription (STAT) proteins in normal development and how these pathways impact cancer and immunity.
After completing his B.Sc (2000), B.Sc(Hons) (2001) in the Department of Pathology at the University of Melbourne, and Ph.D (2006) at the Peter MacCallum Cancer Centre, Daniel moved to New York University in the U.S.A for post doctoral training with Professor David E Levy (Dr. Louis A. Schneider Professor of Molecular Pathology and Professor of Microbiology and Associate Dean for Collaborative Science). During this time Daniel defined a mitochondrial and metabolic role for STAT3 which is necessary for cancers driven by Ras mutation. In 2012 Daniel was recruited to return to Australia to start his laboratory.
Education/Academic qualification
Biochemistry, PhD, University of Melbourne
Award Date: 1 Jun 2006
Research area keywords
- Stat3
- Mitochondria
- Lung Cancer
- mouse models
- novel therapeutics
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
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Developing new therapies to improve Small Cell Lung Cancer patient outcomes
1/04/20 → 31/03/24
Project: Research
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Hudson-Monash Paediatric Precision Medicine Program: Phase 2
Firestein, R., Cain, J., Gough, D., Huang, A., Daly, R., Williams, B. & Rosenbluh, S.
1/09/19 → 30/08/22
Project: Research
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Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer
Gough, D., Watkins, D. N., Sutherland, K. & Shortt, J.
1/01/18 → 31/12/20
Project: Research
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Paediatric Cancer Precision Medicine Pilot Program
Firestein, R., Cain, J., Downie, P., Gough, D., Williams, B., Abud, H., Rosenbluh, S., Algar, E. & Wood, P.
1/09/17 → 30/08/19
Project: Research
Research output
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Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease
Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., D'Costa, K., Deswaerte, V., Dev, A., Sievert, W., Gough, D. J., Bhathal, P. S., Ferrero, R. L. & Jenkins, B. J., Jun 2020, In : American Journal of Pathology. 190, 6, p. 1256-1270 15 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation
Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P. & Jenkins, B. J., Jun 2020, In : Cytokine. 130, 6 p., 155059.Research output: Contribution to journal › Article › Research › peer-review
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Balic, J. J., Albargy, H., Luu, K., Kirby, F. J., Jayasekara, W. S. N., Mansell, F., Garama, D. J., De Nardo, D., Baschuk, N., Louis, C., Humphries, F., Fitzgerald, K., Latz, E., Gough, D. J. & Mansell, A., 30 Jul 2020, In : Nature Communications. 11, 1, 11 p., 3816.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
A sexually dimorphic role for STAT3 in sonic hedgehog medulloblastoma
White, C. L., Jayasekara, W. S. N., Picard, D., Chen, J., Watkins, D. N., Cain, J. E., Remke, M. & Gough, D. J., 1 Nov 2019, In : Cancers. 11, 11, 13 p., 1702.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, , 7 Mar 2019, In : Oncogene. 38, 10, p. 1661-1675 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus)